Latest / Yoshi's Podcast / #058 | JP Schell | ENG – biotech, corruption, US decay, psychedelics, dystopia & much more

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#058 | JP Schell | ENG – biotech, corruption, US decay, psychedelics, dystopia & much more · Yoshi's Podcast

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SPEAKER_00: this
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SPEAKER_00: Alright, so sitting here with JP Schell, welcome.
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SPEAKER_00: Thank you, thank you.
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SPEAKER_00: JP stands for?
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SPEAKER_00: John Paul.
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SPEAKER_00: John Paul, right.
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SPEAKER_01: Yes, not the biblical, or not the Pope, and not the Beatles either, but it was my dad and my grandfather's name put together.
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SPEAKER_00: It's a cool name, pretty gory.
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SPEAKER_01: I'm starting to be I mean, that's that's what I'm working on right now I think that's where like culmination of kind of my scientific perspective and also my like deep love of like kind of sci-fi horror like a big Frank Herbert big Stephen King fan, you know and Michael Crichton kind of just with the scientific aspect and
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SPEAKER_01: to talk about
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SPEAKER_00: There's a lot going on in that area right now, but but to give people a background like what have you worked with?
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SPEAKER_01: So like pluripotent stem cells is kind of the biggest like pluripotent Yeah, so totipotency and pluripotency are these kind of physiological condition stages of cellular life and it's the ability to turn into any other cell type and
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SPEAKER_01: 8 years almost they said like you have to there's like a law change like you have to go basically you have to you have to graduate but I was doing this for that back in San Diego at the Scripps Research Institute and Jean Loring's lab she's one of the real pioneers in this field of induced pluripotent stem cells so this is the idea of you can take any skin cell or any type of cell from your body hair cell
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SPEAKER_01: and using these four factors that now the a guy named Shinya Yamanaka he won the Nobel Prize a few years ago now for the ability to turn these any basically a fibroblast or a skin cell into a stem cell and from that stem cell you can basically grow you know brain cells cardiac cells beating cells you know and so that's that's the the focus is the idea of taking something that's an adult cell type and
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SPEAKER_01: expose them to certain factors and whatnot that we've studied to basically push those cells directly into the cell type that you're missing in the substantia nigra of parkinson's patients so this is like treating it's like a direct way of treating replacing the cell type that's gone in parkinson's patients and now they've created a company out of it and it's pushing to like clinical trials i mean it's it this is one of the highest hopes for that this kind of like technology is really going to is going to work
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SPEAKER_01: So that's the pluripotent stem cell side of stuff, and that's the induced pluripotent stem cell side, meaning induced as in pushed to pluripotency.
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SPEAKER_01: But yeah, that idea, that physiology, that property of pluripotency is kind of the thing that I've been focusing on for so many years because I thought it was the coolest thing.
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SPEAKER_01: What I worked on before my PhD, I went to, I moved to Sweden about nine years ago to work in the lab of Frederick Lanner.
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SPEAKER_01: And the reason I came here directly is I mean, obviously, Karolinska was the home of the Nobel Prize.
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SPEAKER_01: And despite the fact that this was during all the Macchiarini fiasco happened right after I like got there, but and I actually did apply like didn't apply directly to his lab, but was like looking at because Oh, man, everybody was like,
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SPEAKER_01: and much more.
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SPEAKER_01: But anyway, that's like a whole nother line of work.
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SPEAKER_00: Lying turns out to be pretty impressive.
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SPEAKER_01: Yeah, yeah, yeah.
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SPEAKER_01: But also like not checking.
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SPEAKER_01: And so that's the thing is like my, you know, but, but also I understand the wool was over their eyes.
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SPEAKER_01: They were seeing this person from like a perspective of social media and, and like just the not social media, like the actual media saying like, this person is amazing.
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SPEAKER_01: They're the personal doc, you know, etc, etc.
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SPEAKER_01: And one of you know, like even my mentor at the time he was, he was on the committee and he had to step down.
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SPEAKER_01: Kenneth Chen
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SPEAKER_01: and much more
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SPEAKER_00: 058 – Yoshi's Podcast
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SPEAKER_00: a lot of people probably don't know much about this world.
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SPEAKER_00: So if I understand the pluripotent cells, it's different from stem cells, like classic stem cells, you would have to get from certain parts of the human body, but this you can get from any cell.
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SPEAKER_01: So adult stem cells are basically what you've seen in like therapies currently and they work really well.
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SPEAKER_01: Adult stem cells, specifically hematopoietic stem cell, this is an idea where if you, you know, for bone marrow replacement, if somebody has some type of blood disease or some type of immune disease, the body can be completely irradiated.
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SPEAKER_01: Yeah, well, I mean that and that's the thing is like or half the time it doesn't work a lot of time because the body rejects Yeah, it just or they said the number of cells that were the right ones These hematopoietic stem cells are not the one or there's just you know, or they're not they're not happy in that situation They go into the body and they probably like die, you know, and or there's and takes care Yeah, or the immune system.
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SPEAKER_01: Yeah attacks these cells.
