Why Finding the Right Drug Dose Is So Difficult | Dr. Ewoud-Jan van Hoogdalem
A drug shows promise in a small patient study. How much does that tell you about the dose you should test next?
Gregory Austin and Dr. Chad Briscoe explore that question with Dr. Ewoud-Jan van Hoogdalem, a board-certified clinical pharmacologist and former Vice President of Clinical Pharmacology at ICON. He explains how first-in-human studies inform dose selection, why an early signal in patients can leave important questions unanswered, and how a dose that makes it through development can still prove difficult for patients to tolerate in everyday use.
Drawing on his experience in small…
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