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390: Histamine Intolerance, MCAS + Mastocytosis: What’s The Difference? w/ Dr. Mariana Castells

Histamine intolerance is typically mild, but Mastocytosis is the most severe form of mast cell disorder—often taking nearly a decade to diagnose. Symptoms can affect multiple organs, from rashes and GI issues to life-threatening anaphylaxis, and standard treatments like low-histamine diets and antihistamines often fail.

Many doctors aren’t familiar with testing or treatment options for mast cell issues like Mastocytosis and MCAS.

Today, I’m joined by Dr. Mariana Castells, a leading expert in allergy and immunology at Brigham and Women’s Hospital. She directs the renowned Mastocytosis Center…

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