Latest / Hardiness with Dr Paul Taylor / How to Transform Your Longevity Strategy in 6 Months Using Holistic Regenerative Approaches with Dr. Jeff Gross
Transcript
- 0:00Speaker 1: You might have a small benefit from a regenerative medicine approach,
- 0:04Speaker 1: but if you're not living clean and your your cells
- 0:06Speaker 1: are going to flip right back to their bad biology
- 0:08Speaker 1: in a minute. So we like to optimize people ahead
- 0:11Speaker 1: of time. Diet, sleep, exercise strategies, supplements, hormone optimization in
- 0:16Speaker 1: some cases, or mesas all of the above. The better
- 0:20Speaker 1: your body is receptive to these, the more you'll get
- 0:22Speaker 1: out of it.
- 0:33Speaker 2: Hey everyone, before we get into this week's podcast, we
- 0:36Speaker 2: got a pretty cool announcement to make you are not
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- 0:41Speaker 3: We have a pretty cool little widget that's on the website.
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- 1:03Speaker 3: Now, the first thing I want to do.
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- 1:10Speaker 2: So all you gotta do if you got a question
- 1:12Speaker 2: that we want me to cover is just go to
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- 1:25Speaker 2: me anything and leave your name.
- 1:27Speaker 3: We will call it out on the show. I'll get
- 1:29Speaker 3: that all put together. And the other thing you can
- 1:31Speaker 3: do is just leave us a message about what you
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- 1:36Speaker 3: day I talk too much, all of that sort of stuff,
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- 1:46Speaker 2: Doctor Jeff Gross, Welcome to the podcast.
- 1:50Speaker 4: Happy to be here in great meeting you today, Paul,
- 1:53Speaker 4: and you are as I was just saying, you're the
- 1:55Speaker 4: second person in two days that I've interviewed from Las Vegas, Nevada.
- 2:00Speaker 1: It's a new destination center for migration within the US,
- 2:05Speaker 1: growing tech, growing other industries, not just casinos. So probably
- 2:14Speaker 1: there's a huge migration of Californians who are trying to
- 2:18Speaker 1: get away from the disaster of California and Las Vegas
- 2:24Speaker 1: and Reno, which you add those two together, you have
- 2:28Speaker 1: probably ninety five percent of the Nevaden population our destinations
- 2:35Speaker 1: with significant benefits at this time.
- 2:39Speaker 2: Oh, that's really interesting. So were you an original resident
- 2:43Speaker 2: of well for many years.
- 2:45Speaker 1: I was a Californian till about two thousand and fifteen
- 2:50Speaker 1: or so, and before that, I've lived on the East
- 2:52Speaker 1: Coast in the Washington DC area. I've lived in the
- 2:56Speaker 1: Midwest in Ohio and for a couple of years in Albuquerque,
- 3:00Speaker 1: New Mexico.
- 3:01Speaker 2: Wow, you've been around. Yeah. I had to tell you what.
- 3:04Speaker 2: It's almost like those places that you talked about. It's
- 3:07Speaker 2: almost like different countries in the States.
- 3:10Speaker 1: Isn't it. It really is. You know, the different geography.
- 3:15Speaker 1: You know, you are mountains, We've got the coast, and
- 3:18Speaker 1: now I live in the desert.
- 3:19Speaker 2: Yeah, and Jesus gets bloody hot. I've been in Las
- 3:22Speaker 2: Vegas once. It was twenty years ago. Was a death
- 3:25Speaker 2: valley as well. But just even in Las Vegas, God
- 3:28Speaker 2: in summer. You know all about it, don't you, Yes, sir,
- 3:33Speaker 2: so Jeff, we are going to talk about a really
- 3:36Speaker 2: interesting topic in medicine, and that's stem cell therapies. It's
- 3:41Speaker 2: obviously not without its controversies, but you are extremely well
- 3:46Speaker 2: qualified to talk on the subject. I was really interesting
- 3:49Speaker 2: your background, having a degree in biochemistry and molecular biology,
- 3:54Speaker 2: then going on to study medicine and then surgery. So
- 3:58Speaker 2: just give us, give the listeners. There's a little bit
- 4:00Speaker 2: of a toure of your background and also how you
- 4:05Speaker 2: brought yourself to this place to looking at stem cell
- 4:09Speaker 2: therapies and longevity benefits. Particularly, thank you.
- 4:12Speaker 1: I appreciate the opportunity. I'll start at the at the
- 4:17Speaker 1: basic level, and I think I mean this in a
- 4:20Speaker 1: positive way. You'll identify with this. I'm a nerd, so
- 4:23Speaker 1: when the when the science is interesting, I follow it.
- 4:26Speaker 1: So so my my undergraduate you know, background is heavily
- 4:30Speaker 1: into cellular biology and biochemistry. And then you know, in America,
- 4:35Speaker 1: you go you go right from undergrad typically to medical school,
- 4:38Speaker 1: which is another four years, and then residency and fellowship
- 4:41Speaker 1: mind was another seven on top of that. So you
- 4:44Speaker 1: get so busy and narrowed down the specialty pipeline that
- 4:48Speaker 1: the molecular biology piece that you know, stimulated your brain
- 4:52Speaker 1: so much sort of got you know, put on a shelf.
- 4:55Speaker 1: And I was practicing for this is now my I
- 4:59Speaker 1: think twenty fifth year or just started my twenty sixth
- 5:02Speaker 1: year of I'm a neurosurgeon and I have a spine specialty.
- 5:05Speaker 1: I do a lot of neck and backcare. Second opinions.
- 5:08Speaker 1: I'd take on the failed cases that were treated elsewhere,
- 5:12Speaker 1: and I've always tried to, you know, reduce and avoid surgery,
- 5:16Speaker 1: you know, that being the last option, because we really
- 5:19Speaker 1: aren't doing anything differently than we were doing in the
- 5:23Speaker 1: nineteen fifties. Yeah, maybe there's a smaller incision or a
- 5:26Speaker 1: new gidget or widget or gadget or something, but it's
- 5:30Speaker 1: the same approach. So it became frustrated over the years,
- 5:34Speaker 1: and so did my patients, because my patients would come
- 5:37Speaker 1: in and say, hey, we've tried the physiotherapy, we've tried
- 5:40Speaker 1: the anti inflammatory medications, we've tried the occupuncture of the chiropractic,
- 5:45Speaker 1: the physical training, we've tried maybe even some spinal injections,
- 5:50Speaker 1: but you know those are all temporary. I'm looking for
- 5:52Speaker 1: something that can help me with this ongoing problem, this pain,
- 5:56Speaker 1: this whatever pinsioner disc issue. I'd say, well, I guess
- 5:59Speaker 1: the only thing left talk about is what's on the
- 6:01Speaker 1: surgical menu. And they'd say, oh, but I'm not ready
- 6:04Speaker 1: for that. I'd say, great, I'm happy to hear that,
- 6:07Speaker 1: but I don't have a lot more to offer you
- 6:09Speaker 1: at this time. And they would say, well, how about lasers?
- 6:13Speaker 1: How about how about crystals? How about stem cells? And
- 6:18Speaker 1: you hear it enough times and you you know what,
- 6:21Speaker 1: what about stem cells? So instead of going to the
- 6:24Speaker 1: annual you know, spine neurosurgeons meetings, which I had done
- 6:29Speaker 1: for decades and didn't you know, nothing was changing. I
- 6:33Speaker 1: decided to open my mind and go back to my roots,
- 6:36Speaker 1: and I went to stem cell conferences and got re educated.
- 6:40Speaker 1: This about six years ago, and I did it to
- 6:43Speaker 1: offer something new, a new tool to my patient's suffering
- 6:46Speaker 1: from neck and back pain and problems. But it has
- 6:49Speaker 1: opened up an entire new world for me and people
- 6:53Speaker 1: who see me in offering a new option, in tapping
- 6:57Speaker 1: back into our own blueprint of what creates us, what
- 7:01Speaker 1: heals us, and what maintains us, and using that strategically
- 7:06Speaker 1: to help repair a problem or help you know, heal
- 7:10Speaker 1: or regenerate or slow the aging process of physiologically.
- 7:14Speaker 2: And biologically interesting. I'll tell you what. My daughter is
- 7:19Speaker 2: going to love this, right she is. She's eighteen and
- 7:23Speaker 2: about to go to university. And for years she said
- 7:27Speaker 2: she wanted to study medicine, and we sent her. Last year,
- 7:32Speaker 2: my wife found this medical internship in Nepal for want
- 7:37Speaker 2: to be medical students. So off she went for a
- 7:40Speaker 2: couple of weeks to Nepal with a bunch of other
- 7:42Speaker 2: want to be medical students. Had a blast. They were
- 7:46Speaker 2: shadowing Nepalese doctors in remote Nepal, even in surgery, right.
- 7:51Speaker 2: And she came back. She had a fantastic time. But
- 7:55Speaker 2: she said to me, Dad, I've realized that everybody that
- 7:59Speaker 2: was on that course was so passionate about medicine. I've
- 8:03Speaker 2: realized that my passion is biology. So she wants to
- 8:07Speaker 2: go and study BioMed and we looked into it and
- 8:10Speaker 2: there's so many different pathways once you finish your degree
- 8:14Speaker 2: in BioMed. And I said to her, all that biological engineering,
- 8:19Speaker 2: like that's the future, right, and I presume stem cell
- 8:23Speaker 2: therapies come under that broad umbrella of biological engineering.
