Shows / Aging-US
Aging-US
Aging is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease. Read about the Aging Scientific Integrity Process: https://aging-us.com/scientific-integrity
Episodes
Aging-USNew Aging Framework Shifts Focus of Late-Life Rejuvenation to Systemic Signaling
BUFFALO, NY — November 10, 2026 — A new #research perspective was #published in Volume 18 of Aging on October 20, 2026, titled “From hyperfunction to systemic…
Aging-USEpigenetic Aging Signal Is Linked to Brain Changes Associated With Dementia Risk
Two people can be the same chronological age and yet differ considerably in how quickly their bodies appear to be aging. Scientists have developed “epigenetic…
Aging-USFerroptosis-Related Genes in Muscular Dystrophy May Offer New Insights Into Muscle Aging
BUFFALO, NY — November 5, 2026 — A new #research paper was #published in Volume 18 of Aging on October 14, 2026, titled “Ferroptosis-related hub genes and…
Aging-USNew Aging Framework Proposes Epigenetic Regulation as a Major Limit on Human Lifespan
BUFFALO, NY — November 3, 2026 — A new #review was #published in Volume 18 of Aging on October 9, 2026, titled “The polycentric aging framework: epigenetic…
Aging-USLongevity & Aging Series (S4, E8): Rose S. Al-Saadi
In this episode of the Longevity & Aging Series (S4, E8), Rose S. Al-Saadi from the Institute of Ecology and Evolution, University of Oregon, Eugene, joins…
Aging-USSmall Extracellular Vesicles Found to Spread Cellular Senescence in Models of Aging
BUFFALO, NY — October 29, 2026 — A new #research paper was #published in Volume 18 of Aging on October 8, 2026, titled “Small extracellular vesicles as…
Aging-USBody Composition, Rather Than Masculine Physical Traits, Linked to Aging Markers in Middle-Aged Men
BUFFALO, NY — October 28, 2026 — A new #research paper was #published in Volume 18 of Aging on October 6, 2026, titled “Body composition, but not morphological…
Aging-USProgerin Expression Creates a Yeast Model of Premature Aging
Aging is shaped not only by changes in DNA and metabolism but also by the gradual accumulation of proteins that cells struggle to remove. One striking example…
Aging-USHypomagnetic Fields Extend Survival but Reduce Mobility in Fly Model of Parkinson’s Disease
BUFFALO, NY — October 22, 2026 — A new #research paper was #published in Volume 18 of Aging on September 23, 2026, titled “Hypomagnetic fields modulate…
Aging-USmTOR Signaling Emerges as a Key Regulator of Aging, Highlighting Need for Targeted Interventions
BUFFALO, NY — October 20, 2026 — A new #review was #published in Volume 18 of Aging on September 19, 2026, titled “mTOR signaling in aging: from causality to…
Aging-USBehind the Study: Drug Combo Targets Cancer & Senescent Cells, Extends Lifespan in Old Mice
Aging Editorial Board member Dr. Irina Conboy and Dr. Zachery Robinson from the Department of Bioengineering and QB3 Institute at the University of California…
Aging-USLongevity & Aging Series (S4, E7): Dr. Irina Conboy and Dr. Zachery Robinson
In this episode of the Longevity & Aging Series (S4, E7), Dr. Irina Conboy and Dr. Zachery Robinson from the Department of Bioengineering and QB3 Institute at…
Aging-USEditors’ Choice: Social determinants of health and risk of dementia in people with and without type 2 diabetes
This month’s Editor’s Choice features the #research paper recently #published in Aging, titled “Social determinants of health and risk of dementia in people…
Aging-USNew Control Theory Framework Proposes a Safer Approach to Aging Drug Discovery
BUFFALO, NY — October 15, 2026 — A new #research paper was #published in Volume 18 of Aging on September 16, 2026, titled “Control theory of aging and…
