Domino Liver Transplantation

Trenches in Transplant Surgery · Aug 16, 2025 · 34m

Domino liver transplantation is a unique and innovative surgical strategy designed to expand the donor organ pool by utilizing the explanted liver from a patient with a non-cirrhotic metabolic liver disease—such as familial amyloid polyneuropathy or maple syrup urine disease—as a graft for a second recipient. While the donor liver carries a genetic or enzymatic defect, it remains structurally and functionally normal, and the recipient is carefully selected to minimize the risk or impact of the transmitted condition. Since its introduction in the mid-1990s, this technique has demonstrated…