- 8:29Speaker 1: Yeah, so there's the biological side of bioengineering. There's the
- 8:33Speaker 1: tech side of bioengineering. When you think about elon MUSK
- 8:36Speaker 1: and neurolink and things like that. So and then there
- 8:40Speaker 1: have to be people that help bridge those So I
- 8:44Speaker 1: think that there are those faults under that and bro.
- 8:46Speaker 2: Yeah, awesome. So give us a bit of an overview
- 8:49Speaker 2: of stem cell therapies and particularly the different types. Right,
- 8:55Speaker 2: So I know there's embryonic theory potent, there's adult stem
- 8:58Speaker 2: cell therapy. So just give our listeners who maybe not
- 9:03Speaker 2: all over this topic, just a bit of a high
- 9:05Speaker 2: level overview.
- 9:06Speaker 1: Perfect. So stem cell one oh one is basically it
- 9:11Speaker 1: comes in different forms. Although we use the phrase stem cells,
- 9:15Speaker 1: not everything we do involves the use of stem cells.
- 9:19Speaker 1: For example, there's a lower level regenerative medicine biologic called
- 9:25Speaker 1: PRP or platelet rich plasma, and it comes in different forms.
- 9:28Speaker 2: I've had PRP in an achilles injury and I'm currently
- 9:34Speaker 2: recovering from an acl and the sports medicine doctors suggested PRP, right,
- 9:39Speaker 2: which is why they spin your own blood and pull
- 9:41Speaker 2: off the plate reach plasma right.
- 9:44Speaker 1: Right, So what's in that platelet rich plasma are many
- 9:47Speaker 1: of the things that stem cells make to help you heal.
- 9:51Speaker 1: They make proteins, peptides, growth factors, proteins that involve the
- 9:56Speaker 1: production of collagen when you want to help maintain or
- 10:00Speaker 1: in your case, heal and injury. And they also put
- 10:02Speaker 1: off cell signaling bodies called extracellular vesicles or for short, exosomes.
- 10:09Speaker 1: So there's concentrated from your blood, they get centrifuged and
- 10:13Speaker 1: separated and re delivered into an area that needs more
- 10:17Speaker 1: love than it could. You could, your body could give
- 10:19Speaker 1: it on its own. So that's great, and that's kind
- 10:21Speaker 1: of a low level offering that's available almost ubiquitously now
- 10:25Speaker 1: in most of the world. Sometimes it takes a few sessions,
- 10:28Speaker 1: and it's certainly easy enough and worth trying before you
- 10:31Speaker 1: undergo something more invasive or major, Right, why not try it? Okay?
- 10:36Speaker 1: So the next step up from that would be to
- 10:39Speaker 1: actually deliver stem cells. And stem cells come from two sources,
- 10:44Speaker 1: and those sources would be an adult. Like you said,
- 10:47Speaker 1: you can harvest your own stem cells, hopefully with the
- 10:50Speaker 1: help of a clinician. You know, you don't, don't under yourself.
- 10:53Speaker 1: But it can come from your bone marra. It could
- 10:56Speaker 1: come from a you know, fatty tissue and other places,
- 10:59Speaker 1: but bone is probably the richest source. And you think
- 11:02Speaker 1: about it. If a sad case, if a child has
- 11:04Speaker 1: leukemia and they have to undergo a complete chemotherapy, killing
- 11:08Speaker 1: of the bone marrow and a replacement with a bone
- 11:11Speaker 1: marrow donor to save that child. That is a replacement
- 11:14Speaker 1: of that child's stem cells in the bone marrow. So
- 11:17Speaker 1: now that requires matching because it's such a significant replacement.
- 11:21Speaker 1: But typically stem cells don't require any matching. They're not rejected.
- 11:26Speaker 1: Theoretically they can be, but I've never seen it or
- 11:28Speaker 1: read about it. So they're immunoprivileged. So the immune system says,
- 11:32Speaker 1: come on in. But the other source is what we
- 11:34Speaker 1: call perry natal. Pery natal means it comes from the
- 11:37Speaker 1: afterbirth products from a mother who is, you know, congratulations,
- 11:41Speaker 1: here's your baby that we just delivered by c section.
- 11:45Speaker 1: Instead of throwing away the amniotic fluid, the umbilical cord,
- 11:48Speaker 1: the placenta, can we keep it and use it, you know,
- 11:51Speaker 1: in medical purposes. That's how that happens. So it's a
- 11:53Speaker 1: very ethical process. There are myths, you know, of some
- 11:57Speaker 1: nefarious things happening, you know, but I've ever really seen that.
- 12:01Speaker 1: I think it's more of a smear campaign that pharmaceutical
- 12:05Speaker 1: companies and other companies want out there. So that's the
- 12:08Speaker 1: most active and richest source, Paul. So when you when
- 12:11Speaker 1: you take your car and you go for an oil change,
- 12:15Speaker 1: you know, you don't put the old oil back in.
- 12:17Speaker 1: So I like that young, fresh, bioactive that you know,
- 12:23Speaker 1: cells and other products that aren't affected by years of
- 12:28Speaker 1: electromagnetic waves and toxins in the pollutants and whatever. We
- 12:32Speaker 1: you know, neuro stress from giving yourself the wrong mental
- 12:35Speaker 1: signals and.
- 12:36Speaker 2: All that because not Jeff, sorry to interrupt. It is
- 12:39Speaker 2: one of the mechanisms of aging is stem cell exhaustion,
- 12:44Speaker 2: isn't it. So that's why those embryonic stale sales are
- 12:48Speaker 2: those ones that you're talking about. They're cleaner if you
- 12:52Speaker 2: like stem sales set.
- 12:54Speaker 1: Yeah, they're the most active because they have not been
- 12:57Speaker 1: ruined by the world in the environment, and they're as
- 13:00Speaker 1: naive and active as they come. Now we call these
- 13:04Speaker 1: perinatal embryonic is actually involved in the embryo making a
- 13:08Speaker 1: feed in and you can induce certain these stem cells
- 13:13Speaker 1: at the time of a birth or an adult back
- 13:16Speaker 1: into the embryonic state. There's a Nobel prize about how
- 13:20Speaker 1: to do that. And those cells have even more power
- 13:23Speaker 1: and we're learning how to harness them. And only very
- 13:25Speaker 1: certain circumstances are those in use in the world, and
- 13:28Speaker 1: here in the us A they are. They are under
- 13:31Speaker 1: research and they're called you know, induced pluripotent stem cells,
- 13:35Speaker 1: which are more of an embryonic state. Now, those are
- 13:38Speaker 1: the cells someday that are going to help us regrow
- 13:40Speaker 1: a finger or a limb or an organ better than
- 13:44Speaker 1: what we have right now?
- 13:45Speaker 2: Are they some of the ones that you can you
- 13:47Speaker 2: hear some people go into Mexico to get done or yeah, okay, cool, Yeah, So.
- 13:54Speaker 1: Let's take let's take that comment for a minute and
- 13:56Speaker 1: build on it. In the US we're actually late to
- 13:59Speaker 1: the game. Europe and Asia are way ahead in the
- 14:03Speaker 1: regenerative medicine field, and most of the professional athletes who
- 14:07Speaker 1: needed some type of stem cell based treatment would go
- 14:10Speaker 1: to Europe for decades, right, you know, Tiger Woods, Peyton
- 14:14Speaker 1: manning some of these players. And if you read the
- 14:17Speaker 1: Asian literature, and a lot of the good clinical medicine
- 14:20Speaker 1: that we follow here in US are based on studies
- 14:23Speaker 1: with years of follow up that are done in these
- 14:26Speaker 1: other countries. Mexico and Central America is a little less regulated,
- 14:31Speaker 1: but they also have access to not only we'll call
- 14:34Speaker 1: them multipotent stem cells, which are usually the ones at
- 14:38Speaker 1: birth or thereafter, but they do, like you said, have
- 14:41Speaker 1: access to these induced embryonic state stem cells. So that's
- 14:46Speaker 1: a growing idea. And then back to the underlying question
- 14:49Speaker 1: here is there's a third level of regenerative medicine, and
- 14:53Speaker 1: that's based on these cell signaling particles called extracellular vesicles
- 14:58Speaker 1: or exosomes that stems and in fact all cells produce,
- 15:02Speaker 1: but the actual work that one's own body does, that
- 15:07Speaker 1: needs a little re encouragement to behave at a more
- 15:10Speaker 1: youthful restorative you know, anti inflammatory status comes from these
- 15:15Speaker 1: stem cells signaling. So, Paul, if I gave you in
- 15:19Speaker 1: your vein a dose of stem cells in ten to
- 15:22Speaker 1: fourteen days, they be gone, but the benefits would last
- 15:26Speaker 1: weeks and months, if not some of the benefits permanent.
- 15:29Speaker 1: Why is that because those stem cells have produced and
- 15:32Speaker 1: delivered these exosomes full of heat shock proteins and peptides
- 15:37Speaker 1: and growth factors and re education and encouragement to their
- 15:41Speaker 1: neighboring cells of your body that does the actual work.
