New Aging Framework Proposes Epigenetic Regulation as a Major Limit on Human Lifespan
BUFFALO, NY — November 3, 2026 — A new #review was #published in Volume 18 of Aging on October 9, 2026, titled “The polycentric aging framework: epigenetic regulation as a dominant lifespan-limiting center in human aging.” The review introduces the Polycentric Aging Framework (PAF), which proposes that aging results from several interacting biological processes rather than a single universal mechanism. Drawing on evidence from cellular reprogramming, DNA methylation, metabolic signaling and human intervention studies, the authors suggest that epigenetic regulation may be a dominant, but not…
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