Shows / This Is Why with Dr. Busti
This Is Why with Dr. Busti
This Is Why exists to help medical professionals understand the why behind the decisions they make every day in patient care. Our approach is about integrating evidence, clinical relevance and real-world application so that what your learn connects directly with the patients you serve.
Episodes
- This Is Why with Dr. Busti
Furosemide (Lasix) PO to IV Dose Conversions Explained
Dr. Busti explains furosemide (Lasix) PO to IV dose conversion and why the appropriate Lasix IV dose depends on the patient's clinical state and treatment…
- This Is Why with Dr. Busti
How to Report & Evaluate a Systematic Review: PRISMA & AMSTAR-2
PRISMA 2020 and AMSTAR-2 are two important tools for evaluating how systematic reviews are reported and critically appraised. In this episode of This Is Why…
- This Is Why with Dr. Busti
Understanding GRADE in Meta-Analysis: How to Judge Quality of Evidence
GRADE is one of the most widely used systems for evaluating the quality and certainty of evidence in systematic reviews and meta-analyses. In this episode of…
- This Is Why with Dr. Busti
Gallbladder Anatomy & Physiology Made Clinically Relevant
Dr. Busti will explain gallbladder anatomy and gallbladder physiology, connecting bile flow and gallstones to the clinical findings healthcare professionals…
- This Is Why with Dr. Busti
How to Interpret a Forest Plot in a Meta-Analysis
Forest plots are an important tool in evidence-based medicine, yet many clinicians can recognize one without confidently interpreting what it is actually…
- This Is Why with Dr. Busti
How a Systematic Review & Meta-Analysis is Done: Key Steps Explained
Systematic reviews and meta-analyses are often considered among the highest levels of clinical evidence—but only when they are performed using rigorous…
- This Is Why with Dr. Busti
Systematic Review vs Meta-Analysis: What's the Difference?
Systematic Review vs Meta-Analysis is one of the most commonly misunderstood topics in evidence-based medicine. In this episode of This Is Why, Dr. Busti…
- This Is Why with Dr. Busti
PARADIGM-HF Trial: Why Sacubitril/Valsartan Changed HFrEF Care
Dr. Busti explains why the PARADIGM-HF trial changed treatment for heart failure with reduced ejection fraction (HFrEF), connecting sacubitril/valsartan to the…
- This Is Why with Dr. Busti
TMP-SMX + Spironolactone Drug Interaction: Why Potassium Can Rise
Trimethoprim-sulfamethoxazole, or TMP-SMX, and spironolactone can impair renal potassium excretion through different mechanisms. This lecture explains how…
- This Is Why with Dr. Busti
Amiodarone and Digoxin: Drug Interaction Explained
The amiodarone and digoxin drug interaction is one of the most clinically important cardiovascular drug interactions to understand because it can raise digoxin…
- This Is Why with Dr. Busti
Likelihood Ratios (LR) Explained for Diagnostic Testing
Likelihood ratios (LR) are one of the most clinically useful tools in diagnostic testing because they help clinicians determine whether a test meaningfully…
- This Is Why with Dr. Busti
Positive and Negative Predictive Values Explained Clinically
Positive and negative predictive values are critical for understanding what diagnostic test results actually mean in clinical practice. In this episode of This…
- This Is Why with Dr. Busti
ROC Curves Explained: Understanding Diagnostic Cutoffs
ROC curves and the AUC (or c-statistic) are some of the most important — and most misunderstood — concepts in diagnostic testing and evidence-based medicine…
- This Is Why with Dr. Busti
Sensitivity & Specificity Explained for Clinical Practice
Sensitivity and specificity are some of the most misunderstood concepts in evidence-based medicine and diagnostic testing. In this episode of This Is Why with…
- This Is Why with Dr. Busti
Diagnostic Tests Explained: Precision & Accuracy in Practice
Diagnostic tests used in research and clinical practice are essential to evidence-based medicine because they shape how clinicians diagnose disease, interpret…
- This Is Why with Dr. Busti
Diagnostic Tests & Studies: How to Use & Evaluate in Practice
Diagnostic studies are foundational to evidence-based medicine because they help clinicians determine disease presence, severity, progression, and treatment…
- This Is Why with Dr. Busti
Regression Analysis Explained: Confounders & Clinical Meaning
Regression analysis explained — understanding how variables influence outcomes is essential for interpreting clinical research in this episode of This Is Why…
- This Is Why with Dr. Busti
SUSPEND Trial | Tamsulosin for Kidney Stones Explained
Tamsulosin for kidney stones is one of the most commonly prescribed therapies for ureteral stones — but does it actually help? In this episode of This Is Why…
- This Is Why with Dr. Busti
Epistaxis Explained Why Nosebleeds Happen | Dr. Busti
Epistaxis explained by Dr. Busti. In this episode on This Is Why, we break down why epistaxis happens, how clinicians think through causes of bleeding, and why…
