Latest / This Is Why with Dr. Busti
MAOI Antidepressants: Pharmacology Made Easy & Clinically Relevant
Dr. Busti breaks down monoamine oxidase inhibitors (MAOIs)—where they still fit in modern care, how they work, and how to use them safely.
In this episode you’ll learn:
Why MAOIs remain relevant for treatment-resistant depression
How irreversible MAO-A/B inhibition elevates serotonin, norepinephrine, and dopamine
Practical washout rules (why 14 days after MAOI, generally 7 days before starting an MAOI; longer with fluoxetine)
High-yield differences (e.g., selegiline transdermal for depression vs. oral formulations for Parkinson’s disease)
Key drug–drug risks (serotonergic agents, certain…
The skinny
The skinny isn't ready yet — notes appear once the transcript is processed.