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SPEAKER_01: It's not and so that's yeah, so we have
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SPEAKER_01: and environmental factors.
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SPEAKER_01: The cell has a nucleus, the eukaryotic cell meaning the mammalians and everything animal has a nucleus meaning kind of a encapsulation inside of the sphere cell part in the first place.
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SPEAKER_01: And in there you have DNA.
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SPEAKER_01: And the DNA is basically the blueprint for everything.
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SPEAKER_01: But what may not be understood is that the DNA condenses and basically opens unravels
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SPEAKER_01: much influencing how the DNA is opening and closing in different parts and so basically it's like You know it has an identity and a lot of times when you see something like cancer emerge It's when they have an identity crisis essentially where they start getting cues that are not necessarily the cue that is appropriate for maintaining the cell type that they actually are and
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SPEAKER_01: can we get there
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SPEAKER_00: 058 – David Sinclair
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SPEAKER_01: like
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SPEAKER_01: just a little bit and not too much like if you do it too much you're just gonna cause cancer I mean you're gonna actually develop another embryo essentially in the in the cavity of this animal you know and so you don't want that but you do want to basically reset I think under his findings it's resetting this epigenetic control and the epigenetics is this where is it condensed on the DNA where is it open
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SPEAKER_01: yeah a little piece of code and then that gene is made into a specific protein and that's what also gives us a completely like open end of now with mRNA technology taking off so that's what that's what my last position at smart cell a solution a be they you know the idea of behind that that is that now that the the mRNA vaccine is out and it's been administered to you know billions of times now
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SPEAKER_01: perfect for you.
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SPEAKER_00: Like many people over the past few years.
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SPEAKER_00: I have to learn about mRNA and
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SPEAKER_00: i i'm very i'm a very curious person so i i've tried to read everything about the vaccine and how it works and it's it's interesting some people would say it's not really a vaccine because a classical vaccine is a pathogen inactivated pathogen that you inject in your body's immune system reacts to it and and learns how to deal with that pathogen whereas the mRNA like you said it it goes into your cell and makes your own body in this case produce the covid spike protein yeah and then your body reacts to that yeah
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SPEAKER_00: of course a lot of people are worried about this like what what does that even mean like um since it's not a pathogen it's it's just a spike protein yeah the spike protein can obviously or the the virus can obviously evolve and maybe not have the same spike protein yeah and then you have messenger RNA instructing your cells to create something and where does all of that go that's a good question is is that i mean you you didn't work on the vaccine so no this is not a
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SPEAKER_01: and actually what that's intended to do is also elicit an immune response when it's injected because you want a local response.
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SPEAKER_01: You want the immune system to come there.
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SPEAKER_01: It's actually, I mean, the ideology behind this is perfect.
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SPEAKER_01: I feel like that makes sense.
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SPEAKER_01: It makes a lot of sense that you would want to elicit this small, localized
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SPEAKER_01: Emily Cop
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SPEAKER_00: It's on a publication called US Right to Know, I think.
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SPEAKER_00: They foiled some documents and basically these documents tell the whole story that the US was involved in ordering the specific virus from the Wuhan lab.
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SPEAKER_00: 058 – JP Schell
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SPEAKER_00: because we were developing, you know, what do you call them?
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SPEAKER_00: Antibiotics and stuff like that in the past and it wasn't this massive behemoth of an industry and stuff was still happening back then.
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SPEAKER_00: Vaccines, antibiotics, a lot of good stuff was invented, you know, a hundred years ago where it wasn't like this.
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SPEAKER_00: what has happened that now the barriers to entry are so high?
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SPEAKER_01: Yeah, you can have all these quality control checks.
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SPEAKER_01: And now we have this thing called GMP, good manufacturing practice, you know, and like, basically, I mean, the rules are so rigorous in order to get something through this, you know, you have to have some every chemical that you add, you have to, like have somebody else behind you documenting that it was added at this exact time, this exact stage.
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SPEAKER_01: but
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SPEAKER_01: yeah they I mean they but they take stem cells they differentiate them into a certain type of neural neural stem cell and then those cells actually can you know remyelinate they can reconnect by now just like there's several factors and you can you can do yeah there's quite there's quite a bit of research around this now but you can get them to walk again and now now it's it's quite amazing you know so stuff that's been also paralyzed for quite some time
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SPEAKER_01: but anyway like the but the quality checks to to get these done at least this company geron they tried doing it just with bare stem cells i don't think they differentiated them but the idea was put in this like progenitor cell type they'll figure out what the you know what's going to happen and they'll they'll differentiate and i think they must have had like really good results with their mouse model but when they took that mouse model when they took that model to or when they took that uh therapy to the clinic
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SPEAKER_01: The legal thing was that they could not inject any more cells into the human that they injected into the mouse.
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SPEAKER_01: 058 – JP Schell
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SPEAKER_00: and more.
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SPEAKER_01: but translating that to like humans is going to be it's always just very difficult and and you go too fast you end up like in a macchiarini situation you go too slow then it's just therapies never happen or they happen somewhere else and then people go on you know
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SPEAKER_01: of
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SPEAKER_01: I was
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SPEAKER_01: for you.