- 15:44Speaker 1: So we're now skipping ahead of stem cells. So the
- 15:46Speaker 1: latest and greatest are these stem cells derived exosomes, And
- 15:51Speaker 1: they have advantages. They're less costly, they penetrate the body better,
- 15:57Speaker 1: they can cross the blood brain barrier and get into
- 15:59Speaker 1: the brain. They are also more easily handled and stored
- 16:03Speaker 1: and they don't have anyone else's DNA and some people
- 16:06Speaker 1: like that, and these are just generic. We have some
- 16:09Speaker 1: designer ones coming that are available in China that I
- 16:13Speaker 1: think will be fantastic. You know, some for helping build
- 16:16Speaker 1: muscle mass, which is correlated with longevity, helping improve bondency.
- 16:21Speaker 1: Some are from the immune cells that help identify and
- 16:24Speaker 1: remove abnormal cells like sinessence cells and cancer cells. So
- 16:28Speaker 1: we are just at the forefront.
- 16:30Speaker 2: Interest interesting that the exosomes are really coming to the
- 16:35Speaker 2: forefront eye. I did interview a professor who's in the
- 16:39Speaker 2: area of exosomes and we were talking about the interaction
- 16:42Speaker 2: with miokinds produced in muscle yes and exosomes and how
- 16:46Speaker 2: they work together.
- 16:47Speaker 1: Yeah, you're singing my song there. Myokinds are amazing. And
- 16:52Speaker 1: one way to stimulate your own stem cells is move exercise.
- 16:56Speaker 1: You know, we call this hormesis where you give the
- 16:59Speaker 1: body a little bit the stress to build resilience when
- 17:02Speaker 1: your body, you know, needs it, and that helps release
- 17:05Speaker 1: stem cells. It helps clear out zombies and essence cells
- 17:09Speaker 1: which are taking up space and resources but not doing
- 17:12Speaker 1: any good, so that you have a younger population of cells.
- 17:15Speaker 1: And when you do you have a younger you know,
- 17:18Speaker 1: physiologic body and this can be measured in biological age
- 17:21Speaker 1: tests through certain markers and probably with the biofitness bioage
- 17:26Speaker 1: fitness testing that you do.
- 17:28Speaker 2: So yeah, yes, interesting and very interesting that you mentioned hormesis.
- 17:33Speaker 2: We could go down that rabbit hole, which we won't,
- 17:36Speaker 2: and I'm about to start a lab with Professor Grant
- 17:39Speaker 2: Scofield called the Hormesis Lab, love it, where we are
- 17:43Speaker 2: looking at hormetic interventions to enhance health span. Right, so
- 17:48Speaker 2: it's his exercise saun a cold exposure. You know, these
- 17:52Speaker 2: small It's amazing how the body adapts to small doses
- 17:58Speaker 2: of stressors, right right. It's through the signaling, the cellular
- 18:03Speaker 2: signaling that all of this takes place, right, which is
- 18:07Speaker 2: why you're obviously so interested in this area. So talk
- 18:11Speaker 2: to you about some of the use kisses, both currently
- 18:16Speaker 2: the stuff that you do and that others are doing
- 18:19Speaker 2: in those use cases, and then we'll come back to
- 18:21Speaker 2: some potential future use cases. But let's give us the
- 18:24Speaker 2: state of play right now.
- 18:26Speaker 1: Right, So, the low hanging fruit all is muscular skeletal
- 18:31Speaker 1: structural things like joints, particularly degenerated joints. Loss of cartilage, osteoarthritis,
- 18:38Speaker 1: or bone on bone. Those are all part of the
- 18:41Speaker 1: same package. We follow a French protocol whereby the fifteen
- 18:45Speaker 1: year follow up clinical data was published a few years back,
- 18:48Speaker 1: so they're probably ready to publish their twenty year in
- 18:52Speaker 1: which at that time they only had stem cells. Exosomes
- 18:55Speaker 1: are only available in the last five or five or
- 18:58Speaker 1: eight years, depending on what part of the world. So
- 19:00Speaker 1: they injected stem cells into patients knees who were already
- 19:06Speaker 1: recommended a knee replacement surgery. So they took patients they said,
- 19:10Speaker 1: you need to need replacement, Well, wait a minute, would
- 19:12Speaker 1: you like to join our study to try not to
- 19:14Speaker 1: have one? So they had no problem signing up people.
- 19:17Speaker 1: And this is doctor Philippe Hernegeau. I probably mispronounced that,
- 19:21Speaker 1: but University of Paris East, an orthopedic surgeon who published this,
- 19:27Speaker 1: and they did half the patients they injected into the
- 19:30Speaker 1: cartilage of the joint, and we use the word intra
- 19:33Speaker 1: articular when we do that, and half the patients got
- 19:36Speaker 1: it into the bone edge just above them below the joint,
- 19:41Speaker 1: which is called the subchondri bone. It's an old leftover
- 19:45Speaker 1: part of the growth plate. But you know it lives
- 19:46Speaker 1: in there. The cells that produce cartilage, they're called chondrocytes,
- 19:52Speaker 1: and those cells are the cells that produced that cartilage,
- 19:57Speaker 1: that meniscus, that acl in the first place. And they
- 20:01Speaker 1: found over fifteen years that the best results and longest
- 20:05Speaker 1: lasting results come from and injecting the bone edges. So
- 20:08Speaker 1: that's what we do. You might say, wait a minute,
- 20:11Speaker 1: the bone injection. That sounds painful. Well, we do give
- 20:14Speaker 1: a little twilight sedation for that, and it's usually a
- 20:18Speaker 1: one and done in most cases, and there's no downtime.
- 20:21Speaker 1: You can go right back to sports. You'd be sore
- 20:25Speaker 1: for a week, but what have you go back to
- 20:27Speaker 1: your thing. And we've seen, you know, months down the line,
- 20:30Speaker 1: we have some patients we've done some MRIs after the
- 20:32Speaker 1: fact and we've seen restoration in cartilage thickness and improvement
- 20:38Speaker 1: that goes with that in pain and improvement and functions.
- 20:41Speaker 1: So we are seeing a reversal and a regeneration of
- 20:45Speaker 1: the cartilage of the joint because we're putting in a
- 20:47Speaker 1: factory order to the factory for some new cartilage in
- 20:51Speaker 1: a person whose body, like you said, is stem cells
- 20:53Speaker 1: are exhausted. Otherwise they would have healed it themselves already.
- 20:56Speaker 2: Yeah. That for somebody like you used to doing surgery.
- 21:01Speaker 2: When you see that and done those operations, that must
- 21:05Speaker 2: just blow your mind.
- 21:06Speaker 1: It's a renewal of my interest in clinical medicine because
- 21:10Speaker 1: I was in a rut doing these same surgeries over
- 21:13Speaker 1: and over again, or trying to keep people away from them.
- 21:15Speaker 1: You know, here's a very simple way that we can
- 21:18Speaker 1: help people without surgery, not in every case, but in
- 21:22Speaker 1: many cases, or maybe push out the surgery because there
- 21:25Speaker 1: are always new things coming, push it out ten years
- 21:27Speaker 1: and by then we have another stem cell solution. So
- 21:30Speaker 1: it's been wonderful and remarkable. I wish I had this
- 21:33Speaker 1: tool my entire career.
- 21:35Speaker 2: So knaseed hips would obviously lend themselves to this very
- 21:39Speaker 2: very strongly. And the amount of knee and hip replacements
- 21:42Speaker 2: that are to is just ridiculous. What about the spine
- 21:46Speaker 2: as well, because I know, you know, in extreme cases
- 21:48Speaker 2: when people have long term spinal issues, sometimes they get
- 21:53Speaker 2: spinal fusion, which my understanding has a hit rate of
- 21:58Speaker 2: around our success rate of around fifty percent. I think
- 22:01Speaker 2: there was some Harvard doctor who did placebo operations and
- 22:05Speaker 2: got similar results from.
- 22:08Speaker 1: I don't know who would sign up for the placebo spine.
- 22:11Speaker 2: Yeah, no exactly, but has it got use cases there
- 22:15Speaker 2: in spinal difficulties as well.
- 22:18Speaker 1: Yeah. Now, the key to understanding the spine, because it's
- 22:21Speaker 1: a complex structure, is to know exactly where the pain
- 22:24Speaker 1: is coming from. Is it coming from a disk source,
- 22:27Speaker 1: Is it coming from a facet joint, which are the
- 22:29Speaker 1: joints in the back of the spine. Is it coming
- 22:31Speaker 1: from both or something else, or has the spine become
- 22:34Speaker 1: debilitated whether aren't the muscular support. So we have to
- 22:39Speaker 1: come to an understanding, and we have to you know,
- 22:41Speaker 1: practically test that sometimes with some numbing shots to see
- 22:44Speaker 1: what temporarily resolves pain. And based on that, based on
- 22:49Speaker 1: a good exam, based on some high quality MR images
- 22:52Speaker 1: done in a very special way, we put all that
- 22:55Speaker 1: information together and come with some kind of plan. Not
- 22:58Speaker 1: everyone we can. If we can treat part of it
- 23:01Speaker 1: and that's good enough to keep someone away from surgery,
- 23:04Speaker 1: that could be something we do. So we treat plenty
- 23:07Speaker 1: of spines. Spines take longer, usually nine months or more
- 23:12Speaker 1: to improve. This is my observation. We'll collect all these
- 23:15Speaker 1: someday and publish them but I'm not. I don't have
- 23:19Speaker 1: a reason why that is, but except that spinal disc
- 23:22Speaker 1: isn't like a nimaniscus. Spinal disc has two different forms
- 23:25Speaker 1: of cartilage, and I think that's part of the reason.
