Latest / hol+ with Dr. Taz MD | The Future of Medicine is Holistic / GLP-1s Aren’t Metabolic Health: How Gut, Hormones, Stress, Muscle, and Cellular Energy Shape Long-Term Weight and Longevity
Transcript
- Dr. Taz: [00:00:00] Okay. Real talk. I get the best dms from you guys after each episode. So before we start, if you've been listening and you're thinking, that's me, go ahead and send me a quick message on Instagram at Dr. Taaz md. I love hearing what resonates, what you're struggling with, and what you want more of. That's how whole plus stays real in the conversation. Dr. Taz: And it's not just a lecture. Let's jump in. Every January, millions of people chase new diets and quick fixes, but few ever [00:00:30] reset the real system that controls their energy, focus and longevity. Their metabolism in this episode will uncover what true metabolic health means, how to spot the early warning signs of dysfunction, and the steps to reboot your system naturally, because when your metabolism works. Dr. Taz: Everything else in your body follows. Do we even need to have a conversation about weight and metabolism in the age of GLP ones? The answer is [00:01:00] yes. And my follow-up question is, do we all really wanna be married to a medication for the rest of our lives? That answer in my opinion is no. So how do we reconcile these two concepts? Dr. Taz: Now, we've talked a lot about GLP ones in the past, right? You guys know what they are? Medications. Everybody's on 'em. The Ozempic, the Terre, tirzepatide, Majaro, Upbound. Pick your name, run with it. It feels like everybody's on it. Everyone's getting skinny. So much so that we feel [00:01:30] like the 2000 version of the body type is coming back and we're not all really happy about it, especially people like me that have curves. Dr. Taz: But here's the issue, okay? That I have. I am writing these prescriptions. I am microdosing them for a lot of our patients at Whole Plus, as are my team members. We don't have a problem with that. Here's what we have a problem with. The problem is a GLP one is not the answer for metabolic health. The GLP one will help you lose weight, but it is not answering [00:02:00] the question around your overall metabolic health. Dr. Taz: And in this next episode, a. We're gonna talk about what metabolic health means and looks like and what we need to be thinking about when it comes to your metabolism, which is something that you have to live with for a very long time, even though the numbers on the scale are gonna go up and down and all around, depending on what life is doing to you or what you are doing in life. Dr. Taz: And if you're a woman. Listening to me, they're also gonna go up and down [00:02:30] depending on what your hormones are doing. So while I bless everybody in terms of worrying about their weight and. Really wanting to be on these medications to get to the point of healthy weight loss, which by the way is slow and steady, not super fast. Dr. Taz: I also wanna fill in the gaps of the conversations that are not happening, and those conversations are, are around metabolism. Here's the definition of metabolism. Metabolism goes back to the health [00:03:00] and the efficiency of the cells, organs, and tissues in your bodies. This means how well you digest your food, what your hormones are doing, what your muscles are doing, what your liver is doing, and how it detoxes what you are doing from a nervous system standpoint in terms of stress and cortisol. Dr. Taz: That's metabolism. Some of it you can measure through blood work. You can measure it through a VO two max, or even at the practice. What we do is resting energy expenditure. [00:03:30] You can absolutely measure some of these markers and start to get an understanding of what your metabolic health is looking like. Dr. Taz: But here's where everybody is starting to fall off and fall into trends and fads that are going nuts and confusing everybody and adding to the noise without really coming in and narrowing down a clear conversation around what you need to be thinking about when it comes to your metabolic health. So here's where we're gonna dive in. Dr. Taz: I'm gonna make the assumption that you [00:04:00] are on a GLP one of some kind. I'm just gonna do it. I didn't look up the stats before jumping on here, but I'm sure they're pretty high. Whether you are microdosing or you are megadosing or you are somewhere in between, more than likely you or someone you know or love is on a GLP one. Dr. Taz: And the follow up question to that. Now, after all the years of this medication coming, coming in vogue is how do I get off this thing? I don't wanna be on it forever. The fallout of the GLP one is this loss [00:04:30] of muscle mass, loss of