1510-GasderminE-Viral Pyroptosis to Lethal Hepatic Steatosis
The research study examines the pathogenic mechanisms of the emerging tick-borne wetland virus (WELV), identifying it as a significant cause of lethal liver dysfunction. The authors demonstrate that infection triggers GSDME-dependent pyroptosis, a form of inflammatory cell death, through the activation of both intrinsic and extrinsic apoptotic pathways. This process is initiated when viral RNA is recognized by the RIG-I sensor, which subsequently drives a pyroptosis-metabolism axis. A key finding reveals that GSDME physically stabilizes fatty acid synthase (FASN), preventing its degradation…
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