- 23:28Speaker 1: So we're learning more about it all the time.
- 23:31Speaker 2: Yeah, that's definitely more complicated than nas and hips, and
- 23:34Speaker 2: so let's not talk about just overall the difference between
- 23:41Speaker 2: the benefits of these regenerative treatments versus the typical medical approaches.
- 23:48Speaker 2: So you've mentioned their return to daily activities, that's one benefit.
- 23:54Speaker 2: What other benefits d you see other than like avoiding surgery? Right,
- 23:58Speaker 2: So I had a actually, let's take I recently, a
- 24:01Speaker 2: couple of years ago, had a hip resurfacing, right, and
- 24:06Speaker 2: the rehab took quite a while. It took quite a
- 24:09Speaker 2: few months. I'm not a couple of years, and the
- 24:11Speaker 2: hip feels fantastic. But that ain't gonna last forever, right,
- 24:15Speaker 2: I'm gonna have to go and revisit that at some stage.
- 24:19Speaker 2: So talk about what some of the other benefits would
- 24:23Speaker 2: be other than quicker recovery.
- 24:26Speaker 1: Well, besides the you know, the quicker recovery, least, lesser invasion,
- 24:30Speaker 1: less risk of infection, and less. Yeah, you don't have
- 24:33Speaker 1: the long recovery, you don't need a bunch of pain
- 24:35Speaker 1: medicines after, and potentially a reduced costs because if you
- 24:40Speaker 1: you know, if you're someone who has to recover from
- 24:42Speaker 1: a surgery and miswork, miss income, you know, pain and
- 24:46Speaker 1: suffering that goes with that. I mean, at the end
- 24:49Speaker 1: of the day, these procedures are are more affordable, especially
- 24:52Speaker 1: using the stem cell derived exosomes and related growth factors.
- 24:56Speaker 1: They're they're less costly than stem cells in some cases.
- 25:00Speaker 1: For example, if we did a knee and it required
- 25:02Speaker 1: a dose above and a dose below, usually something like
- 25:05Speaker 1: that is in the ten to twelve thousand dollars US
- 25:08Speaker 1: dollar range includes everything. So that's you know, you look
- 25:13Speaker 1: at a you know, a knee surgery depending on what
- 25:17Speaker 1: your health insurance may or may not cover. Here in
- 25:19Speaker 1: the US, it's complex. They have deductibles you have to meet,
- 25:22Speaker 1: and cope's and things. You may be saving money doing
- 25:25Speaker 1: the regenerative medicine approach.
- 25:28Speaker 2: Yeah, and then the other thing is that you don't
- 25:30Speaker 2: have any foreign bodies inside. You read yesterday, Actually some
- 25:36Speaker 2: cases in the UK were hip joints that they had
- 25:41Speaker 2: put in were actually leaking out toxins and causing really
- 25:46Speaker 2: poor health. I remember, they're going to not going shit,
- 25:49Speaker 2: what type of joint was that. I've I've got obviously
- 25:53Speaker 2: foreign bodies in there. I've got metal in my body.
- 25:57Speaker 2: You're not introducing foreign bodies in there. Now, generally these
- 26:00Speaker 2: things are pretty See if I think that was just
- 26:02Speaker 2: one type of hip joint that had it had a
- 26:04Speaker 2: couple of different joins and that was the issue with it.
- 26:08Speaker 2: But that's got to be a benefit if you're not
- 26:12Speaker 2: introducing foreign substances into the body.
- 26:15Speaker 1: Oh, absolutely true. You know, all of those things have
- 26:17Speaker 1: frictional wear and and material you know, failure over time.
- 26:23Speaker 1: And the other benefit here with going in a regenerative
- 26:26Speaker 1: injectional route is you know, you talk about like you're resurfacing.
- 26:30Speaker 1: Anytime you go into a joint to trim some cartilage
- 26:34Speaker 1: or you know, try to help in a regular surface
- 26:37Speaker 1: become more regular so it moves smoother. You're actually increasing
- 26:42Speaker 1: the development of osteoarthritis. You know, some doctors just use
- 26:46Speaker 1: the word arthritis in that joint. Over time, Yes, you
- 26:49Speaker 1: have benefit for a while, but you're accelerating the process.
- 26:52Speaker 1: So we seek to do the reverse of that. Right,
- 26:55Speaker 1: So we would take someone like you, and I would
- 26:58Speaker 1: have loved to have you. You know, at the time
- 27:00Speaker 1: of your resurfacing inject you know, the surface, the edge
- 27:04Speaker 1: of the bone and the ball of your hip joint
- 27:06Speaker 1: and maybe even also the receptor part the cup of
- 27:09Speaker 1: the joint with the regenerative biologics. You're still candidate, but
- 27:12Speaker 1: that would be what we would do to try to improve. Now,
- 27:17Speaker 1: now that you have a nice shape in your hip,
- 27:18Speaker 1: we want to help you produce and maintain that joint,
- 27:21Speaker 1: better lubricate it, better produce the proteins and growth factors
- 27:25Speaker 1: and the collagen and the cartilage in there to help
- 27:28Speaker 1: restore interesting.
- 27:30Speaker 2: I think when the other hips roady, I'll be coming
- 27:32Speaker 2: to you.
- 27:34Speaker 1: Perfect.
- 27:35Speaker 2: So let's talk about your journey and when you were
- 27:38Speaker 2: shifting across from the traditional stuff. What were some of
- 27:43Speaker 2: the challenges that you went through.
- 27:45Speaker 1: Well, some people, you know, are completely dependent on their
- 27:48Speaker 1: health insurance here in the US, and they don't have
- 27:51Speaker 1: the resources, even though these are reasonably affordable compared to
- 27:54Speaker 1: most things, so some people have trouble with that. Luckily,
- 27:58Speaker 1: we've been able to work with some charitable programs. There's
- 28:01Speaker 1: a there's a Veterans group, we support being able to
- 28:04Speaker 1: provide some you know, pro bono care. There there are
- 28:07Speaker 1: some people who think that they're that these procedures are
- 28:10Speaker 1: illegal because we are not allowed in the US to
- 28:14Speaker 1: make marketing claims that we're curing or treating anything. Certainly,
- 28:19Speaker 1: doctors can't give guarantees about anything, but we're very cautious
- 28:22Speaker 1: not to make claims. So anything we say here today,
- 28:25Speaker 1: Paul is for educational purposes and and I'm allowed to
- 28:29Speaker 1: speak to anecdotal results, which I have, and but I'm
- 28:33Speaker 1: not allowed to make a claim. So despite what you
- 28:35Speaker 1: think in the US about free speech, it's uh, there
- 28:38Speaker 1: are limitations.
- 28:39Speaker 2: Is that different to you doing surgery? Could you make
- 28:43Speaker 2: our ours? That? Is that the same across the board
- 28:45Speaker 2: that you can't make claims. Are they particularly tight on
- 28:50Speaker 2: stem cell therapies?
- 28:51Speaker 1: Well, I think I think the stem cell therapies are
- 28:54Speaker 1: an exciting area for governmental regulation. I don't know if
- 28:58Speaker 1: there are any tighter but doc aren't supposed to make
- 29:01Speaker 1: claims about anything that hasn't been given approval for said claims.
- 29:07Speaker 1: And these these are usually drugs and devices. So a
- 29:12Speaker 1: surgery is unregulated by the FDA, by the government regenerative
- 29:17Speaker 1: medicine is regulated and there are no yet any approvals.
- 29:21Speaker 1: There are no disapprovals. Just so we're clear. It's sort
- 29:24Speaker 1: of this in limbo state.
- 29:27Speaker 2: Right, got it? Interesting type rope that you've got to
- 29:30Speaker 2: walk in. And then let's just talk about other potential
- 29:34Speaker 2: use cases. So you're in a particular area, but I
- 29:37Speaker 2: have seen the some potential for stem cell therapies for
- 29:43Speaker 2: like diabetes, neurodegenerative disorders, those sorts of things. Get just
- 29:49Speaker 2: give our listeners. I know it's not your particular specialization,
- 29:52Speaker 2: but just you know, what's the potential here.