good, healthy metabolic gut function, shifting hormones, inflammation that starts to rise when the weight loss is too great, and of course, changes in cellular and mitochondrial health. Dr. Taz: Now there is a sweet spot for a GLP one, just as there is for a hormone, for a medication for so many other things. So I'm not saying it's all bad. I'm saying we need to think bigger, larger, and broader, and have a plan to actually come off [00:05:00] those medications once you become metabolically active. So how do you become metabolically active? Dr. Taz: You're on this medication, you're losing weight, but you're also losing muscle and your gut's slowing down. How do you become metabolically active? Here's what we are gonna lay out today is a clear understanding of the six different metabolic engines that we need to be paying attention to and how you can know which one to focus on. Dr. Taz: Because with all the noise that's swimming out there, none of us have [00:05:30] time. I have access to everything, guy. I don't have time to do 50 million things. It's gotta be efficient. Targeted and really focused on your blind spots or your weakest spots. So let's get into it. You are losing weight, the weight's coming off. Dr. Taz: So is your muscle mass. So is your gut health kind of being impacted in different ways? Where do you go next when you are at your desired weight or while you are actively losing weight? The number one metabolic engine that you've got to [00:06:00] be dialed into. If you wanna ignore the rest of this episode, I'm fine with it, but the number one metabolic engine I need you guys to be dialed into is the gut. Dr. Taz: It's ground zero for your health. That gut microbiome, that sea of bacteria that lives in your belly is determining everything. Everything from what your hormones are gonna do to what your inflammation's gonna look like, to where your cortisol levels are today, to whether you're gonna store fat or burn fat, and so much in between. Dr. Taz: So a medication [00:06:30] that fundamentally acts on the gut to decrease your appetite is not a good long-term strategy. And I see this in practice day in and day out. It is a fine short-term strategy, not a long-term one. So what do you need to know? We need a gut that digests well, that has good bile flow, meaning you can take a fat, you can break that fat down, you can chop it up, and it goes off to where it needs to go because it helps to balance gut bacteria. Dr. Taz: We need a gut that has a [00:07:00] diet that takes in a lot of fiber to produce something called butyrate, which then in turn feeds good bacteria so that again, the microbiome can do what it's supposed to do. And you need a gut that has the right bacteria to take hormone metabolites, toxins in the environment, and so much more, package them up and ship them out. Dr. Taz: So they are not causing cancer, autoimmune disease, cognitive diseases or neurological diseases like Parkinson's and a LS in your [00:07:30] body. You need the gut to do that. That is your first metabolic engine. So how do you know you have a problem here? Well, there are many things to be thinking about when it comes to gut health, and again, I talk a lot about gut health in lots of different sections. Dr. Taz: In fact, I think we have a dedicated podcast episode to gut health that I would encourage you guys to check out. But if you're not going to the bathroom consistently, if you've got bloating or reflux, if you have rashes that you can't explain. All of these are signs that your [00:08:00] digestion, your gut, is not working to its best capacity, and it works well. Dr. Taz: It behooves you well to get the gut tested, to understand the microbiome and what it's doing, and where you may need to alter what you're doing with your plan. Trying to keep it super easy so everybody is clear on what's going on there. The next metabolic engine that we've gotta pay attention to, in fact, I might've written a book or two on this, is the hormones, okay? Dr. Taz: For men and women and children. The hormones [00:08:30] Symphony is. Diverse and complex, but they all communicate and talk to each other. Meaning if you've got too much stored estrogen, you're going to have high blood sugar or higher insulin levels. You're gonna store fat more. When you have too little estrogen, there's actually a molecule in the liver that gets activated that triggers you to store fat. Dr. Taz: It's like, what are you supposed to do? And for those of us doing hormone replacement therapy, it can be super confusing. That goes back to the sweet spot, this middle [00:09:00] spot where you have just enough estrogen but not too much estrogen so your metabolism is humming. We can have that same exact conversation around