The “Guardian Paradox” Links Chronic DNA Damage Response to Aging
BUFFALO, NY — September 21, 2026 — A new #review was #published in Volume 18 of Aging on August 31, 2026, titled “The guardian paradox: DNA damage response overactivation as an integrative driver of aging – a tumor suppressor–negative regulator framework.” The review presents a new framework proposing that chronic overactivation of the DNA damage response (DDR) may serve as a major integrating driver of biological aging. Rather than framing aging in the same mutation-centered terms often applied to cancer, the framework suggests that many tumor-suppressor pathways remain structurally intact…
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