Shows / No Priors: Artificial Intelligence | Technology | Startups
No Priors: Artificial Intelligence | Technology | Startups
At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world's leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? “No Priors” is your guide to the AI revolution. Email feedback to show@no-priors.com. Sarah Guo is a startup investor and the founder of Conviction, an investment firm…
Episodes
No Priors: Artificial Intelligence | Technology | StartupsTaking on ServiceNow: Coding Agents the Rest of Us with Serval Co-Founder and CEO Jake Stauch
What happens when you put code-generation agents in the hands of enterprise IT teams? With Serval, you get a system where it's easy for everyone to be a…
No Priors: Artificial Intelligence | Technology | StartupsDemocratizing Security for the Agentic Web with Cloudflare CTO Dane Knecht
In the transition to the agentic web, security has become an afterthought. Now, organizations are racing to figure out what AI security means, and how to keep…
No Priors: Artificial Intelligence | Technology | StartupsThe New Apex Predator: CrowdStrike CEO George Kurtz on Adversaries Armed With AI Agents
Adversaries are already running AI agents, and the fastest attacks now play out in seconds. Sarah Guo and Elad Gil sit down with CrowdStrike president and CEO…
No Priors: Artificial Intelligence | Technology | StartupsThe Changing Physics of Cybersecurity and Drug Development with OpenAI President Greg Brockman
Technology has always been the fundamental driver of improvement for human quality of life. And with the recent rollout of advanced frontier models, like…
No Priors: Artificial Intelligence | Technology | StartupsBeam: The Great American Open Model with ReflectionAI Co-Founder and CEO Misha Laskin
Is the future of frontier AI open or closed? ReflectionAI co-founder and CEO Misha Laskin joins Sarah Guo and Elad Gil to discuss the launch of Beam, the…
No Priors: Artificial Intelligence | Technology | StartupsFrontier Chips for Frontier AI Labs, with Walter Goodwin, Founder/CEO of Fractile
Founder and CEO of full-stack AI chip company Fractile, Walter Goodwin, joins Sarah Guo to discuss the bets he’s made on the future of the chip market as other…
No Priors: Artificial Intelligence | Technology | StartupsRe-Founding Incumbents for the AI Era with Sequence Holdings Co-Founder and CEO Michael Lee
Can AI transform legacy incumbents rather than replacing them? Sequence Holdings co-founder and CEO Michael Lee joins Sarah Guo to discuss how holding company…
No Priors: Artificial Intelligence | Technology | StartupsWhy Diffusion Will Win AI Inference with Inception Co-Founder and CEO Stefano Ermon
As generative AI hits hardware and latency bottlenecks, Stanford professor, diffusion pioneer, and Inception co-founder and CEO Stefano Ermon is betting on a…
No Priors: Artificial Intelligence | Technology | StartupsCoinbase’s Everything Exchange: Agentic Finance, Stablecoins, and Tokenization with CEO Brian Armstrong
From the tokenization of real-world assets to funding research on anti-aging therapeutics, Coinbase co-founder and CEO Brian Armstrong is focused on solving…
No Priors: Artificial Intelligence | Technology | StartupsRedefining Chip Architecture with Arm CEO Rene Haas
From data center orchestrators to AGI and robotics, CPUs remain the heart of modern computing. Arm CEO Rene Haas joins Elad Gil and Sarah Guo to explore how…
No Priors: Artificial Intelligence | Technology | StartupsRethinking Legacy Data Infrastructure with Eon Co-Founders Ofir Ehrlich and Gonen Stein
Google’s purchase of Spirit Airlines’ data out of bankruptcy signaled a shift in how the tech world values real-world datasets. Although compute and models get…
No Priors: Artificial Intelligence | Technology | StartupsFrom Restoring Sight to Reimagining the Brain, with Max Hodak
Max Hodak, co-founder and CEO of Science Corporation, joins Sarah Guo to discuss the future of vision, brain-computer interfaces, and the human experience. Max…
No Priors: Artificial Intelligence | Technology | StartupsWhat Chess.com Teaches US About Superhuman Capabilities, with CEO Erik Allebest
In a world of infinite gaming and entertainment possibilities, how does a centuries-old game stay so popular? Chess.com co-founder and CEO Erik Allebest joins…
No Priors: Artificial Intelligence | Technology | StartupsChasing Trillion-Dollar Companies, Founder Ambition, Token Budgets, and Regulatory Capture with Sarah & Elad
Is the tech industry moving too quickly, or are founders letting fear of AI labs stunt their ambitions? Sarah and Elad explore the current landscape of…