testosterone, around your thyroid, around insulin, around cortisol, DHEA, probably forgotten one. Dr. Taz: The a progesterone I knew I forgotten one. And progesterone. They all need to live in a sweet spot that is catered to you. And when they are not in balance, then again, yes, the body is [00:09:30] primed to gain weight, to be sluggish and to slow down. I see patients all the time who have a slow metabolic rate, but actually have muscle mass, and the conversation right now is just on like protein to build muscle, but not understanding what all the different layers of the metabolic engines are and how to tackle them. Dr. Taz: So how do you know that's your starting point? Well, I think if you've had a hormone shift, right? So for everybody, honestly, from about 40 to 55, 60, you are in the throes of hormone [00:10:00] shifts, male or female, and you need to understand what your hormones are doing. If you really wanna have a conversation around sustained metabolic health, because as those hormones shift and you get outta that sweet spot, guess what else happens? Dr. Taz: All your metabolic markers, they go haywire. That means the way we traditionally track metabolism with cholesterol and A one Cs, and blood pressure, you know, fasting, glucose, all of these different things. [00:10:30] First are normal and fine, and all of a sudden you have a hormone shift. They're completely in a different place, and I see that over and over again in the exam room. Dr. Taz: So understanding that your second metabolic engine, your second most important metabolic engine, or your hormones is an important place to really start to look at what you need to do for sustained metabolic health. That helps your brain, your all your different organs, your heart, and so much more. [00:11:00] All right, hormones. Dr. Taz: Let's do another one next. Metabolic, and this is by the way, I would say an order of priority, honestly. And notice how I'm putting gut first, then hormones. Now I'm moving to cellular health. Each cell within your body is a metabolic engine. It's either working for you or it's working against you. And it's important to understand that each of those cells are providing energy, and that energy is responsible for things like a TP production, how you're going to really [00:11:30] process fat in your body, how much metabolic flexibility you're gonna have when different things are exposed, or there's a new stressor for you. Dr. Taz: That metabolic flexibility is dependent on good, healthy cells, specifically the mitochondria. So if the mitochondria don't have what they need, your metabolic health is going to start to decline. And you see it in things like weakness, right? Your muscle strength is going down, your cognitive capacity is going down, your ability to focus and concentrate [00:12:00] is going down. Dr. Taz: All of these are signs that it is actually your cellular health that needs some attention and needs some support. Another engine that we need to connect to. And I know you want me to go to Muscle, but I'm not that's gonna gonna come down as, uh, probably number five or six, which I know is counter to what you're hearing and seeing everywhere right now. Dr. Taz: But the next place we need to go when we think about metabolic engines are your liver, the health of your liver, right? The liver lives right up here, right in this right upper [00:12:30] area. 30% of adults, at least here in the United States, and I would venture to say it's probably global, have some level of fatty liver disease, meaning the liver's holding onto fat, visceral fat, and they're in a lower sluggish metabolic state. Dr. Taz: The liver is also primarily the home of where we filter environmental toxins and chemicals. We hold emotions in the liver like anger and stress. So even in our children, we are seeing [00:13:00] levels of liver sluggishness. Again, Chinese medicine, Ayurvedic medicine. These older systems of medicine are ahead of the curve in terms of identifying and diagnosing and acting on that very quickly. Dr. Taz: So the liver is something that you need to be thinking about and thinking forward about when it comes to your metabolic health. Not only do we know that fatty liver is a sign of liver dysfunction, but we also know that many different behaviors that we engage in. Impact metabolic health when it comes to [00:13:30] the liver's ability to do its job. Dr. Taz: That's excessive use of pharmaceutical medications. The US is number one in the use of pharmaceutical medications in the world. I think the stat I saw was that 80% of the world's pharmaceutical supply is used by the US United States of America. The rest of the world is only using 20%. Like what is happening? Dr. Taz: Well, all of that is