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NINDS Trial Explained Stroke Thrombolysis Risks and Benefits
Stroke thrombolysis changed emergency neurology forever—but understanding why the NINDS trial mattered is what transforms memorization into clinical decision-making. In this episode of This Is Why with Dr. Busti, we break down the landmark NINDS rt-PA trial that established alteplase as a treatment for acute ischemic stroke and explore the real-world balance between functional recovery and intracerebral hemorrhage risk.
Dr. Busti explains how to interpret the trial beyond headlines by walking through the study design, inclusion criteria, outcomes, NNT and NNH calculations, odds ratios…
The skinny
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