Minimizing Immunosuppression and Achieving Tolerance in Liver Transplant

Trenches in Transplant Surgery · Jun 25, 2025 · 23m

Immunosuppression minimization and withdrawal in liver transplantation is an area where clinical practice and cutting-edge research intersect. The driving rationale is clear – mitigating the long-term deleterious effects of chronic immunosuppressive therapy – but the execution requires navigating complex immunological and ethical terrain. Over the past two decades, we have learned that operational tolerance, once deemed a rare curiosity, is attainable in a meaningful subset of liver recipients, particularly under ideal circumstances. Pioneering trials in both adults and children have mapped…