SNRI Antidepressants: Pharmacology Made Easy & Clinically Relevant

This Is Why with Dr. Busti · Oct 7, 2025 · 29m

Discover serotonin-norepinephrine reuptake inhibitors (SNRIs)—safe, effective antidepressants for depression, anxiety, and pain syndromes.

In this episode, you’ll learn:

- How SNRIs work in the brain and differ from SSRIs, TCAs, and MAOIs

- Key medications: venlafaxine, desvenlafaxine, duloxetine, milnacipran, levomilnacipran

- Important side effects, including blood pressure changes and SIADH in older adults

- Tips for safe switching, monitoring, and counseling patients

Companion tables (indications, mechanisms, PK/PD, side-effect grid, and monitoring prompts) are available for download and…