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SPEAKER_00: about Yoshi's Podcast
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SPEAKER_01: ethnic diversity project because the thing is, is obviously like, you know, genetics is not the same across the board.
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SPEAKER_01: And somehow the behavior of the cells is also influenced by the genetic background.
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SPEAKER_01: So they were trying to make a stem cell bank.
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SPEAKER_01: And so they had like a variety of different, you know, stem cells, and I'm Native American descendant.
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SPEAKER_01: And so my grandmother actually volunteered to be there, like,
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SPEAKER_01: I was
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SPEAKER_01: but yeah it was a good good upbringing you know my parents my father was an attorney or a lawyer he went to the what do you call it the supreme court before you know a couple times i think and it was a you know some big cases and stuff but he always fought for the good guys he was he was on the government side
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SPEAKER_01: about Yoshi's Podcast
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SPEAKER_01: and uh so i get this uh that like because it shows when you have relatives you know so 23andme is like a genetic testing you just do a saliva i could be like a poster child for them now but yeah yeah a little swab send the saliva back and uh and they sequence your entire genome and i guess they compare it with everybody else who's been sequenced and everybody through the history of like they have a really amazing database now it's pretty it's pretty impressive
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SPEAKER_01: Like okay like news to me like yeah, but you know it was the 80s and they said like ah they mix dad and Donor and who knows and the thing is is like I'm super like my dad like like I was super like my dad like same build as him in the military same height same like Personnel like the way we get up from chairs and stuff like we make the same expressions and everything like this and it was just like
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SPEAKER_01: but uh but no apparently he was a mdphd who moved to california at berkeley and uh and that's he was a donor in wisconsin that's how my half sister was conceived and then he moved to uh
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SPEAKER_01: What a crazy thing to learn at 35.
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SPEAKER_01: was your dad right about your being liberal in your youth going Republican or Republican but like definitely more conservative I'd say like not not conservative in any like social aspects I think that's maybe a little bit too but like but I don't know I think no
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SPEAKER_01: where you grow up where your socioeconomic you know
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SPEAKER_01: I don't know I feel like my my views are not really going very political in any in any respect now I don't I don't follow too much politics that much especially American politics anymore it's always just like I mean it's disgraceful mostly and like and it's just so confusing and the people that are attracted to politics I mean not to watching it just I mean people attracted to being in those positions they tend to be very
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SPEAKER_01: America has this thing, let's keep people under enough debt, under enough stress, under enough other shit that you just cannot pay attention to what's happening.
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SPEAKER_01: The sky is falling, but nobody's even looking up.
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SPEAKER_01: It's just because they're stressed out.
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SPEAKER_01: Because it's hard to be political if you're barely making ends meet.
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SPEAKER_01: And I think
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SPEAKER_01: and much more
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SPEAKER_01: yeah how did your thoughts evolve on that question then i think they just kind of i lost i like yeah i don't know there's uh
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SPEAKER_01: they didn't really evolve too much they're just kind of I mean now now I'm more conscientious about I see America in a very different light I see it in a in a light of of like a desperate place with no with no how do you no parachute you know where people it is yeah I mean it's based off of like you tell every kid you know they're gonna be amazing you're gonna rule the world
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SPEAKER_01: I don't know if you've heard this.
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SPEAKER_01: It was probably just a meme, but it was supposed to be a statistic of what Americans want to do, or what Western society.
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SPEAKER_01: Interviewed a bunch of Chinese kids.
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SPEAKER_01: And this was, I think, based off of TikTok influence.
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SPEAKER_01: You've heard of this?
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SPEAKER_01: I think I know what you're talking about.
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SPEAKER_01: So it was like, oh, the Chinese kids, they all aspire to be astronauts, or most of them now.
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SPEAKER_01: Scientists.
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SPEAKER_01: That's the most popular.
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SPEAKER_01: Yeah, scientists.
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SPEAKER_01: And it's like, influencer is like the-
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SPEAKER_01: Yoshi Ziga
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SPEAKER_00: I think sooner or later I'll have to tip over, but how difficult that process gets is a big question, because that's what we do.
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SPEAKER_00: Human history is a battle between centralized and decentralized power forever.
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SPEAKER_00: It was the Catholic Church or it was...
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SPEAKER_00: to come…
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SPEAKER_01: easily yeah and that's dangerous clearly that's too much centralized power you know sooner or later it's gonna have to tip over but how and you know what what the price tag is for that tipping over that's gonna be do you think Amazon is dangerous in my in my story I actually have something called prime is like as the name of a state because Amazon basically bought Nevada but anyway that's something
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SPEAKER_00: that makes a lot of sense i always think about like google if google you know the the leadership there is you know doing nice things they're they're helping people with a lot of great products and all that stuff just imagine someone crazy takes over google how much damage could be done in like one day
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SPEAKER_00: and more.
1:02:05
SPEAKER_01: about Yoshi's Podcast
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SPEAKER_01: 058
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SPEAKER_00: Have you followed at all the developments in psychedelics for veterans?
