VCs Would Bet on Open-Source AI Over OpenAI and Anthropic | E2341

This Week in Startups · Sep 23, 2026 · 1h 27m

This Week In Startups is made possible by:

Northwest Registered Agent: https://www.northwestregisteredagent.com/twistdomain

Odoo: https://odoo.com/twist

Rippling: https://rippling.ai/twist

Plaud: https://plaud.ai/twist

Harmonic: https://harmonic.ai/twist

Today’s show:

Anthropic and OpenAI released cheaper models on the same day with Claude Opus 5.5 and GPT-6, and these VCs would still bet on open source. Jason brings on Dave McClure of Practical Venture Capital, Jeff Clavier of Uncork Capital, and Jenny Fielding of Everywhere Ventures to discuss the argument for open-weight models over the…