No Priors: Artificial Intelligence | Technology | StartupsBuilding an Autonomous Enterprise for Real-World Services with Netic Founder Melisa Tokmak
When your AC fails in a heatwave, you don’t want a busy signal; you need a solution. Netic founder and CEO Melisa Tokmak joins host Elad Gil to explain how…
No Priors: Artificial Intelligence | Technology | StartupsBuilding an Autonomous Delivery Experience with DoorDash Co-Founders Andy Fang and Stanley Tang
DoorDash is not just a delivery company. From its inception, co-founders Andy Fang and Stanley Tang operated it as a robotics and autonomy company. Andy and…
No Priors: Artificial Intelligence | Technology | StartupsTravel Through the Lens of AI with with Booking.com CEO Glenn Fogel
When Glenn Fogel joined Priceline in 2000, the business was worth a few hundred million dollars. One week later, the Nasdaq peaked, eventually sending its…
No Priors: Artificial Intelligence | Technology | StartupsHow Nuclear Will Unlock Energy Abundance with Valar Atomics Founder Isaiah Taylor
While the rest of the nuclear industry still relies on simulations and paper designs, Valar Atomics is busy splitting atoms. In fact, they just powered an…
No Priors: Artificial Intelligence | Technology | StartupsReally Big Test-Time Compute in AI Changes Benchmarks, Safety and Research with OpenAI Research Scientist Noam Brown
When a new AI model drops, it’s judged based on a static benchmark grid that doesn’t account for how long the model is allowed to think. How then should we…
No Priors: Artificial Intelligence | Technology | StartupsRe-engineering the Semiconductor Supply Chain with Intel CEO Lip-Bu Tan
At 66 years old, instead of heading towards retirement, former Cadence CEO and legendary investor Lip-Bu Tan decided to take on the hardest job in tech…
- No Priors: Artificial Intelligence | Technology | Startups
Biohub: The Future of Biology is Open-Source with Co-Founders Mark Zuckerberg, Priscilla Chan, and Head of Science Alex Rives
Biohub started with an ambitious goal of curing, preventing, and managing all disease by the end of the century. A decade later, thanks to the convergence of…
No Priors: Artificial Intelligence | Technology | StartupsWe Need An Ecosystem in AI, And Every Company Can Win A Place In It
What does it mean for a business to truly operate at the AI frontier? In a special crossover episode at Microsoft Build, Sarah Guo and Elad Gil team up with…
No Priors: Artificial Intelligence | Technology | StartupsBuilding an AI Guardian for Enterprise with Onyx Security CEO Maxim Bar Kogan
We are now closer than ever before to living in a world where AI agents are smart enough to run our power grids and manage water supplies. How do we keep them…
No Priors: Artificial Intelligence | Technology | StartupsThe Story Behind Cerebras’ $63 Billion IPO with Founder and CEO Andrew Feldman
Companies in Silicon Valley from Nvidia to AMD are racing to fuel the AI revolution with postage stamp-sized AI chips. Meanwhile, a chip the size of a dinner…
No Priors: Artificial Intelligence | Technology | StartupsPax Silica: Inside the Trump Administration’s Tech Strategy with US Under Secretary of State for Economic Affairs Jacob Helberg
Securing AI dominance requires more than just semiconductors; it demands a complete overhaul of how the West manages everything that goes into them, from rare…
No Priors: Artificial Intelligence | Technology | StartupsAmex Global Business Travel: The World’s First AI Take Private with Long Lake CEO Alexander Taubman
The world’s first AI-take-private just proved that AI can revolutionize the real economy. Long Lake Management co-founder and CEO Alexander Taubman joins Elad…
No Priors: Artificial Intelligence | Technology | StartupsBaseten CEO Tuhin Srivastava on the AI Inference Crunch, Custom Models, and Building the Inference Cloud
Baseten CEO and co-founder Tuhin Srivastava sits down with Sarah Guo and Elad Gil to discuss the rapid growth of AI inference demand, Baseten’s 30x growth, and…
- No Priors: Artificial Intelligence | Technology | Startups
SAP: Bringing the ‘Operating System’ of a Company into the AI Era with CTO Philipp Herzig
More than fifty years ago, the modern idea of the standard enterprise software was birthed at SAP. Now, after managing companies through technological shifts…
No Priors: Artificial Intelligence | Technology | StartupsScaling Global Organizations in the Age of AI with ServiceNow Chairman and CEO Bill McDermott
Few teens are business owners, but by age 16, Bill McDermott had purchased and was running a local deli. Now he runs leading global technology powerhouse…