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SPEAKER_01: Yeah, actually I talked to one of the veterans about this, about psychedelic mushrooms or psilocybin mushrooms.
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SPEAKER_00: Seems very, very promising.
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SPEAKER_01: Yeah, and actually apparently MDMA.
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SPEAKER_01: I've never been a big, strong proponent of MDMA ever.
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SPEAKER_01: I actually wrote a thing in
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SPEAKER_01: college about like there was some studies that were originally published and now that i mean they've been kind of pushed over now or like they were turned out the MDMA was like mixed with amphetamine or something and that's why you had negative effects but yeah
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SPEAKER_01: There's an organization called Nätverk för psykedelisk vetenskap, the network for psychedelic science here in Sweden.
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SPEAKER_00: 08.
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SPEAKER_00: Aljosja
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SPEAKER_01: i have heard that was it dent no is it finland oh now i don't remember exactly who was it it's either denmark or finland was saying that they were going to go completely uh nicotine free by like 2025 or something like that okay i'll do you got a fact i don't know i'm when it comes to these things yeah i'm i'm not for like banning stuff yeah i think adults should be able to do what what they want but
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SPEAKER_00: I'm against marketing.
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SPEAKER_00: There's this book called On Liberty, the classic book on libertarianism or classic liberalism.
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SPEAKER_00: What's his name?
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SPEAKER_00: John Stuart Mill.
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SPEAKER_00: And he talks about how to handle gambling in that book.
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SPEAKER_00: and i think that's a great way to handle like pretty much any addictive all yeah all vices all all of these things that adults should be able to do but we don't want them in society on a on a broad scale yeah basically says adults should be allowed to gamble in their own homes yeah police whatever authorities shouldn't be able to go into people's homes and you know stop them from doing it yeah but they are not allowed to put up a sign saying casino yeah okay like gamble here yeah
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SPEAKER_00: because we're never going to stop it even if we you know that's true otherwise it'll go underground and it'll become a whole nother network of but here in sweden you're not allowed to advertise alcohol yeah there are some like you know non-alcoholic yeah they're doing a tricky 0.0 yeah but it still looks like a beer but basically you're not allowed to advertise alcohol and it's like yeah that makes sense that makes sense and then people who want to do it they'll find ways to do it
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SPEAKER_01: I was
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SPEAKER_01: That's the American way though.
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SPEAKER_01: No, that is that it I mean it is it is so disturbing like every time I go back home like just watching like my mom also like she leaves she leaves a lot of Fox it's not Fox it's like CNN or something but like sometimes it's Fox too and I'm like it's just the commercials you know and then it's just news all the time and the news is always so negative I'm like ah I just want to see like a puppy being born today or something like give me some good news like there's just no good news you know like
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SPEAKER_01: I always ask my dad, why do you watch this?
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SPEAKER_00: It's so depressing.
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SPEAKER_00: He's like, I like the weather.
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SPEAKER_01: Just go to the weather channel.
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SPEAKER_01: I don't know we had a weather channel.
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SPEAKER_00: Yeah, it's it's rough.
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SPEAKER_00: It's rough.
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SPEAKER_00: TV over there is crazy.
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SPEAKER_01: No, it's it's getting crazy.
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SPEAKER_01: Apparently a lot of people also don't have access to like fast internet and stuff like that too.
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SPEAKER_01: So you're only getting just the public television or not public television, but yeah, probably like whatever.
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SPEAKER_01: That's the thing like that.
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SPEAKER_01: It's like so many really indoctrinate people when you're that's all the channels they have.
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SPEAKER_00: So many things in the US are so far behind from where they should be.
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SPEAKER_00: That's why I'm saying I think the tipping point is coming.
1:12:02
SPEAKER_00: People are not going to... No more checks.
1:12:05
SPEAKER_00: People are not going to take this for too long.
1:12:09
SPEAKER_00: And because it's still somewhat of a democracy, I'm hopeful someone will come along who sees this and is like, all right, time to flip things over without violence.
1:12:21
SPEAKER_00: I think the more...
1:12:23
SPEAKER_01: It's been an issue because people, like I say, have been desperately stressed out and were overworked.
1:12:29
SPEAKER_01: Well, now I think like, you know, automation will eventually take out so many jobs, and you'll have so many people living, you know, in real poverty, basically, that unless there is, there will be some time.
1:12:42
SPEAKER_01: I mean, do you hear about what's going to happen in Seattle?
1:12:44
SPEAKER_01: What was it called?
1:12:48
SPEAKER_00: to come.
1:12:58
SPEAKER_01: 058
1:13:19
SPEAKER_01: 058 058 058 058 058
1:13:48
SPEAKER_00: Why would they you know be proud of their country at this point?
1:13:53
SPEAKER_00: Or what their you know, believe that their country is a force for good because there's so much Evidence to the contrary.
1:14:00
SPEAKER_00: Yeah, and that's a sad thing because you're gonna have a generation of people who?
1:14:04
SPEAKER_00: Want to tear things down exactly.
1:14:06
SPEAKER_00: Yeah It needs to be turned down like some some of the political stuff is maddening and we need a change Yeah, but that does not mean tear the u.s.
