Latest / This Is Why with Dr. Busti
H2 Receptor Antagonist Antacids (H2RA): Pharmacology Made Easy & Clinically Relevant
H₂ receptor antagonists like famotidine and cimetidine have been around for decades, but they still play an important role in managing GERD, dyspepsia, ulcers, and even acute GI bleeding. In this episode, Dr. Busti reviews the history, pharmacology, and clinical relevance of this class, including the withdrawal of ranitidine.
You’ll learn how H₂ blockers fit into the larger category of antacid therapy, why they’re effective for mild cases but limited in long-term control, and how tolerance can reduce effectiveness. Cimetidine’s drug interaction profile is explored in detail, including CYP450…
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