Aging-USNew Gene–Phenotype Catalogue Maps the Genetic Landscape of Premature Aging
Rare genetic disorders that cause features of aging to appear much earlier than expected can offer an unusual window into the biology of human aging. Yet…
Aging-USTargeting PLA2G15 Reduces Senescence and Alters Lipid Metabolism in Kidney Cells
BUFFALO, NY — October 13, 2026 — A new #research paper was #published in Volume 18 of Aging on September 16, 2026, titled “Targeting phospholipase Pla2g15…
Aging-USBehavioral Complexity Could Offer New Insights Into Aging and Frailty
BUFFALO, NY — October 8, 2026 — A new #commentary was #published in Volume 18 of Aging on September 12, 2026, titled “Complexity, variability, and the…
Aging-USMini-GRID Radiotherapy Reduces Senescence While Preserving Growth Inhibition in Glioma Cells
BUFFALO, NY — October 6, 2026 — A new #research paper was recently #published in Volume 18 of Aging, titled “Spatially fractionated mini-GRID radiotherapy…
Aging-USAging Supports the 11th International Cell Senescence Association Conference
BUFFALO, NY — October 5, 2026 — Aging is pleased to support the 11th International Cell Senescence Association (ICSA) Conference, taking place November 3–5…
Aging-USAdverse Social Determinants Linked to Higher Dementia Risk in People With Type 2 Diabetes
BUFFALO, NY — October 1, 2026 — A new #research paper was #published in Volume 18 of Aging on September 10, 2026, titled “Social determinants of health and…
Aging-USATF5 Helps Preserve Mitochondrial Quality and Muscle Endurance During Aging
Aging is commonly associated with the gradual loss of skeletal muscle mass and function. While preserving muscle mass is important, muscle health also depends…
Aging-USDevelopmental Senescence Emerges as a Candidate Mechanism in CHARGE Syndrome
BUFFALO, NY — September 29, 2026 — A new #review was #published in Volume 18 of Aging on September 8, 2026, titled “Developmental senescence misregulation in…
Aging-USLongevity & Aging Series (S4, E6): Dr. Adam Bohnert
In this episode of the Longevity & Aging Series (S4, E6), Dr. Adam Bohnert from the Department of Biological Sciences at Louisiana State University (Baton…
Aging-USExceptional Longevity Across Species Linked to DNA Maintenance, Stemness and Stress Resistance
BUFFALO, NY — September 24, 2026 — A new #review was #published in Volume 18 of Aging on September 8, 2026, titled “How to live for centuries: common…
Aging-USThe “Guardian Paradox” Links Chronic DNA Damage Response to Aging
BUFFALO, NY — September 21, 2026 — A new #review was #published in Volume 18 of Aging on August 31, 2026, titled “The guardian paradox: DNA damage response…
Aging-USEDITORS’ CHOICE: Human-relevant Ptpn6 mutation alters immune and hepatic functions during aging
A research paper recently published in Aging, titled “Human-relevant Ptpn6 mutation alters immune and hepatic functions during aging,” investigated how a…
Aging-USHuman-Relevant Ptpn6 Mutation Reveals Complex Links Between Immunity, Metabolism and Liver Aging
BUFFALO, NY — September 16, 2026 — A new #research paper was #published in Volume 18 of Aging on August 28, 2026, titled “Human-relevant Ptpn6 mutation alters…
Aging-USEvidence for Cellular Senescence as a Driver of Aging Stronger Than for Somatic Mutations
BUFFALO, NY — September 14, 2026 — A new #review was #published in Volume 18 of Aging on August 26, 2026, titled “Assessing mechanisms and evidence of a causal…
Aging-USMisha Blagosklonny’s Ideas Reshaped Thinking About Aging
Scientific progress often begins with questioning assumptions that have shaped a field for decades. Few researchers embodied this approach as strongly as Dr…
Aging-USReduced Insulin/IGF-1 Signaling Dramatically Extends Male Lifespan in C. elegans
