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Latest / Trenches in Transplant Surgery

NAFLD/NASH in Liver Transplantation: Global Trends and Clinical Impact

NAFLD/NASH epidemic has two-fold impact on transplantation: it threatens the donor supply (steatotic grafts have higher risk) and creates a new high-risk recipient population (with metabolic complications and graft steatosis). Recent consensus and meta-analytic data emphasize using donor livers with ≤30% macrosteatosis whenever possible, careful evaluation with advanced imaging (CAP, CT) and possibly machine perfusion for high-fat grafts. Post-LT, aggressive control of weight and cardiometabolic factors is needed to prevent graft fattening and cardiovascular events.

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