wearing down the liver. Causing the liver to not really do its job effectively. [00:14:00] GLP ones. The reason tirzepatide sometimes work better than maybe in Ozempic is because the GLP ones at the TIRZEPATIDE in particular, will help to work on the liver and the liver's ability to take up blood glucose and insulin. Dr. Taz: So a GLP one may improve a symptom of the liver here or there, but it is not fully improving liver function. Okay, so that's another metabolic engine that we need to be thinking about. All right, let's move to two more [00:14:30] and then we're going to get into the what to do, right? We're talking about metabolic health and the age of GLP ones, what we need to be thinking about, what we need to be focused on, and how you know where to start. Dr. Taz: All right. The next metabolic engine that I want us to be thinking about. Now, this is no surprise. This is your nervous system. This is tying us back to cortisol. It's tying us back to stress and what is happening with stress. Here's where the science is. Stress increases caloric intake by [00:15:00] 45%, right? You're taking this GLP one, but stress might be at the root of why everybody needs to be on it, that. Dr. Taz: Fogles my mind that we need a medication to deal with what stress is actually doing to our bodies. We know that vagal tone predicts metabolic resilience, meaning how healthy is that parasympathetic system, the system that calms us down? How does that help with our ability to burn fat, retain muscle [00:15:30] digest efficiently, and for all these other things to do what they need to do? Dr. Taz: So stress and the nervous system regulate everything from emotional eating to your cravings, your sleep patterns, all of which play a role into metabolic health. And now last, but certainly not least, is the metabolic engine that you've heard the most about, which is muscle health, right? You need muscles for good glucose uptake. Dr. Taz: We need muscles to help us with burning and regulating blood sugar a little bit more [00:16:00] efficiently. We know that more muscle mass means. A better overall resting energy expenditure. Remember the number I talked about that we measure in practice? It also means be a better overall basal metabolic rate, which is another number we can tactically and tangibly measure. Dr. Taz: So muscle mass is incredibly important when it comes to metabolic health, and yes, we should gain muscle. Here's a fun fact though. Up to 25% of weight loss on a GLP [00:16:30] one is muscle. This is a 2023 study. Muscle mass, according to a LAN set article in 2018 actually predicts longevity very efficiently, so we can't ignore the health of our muscles. Dr. Taz: So these are like the six probably main metabolic engines that I think we need to be thinking about. And. As we think about metabolic health, what I'm hearing, again, the fads crack me up guys, by the way. 'cause I've [00:17:00] been doing this for a long time and it's super interesting to see things come in and come out of the picture. Dr. Taz: But anyhow, these six metabolic health engines that you need to know are never gonna go outta style. These are things you're gonna need to know. Even 20 years from now, we're gonna be saying that the gut is the number one engine with hormones and cellular health and sort of the liver being right behind it, right? Dr. Taz: We're gonna be holding onto these concepts for a very long period of time. The problem is, in the age of GLP ones, we think one and done. We don't need to [00:17:30] think about this anymore, and we can be on these medications forever and and that's what I don't want us to do. But before I get you guys feeling overwhelmed. Dr. Taz: I just walked through the major metabolic engines. I hope you have kind of imprinted in your mind the one that you really need to work on. And if you're even remotely thinking about peptides or peptide therapy, which I don't know about you, is like flooding my feed. And every time I do a search, there's a peptide, something everywhere. Dr. Taz: And yes, [00:18:00] we also do peptides at Whole Plus. We are gonna walk through a plan that helps you with what to use, when, and how it's appropriate to really make your plan efficient and metabolically active at the same time. And this is assuming that you might be on a GLP one, or you might be ready to start to tone down your dosing of a GLP one. Dr. Taz: So again, let's get into it with the gut. I talked about the importance of the microbiome and microbial diversity. One of [00:18:30] the number one things we do there is increase fiber, increase healthy fats, and oftentimes we may add a probiotic that's high quality that has at least 50 to a hundred billion CFUs in it, along with digestive enzymes to