1:14:15
SPEAKER_00: Down.
1:14:15
SPEAKER_01: Yeah true.
1:14:16
SPEAKER_01: No looting
1:14:17
SPEAKER_01: 08.
1:14:40
SPEAKER_01: 058
1:15:00
SPEAKER_01: 058
1:15:17
SPEAKER_01: 058.
1:15:43
SPEAKER_01: 058
1:16:02
SPEAKER_01: 058 –
1:16:31
SPEAKER_00: 058
1:16:48
SPEAKER_00: I think war in Sweden is still, you know, far fetched.
1:16:53
SPEAKER_01: Far fetched for me, yeah.
1:16:54
SPEAKER_00: Yeah, far away.
1:16:55
SPEAKER_00: It would probably mean we're pretty much in World War III.
1:16:59
SPEAKER_00: Yeah, yeah.
1:17:00
SPEAKER_00: But that is not that far away either.
1:17:05
SPEAKER_00: World War III is, you can see it happening at this point, like with what's going on in the Middle East.
1:17:10
SPEAKER_01: Well, at least Finland is going to probably get attacked first, if anything.
1:17:12
SPEAKER_01: So like, we'll have like, so there's some buffer there, unless I go all through the North, but it's like...
1:17:17
SPEAKER_01: Yoshi Ziga
1:17:22
SPEAKER_00: I'm hopeful, I'm optimistic, I think, like I said, the US is the key player here.
1:17:29
SPEAKER_00: And as long as it's still somewhat of a democracy, there's hope that someone comes along and is like, hey guys, maybe we should kind of not start World War III and focus on, you know, not having hundreds of thousands of people die from fentanyl every year.
1:17:44
SPEAKER_00: People can't afford homes.
1:17:47
SPEAKER_00: Can we deal with this?
1:17:49
SPEAKER_00: Someone more charming than Trump?
1:17:51
SPEAKER_00: yeah that's true having like uh you know make america great again message exactly i think is probably gonna happen sooner or later but we need it to happen sooner later because later now i think it's see see where we are it's like watching
1:18:09
SPEAKER_01: 058.
1:18:38
SPEAKER_01: to come.
1:18:55
SPEAKER_01: get the job done cheaper, and then make me a profit, you know, and that like type of like, even even new car companies are coming out with new cars still every single year, you know, and they it's just like, how much energy and stuff it goes into that, you know, and it's just like, how is this even like, it's like, Oh, yeah, but we're making electric cars now.
1:19:13
SPEAKER_01: It's like, yeah, but you're still making cars, you know, it's like, and, and I don't know if that's, that's something that
1:19:22
SPEAKER_01: as a whole
1:19:46
SPEAKER_01: and more.
1:20:01
SPEAKER_01: like
1:20:26
SPEAKER_00: i think like you said the next generations they have reason to blame us and the previous generations and you know blame whoever you want that's fine yeah but work on fixing things yeah work less on complaining work more on fixing the actual problem the thing is like a lot of people don't believe in the human
1:20:45
SPEAKER_00: 058
1:21:03
SPEAKER_00: our surroundings better most of us as much as we can we mess up for sure and that's bad but we generally want to do things you know good we want to be nice to each other that's true so that is what worries me more than anything else that like so many young people have this attitude of like we are the problem
1:21:23
SPEAKER_00: 058
1:21:44
SPEAKER_00: and much more
1:22:03
SPEAKER_01: It does operate in a similar attitude.
1:22:07
SPEAKER_01: I've seen stuff under the microscope where the first day you'll see this little wiggling microbe and I'm like, wow, this guy's much more active than this.
1:22:18
SPEAKER_01: I mean, it shouldn't be there though.
1:22:19
SPEAKER_01: It shouldn't be there because the environment is very set up for the stem cells.
1:22:25
SPEAKER_01: 058
1:22:42
SPEAKER_01: 058
1:22:58
SPEAKER_01: to
1:23:28
SPEAKER_01: to come.
1:23:55
SPEAKER_01: the environment is like just change the individual so that they don't… This is how a whole AI horror movie starts, like dystopian, yeah.
1:24:02
SPEAKER_01: I was like, that's an interesting concept, but like… What did I say?
1:24:05
SPEAKER_01: That the road to hell is paved with good intentions, right?
1:24:07
SPEAKER_01: Exactly, exactly.
1:24:08
SPEAKER_01: No, and that is like, I mean, but theoretically, you know, unless you're investing in these sciences right now also, like if in 20 years we can't breathe the atmosphere or we can't go outside without having like,
1:24:21
SPEAKER_01: 058
1:24:33
SPEAKER_01: I think they've also thought of this for like if they send people to like Mars or different, you know, different, like different planets is like, okay, well, in a low gravity environment, like your body really takes a toll, like it really is harmful to the body.
1:24:48
SPEAKER_01: How could you make it less harmful to the body?
1:24:50
SPEAKER_01: Could you put these genes into people who are then going to be the ones who go on these trips?
1:24:56
SPEAKER_01: 1.
