Latest / This Is Why with Dr. Busti

Loop Diuretics: Pharmacology Made Easy & Clinically Relevant
MRAs—spironolactone, eplerenone, and finerenone—do far more than nudge blood pressure. They improve outcomes in heart failure, offer targeted benefits in CKD with T2D, and play a unique role in cirrhosis-related ascites. In this focused review, Dr. Busti walks through the why behind the what: aldosterone receptor blockade, tissue selectivity (kidney vs heart), and how those differences drive real-world choices, dosing, and safety.
We compare agents head-to-head, unpack RAAS physiology, and translate it into exam-ready pearls and bedside judgment—covering hyperkalemia risk, gynecomastia…
The skinny
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