assist bile flow. Dr. Taz: That's like 1 0 1 of what we do when it comes to assisting God health. Some of you have celiac issues, some have dairy, some have something that is an investigative process that happens within the exam room, but if you want a quick cheat sheet, there it is. That's what we want you to do. If you [00:19:00] want to go to the next level because you're not having results and you're worried about the gut as being the metabolic engine at most risk, then there are two peptides that we will often add. Dr. Taz: One is BPC 1 57. The other is KPV. Now, BPC 1 57 is not recognized by the FDA, so we've instead been using something called PDA, which is recognized in something that helps with gut inflammation. Gut biodiversity. KPV in particular. Can help with candida [00:19:30] or candida overgrowth. So that's the role of peptides in a scenario where the gut is the primary issue when it comes to metabolic health. Dr. Taz: But you may be listening and thinking, it's not the gut, it's, it's my hormones. Or you know, one of the other ones. And with hormones, that is the conversation around hormones and hormone balance. What is your sweet spot for the seven major hormones that we talk about all the time? Estrogen, testosterone, progesterone, insulin, thyroid, cortisol, DHEA. Dr. Taz: Uh, again, what did I forget? I'm sure I've [00:20:00] forgotten one. But anyhow, the seven major hormones need to be in their sweet spot and personalized towards you. And that way they are metabolically efficient for you. So sometimes it does mean some level of hormone replacement or that's where we may try an herbal approach first. Dr. Taz: There are many different herbs that balance different hormones. I don't wanna take the entire length of today's episode to talk about all of those, but I definitely talk about those a lot on social and, and throughout a lot of the articles that we post on Whole Plus as well. [00:20:30] But again, hormone balancing. Dr. Taz: Incredibly important if we're gonna bring peptides into the conversation after the gut is healthy. After you have looked at things like what your, uh, overall diet is like, then you bring in hormone replacement, then the next step. If we're trying to create a cohesive path is maybe thinking about peptides for hormone regulation. Dr. Taz: If you're not getting to where you wanna get, here are the hormones that we like for that. The CJC and [00:21:00] IOR and combo will indirectly increase testosterone and help with growth hormone. Or sometimes we actually give growth hormone in the form of Lin. That is a combination we like. Sometimes we will add something called follow statin to it as well, but these are different peptides that work in the hormone domain versus working necessarily in one of the other metabolic engines. Dr. Taz: Peptides, by the way, we like to cycle, right? They don't want, we ne don't necessarily like to do them continuously. We do like to cycle those. Next, we [00:21:30] talked about your cellular health, right? The engine, you know, that's. Powering everything. The mitochondria, do they have what they need to have? Well, mitochondria thrive on an anti-inflammatory, high antioxidant diet. Dr. Taz: That means a lot of those like dark leafy greens, dark berries, things that are giving you the A's and the B's and the C's, and all these nutrients that the mitochondria need. To really do what they need to do. Mitochondria need protein as well. Protein provides things like [00:22:00] glutathione and even glutamine, essential amino acids that help the body do the jobs it needs to do. Dr. Taz: Mitochondrial, uh, as we talked about before, mitochondrial dysfunction, we know, does drive things like weight gain and obesity. We've seen that in many studies. You know, there was a study in 2019 that talked about that as well. So how do you support mitochondrial function? Beyond diet and beyond, sort of like the basics of providing the body with the nutrients it needs. Dr. Taz: That's where sometimes you need targeted supplementation. [00:22:30] And in the practice we are doing tests to help you identify where you need to focus, right? So it's not just another product popping up and saying, Hey, it's a fad. Take this. Like, what do you need? Do you need nac? Do you need coq 10? Do you need glutathione? Dr. Taz: Actually, you know, like what do you need to get your mitochondria to function more efficiently? And there are patients that have mitochondrial dysfunction and that looks like weakness and fatigue and, and burnout. And for them, we actually formulate a mitochondrial cocktail [00:23:00] to help them get cellular energy at the end of the day. Dr. Taz: All right, moving on from that. We talked about the liver. Oh, hang