- 29:55Speaker 1: Yeah, no, we we do some of this too. You
- 29:57Speaker 1: can you cannot be in the regenerative medicine fel to
- 30:00Speaker 1: not you know, easily expand into other areas. But we
- 30:04Speaker 1: have IV treatments for people who have any type of
- 30:09Speaker 1: inflammatory burden. Inflammatory is a code word for you know,
- 30:13Speaker 1: degeneration of the cell, the tissues the body, which is
- 30:16Speaker 1: another theory of aging, right, this whole inflammating. So anything
- 30:20Speaker 1: we can do to slow, reverse reverse the inflammatory activities
- 30:25Speaker 1: inside of a cell, we call that cellular metabolism and
- 30:28Speaker 1: flip it into an anti inflammatory mode, which is more
- 30:31Speaker 1: of an optimal mode. And optimal mode heals better, restores,
- 30:38Speaker 1: maintains the adult bodies. So that's what we're seeking. So
- 30:42Speaker 1: we do IV for people with organ damage with type
- 30:45Speaker 1: two diabetes that has an inflammatory component. Most of the
- 30:49Speaker 1: diseases of aging are diseases of inflammation. Right coronary artery disease,
- 30:54Speaker 1: have the plaques, has an inflammatory component, Alzheimer's disease, misfolded
- 30:58Speaker 1: proteins has an inflammatory component. We look at osteoarthritis we've
- 31:02Speaker 1: talked about of course has a huge inflammatory component. And
- 31:05Speaker 1: then people with inflammatory issues in general like autoimmune you know,
- 31:10Speaker 1: flammatory bowel problems, exzema, psoriasis, other arthritis type problems, thyroid problems,
- 31:17Speaker 1: and certain infections that are known to have a very
- 31:20Speaker 1: hyper inflammatory reaction like COVID nineteen and line disease. I
- 31:25Speaker 1: don't know if you have that in your part of
- 31:26Speaker 1: the world. Okay, these are things we see that are
- 31:29Speaker 1: quite helpful. And then recovery from stroke and heart attack,
- 31:33Speaker 1: you know, there's an inflammatory component. And even after traumatic
- 31:37Speaker 1: brain injury, we're seeing some benefits now using the exosomes.
- 31:41Speaker 2: Wow, So the exosomes go into the IV.
- 31:45Speaker 1: They can do IB and the other way to give
- 31:47Speaker 1: them into the brain. Is nasal spray.
- 31:50Speaker 2: Oh yeah, there's some really interesting stuff coming out on
- 31:54Speaker 2: nasl spray. Somebody was talking me the other day about
- 31:56Speaker 2: BDNF in the nasole spray. I'm like, what, because that
- 32:01Speaker 2: is direct access to the brion, isn't it.
- 32:03Speaker 1: It is? There are a couple of different ways to
- 32:05Speaker 1: you know, get to the brain through the back of
- 32:07Speaker 1: the nose. There's a ganglion in the back of the nose,
- 32:10Speaker 1: but the cribber form plate, which is where you know
- 32:15Speaker 1: there's nerves that transmit smell sneak up into the skull
- 32:19Speaker 1: and get to that part of the brain. We're using
- 32:21Speaker 1: that little railway, if you will.
- 32:24Speaker 2: That is an absolute game changer, right. I was a
- 32:28Speaker 2: little bit aware of stem cells. There's there's so much
- 32:31Speaker 2: regulation here in Australia, like trying to get stem cells
- 32:33Speaker 2: orotpy in Australia. That this is why Australians go to
- 32:37Speaker 2: whether they go to Mexico, Panama or the United States,
- 32:40Speaker 2: if they want something that's a little bit less controversial
- 32:43Speaker 2: and more regulated, but that that delivery through ivy of exosomes.
- 32:51Speaker 2: That is a potential game changer for so much stuff
- 32:54Speaker 2: because as you rightly say. If you look at most
- 32:57Speaker 2: chronic diseases have an inflammatory component, and it is one
- 33:02Speaker 2: of the major ways that we use is that cellular inflammation.
- 33:06Speaker 2: So you can actually target certain types of information or
- 33:10Speaker 2: inflammation in certain areas. Or does it just when you'd
- 33:14Speaker 2: introduce the exosomes through an IV does it just have
- 33:17Speaker 2: wide spread effects throughout the whole system. Give me a
- 33:20Speaker 2: little bit of a steer on it.
- 33:22Speaker 1: Yeah, So stem cells tend to target areas of inflammation.
- 33:25Speaker 1: Exosomes are not so smart they go everywhere. They just
- 33:29Speaker 1: go to the wherever. But because they are so small,
- 33:32Speaker 1: not that cells aren't small, that these are. You know,
- 33:35Speaker 1: they're called nanoparticles because they're measured in diameter by nanometers,
- 33:39Speaker 1: so there are a thousand times smaller than a cell,
- 33:42Speaker 1: which is measured in microns. So these particles just they
- 33:46Speaker 1: diffuse as if they're part of the fluid. The problem
- 33:48Speaker 1: with stem cells IV is such a large percentage of
- 33:52Speaker 1: that does first goes up the vein to the heart,
- 33:55Speaker 1: then to the lungs, then back to the heart to
- 33:58Speaker 1: get pumped to the body. Turns out those cells are
- 34:00Speaker 1: sticky and the heart lung heart shuttle can take eighty
- 34:05Speaker 1: percent or more of those cells and the body is
- 34:08Speaker 1: doesn't get the type of volume of those cells that
- 34:12Speaker 1: we desire.
- 34:14Speaker 2: That's interesting, okay. And the exosomes that they behave differently
- 34:18Speaker 2: are are they.
- 34:20Speaker 1: They're just they're part of the fluid of the plasma
- 34:22Speaker 1: of the blood and they just they're not sticky. They
- 34:24Speaker 1: just go wherever and they don't get hung up because
- 34:27Speaker 1: of their size and stickiness. Stickiness could be the receptors
- 34:30Speaker 1: and things. Exosomes have minimal, if any receptors on them.
- 34:34Speaker 2: Wow, that is fascinating. And are there any known negative
- 34:39Speaker 2: effects of exisomes going throughout the entire body?
- 34:43Speaker 1: So the only issues you have besides you know pain
- 34:46Speaker 1: at the IV side or you know, bleeding from the
- 34:48Speaker 1: IV site is if you harbor a lot of inflammation already,
- 34:52Speaker 1: whether it's limes disease or something. Your cells store produce
- 34:57Speaker 1: and store cells signaling proteins called cytokinds that call for
- 35:03Speaker 1: the immune system. This is the whole cytokind storm during COVID, right,
- 35:07Speaker 1: and your body has to get rid of those. So
- 35:09Speaker 1: when you get the stem cell derived exosomes, those cells
- 35:13Speaker 1: have to flip over their factory machinery from defense mode
- 35:16Speaker 1: to peace time, from inflammation to anti inflammation. When they
- 35:21Speaker 1: do that, they still have to purge out that old
- 35:24Speaker 1: the stock on the shelves, if you will. And so
- 35:26Speaker 1: some people as they release those, have a day or
- 35:30Speaker 1: two of a flu like set of symptoms, not the
- 35:33Speaker 1: flu itself, but flu like syndrome. Of you have a
- 35:36Speaker 1: low grade fever. You can have aches and pains, you
- 35:38Speaker 1: can be sleepy and sluggish because those going into your
- 35:40Speaker 1: bloodstream and they have to go out your body. So
- 35:43Speaker 1: as you're flipping over, turning over a new leaf, if
- 35:46Speaker 1: you will. In the minority of patients, we do see.
- 35:48Speaker 2: That with IV okay, but no big long term issues. Now.
- 35:53Speaker 2: That then opens the door in my mind and tell
- 35:57Speaker 2: me if I'm wrong. From somebody coming in and going
- 36:01Speaker 2: I have a particular inflammatory issue, to someone coming in
- 36:06Speaker 2: and going, hey, I'm in my fifties, I feel good,
- 36:08Speaker 2: but I want to go from good to great.
- 36:10Speaker 1: Yes. So we have the biohacking crowd.
- 36:14Speaker 2: I'm one of them. I do them.
- 36:16Speaker 1: I do IV exosomes on myself four times a year,
- 36:19Speaker 1: just because you know, preventative. We have some even younger people,
- 36:23Speaker 1: some people in their upper twenties who want to stay
- 36:26Speaker 1: young because the earlier you start, the better, and they
- 36:30Speaker 1: don't always feel a difference. People with a lot of
- 36:32Speaker 1: information will tend to feel a difference. More energy you need,
- 36:35Speaker 1: more cognitive you know, sharpness recovery after workouts has improved.
- 36:40Speaker 1: But the young people will say, I don't really feel much.
- 36:42Speaker 1: But I had one young athlete who tracks his heart
- 36:44Speaker 1: rate variability HRV. I can't remember what device he was using,
- 36:49Speaker 1: maybe a whoop band or something, or or a ring.
- 36:51Speaker 1: He said, I don't really feel much. But the next
- 36:53Speaker 1: day he sent me a snapshot of his HRV which
- 36:57Speaker 1: had jumped without any other intervention by fifty which is,
- 37:00Speaker 1: as you probably know, huge, right. So we've seen that
- 37:03Speaker 1: in multiple people as an observation, so we know there
- 37:07Speaker 1: is a physiologic benefit to the stem cell derived exystems
- 37:12Speaker 1: even if you don't feel it.
- 37:14Speaker 4: Yeah, yeah, yeah, And then this is the thing, right,
- 37:16Speaker 4: if people don't feel that people there are people walking
- 37:19Speaker 4: around with chronic disease who are not aware of it.