BUFFALO, NY — September 10, 2026 — A new #research paper was #published in Volume 18 of Aging on August 24, 2026, titled “Disruption of the insulin/IGF-1…
Aging-USThree Herbal Extracts Protect Mitochondrial Function in a Cellular Model of Parkinson’s Disease
BUFFALO, NY — September 9, 2026 — A new #research paper was #published in Volume 18 of Aging on August 13, 2026, titled “Protective effects of three herbal…
Aging-USBehind the Study: How Aging Impairs Tuberculosis Clearance
Dr. Falak Pahwa, Dr. Ranjan Kumar Nanda, and Mr. Ashish Gupta from the International Centre for Genetic Engineering and Biotechnology (ICGEB) in New Delhi…
Aging-USIndy Gene Reduction Linked to Healthier Gut Microbiota and Longer Lifespan in Fruit Flies
BUFFALO, NY — September 3, 2026 — A new #research paper was published in Volume 18 of Aging on August 12, 2026, titled “Indy reduction decreases aging-related…
Aging-USDevelopmental Programs Could Help Drive the Aging Process
Why do we age? For decades, one of the dominant explanations has been that cells and tissues gradually accumulate molecular damage until they can no longer…
Aging-USHigher TMAO Levels Linked to Cardiometabolic Risk and Brain Atrophy in Older Adults
BUFFALO, NY — August 31, 2026 — A new research paper was published in Volume 18 of Aging on August 11, 2026, titled “TMAO is associated with higher age…
Aging-USMetformin Emerges as a Promising Candidate at the Intersection of Aging and Longevity
BUFFALO, NY — August 26, 2026 — A new #review was #published in Volume 18 of Aging on August 10, 2026, titled “Metformin at the convergence of aging and…
Aging-USTargeting POLG Reduces Breast Cancer Stemness Through Mitochondrial Dysfunction
BUFFALO, NY — August 24, 2026 — A new research paper was published in Volume 18 of Aging on August 8, 2026, titled “Investigating POLG-driven modulation of…
Aging-USAging Partners with Aging Research and Drug Discovery Meeting (ARDD) as Media Partner
BUFFALO, NY — August 24, 2026 — Aging is pleased to announce its partnership as a media partner of the 13th Aging Research and Drug Discovery Meeting (ARDD)…
Aging-USEDITORS’ CHOICE: Slowing intervertebral disc aging in mice through long-term systemic treatment
A #Research paper recently #Published in Volume 18 of Aging, titled “Slowing intervertebral disc aging in mice through long-term systemic treatment with the…
Aging-USTranscriptomic Aging Clock Reveals Age-Related Molecular Patterns in Opioid Dependence
BUFFALO, NY — August 12, 2026 — A new #research paper was #published in Volume 18 of Aging on July 27, 2026, titled “Transcriptomic aging clock analysis…
Aging-USMisha Blagosklonny’s Scientific Legacy Continues to Shape Modern Aging Research
BUFFALO, NY — August 10, 2026 — A new #essay was #published in Volume 18 of Aging on August 6, 2026, titled “Misha Blagosklonny: a life of ideas.” The article…
Aging-USHyperfunction Theory Offers a New Perspective on Why We Age
BUFFALO, NY — August 6, 2026 — A new #research perspective was #published in Volume 18 of Aging on July 24, 2026, titled “A brief history of the hyperfunction…
Aging-USLongevity & Aging Series (S4, E5): Dr. Kan Cao
In this episode of the Longevity & Aging Series (S4, E5), Dr. Kan Cao of the Department of Cell Biology and Molecular Genetics at the University of Maryland…
Aging-USFatty Liver Disease Linked to Early Cardiovascular and Cognitive Changes
BUFFALO, NY — August 5, 2026 — A new #research paper was #published in Volume 18 of Aging on July 23, 2026, titled “Adipo-neuroinflammation, cognitive…
Aging-USHypertonic Saline Plus Furosemide Improves Heart Failure Biomarkers in Randomized Trial
Heart failure remains one of the leading causes of hospitalization among older adults worldwide. During episodes of acute decompensated heart failure (ADHF)…
