Too Sick to Transplant?

Trenches in Transplant Surgery · Oct 14, 2026 · 39m

Acute-on-chronic liver failure is a critical medical syndrome characterized by the acute deterioration of chronic liver disease, resulting in severe organ failures and high short-term mortality. The condition is primarily driven by an excessive systemic inflammatory response triggered by factors such as bacterial infections, alcohol abuse, or viral hepatitis relapses. Because traditional scoring systems often fail to account for extrahepatic complications, specialized tools like the CLIF-C ACLF score have been developed to more accurately assess patient prognosis and track dynamic clinical…