Evolving Contraindications and Management Strategies for Infectious Diseases in Deceased Organ Donation

Trenches in Transplant Surgery · Jul 16, 2025 · 20m

The critical organ shortage has driven a paradigm shift in utilizing deceased donors with infectious diseases, transforming many historical absolute contraindications into relative ones through advanced diagnostics and targeted therapies. While universally fatal or untreatable infections like active rabies, prion diseases, untreated disseminated fungal infections, or multidrug-resistant sepsis remain absolute contraindications, most infections now undergo rigorous risk-benefit analysis. Groundbreaking management strategies, particularly the advent of direct-acting antivirals (DAAs), enable…