1:24:56
SPEAKER_01: Ethnically selective biological weapons
1:25:16
SPEAKER_01: Okay, yeah, that's I mean you could do it even more specific than that I mean that that is one thing but also what about just in I mean, well, yeah, okay, we would want individualized bioweapons One guy it's like we're gonna be possible someday, but yeah also this idea of you know of a specific ethnicity You probably have a lot of off-target
1:25:45
SPEAKER_01: people have died from it.
1:26:02
SPEAKER_00: so it's like all across the board so like whatever genes there are i mean whichever one you chose as being the one oh if you have going down no matter what if you have this active like you're gonna die it's like yeah there's gonna be a lot of off-target it's just crazy that people are doing these things they're studying these things it's like just like we're talking about with the with the covid virus i mean one of these things can just leak yeah suddenly like everyone of this ethnicity don't study that it's like jesus what are we doing like can we can we study something more reasonable than that jeez
1:26:31
SPEAKER_01: Let's study how to make unicorns.
1:26:35
SPEAKER_00: Not how to kill all the muslims.
1:26:40
SPEAKER_00: People are doing weird stuff.
1:26:43
SPEAKER_00: We're doing a lot of beautiful stuff too, though.
1:26:45
SPEAKER_00: That's true.
1:26:46
SPEAKER_00: All the diseases.
1:26:47
SPEAKER_00: I feel like I'm killing my own point here.
1:26:51
SPEAKER_00: I'm like, human beings are great, and now we're also doing ethnically selective bioweapons.
1:26:57
SPEAKER_01: and more.
1:27:24
SPEAKER_01: 058
1:27:44
SPEAKER_01: way worse it's like oh yeah like my dad he was remembering he was like oh yeah when they used to spray ddt the kids used to go out and like literally like bathe in like it's just spraying ddt it's like yeah no wonder you got cancer at this ages you know like jesus but no for sure like the whole history of colonialism and slavery i mean we just went to other countries and did whatever we wanted no internet no one's gonna spread that on tiktok so
1:28:09
SPEAKER_01: yeah exactly so now we just know about the stuff and a lot of the stuff and the stuff that's depressing and scary and sad is the most attractive and like sound bitey for the media and propagate and propagate and propagate and now like you know you're just living in a world where you're like constantly like
1:28:29
SPEAKER_00: 08.
1:28:48
SPEAKER_00: 058
1:29:05
SPEAKER_01: 08.
1:29:33
SPEAKER_01: and more.
1:29:50
SPEAKER_01: 058
1:30:10
SPEAKER_01: yeah yeah i mean it was like she was going into labor and uh but then also like started to run a fever she started running a fever when she was in labor and they had to stop everything like a dilating whatever whatever and give a corona test
1:30:24
SPEAKER_01: 058
1:30:44
SPEAKER_01: social care for helping out with the kid you know he goes to preschool like five minutes away so i mean it's i really cannot complain raising a kid is a lot easier here than it would be at home despite the fact that i don't have like a family here you know i think that's the that's the only down downfalls like it's far from home and you know it would be nice to have like drop them off at grandma's once in a while of course
1:31:09
SPEAKER_01: but there's a lot of fun stuff.
1:31:11
SPEAKER_01: We got the swimming pool and all sorts of cool stuff here.
1:31:14
SPEAKER_00: A lot of people feel like it's hard to kind of connect with Swedes to establish a new group of friends and stuff here.
1:31:23
SPEAKER_00: Have you experienced that?
1:31:25
SPEAKER_01: I have some really good friends.
1:31:27
SPEAKER_01: They're both Swedes.
1:31:29
SPEAKER_01: I mean, they're both kind of like... Yeah, they're both Swedes.
1:31:32
SPEAKER_01: to come.
1:31:49
SPEAKER_01: to come.
1:32:13
SPEAKER_01: to come.
1:32:37
SPEAKER_01: 058.
1:32:52
SPEAKER_00: 058
1:33:10
SPEAKER_00: 058
1:33:40
SPEAKER_01: Yeah, that's, yeah, Scandinavia is a nice place to live.
1:33:43
SPEAKER_01: And whether or not it's, it's cold during the winters, I think people also warm up during like the summertime as well.
1:33:51
SPEAKER_01: So you get this kind of, but that's why I mean, I think the ideal would be to, to leave during the winter.
1:33:55
SPEAKER_01: Honestly, that's kind of my
1:33:58
SPEAKER_01: If the writing really can be pushed to the next level, I think that's where my goal is.
1:34:05
SPEAKER_01: So tell me about your writing.
1:34:07
SPEAKER_01: So yeah, I'm writing a book.
1:34:08
SPEAKER_01: It's about 100 pages done right now, but like solid and I'll probably, it's probably about a third way done, but it's called Variant Rising and variant as being like a genetic variant.
1:34:19
SPEAKER_01: But
1:34:20
SPEAKER_01: and more
1:34:49
SPEAKER_01: 058.
1:35:16
SPEAKER_01: 058
1:35:35
SPEAKER_01: 058.
1:36:01
SPEAKER_01: 058 –
1:36:29
SPEAKER_01: 058
1:36:39
SPEAKER_01: and more.
