Latest / Trenches in Transplant Surgery
Omics Technologies in Kidney and Liver Transplantation - Enabling Precision Immunosuppression
The past 5–10 years have witnessed remarkable progress in applying genomics, proteomics, and metabolomics to kidney and liver transplant medicine. Genomic tools are uncovering polymorphisms and gene expression signatures that predict rejection or identify tolerance, as well as informing tailored drug dosing. Proteomic studies have yielded noninvasive protein biomarkers (chemokines, injury molecules) for early rejection detection and provided mechanistic insights into how rejection alters graft metabolism and immunity. Metabolomic profiling has revealed distinctive metabolic fingerprints of…
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