Sunday Science Testosterone 2026_04_19

Go Un-Pro · Apr 20, 2026 · 22m

Sunday Science: Testosterone Therapy – Risks, Benefits & Longevity Debate

Summary by Speaker

Dr. Brent Laartz

Discusses testosterone decline with age (0.4-2.6%/year, 30-50% by 50-60), low T (

Reviews studies:

- Low T associated with 1.5-2.3x higher all-cause, CV, cancer mortality (2010 European Heart Journal cohort; 2011 JCEM meta-analysis).

- Frailty mediates 35% of low T mortality risk.

- Eunuch/castration studies (Korea, Poland, animals): 10-20% longer lifespan, but pre-puberty vs. late-life low T.

- TRT studies: Decreased mortality if levels normalized (2012, 2015 European Heart Journal…