1389-Stem Cell Models of Leukodystrophies
This scoping review examines the transformative role of stem cell technology in the study of leukodystrophies, a complex group of genetic disorders that cause neurological decline by damaging brain white matter. Because human brain tissue is difficult to access and animal models often fail to replicate human pathology, researchers increasingly utilize induced pluripotent stem cells (iPSCs) to create patient-specific models. These "disease-in-a-dish" platforms allow scientists to differentiate cells into various types, such as oligodendrocytes, astrocytes, and neurons, to observe the…
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