- This Is Why with Dr. Busti
Effect Size (Relative Risk (RR), Odds Ratio (OR), NNT/NNH) Made Simple
Effect size (Relative risk vs odds ratio vs hazard ratio & NNT and NNH explained — This Is Why understanding these concepts is essential for interpreting…
- This Is Why with Dr. Busti
D-Dimer Explained: When Suspected DVT Needs Ultrasound
D-dimer explained for DVT evaluation. This Is Why healthcare professionals must understand what an elevated D-dimer actually means before jumping to…
- This Is Why with Dr. Busti
NINDS Trial Explained Stroke Thrombolysis Risks and Benefits
Stroke thrombolysis changed emergency neurology forever—but understanding why the NINDS trial mattered is what transforms memorization into clinical…
- This Is Why with Dr. Busti
95% Confidence Intervals Explained for Medical Literature
Confidence intervals are one of the most misunderstood concepts in evidence-based medicine. In this episode of This Is Why with Dr. Busti, we break down what…
- This Is Why with Dr. Busti
Tinnitus Explained: Symptom vs Diagnosis
Tinnitus explained clearly—This Is Why it matters clinically with Dr. Busti. Understanding tinnitus as a symptom, not a diagnosis, changes how you think…
- This Is Why with Dr. Busti
P Values Explained Clearly: Statistical vs Clinical Significance
P values explained clearly in clinical research — This Is Why understanding what a P value means (and does NOT mean) with Dr. Busti is critical for…
- This Is Why with Dr. Busti
Why Sulfonylureas Cause Hypoglycemia Explained
Why sulfonylureas cause hypoglycemia becomes much easier to understand once you know how pancreatic beta cells regulate insulin secretion. In this episode of…
- This Is Why with Dr. Busti
Correlation vs R Squared Explained This Is Why It Matters
In this episode on This Is Why, Dr. Busti breaks down one of the most commonly misunderstood biostatistics concepts: correlation vs coefficient of…
- This Is Why with Dr. Busti
Biostatistics Framework | Mean, Median, Mode Explained + SD vs SEM
Mean, median, mode, standard deviation, and standard error explained in the context of clinical research and data interpretation. In this This Is Why lecture…
- This Is Why with Dr. Busti
GISSI-3 Trial: ACE Inhibitors After MI Explained
ACE inhibitors after myocardial infarction — Dr. Busti explains the GISSI-3 trial and what it actually changed in clinical practice on this episode of This Is…
- This Is Why with Dr. Busti
Amiodarone in Cardiac Arrest: ARREST Trial Explained
Amiodarone in cardiac arrest — Dr. Busti breaks down the ARREST trial and what it actually means for patient outcomes in this episode of This Is Why. When…
- This Is Why with Dr. Busti
Medical Terminology: Sternutate
What does “sternutate” actually mean, and why does medicine use complex terms for simple human experiences like sneezing? In this episode of This Is Why, Dr…
- This Is Why with Dr. Busti
Power Analysis Explained: Type II Error, Beta, and Sample Size
Power analysis is essential for interpreting clinical research and determining whether a study can truly detect a meaningful difference. In this lecture on…
- This Is Why with Dr. Busti
Alpha Value Explained (Type I Error)| Biostatistics Series
Alpha value and Type I error are foundational concepts in biostatistics and clinical research interpretation. In this lecture on This Is Why, Dr. Busti will…
- This Is Why with Dr. Busti
Parametric vs Non-Parametric Statistical Tests Explained
Parametric vs Non-Parametric statistical tests are explained, and how they relate to data type, distribution, and study design. In this lecture on This Is Why…
- This Is Why with Dr. Busti
Independent vs Paired Groups Explained (Choose the Right Test)
Independent vs paired study groups explained and how they determine the correct statistical test in clinical research. In this This Is Why lecture, Dr. Busti…
- This Is Why with Dr. Busti
Practice Question: Parkinson Disease Medication Discontinuation Safety
Parkinson disease medication discontinuation safety is the focus of this episode of This Is Why with Dr. Busti. In this board-style practice question, we work…
- This Is Why with Dr. Busti
Types of Data Explained: Nominal, Ordinal, or Continuous?
Types of data for a study's endpoint are explained—nominal, ordinal, or continuous—and how each determines the appropriate statistical test in clinical…
- This Is Why with Dr. Busti
Intro to Biostatistics: How to Pick the Right Statistical Test
How do you choose the right statistical test in clinical research? In this This Is Why (TIW) lecture, Dr. Busti introduces the biostatistics decision-making…
- This Is Why with Dr. Busti
What Is Dyspnea? (Shortness of Breath Explained)
What is dyspnea, and why does it matter in clinical practice? In this episode of This Is Why, Dr. Busti breaks down the medical term dyspnea—commonly described…
- This Is Why with Dr. Busti
Internal and External Validity in Research: Are the Results Real?