No Priors: Artificial Intelligence | Technology | StartupsThe Agentic Economy: How AI Agents Will Transform the Financial System with Circle Co-Founder and CEO Jeremy Allaire
AI agents can already collaborate, but they lack a trustworthy medium in which to store value and execute contracts. Enter Circle’s Arc Blockchain, an economic…
No Priors: Artificial Intelligence | Technology | StartupsAI for Atoms: How Periodic Labs is Revolutionizing Materials Engineering with Co-Founder Liam Fedus
What happens when you apply the scaling laws of large language models to the physical work of atoms? Elad Gil sits down with Liam Fedus, co-founder at Periodic…
No Priors: Artificial Intelligence | Technology | StartupsAndrej Karpathy on Code Agents, AutoResearch, and the Loopy Era of AI
What happens when AI agents can design experiments, collect data, and improve — without a human in the loop? Andrej Karpathy joins Sarah Guo on the state of…
No Priors: Artificial Intelligence | Technology | StartupsFrom Coder to Manager: Navigating the Shift to Agentic Engineering with Notion Co-Founder Simon Last
Notion isn’t designing AI agents that just use tools. Their agents can autonomously build their own integrations, as well as write the code needed to finish a…
No Priors: Artificial Intelligence | Technology | StartupsHow Capital is Powering the AI Infrastructure Buildout with Magnetar Capital Managing Director Neil Tiwari
By the end of 2026, AI capital expenditure is projected to hit nearly $700 billion. The question isn’t who has the best model, but who has the most creative…
No Priors: Artificial Intelligence | Technology | StartupsFrom SaaS to AI-First: How Companies Are Reshaping Innovation
In this episode of No Priors, Sarah and Elad dive into the evolving landscape of software, exploring how AI is transforming the traditional SaaS model. They…
No Priors: Artificial Intelligence | Technology | StartupsRivian’s Roadmap to AI Architecture and Autonomy with Founder and CEO RJ Scaringe
Autonomous vehicle technology has moved past human-coded rules and into an era of neural networks and custom computer chips. And to solve the most difficult…
- No Priors: Artificial Intelligence | Technology | Startups
Introducing 4D Creation Open Beta: NPCs, 4D Worlds, and the Future of Gaming with Roblox CEO Dave Baszucki
From “virtual doppelgängers” to “real-time dreaming,” online gaming platform Roblox is using AI technology to build the “Holodeck” envisioned in science…
No Priors: Artificial Intelligence | Technology | StartupsWhy Cryopreservation is No Longer Science Fiction with Until Co-founder and CEO Laura Deming
What if we could pause biological time to wait for a cure for a disease? Thanks to innovations and research in reversible cryopreservation, this possibility is…
- No Priors: Artificial Intelligence | Technology | Startups
No Priors Live: Building Durable Software in the AI Age with MongoDB President & CEO CJ Desai
Why are there only a handful of companies in the world with over $10 billion in pure-play software revenue? CJ Desai believes the reason is that products are…
- No Priors: Artificial Intelligence | Technology | Startups
AI and the Future of Warfare with US Under Secretary of War Emil Michael
Today’s arms race looks a little different from those of the past. Under the Trump administration, the US Department of War (DoW) is deploying generative AI to…
- No Priors: Artificial Intelligence | Technology | Startups
NVIDIA’s Jensen Huang on Reasoning Models, Robotics, and Refuting the “AI Bubble” Narrative
Even if ChatGPT never existed, the tech giant NVIDIA would still be winning. The end of Moore’s Law—says NVIDIA President, Founder, and CEO Jensen Huang—makes…
- No Priors: Artificial Intelligence | Technology | Startups
The 2026 AI Forecast: Foundation Models, IPOs, and Robotics with Sarah Guo and Elad Gil
Pundits are screaming about the so-called “AI bubble.” But historically slow-to-adopt industries like medicine and law are actually embracing AI at an…
- No Priors: Artificial Intelligence | Technology | Startups
The Future of Voice AI: Agents, Dubbing, and Real-Time Translation with ElevenLabs Co-Founder Mati Staniszewski
Imagine learning chess from a grand master, or negotiating tactics from an expert FBI hostage negotiator. ElevenLabs’ voice AI technology is making that unlock…
- No Priors: Artificial Intelligence | Technology | Startups
Scaling Legal AI and Building Next-Generation Law Firms with Harvey Co-Founder and President Gabe Pereyra
In just over three years, Harvey has not only scaled to nearly one thousand customers, including Walmart, PwC, and other giants of the Fortune 500, but…
- No Priors: Artificial Intelligence | Technology | Startups