- 37:24Speaker 2: Like it's not like chronic disease just happens overnight. The processes,
- 37:30Speaker 2: the cellular mechanisms are there for decades right before people
- 37:36Speaker 2: feel any type of symptoms. So that's really interesting. So
- 37:41Speaker 2: for the skeptics in this area, there are there's quite
- 37:45Speaker 2: a few skeptics, right, there's the believers and the non believers.
- 37:49Speaker 2: And what's your message to these skeptics.
- 37:52Speaker 1: Yeah, you'll you'll be surrounded on your deathbed by the
- 37:55Speaker 1: non skeptics. So it's it'll play out on its own.
- 38:00Speaker 1: So you know, listen, you know, we try to post
- 38:05Speaker 1: our success stories, uh, you know, on our social media,
- 38:08Speaker 1: so people we interview patients, you know, tell us what
- 38:11Speaker 1: you feel, what you've gotten out of this. That doesn't
- 38:14Speaker 1: mean everyone gets that result, but you know, hippocratic oath says,
- 38:18Speaker 1: we have to try to help people with our knowledge, right,
- 38:21Speaker 1: And I don't want to let, you know, government over
- 38:25Speaker 1: regulation or naysayers, you know, detract from my fulfilling my oath.
- 38:31Speaker 1: So this is just an in advancement on what I
- 38:34Speaker 1: can do for people who are interested. It's an option.
- 38:36Speaker 1: It's not the only option. No one's going to twist
- 38:38Speaker 1: your arm to do it. If you're skeptical, do your homework.
- 38:42Speaker 1: Search all the clinical publications in medical journals on a
- 38:46Speaker 1: certain topic and see what's out there. Look at the
- 38:49Speaker 1: biology of it. Just because it's not being done everywhere
- 38:52Speaker 1: doesn't mean it's wrong. Think about when someone said, hey,
- 38:56Speaker 1: we've got this mold, it's going to help cure bacterial infection.
- 39:00Speaker 1: People probably thought penicillin was a little wacky at the
- 39:03Speaker 1: beginning too.
- 39:03Speaker 2: So yes, yeah, but that is the best answer I've
- 39:07Speaker 2: ever heard. You're going to be Surroundedn't your fight nonst
- 39:12Speaker 2: rafts cracky? So let's talk about the with this regenerate
- 39:18Speaker 2: medsine and particularly what you're doing the interaction with lifestyle,
- 39:22Speaker 2: because you could see the potential for some people to go, oh,
- 39:26Speaker 2: you know what, I don't need to worry about exercise
- 39:29Speaker 2: and healthy eating. I'll just go and get my stem
- 39:31Speaker 2: cells are exosomes done on an ivy every couple of months,
- 39:34Speaker 2: and then it'll be good.
- 39:35Speaker 1: Yeah, listen, it's it's the whole package. Right. If you
- 39:38Speaker 1: might have a small benefit from a regenerative medicine approach,
- 39:42Speaker 1: but if you're not living clean and your your cells
- 39:45Speaker 1: are going to flip right back to their bad biology
- 39:47Speaker 1: in a minute. So you know, we we like to
- 39:49Speaker 1: optimize people ahead of time, diet, sleep, exercise strategies, supplements,
- 39:55Speaker 1: Hormone optimization in some cases or misis all of the above.
- 39:59Speaker 1: The better your body is receptive to these, the more
- 40:02Speaker 1: you'll get out of it, and the more and the
- 40:03Speaker 1: more prolonged response.
- 40:05Speaker 2: Theoretically, and in terms of the length of the benefits,
- 40:11Speaker 2: presumably that depends on the state of the individual that's
- 40:17Speaker 2: coming in. I'm guessing, but.
- 40:18Speaker 1: It's just like a degenerated joint. If we see, you know,
- 40:21Speaker 1: of an end stage worn down joint, what we call
- 40:25Speaker 1: bone on bone, generally speaking, it's gonna take a lot
- 40:28Speaker 1: more to help that person get the regenerative benefits they're
- 40:32Speaker 1: looking for. If someone is only partially degenerated and starting
- 40:35Speaker 1: to have symptoms on the earlier side, then there's a
- 40:38Speaker 1: lot less travel that has to be done to get
- 40:40Speaker 1: that joint to improve. So we like to get to
- 40:42Speaker 1: things earlier. Although I wouldn't turn away someone bone on bone,
- 40:47Speaker 1: because if I can help someone avoid a knee replacement
- 40:49Speaker 1: or hip replacement or shoulder replacement or something, I think
- 40:53Speaker 1: that I think that's a good service.
- 40:56Speaker 2: Now, interesting question here, because I was, just as you
- 40:59Speaker 2: were talking about it, thinking about some of the recent
- 41:02Speaker 2: research you may be aware of that said that humans
- 41:07Speaker 2: seem to age it's not linear. There was that paper
- 41:11Speaker 2: that was released saying that there seemed to be a
- 41:14Speaker 2: couple of aging spurts, one in the early forties, one
- 41:19Speaker 2: around sixty, and then there was another paper I find
- 41:22Speaker 2: that there was seem to be a third one around
- 41:25Speaker 2: seventy eight or eighty. That first study didn't follow people
- 41:29Speaker 2: to that age, So there's this suggestion now that aging
- 41:33Speaker 2: is not linear. I think that study needs to be
- 41:35Speaker 2: repeated because the sample size was relatively small. Right, there's
- 41:39Speaker 2: all these headlines around it. But if true and it
- 41:43Speaker 2: seems to be certainly within that population, does that then
- 41:47Speaker 2: suggest that there would be optimal times of your life
- 41:51Speaker 2: forgetting this, or if you were talking to your younger self,
- 41:58Speaker 2: would you be saying, hey, to just start this really early?
- 42:02Speaker 2: Like what? So, I guess what I'm asking, when do
- 42:05Speaker 2: you start to see those signs of significant cellular wir
- 42:09Speaker 2: in te where this sort of interventions would be the
- 42:14Speaker 2: best buying for your buck in terms of the marie
- 42:17Speaker 2: you're going.
- 42:17Speaker 1: It's a great question. It's a it's a thought question.
- 42:20Speaker 1: So I think what we need to know is more
- 42:23Speaker 1: about why we have these we'll call it steep falloffs
- 42:28Speaker 1: in you know, cellular activity in the forties and in
- 42:31Speaker 1: the sixties, because nothing in biology is truly linear anyway. Yes,
- 42:36Speaker 1: and so is it because you know we we deplete
- 42:40Speaker 1: you know, stem cell activity. Is it because of hormonal
- 42:44Speaker 1: changes or is it the perfect storm of more than
- 42:47Speaker 1: one of these things? And in biology it always is, right,
- 42:50Speaker 1: it's a it's a combination of competing factors. So if
- 42:54Speaker 1: we could, if we could start regenerative medicine before that first,
- 42:59Speaker 1: and before that's can peak, can we push that peak
- 43:02Speaker 1: off in time? I think that is really the strategy here.
- 43:07Speaker 1: That doesn't mean in the middle of one of those
- 43:10Speaker 1: big cliffs of the aging process we couldn't help someone
- 43:14Speaker 1: slow or you know, lessen the height of the cliff
- 43:18Speaker 1: on the curve either. But I think you have to
- 43:22Speaker 1: start early and often and get ahead of it in
- 43:25Speaker 1: a preventative manner, which is really what good medicine is
- 43:29Speaker 1: all about. Is promoting health and wellness and preventing illness
- 43:32Speaker 1: not having to treat it is the big win.
- 43:35Speaker 2: Wow, now you are taught. That's very controversial, Jeff. You're
- 43:39Speaker 2: talking about a healthcare system rather than a sick car
- 43:41Speaker 2: system there, because in this Cardana, I'm pretty sure it's
- 43:46Speaker 2: very similar in the States. In this country, ninety seven
- 43:51Speaker 2: or ninety eight percent of all government healthcare spending is
- 43:55Speaker 2: on tertiary treatment, and there's very very little on primary
- 44:00Speaker 2: and secondary prevention. I often say, we don't have a
- 44:03Speaker 2: health care system in this country. We have a sick
- 44:06Speaker 2: cur system in this country.
- 44:07Speaker 1: Yes, same here. You know, it's even if they spent
- 44:10Speaker 1: more money here in the US on preventative care, they
- 44:14Speaker 1: would also in parallel have to remove all the nasty
- 44:19Speaker 1: inclusions in our food source and water and EMPs and
- 44:22Speaker 1: all kinds of things going on. So it's going to
- 44:24Speaker 1: take more than just preventive healthcare. It's going to take
- 44:27Speaker 1: preventative behaviors for our entire population.
- 44:31Speaker 2: Yeah, yeah, absolutely so, given that the amazing advances and
- 44:36Speaker 2: technology that are happening right now, you know, going even
- 44:41Speaker 2: in this field, going from stand cells to the end
- 44:43Speaker 2: harnessing x zones, what do you think the future trajectory
- 44:49Speaker 2: is for this longevity regenerative medicine, call it whatever you want.
