Crossmatching in Abdominal Transplantation - Understanding T and B Cell Risk

Trenches in Transplant Surgery · Jul 27, 2025 · 25m

In this episode, we explore the science and clinical importance of crossmatching in abdominal organ transplantation—focusing on kidney and liver grafts. We delve into the key differences between T cell and B cell crossmatches, examining the roles of complement-dependent cytotoxicity (CDC) and flow cytometry in detecting donor-specific antibodies (DSAs). While a positive T cell crossmatch—particularly in kidney transplantation—often signifies a prohibitive immunologic risk due to class I HLA antibodies and hyperacute rejection, B cell crossmatches reveal subtler threats like class II DSAs. We…