Direct Thrombin inhibitors (DTI): Pharmacology Made Easy & Relevant

This Is Why with Dr. Busti · Jan 13, 2026 · 38m

Direct Thrombin Inhibitors (DTIs) made simple and clinically relevant! In this lecture from This is Why, Dr. Busti will help you master direct thrombin (Factor IIa) inhibitors—including the oral DTI dabigatran (Pradaxa) and key parenteral DTIs like bivalirudin (and where argatroban fits clinically, especially in the acute care setting)

You’ll learn how to:

- Where direct thrombin inhibitors work in the coagulation cascade

- How dabigatran works (mechanism of action), major indications, and high-yield adverse effects

- What to monitor, common drug interactions, and who is at higher bleeding…