1:37:06
SPEAKER_01: 058
1:37:24
SPEAKER_01: 058.
1:37:51
SPEAKER_01: so much more
1:38:12
SPEAKER_01: and more.
1:38:28
SPEAKER_01: and more
1:38:58
SPEAKER_01: there are people who are like like hollywood stars yeah that people are talking about that have done this oh i'm sure with fetuses also with fetuses yeah yeah it's like it's like i i have no idea how valid this is but i've heard people talking about that i mean i believe it in the name of vanity and that's actually who this character is she's just uber vain and uber after like throw anything at it to try to get me you know yeah eternal
1:39:24
SPEAKER_01: Yoshi Ziga
1:39:35
SPEAKER_01: 058
1:40:04
SPEAKER_01: 058 058 058
1:40:34
SPEAKER_01: and more.
1:40:49
SPEAKER_01: 058
1:41:05
SPEAKER_01: 058
1:41:22
SPEAKER_01: regulating
1:41:41
SPEAKER_01: for improvement.
1:42:10
SPEAKER_01: and more.
1:42:32
SPEAKER_01: this would be like kind of the yellow zone you know like uh of whether or not to use this and they're saying like no still not that you know it's like and the green of where like this there's a consensus of yes we should use this technology as soon as it's safe is if it's a life debilitating like disorder like the ones i'm describing monogenic diseases that are just really deleterious to the way of life that's expensive for the society because you know you're paying for this it's horrible for the family because you know
1:43:01
SPEAKER_01: and much more
1:43:17
SPEAKER_01: so the idea is is like where how can we get to this place and the way we can get to this place is well we need to understand what we're putting in the embryo and whether or not it's creating more mutations or less mutations because the big the big issue the big question mark of using CRISPR-Cas
1:43:36
SPEAKER_01: 058
1:44:02
SPEAKER_01: 058
1:44:24
SPEAKER_01: basically digest or dissolve into the system eventually and like so how how long will it until it naturally degrades and so there's there's but a lot of this timetable of like well how much and how and you know and that's where it becomes really scary is because
1:44:40
SPEAKER_01: Like I said, with all of these things, you know, like you expose it to a little bit too much.
1:44:43
SPEAKER_01: Now you're doing something very damaging.
1:44:46
SPEAKER_01: You do it too little, then you're not, you know, it's the Goldilocks effect here that's necessary.
1:44:51
SPEAKER_01: And but there's been really no way of studying that for when we're talking about a system that's just a very few cells.
1:44:59
SPEAKER_01: You know, I mean, this is a blastocyst.
1:45:01
SPEAKER_01: So this is like about seven days after, you know, sperm meets egg.
1:45:06
SPEAKER_01: to come.
1:45:36
SPEAKER_01: like
1:46:04
SPEAKER_01: and more.
1:46:25
SPEAKER_01: when you have two parents come together, you also make a bunch of mutations.
1:46:29
SPEAKER_01: So now that's where the stem cell world and this like embryo world kind of are coming together is it turns out that there's been, I mean, there's a Nicholas Riveron, I think he's one of the biggest pioneers in this.
1:46:41
SPEAKER_01: He's created these things called blastoids.
1:46:43
SPEAKER_01: And it's basically taking stem cells and pulsing them with the right cocktail of nutrients and whatnot.
1:46:50
SPEAKER_01: to come.
1:47:14
SPEAKER_01: So they will be so that that's the thing is like since these are from a stem cell the stem cell is genetically identical That's the thing is I say like I you can take it even from your own cell and then it's whatever gene pool You know, whatever genetics it has.
1:47:27
SPEAKER_01: It's always going to be the same here.
1:47:29
SPEAKER_01: So now you can do this with blastoids You can actually make something that's like an embryo and that's where now you can actually use these technologies to
1:47:37
SPEAKER_01: on
1:48:02
SPEAKER_01: and more
1:48:32
SPEAKER_01: of
1:49:01
SPEAKER_01: and more.
1:49:24
SPEAKER_00: 058 – 058
1:49:48
SPEAKER_01: 058.
1:50:13
SPEAKER_01: 058
1:50:34
SPEAKER_01: 058
1:50:59
SPEAKER_00: about Yoshi's Podcast
1:51:24
SPEAKER_00: and much more.
1:51:41
SPEAKER_01: 058
1:52:11
SPEAKER_01: video games with like colors coming out the wazoo you know it's just like how do you expect a human brain yeah and then that was the idea let's get we're not at all profiting from this to basically like hype you know so we're just doing this because we care about you we're not we're not trying to profit off of this don't worry about that horrible horrible but they that that's the thing is like they were i mean i loved adderall for like a while of like uh just like
1:52:34
SPEAKER_01: and much more
1:52:54
SPEAKER_01: 058
1:53:17
SPEAKER_01: 058.
1:53:46
SPEAKER_01: 058 – 058
1:54:12
SPEAKER_01: 058
1:54:34
SPEAKER_01: and much more
1:54:53
SPEAKER_01: I'm enjoying what I'm writing right now.