- 44:54Speaker 2: I like to call it. I like to focus on
- 44:55Speaker 2: the health span rather than the lifespan. But given that
- 45:00Speaker 2: your finger is well and truly on the pulse here,
- 45:04Speaker 2: what do you think future stey it looks like.
- 45:06Speaker 1: Well, I think the future is already here in some places,
- 45:09Speaker 1: just not here in the US. But we're working on
- 45:11Speaker 1: some projects here in my own clinic to get what
- 45:14Speaker 1: we call designer exosomes. These are exisomes that would be
- 45:16Speaker 1: chalk full of mitochondria, for example, to donate donate those
- 45:21Speaker 1: mitochondria to cells whose mitochondria are less functional, not only
- 45:25Speaker 1: for mitochondria disease, but for frailty and to help improve
- 45:29Speaker 1: muscle mass. As you know, muscle mass and boneens are
- 45:32Speaker 1: correlated with longevity and also brain function. The brain is
- 45:36Speaker 1: highly dependent on mitochondria, and I think we need to
- 45:40Speaker 1: spend more time giving mitochondria our love, and if we
- 45:43Speaker 1: take care of mitochondria, we are taking care of ourselves.
- 45:45Speaker 1: So those will be designer exosomes. The other one we're
- 45:48Speaker 1: working closely with now and hope to have very soon
- 45:51Speaker 1: are a certain subpopulation of exosomes come from immune cells.
- 45:56Speaker 1: And these immune cells, these specific T cells, their job
- 45:59Speaker 1: is to identify and remove by cell death certain abnormal
- 46:04Speaker 1: cells like cancer cells. So you can imagine we have
- 46:07Speaker 1: these targeted exosomes that can help help someone address a
- 46:14Speaker 1: cancer diagnosis and whether it's a solid tumor or a
- 46:19Speaker 1: circulating tumor. And these are in addition to you know,
- 46:22Speaker 1: some of the things that are becoming online here now
- 46:25Speaker 1: these called car T cells where they train kind of
- 46:29Speaker 1: these these regenerative cells through a process to identify and
- 46:34Speaker 1: remove cancer cells. It's almost like your own vaccinated cells
- 46:37Speaker 1: come in and do the job. That's another angle. And
- 46:40Speaker 1: then as I mentioned earlier, these induced pluropotent more embryonic
- 46:44Speaker 1: cells that as you probably saw in the news in
- 46:49Speaker 1: the last few months in China, they cured a person
- 46:52Speaker 1: of diabetes type one. They did it by using some
- 46:55Speaker 1: of these induced pluropotent cells. So those cells have more
- 46:59Speaker 1: ability to do. We just need to control them safely.
- 47:02Speaker 1: That's some of the limitations on those right now.
- 47:05Speaker 2: That's really interesting, and I think obviously the brain has
- 47:09Speaker 2: then got to be a target because as we what
- 47:13Speaker 2: we see in Australia and I would imagine it's very similar,
- 47:17Speaker 2: there is the massive rise in dementia as a killer.
- 47:22Speaker 2: And I think there's a couple of things that are
- 47:24Speaker 2: behind that. Right is number one, unhealthy behaviors that people have.
- 47:31Speaker 2: But secondly, as we live longer, right as the population
- 47:36Speaker 2: is living longer, neurodegenertive diseases and cancers almost become something
- 47:42Speaker 2: that's going to be locked in, right because of just
- 47:45Speaker 2: that overall we're.
- 47:47Speaker 1: In terror of the body, right, agreed. Listen, the older
- 47:51Speaker 1: we live, the more degenerative problems we are for facing.
- 47:55Speaker 1: So the earlier we can start some type of regenerative
- 47:58Speaker 1: behaviors in our lifestyle and our food and maybe even
- 48:03Speaker 1: augmentative regeneritive therapists like we're talking about today, to help
- 48:07Speaker 1: slow that process, that would be a game changer. It
- 48:12Speaker 1: might push the problem down the line. And I think
- 48:14Speaker 1: you could do to delay the formation of the generative
- 48:16Speaker 1: diseases gives us a chance to learn about them more
- 48:21Speaker 1: and have a new solution for them ten or twenty
- 48:23Speaker 1: years from now.
- 48:24Speaker 2: What's your thoughts? So a little bit off pace this question, right,
- 48:29Speaker 2: So in the whole longevity medicine space, there are some
- 48:33Speaker 2: people who are really focused on enhancing health span, and
- 48:38Speaker 2: then there's the other crowd that are focused on enhancing
- 48:41Speaker 2: lifespan and who believe that it's possible and that we're
- 48:47Speaker 2: going to see human beings live to one hundred and
- 48:50Speaker 2: fifty two hundred years old. You have some people talking
- 48:54Speaker 2: about that. What's your view on this? Opinion. Right, this
- 48:58Speaker 2: is obviously a hypothetical question.
- 49:00Speaker 1: Yep, Well, listen, if you all your time and efforts
- 49:04Speaker 1: full time, we're dedicated to living longer, those things that
- 49:08Speaker 1: make you live longer will also make you healthier. So
- 49:11Speaker 1: you're working towards life span, is really also working towards
- 49:14Speaker 1: health span. But you're right, we don't want to just
- 49:16Speaker 1: live longer and be laid up in a nursing home
- 49:19Speaker 1: for decades at the end of our life, right. We
- 49:21Speaker 1: want our we want our health span to fill our
- 49:24Speaker 1: lifespan with really, so they end at the same time. So,
- 49:28Speaker 1: you know, if you had to like a Brian Johnson,
- 49:30Speaker 1: his full time endo it you know, he he does
- 49:33Speaker 1: have a propensity to live beyond one fifty and so forth.
- 49:36Speaker 1: He's doing everything perfectly right, He's Yeah, he's basically like
- 49:40Speaker 1: a pristine you know car that never leaves the garage
- 49:43Speaker 1: or gets an oil change every day whether it needs
- 49:46Speaker 1: it or not. You know, so it's going to last longer,
- 49:49Speaker 1: it's going to you know, people talk about escape velocity
- 49:52Speaker 1: where we're going to live forever.
- 49:56Speaker 2: Talks about escape velocity, Right, I don't.
- 49:59Speaker 1: Know what that's going to teake. I'm not seeking that.
- 50:01Speaker 1: I don't know that anyone. You know, a few people
- 50:04Speaker 1: may have that desire at some point. You know, we're
- 50:08Speaker 1: talking more about you know, the sci fi and things
- 50:11Speaker 1: like that, but that doesn't mean that you're not going
- 50:13Speaker 1: to be less fiction in the future. I'm not working
- 50:16Speaker 1: towards escape velocity. But everything we do to you know,
- 50:19Speaker 1: push health span and longevity, we will see people we
- 50:22Speaker 1: already we already have people living into the one hundred
- 50:25Speaker 1: and twenties. We will see one hundred and fifties in
- 50:28Speaker 1: subgroups of lifelong good behavioring good behavior people who are
- 50:33Speaker 1: doing all the right things along the way. And then
- 50:34Speaker 1: maybe some strategies on top of that with stem cells
- 50:37Speaker 1: and what have you.
- 50:38Speaker 2: Yeah. Interesting, So you think that that is quite quite
- 50:41Speaker 2: a possibility, And right right now I'm interested until that's proven. Right,
- 50:46Speaker 2: I'm interested in you designing these designer XI zomes that
- 50:50Speaker 2: will KP me healthy and vital, and then as soon
- 50:55Speaker 2: as I head one hundred, they all explode and I
- 51:00Speaker 2: that's it. I'm just done.
- 51:01Speaker 1: That's it. Yeah, I don't think we're quite know yet
- 51:04Speaker 1: time living it.
- 51:05Speaker 2: Yeah, So talk about you know what you guys do
- 51:08Speaker 2: the resale stuff. Are you making sure that you're right
- 51:13Speaker 2: on the bleeding edge of all of this stuff.
- 51:16Speaker 1: Well, a few things. One is we only use the
- 51:20Speaker 1: highest quality biologics. So the stem cell drived exostomes we
- 51:24Speaker 1: have come from young, healthy mothers that are screened in
- 51:28Speaker 1: their first trimester and can't be drinking, can't be smoking,
- 51:33Speaker 1: they can't be having high risk behaviors. They have to
- 51:37Speaker 1: be non vaccinated for COVID not because that's necessarily bad,
- 51:42Speaker 1: it's just we just don't know enough. We haven't had
- 51:44Speaker 1: enough time to understand the full linkture of that. So
- 51:48Speaker 1: just to remove that variable, we're using unvaxed donors, and
- 51:53Speaker 1: then those those tissues go to a highly competent and
- 51:56Speaker 1: certified lab where they're tested in screen for all diseases.
- 52:00Speaker 1: So we're only using the best of the best.
- 52:02Speaker 2: And tell our list is why mother's frite, why females?
- 52:05Speaker 2: Why to just give our listeners a sense of that.
- 52:09Speaker 1: Because females have wombs, and those wombs produce the best
- 52:14Speaker 1: stem cells when it's creating and developing a fetus. So
- 52:18Speaker 1: we're taking from the amniotic fluid, the growth factors, the proteins,
- 52:23Speaker 1: the peptides, the exosomes, and we're getting them in a
- 52:26Speaker 1: concentrated way. That's why I mean, that's what I prefer you.