Aging-USNew Drug Combination Targets Cancer and Senescent Cells While Extending Lifespan in Old Mice
BUFFALO, NY — August 3, 2026 — A new #research paper was #published in Volume 18 of Aging on July 17, 2026, titled “Selective targeting of cancer and…
Aging-USItaly Proposes a Healthspan-Focused Framework for Healthy Aging
BUFFALO, NY — July 30, 2026 — A new #research perspective was #published in Volume 18 of Aging on July 16, 2026, titled “Towards integration of healthspan…
Aging-USSenolytic PROTAC Slows Age-Related Intervertebral Disc Degeneration in Male Mice
BUFFALO, NY — July 27, 2026 — A new #research paper was #published in Volume 18 of Aging on July 13, 2026, titled “Slowing intervertebral disc aging in mice…
Aging-USNew Surface Marker Could Advance Precision Therapies for Type 2 Diabetes
BUFFALO, NY — July 23, 2026 — A new #research paper was #published in Volume 18 of Aging on July 8, 2026, titled “TM4SF1 is a surface marker of senescent…
Aging-USBrain Flexibility Is Linked to Hand Coordination During Aging
Coordinating both hands is something most people take for granted. Everyday activities such as buttoning a shirt, preparing a meal, driving, or using a knife…
Aging-USPreserving Peroxisomes Helps Maintain Mitochondrial Health and Extend Lifespan in C. elegans
BUFFALO, NY — July 21, 2026 — A new #research paper was #published in Volume 18 of Aging on July 6, 2026, titled “Inhibition of peroxisomal protein PRX-11…
Aging-USEDITORS’ CHOICE: The multifaceted inducers of cellular senescence
Each month, we will highlight a paper published in Aging chosen as the “Editors’ Choice.” These selections are handpicked by our editors and accompanied by a…
Aging-USSenescent Cells Found to Accumulate Lipid Droplets Across Aging and Alzheimer’s Disease
BUFFALO, NY — July 16, 2026 — A new #research paper was #published in Volume 18 of Aging on July 1, 2026, titled “Senescent cells accumulate lipid droplets.”…
Aging-USSex-Specific Hormones Could Hold the Key to Better Sarcopenia Treatments
BUFFALO, NY — July 13, 2026 — A new #review was #published in Volume 18 of Aging on June 26, 2026, titled “Hormonal dimorphism in sarcopenia disease.” The…
Aging-USLongevity & Aging Series (S4, E4): Dr. Maria Blasco
In this episode of the Longevity & Aging Series (S4, E4), Dr. Maria Blasco of the Spanish National Cancer Centre (CNIO) joins host Dr. Yuan Zhao to discuss the…
Aging-USMultiple Biological Triggers Shape Cellular Senescence in Aging and Disease
BUFFALO, NY — July 7, 2026 — A new #review was #published in Volume 18 of Aging on June 22, 2026, titled “The multifaceted inducers of cellular senescence.”…
Aging-USPlant-Based Dietary Patterns Are Associated With Slower Biological Aging
As people live longer, maintaining good health is becoming just as important as extending lifespan. While chronological age simply reflects the number of years…
Aging-USComprehensive Individual-Patient Analysis Clarifies Life Expectancy Across Rare Progeria Disorders
BUFFALO, NY — July 6, 2026 — A new systematic #review was #published in Volume 18 of Aging on June 18, 2026, titled “Life expectancy and causes of death in…
Aging-USNonhuman Primate Research Reveals How Aging, Stress, Behavior May Interact to Increase Disease Risk
BUFFALO, NY — July 1, 2026 — A new #review was #published in Volume 18 of Aging on June 11, 2026, titled “Age-related dysfunctions of the neuroendocrine axes…
Aging-USCellular Senescence and Stem Cells Share a More Complex Relationship Than Previously Recognized
BUFFALO, NY — June 29, 2026 — A new #review was #published in Volume 18 of Aging on May 30, 2026, titled “The love and hate relationship between cellular…