Internal and external validity are foundational to interpreting clinical research and applying evidence in practice. In this This Is Why lecture, Dr. Busti…
- This Is Why with Dr. Busti
Types of Bias in Clinical Research & Impact on Results
Types of bias in research and their impact on results are critical to understanding study design, internal validity, and clinical decision-making. In this…
- This Is Why with Dr. Busti
Practice Question: Picking the Right Benzodiazepine on Metabolism
Picking the right benzodiazepine based on its metabolism is a critical concept for understanding medication safety, especially when considering hepatic…
- This Is Why with Dr. Busti
Hypothesis Testing Explained for Clinical Research
Hypothesis testing is a core concept in biostatistics and evidence-based medicine. In this This Is Why lecture, Dr. Busti explains how hypotheses guide…
- This Is Why with Dr. Busti
Types of Study Designs in Clinical Research Explained & Made Easy
The ultimate guide to types of study designs used in clinical research is explained and made easy for clinicians and researchers. In this lecture on This Is…
- This Is Why with Dr. Busti
The Steps of Clinical Research & Design Explained
Clinical research design and the NIH clinical research process are explained for clinicians. In this This Is Why lecture, Dr. Busti introduces the foundations…
- This Is Why with Dr. Busti
Practice Question: CHA₂DS₂-VASc Score AF
CHA₂DS₂-VASc score atrial fibrillation is a critical concept for determining when anticoagulation is recommended. In this episode of This Is Why with Dr…
- This Is Why with Dr. Busti
Proctalgia Fugax: Medical Terminology Explained
What is proctalgia fugax, and why does this term matter in real clinical practice? In this episode of This Is Why, Dr. Busti breaks down the meaning of…
- This Is Why with Dr. Busti
LAMA (Long-Acting Muscarinic Antagonists) Bronchodilators for COPD
In this lecture from This is Why, Dr. Busti will explain the COPD maintenance inhalers you’ll actually see in practice. In this pharmacology review, we break…
- This Is Why with Dr. Busti
SAMA (Short-Acting Muscarinic Antagonists) Bronchodilator Pharmacology
Short-acting muscarinic antagonists (SAMAs) are a core bronchodilator drug class you’ll see constantly in COPD care. In this lecture from This is Why, Dr…
- This Is Why with Dr. Busti
GLP-1 Receptor Agonists (eg, Semaglutide) Diabetes Pharmacology Review
Understand the GLP-1 receptor agonists—and why agents like semaglutide (Ozempic/Wegovy/Rybelsus), liraglutide, dulaglutide, and exenatide have become one of…
- This Is Why with Dr. Busti
Insulin Types: Rapid, NPH, Basal for Diabetes - Pharmacology Review
Insulin doesn’t have to be confusing when learning how to treat Type 1 and Type 2 diabetes mellitus. In this lecture from This is Why, Dr. Busti will explain…
- This Is Why with Dr. Busti
LABA (Long-Acting Beta Agonists) Bronchodilators for Asthma & COPD
In this lecture from This is Why, Dr. Busti will explain how Long-Acting Beta Agonists (LABAs) work, where they fit in therapy for the management of asthma and…
- This Is Why with Dr. Busti
Meglitinides (Nateglinide & Repaglinide): Diabetes Pharmacology Review
Meglitinides (Nateglinide & Repaglinide) can feel like the “forgotten” oral diabetes drugs—but they show up on exams, in real-world medication histories, and…
- This Is Why with Dr. Busti
SABA (Short-Acting Beta Agonists) Bronchodilators for Asthma & COPD
In this lecture from This is Why, Dr. Busti will break down SABA (Short-Acting Beta Agonist) bronchodilators, like albuterol, for the acute management of…
- This Is Why with Dr. Busti
SGLT2 Inhibitors (eg, Empagliflozin) for Diabetes: Pharmacology Review
SGLT2 inhibitors (bexagliflozin, canagliflozin, dapagliflozin, empagliflozin, ertugliflozin) don’t just lower glucose and A1C, but these meds have become…
- This Is Why with Dr. Busti
Sulfonylureas (Glyburide, Glipizide): Type 2 Diabetes Pharmacology
Dr. Busti covers one of the most-tested Type 2 diabetes drug classes—sulfonylureas. If you’ve ever mixed up glyburide vs glipizide, worried about hypoglycemia…
- This Is Why with Dr. Busti
TZDs (Pioglitazone) for Type 2 Diabetes: Pharmacology Review
In this lecture from This is Why, Dr. Busti will break down pioglitazone and the thiazolidinediones (TZDs) so you can confidently explain the mechanism…
- This Is Why with Dr. Busti
Alpha-Glucosidase Inhibitors for Diabetes: Pharmacology Made Easy
In this lecture from This is Why, Dr. Busti will teach you about Alpha-Glucosidase Inhibitors for Diabetes — the pharmacology made easy breakdown of acarbose…
- This Is Why with Dr. Busti
Amylin Analogs (Pramlintide) for Diabetes: Pharmacology Made Easy
Amylin Analogs (Pramlintide) for Diabetes: Pharmacology Made Easy. In this lecture from This is Why, Dr. Busti will explain how pramlintide (Symlin/SymlinPen)…
- This Is Why with Dr. Busti
DPP-4 Inhibitors for Type 2 Diabetes: Pharmacology Made Easy
In this lecture from This is Why, Dr. Busti will learn about the application of DPP-4 inhibitors in the management of type 2 diabetes mellitus (T2DM). The…