on. Before I move on to the liver, I, I do wanna mention peptides 'cause this is a place where the peptide Mott C is helpful along with a OD and a combination that we will do sometimes is a OD and Mott C together. And sometimes you can add teso morelin, which was one for more of the hormones. Dr. Taz: You put the three together and that can help to stimulate and really promote healthy mitochondrial function. But again, you see [00:23:30] how the peptide comes after diet and nutrients and targeted supplementation. Then peptides. Otherwise again, you're just doing things to do them and you're not being, you know, efficient about it. Dr. Taz: Alright, next metabolic engine was the liver. Remember the liver I've always called for years? It's the laundromat of the entire body. We need it for bile flow. We need it to detox, we need it for fat metabolism. We need it to clear the very GLP one that you may or may not be on. I've already given you the statistics around the liver [00:24:00] and with the liver. Dr. Taz: Here's what I like to do. Of course, alcohol eats to be under four drinks a week. That is something that is liver toxic. It does wear the liver down over time. It does raise your liver enzymes like a ST and a LT. We also know a reduction in sugar and refined carbohydrates is going to make a difference for the liver as well. Dr. Taz: So paying attention to the dietary aspect of this. And there are many natural herbs that and teas that help. To clean the liver on a regular [00:24:30] basis. Dandelion tea, celery root juice, you know, uh, smarin or milk thistle tea. These are things we love to use when we're thinking about cleaning out the liver and with the liver. Dr. Taz: One of our favorite just general supplements is milk thistle. So milk the soul works really well in terms of being liver protective does even help to bring liver enzymes down. So that's something that I would look at and think about. If you can identify that the liver is the pathway because of alcohol, because of the number of medications [00:25:00] you're on, maybe because of things like stress and anger, that's the place that you really need to focus. Dr. Taz: And that same BPC 1 57, that currently we're using more of something called PDA, but either one of those has been shown to reverse liver inflammation. So again, if the liver is the engine that you know needs your attention, that's the peptide. That's helpful. Nac, tca, these are supplements that we find helpful as well when it comes to the, the liver and how, how well it functions.[00:25:30] Dr. Taz: All right, we've got two more. Metabolic engines that I want you to be aware of in terms of what to do, and if it's you type, plan the muscles. If you are losing muscle mass, you can measure muscle mass. Come to our practice, we can do it for you, or you can do it on your own. There are a lot of different scales nowadays that will give you at least a rough estimate of what your muscle mass is. Dr. Taz: But if your muscle mass is falling below 60% or so, then we've gotta build that muscle back and again, getting adequate protein. Weight training, right? [00:26:00] All of this is assuming you have cellular energy and hormone balance and good gut health, or you're only gonna get fatigued when you go in there to weight train and do all these different things. Dr. Taz: That is going to be the way to help to build and preserve muscle. And from a peptide standpoint, some of the peptides that are boosting testosterone and growth hormone are also the peptides that are gonna help us with muscle mass, right? So again, is diet first, then maybe taking something like branch chain amino acids. Dr. Taz: Then making sure from a mitochondrial standpoint you're in a good [00:26:30] place. And then looking at these peptides like the c, jc, you know, Ipamorelin or Tess Morlin, bringing those, um, into the picture as well. So muscle is our fifth. Metabolic engine. Our sixth one is the nervous system. Again, going back to cortisol and stress, you know, we talked about the role of stress in metabolism, where it's increasing cravings, uh, really leading to disrupted sleep, which again alters your metabolic rate. Dr. Taz: So what do we do? So this is where. [00:27:00] Again, data, if it's helpful for you, knowing things like your cortisol level, knowing where your HRV is, the lower your HRV is, typically the higher your sympathetic sort of nervous system is activating, or you have higher cortisol, that's another way to track or just how you feel. Dr. Taz: You know, if you're having trouble sleeping, if you're anxious, you know, if you're having, you know, like a lot of fearful thoughts or you just feel stressed, you know, you may need to work on the nervous system. Before you work