Progerin Expression Creates a Yeast Model of Premature Aging
Aging is shaped not only by changes in DNA and metabolism but also by the gradual accumulation of proteins that cells struggle to remove. One striking example is Progerin, an abnormal form of lamin A that accumulates at the nuclear periphery in Hutchinson-Gilford Progeria Syndrome, or HGPS. A new study shows that expressing this human protein in budding yeast reproduces several aging-related cellular defects and creates a simple experimental system for studying how toxic proteins accumulate and affect lifespan. A research paper published in Volume 18 of Aging titled “Modeling premature aging…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.