Sulfonylureas (Glyburide, Glipizide): Type 2 Diabetes Pharmacology

This Is Why with Dr. Busti · Jan 27, 2026 · 22m

Dr. Busti covers one of the most-tested Type 2 diabetes drug classes—sulfonylureas. If you’ve ever mixed up glyburide vs glipizide, worried about hypoglycemia, or wanted a clear “when do I pick this?” framework, this drug class review is for you. In this lecture from This is Why, Dr. Busti will break down Sulfonylureas (Glyburide, Glipizide) step-by-step so you can confidently in the context of treating type 2 diabetes (T2DM).

You’ll learn how to:

- Mechanism of action: how sulfonylureas increase insulin release

- Clinical use: where sulfonylureas still fit in modern Type 2 diabetes…