on anything else. And working on the nervous [00:27:30] system is a consistent diet for sure. Dr. Taz: That's higher in protein and healthy fats. We've shown in studies how that actually brings cortisol levels down. It's eating at consistent intervals because that too will help to regulate and balance cortisol. And then in addition to that, it's really adopting some of the self-care techniques, right? Dr. Taz: Whether it's. Breath work or meditation or journaling or signing up for a modality if you can't get your busy brain to calm down. Acupuncture, [00:28:00] yoga, massage, craniosacral therapy, energy healing. These are all things that you can incorporate to really help that particular metabolic engine. We sometimes will give our patients things like CBD gummies to help them relax theanine or gaba. Dr. Taz: If they've got a lot of anxiety, we'll even do things like sort of helping their overall nervous system calm down using an adaptogen like ashwagandha or holy basil. These are things that we keep turning to over and over again to really help this [00:28:30] particular metabolic engine, especially if it's the primary engine that's not. Dr. Taz: Functioning well for the patient sitting in front of us. And with all these different metabolic engines, you may flex, right? You may have seasons where one takes priority over the other, and it's simply understanding that at different times, your regimen and your routine may need to shift. And that's okay. Dr. Taz: 'cause we're all human. Having a human experience. Before we even get to peptides, we should be talking about hormones that help the nervous system. We know, for example, that [00:29:00] progesterone is an anxiolytic. It calms the nervous system down. Super helpful that way, but there are peptides that are helpful. And nervous system regulation. Dr. Taz: Oxytocin is one that I've seen some of my patients come in on or will do if some of these other things start to fail. Cmax or clink are two other peptides that are often used in the context of nervous system regulation, so six different metabolic engines. All needing a focus plan, all [00:29:30] needing everything from proper diet to proper supplementation and proper overall self-care. Dr. Taz: I balance all needing targeted peptide therapy and when we target metabolic health this way, right when we start to prioritize the metabolic engine, we need to be fixated on. Then weight loss becomes a secondary conversation and you are more easily able to transition off that GLP one. So if you're on a GLP one and you're at your [00:30:00] desired weight, then I would start thinking about which of these metabolic engines you want to work on next to make yourself metabolically efficient. Dr. Taz: Or maybe you're just starting a GLP one. Well, then you need to still really look and monitor these six different metabolic engines to make sure you're not sacrificing one of them at the expense of weight loss, which remember 25% of which is loss of muscle. And that's the way we can kind of marry a [00:30:30] pharmaceutical. Dr. Taz: With a holistic plan, a longevity sort of surge and innovative technology that's out there in the longevity field with these fundamental ideas around energy and QI and prana physiology and functional medicine with integrative medicine, and even looking at things like overall conventional medicine and what it has to offer. Dr. Taz: And by putting it all together in a strategic, organized, linear way and understanding that the [00:31:00] toolbox is really big, but our strategy needs to narrow to make it easier for you the patient. You'll have metabolic health that will last through through the decades and through the ages without getting confused and distracted by all the noise that's out there right now. Dr. Taz: Sending everybody spinning in 20 different directions. And that's how you live. Whole Plus, and that's the mission of Whole Plus, is to make these pieces come together into a medical [00:31:30] home for you where we can act as your advocates and help you navigate the craziness that I think is out there right now. Dr. Taz: Alright, I hope this episode helps you set the tone for a healthy year ahead in 2026, and you know where to pull what trigger when. And remember that we're here as your guides and coaches. To help you along the way. We post new episodes every week. I'll see you guys next week. Thanks for joining me on Whole Plus every review, every share, [00:32:00] every message helps us keep bringing you real conversations that make health simple. Dr. Taz: Again, if you have a minute, leave a quick review. It truly makes a difference. And if you're on Instagram, come find me at Dr. Taaz MD and tell me what part of today's episode really spoke to you.