- 52:31Speaker 1: You could take stem cells or you could probably even
- 52:33Speaker 1: derive exisomes from a man, but you have to send
- 52:35Speaker 1: them off and it's very expensive and doesn't doesn't make twist. Okay,
- 52:40Speaker 1: we take them from the baby factories basically, yeah, yeah, okay.
- 52:44Speaker 2: And do you guys use peptides as well as stem
- 52:47Speaker 2: cells and exosomes.
- 52:48Speaker 1: Yeah? It just to be clear, most peptides. Our bodies
- 52:51Speaker 1: make peptides, stem cells derive peptides. Exisomes are chalk full
- 52:54Speaker 1: of peptides. We also use exogenous peptides, supplemental peptides. Usually
- 52:59Speaker 1: if you're here something you want, the Wolverine protocol, the
- 53:02Speaker 1: BPC one fifty seven TB five hundred copper peptid. There
- 53:05Speaker 1: are so many out there. We are learning more and
- 53:08Speaker 1: more about them all the time, and.
- 53:11Speaker 2: The FDA are starting to come down a little bit
- 53:16Speaker 2: on peptides. Have you any concern about the FDA coming
- 53:20Speaker 2: down on exisomes in the future.
- 53:23Speaker 1: Yeah, So the listen anything that the FDA is coming
- 53:26Speaker 1: down on without a foundational basis, meaning they're disregarding the lurture.
- 53:31Speaker 1: There's got to be another reason for that, and you
- 53:33Speaker 1: got to follow all of the influences and the money
- 53:36Speaker 1: for that. But the FDA says they do regulate these things.
- 53:39Speaker 1: Doctors do not prescribe peptides. We can coach and recommend
- 53:44Speaker 1: them and people have to obtain them on their own,
- 53:47Speaker 1: which is easy. And then for the exisomes, we're very
- 53:51Speaker 1: very careful that we aren't making any claims marketing claims
- 53:55Speaker 1: that we're curing or treating something because we want to
- 53:58Speaker 1: remain compliant with the FDA regulates.
- 54:01Speaker 2: I can imagine there's a fur bit of frustration in
- 54:06Speaker 2: your field and people like you around the limitations that
- 54:13Speaker 2: are placed on you know, what you can access, what
- 54:16Speaker 2: you can do for your patients.
- 54:18Speaker 1: Sometimes I think that the patients who are inclined to
- 54:21Speaker 1: look into these treatments understand that they are newer to
- 54:27Speaker 1: the US. We share with our patients all the clinical
- 54:30Speaker 1: literature that they're interested in, usually that's from Asia or
- 54:34Speaker 1: from Europe. We show them what people are doing. They
- 54:38Speaker 1: are approved by the way. In the States. There's one
- 54:41Speaker 1: state that this past may put into effect a law
- 54:45Speaker 1: that was passed a little bit earlier that does approve
- 54:48Speaker 1: the use of regenerative biologics, and that's the state of Utah. So,
- 54:52Speaker 1: like a lot of crazy things in the US, we're
- 54:55Speaker 1: sort of at civil war right where the federal government
- 54:58Speaker 1: has one opinion, the individual state or states have others.
- 55:03Speaker 2: Yeah, that's that's that's really interesting. So give our listeners
- 55:07Speaker 2: just a little bit of a guidance around those who
- 55:11Speaker 2: want to explore regenerative treatments. What sort of guidance would
- 55:16Speaker 2: you give somebody who's thinking about this particularly, You know,
- 55:19Speaker 2: a large part of my audience is in Australia where
- 55:22Speaker 2: we can't access clinics like yours, So what sort of
- 55:26Speaker 2: guidance would you give people in general and who are
- 55:30Speaker 2: interested in this area, because for me it's a very
- 55:33Speaker 2: interesting area. But do you know talking about xisomes, that's
- 55:37Speaker 2: like wow, this is game changing stuff.
- 55:41Speaker 1: Well, if you're in Australia and you are you want
- 55:44Speaker 1: to stimulate your own exosomes, you can exercise, do yoga.
- 55:49Speaker 1: They stimulate stemsar release, which stimulates the exosome activity. You
- 55:53Speaker 1: can imbibe exosomes there. You can get exosomes from healthy
- 55:57Speaker 1: fruits and vegetables. Plants you can have them from they're
- 56:01Speaker 1: very rich in bone marrow or bone broth. They're very
- 56:04Speaker 1: rich in colosstrum. They're available in milk, well closs from
- 56:08Speaker 1: its better mother's milk, the first milk. In some cultures
- 56:12Speaker 1: people actually eat the placenta, so yes, yeah, right, and
- 56:15Speaker 1: it's placental capsules or things like that make you be
- 56:19Speaker 1: animal as well, have to be human. So that's one
- 56:22Speaker 1: way to get some axisomes into your body. And then
- 56:25Speaker 1: if you're interested in something you know more direct than supplemented,
- 56:29Speaker 1: like what we do here, do your homework so you know,
- 56:33Speaker 1: use your your internet searches, search for the kinds of
- 56:36Speaker 1: things you are looking to address, whether it's anti aging
- 56:39Speaker 1: or knee degeneration, or you know, lupus or what have you,
- 56:44Speaker 1: and type in the word stem cells, lupus, what have you.
- 56:47Speaker 1: If you type in exosomes instead of stem cells, you're
- 56:49Speaker 1: not going to get as much literature. We do translate
- 56:52Speaker 1: a lot of a stem cell type of clinical reports
- 56:56Speaker 1: from years gone by into axisomes, since stem cells are
- 56:59Speaker 1: really the delivery of exisomes. And then see what's out there,
- 57:03Speaker 1: and if you find something interesting, see where they're doing it,
- 57:06Speaker 1: you know, and are you willing to travel? I suppose
- 57:08Speaker 1: that might be a way.
- 57:09Speaker 2: I think lots of people will be willing to travel,
- 57:12Speaker 2: so presumably people from overseas can come to your clinic
- 57:15Speaker 2: sure and get these exosome I these or our treatments
- 57:20Speaker 2: for particular stuff. So work this, Jeff. This has been
- 57:24Speaker 2: absolutely fascinating. Where can people go to learn more about
- 57:30Speaker 2: what you do specifically and your clinic and the treatments
- 57:33Speaker 2: that are on offer.
- 57:34Speaker 1: Thank you, Paul. The practice name is called re Celebrate
- 57:38Speaker 1: because we're celebrating the renewal of ourselves. So that's brilliant,
- 57:46Speaker 1: and that's why we walk the dog at night so
- 57:47Speaker 1: we can come up with these ideas.
- 57:49Speaker 2: Right.
- 57:49Speaker 1: It's spelled r e c e l L for sell
- 57:54Speaker 1: e b r A te And if you type that
- 57:57Speaker 1: in your search browser, you will find us. I think
- 58:00Speaker 1: I'm the only person using that word in that spelling.
- 58:03Speaker 1: Our clinic name. That's that's our website, that's our Instagram,
- 58:07Speaker 1: that's our Facebook, that's our LinkedIn, that's our whatever. We
- 58:10Speaker 1: have a YouTube. Just type that in you'll find it.
- 58:13Speaker 2: Ya'll tell you what the day that when you were
- 58:15Speaker 2: walking the dog and you came up with that. I'm
- 58:17Speaker 2: sure you come home and jumped on to see if
- 58:20Speaker 2: that demand name was taken that ought to be in
- 58:24Speaker 2: the day.
- 58:24Speaker 1: You're just like, yes, yes, that's exactly what happened. I
- 58:29Speaker 1: probably bought it, you know, on the walk, you know,
- 58:31Speaker 1: got into my account, checked it out. It's available, go
- 58:34Speaker 1: you know by right then and there. So you're exactly right.
- 58:38Speaker 2: That is brilliant, Je. Look, this must be for you
- 58:42Speaker 2: particularly exciting, right, and a new lease of life for
- 58:46Speaker 2: your career, right, so you're re celebrating your career very
- 58:51Speaker 2: good as well as do all of this stuff. So
- 58:54Speaker 2: it must be must be so cold to be on
- 58:56Speaker 2: the bleeding edge, but also to just be able to
- 59:01Speaker 2: intervene with people in a pretty non indasive way compared
- 59:06Speaker 2: to some of the other traditional treatments and just see
- 59:11Speaker 2: people walking out of your office in completely different health
- 59:14Speaker 2: than they walked in. That's going to be cool.
- 59:16Speaker 1: It's wonderfully rewarding, and you're you're absolutely right. I have
- 59:20Speaker 1: a shot of regenerative activity into my own professional life.
- 59:24Speaker 1: So thank you you well player.
- 59:27Speaker 2: Excellent Jeff, keep up your great work. I'm sure there's
- 59:30Speaker 2: so many people that will benefit. And uh, it's got
- 59:32Speaker 2: to be very exciting to be just on the bleeding
- 59:35Speaker 2: edge here.
- 59:36Speaker 1: Great Thank you for having this has been great.
- 59:38Speaker 2: I think I think you've got yourself at least one
- 59:41Speaker 2: future patient out of this podcast. I can tell you
- 59:43Speaker 2: that right now be happy to help you