Sunday Robotics: Scaling the Home Robot Revolution with Co-Founders Tony Zhao and Cheng Chi
The robotics industry is on the cusp of its own “GPT” moment, catalyzed by transformative research advances. Enter Memo, the first general-intelligence…
- No Priors: Artificial Intelligence | Technology | Startups
How AI Will Accelerate Breakthroughs in Biotechnology with Benchling CEO Sajith Wickramasekara
Bringing new drugs to market is a costly, time-consuming endeavor. On top of that, most medicines fail at some point in the research and development phase…
- No Priors: Artificial Intelligence | Technology | Startups
Meet Snowflake Intelligence: A Personalized Enterprise Intelligence Agent with Sridhar Ramaswamy
Snowflake is moving beyond the data warehouse. Its new Snowflake Intelligence is an agentic platform for every employee, not just data teams. Sarah Guo sits…
- No Priors: Artificial Intelligence | Technology | Startups
The Best of 2025 (So Far) with Sarah Guo and Elad Gil
2025 has thus far been a year of great leaps and advances in AI technology. And Sarah and Elad have spoken with some of the most enterprising founders and…
- No Priors: Artificial Intelligence | Technology | Startups
Reinventing the Developer Terminal with Warp Co-Founder and CEO Zach Lloyd
For decades, the developer terminal has remained largely unchanged. But for Warp CEO and co-founder Zach Lloyd, reinventing this core tool is the key to…
- No Priors: Artificial Intelligence | Technology | Startups
Unlocking the Road to Energy Abundance with Base Power CEO and Co-Founder Zach Dell
With demand from AI for energy already exploding, our electric grid is facing a crisis. Base Power CEO and co-founder Zach Dell is ready to re-architect its…
- No Priors: Artificial Intelligence | Technology | Startups
Humans&: Bridging IQ and EQ in Machine Learning with Eric Zelikman
The AI industry is obsessed with making models smarter. But what if they’re building the wrong kind of intelligence? In launching his new venture, humans&…
- No Priors: Artificial Intelligence | Technology | Startups
The Impact of AI, from Business Models to Cybersecurity, with Palo Alto Networks CEO Nikesh Arora
Between the future of search, the biggest threats in cybersecurity, and the jobs and platforms of tomorrow, Nikesh Arora sees one common thread connecting and…
- No Priors: Artificial Intelligence | Technology | Startups
Reinventing K-12 Education Using AI with Alpha School Principal Joe Liemandt
What if kids could master their academics in just two hours a day and spend the rest of their time developing real-world skills they’re passionate about? Joe…
- No Priors: Artificial Intelligence | Technology | Startups
AI Agents Talking to AI Agents: Reinventing Commerce with Decagon CEO Jesse Zhang
The traditional call center may soon be a thing of the past. Jessie Zhang is building AI agents designed to replace monotonous human labor and transform how…
- No Priors: Artificial Intelligence | Technology | Startups
Jared Kushner: BrainCo, Affinity Partners, and the Geopolitics of AI
From negotiating with world leaders to partnering with top entrepreneurs, businessman and investor Jared Kushner has traveled the unique path of bringing…
- No Priors: Artificial Intelligence | Technology | Startups
A New Operating System for Physicians with OpenEvidence Founder Daniel Nadler
How does a new technology get adopted by 40% of American doctors in just 18 months? In an era where the golden age of biotechnology has also created a dark age…
- No Priors: Artificial Intelligence | Technology | Startups
Reshaping America’s Economy for the Superintelligence Century with Jacob Helberg
AI doomers say that the technology will be the ultimate job-killer. But Jacob Helberg wants people to see AI as a tech that will boost, not replace, human…
- No Priors: Artificial Intelligence | Technology | Startups
How Agentic AI is Transforming The Startup Landscape with Andrew Ng
Andrew Ng has always been at the bleeding edge of fast-evolving AI technologies, founding companies and projects like Google Brain, AI Fund, and…
- No Priors: Artificial Intelligence | Technology | Startups
Chips, Neoclouds, and the Quest for AI Dominance with SemiAnalysis Founder and CEO Dylan Patel
What would it take to challenge Nvidia? SemiAnalysis Founder and CEO Dylan Patel joins Sarah Guo to answer this and other topical questions around the current…
- No Priors: Artificial Intelligence | Technology | Startups
The Shifting Value of Content in the AI Age with Cloudflare CEO Matthew Prince
Cloudflare has spent nearly fifteen years making the Internet faster, more reliable, and more secure. So now that AI systems are changing the way we interact…