1:54:54
SPEAKER_01: I think it's the hyper focus of doing something that I'm actually enjoying because that's the only way I mean that's why I've succeeded I think in the jobs that I have when I'm not in a job that I don't feel purpose that I don't see like the like an output from what I'm doing you know I just have a hard time pushing myself at all
1:55:15
SPEAKER_01: and more.
1:55:31
SPEAKER_01: yeah maybe I don't have that like every single day but but otherwise yeah I don't know just cup of coffee you know like I try to keep a real clean house like that's my that's my that's my way of how do you say
1:55:48
SPEAKER_01: 058
1:56:09
SPEAKER_01: 058 – 058
1:56:39
SPEAKER_01: and more.
1:57:03
SPEAKER_01: and more.
1:57:25
SPEAKER_01: and more.
1:57:45
SPEAKER_01: Do you have a clear end goal for the book or is it developing and you just see where it goes?
1:58:11
SPEAKER_01: I think it's kind of like I have an idea but I think it's more of like because I my my cousin was actually asking me this also she was like do you have an outline like how are you doing this without an outline and I'm like yeah I just like kind of like I'm feeling like I like I'm right like I know what's happening like it's like it's going through me like I don't know Stephen King has kind of like said some of this stuff about how he writes of like as if it's not planned it just kind of like flows from him
1:58:37
SPEAKER_01: It's like entertainment for you too as well
1:59:03
SPEAKER_00: about Yoshi's Podcast
1:59:33
SPEAKER_01: 058 – JP Schell
2:00:02
SPEAKER_01: 058
2:00:20
SPEAKER_00: 058
2:00:50
SPEAKER_00: Yoshi's Podcast
2:00:51
SPEAKER_00: and much more
2:01:21
SPEAKER_01: to come.
2:01:32
SPEAKER_00: But I loved them back then, but now I don't really read fantasy.
2:01:36
SPEAKER_00: No, no.
2:01:37
SPEAKER_01: I think the last thing I'm reading now just like by myself is like The 100, which is a show now.
2:01:42
SPEAKER_01: They made a show of that.
2:01:44
SPEAKER_01: I don't know.
2:01:44
SPEAKER_01: I was like, it's fun, but it's like, it's very like teenage girlish.
2:01:51
SPEAKER_01: I mean, in the sense, it's all like, like, it's like, oh, I mean, I'm like digging it too.
2:01:55
SPEAKER_01: I'm like, oh, this is cute, you know, like, but like, there's a lot of love stories going on.
2:02:01
SPEAKER_00: I'm more into the dystopia stuff, like what you're writing.
2:02:03
SPEAKER_00: I love Brave New World, 1984, these kind of books, masterpieces.
2:02:09
SPEAKER_01: Yeah, if you do get a chance for, I mean, for one of them that's like weird, weird, like Frank Herbert, Other Than Doom series, like he wrote a book called Hellström's Hive.
2:02:20
SPEAKER_01: It sounds Swedish, like, but that is probably one of the weirdest books I've ever read.
2:02:26
SPEAKER_01: And it's kind of like, actually, like,
2:02:28
SPEAKER_01: i was kind of thinking that this book that i'm writing now kind of would fit in as like almost even like a like a prequel to the society that he creates in that but it's a but it's a it's i mean his is is just it's a really brilliant book and just really weird just really do you do you read any non-fiction
2:02:48
SPEAKER_01: 08.
2:03:18
SPEAKER_01: 058
2:03:43
SPEAKER_01: and more.
2:03:59
SPEAKER_01: 058.
2:04:26
SPEAKER_01: to come.
2:04:45
SPEAKER_01: and more.
2:05:13
SPEAKER_01: which is quite nice you know i think that's kind of kind of cool like for sure for sure technology is you know crazy we live in such a cool time we do but also what is this what is this quote like we're like archaic minds with like medievalist institutions and godlike technology something like this like that's it's a scary world you know
2:05:34
SPEAKER_00: It's interesting because we live in a time where we can actually see ourselves either going back to the stone age pretty soon or actually becoming god-like pretty soon.
2:05:45
SPEAKER_00: And the choices we make obviously are going to affect that.
2:05:48
SPEAKER_01: I don't know if I want to become god-like though.
2:05:50
SPEAKER_01: I feel like there's already...
2:05:53
SPEAKER_00: and more.
2:06:18
SPEAKER_01: and more.
2:06:40
SPEAKER_01: as a creature that maybe should have been you know should be outside more than in front of screens all the time you know like I saw some really depressing statistics about like like over a third of our life is going to be like for people who are 18 like a third of your life will be sleep and a third of your life will be in front of a screen or some ridiculous like high proportion I saw something crazy uh let me think I think the average eight-year-old today
2:07:06
SPEAKER_00: 058
2:07:22
SPEAKER_01: 058
2:07:41
SPEAKER_01: The most addictive pattern is positive reinforcement randomly distributed.
2:08:11
SPEAKER_00: that's that's the most addictive pattern like a slot machines oh yeah you know every now and then you win you get the positive reinforcement but it's random it's not every third time it's not every fifth times now and then yeah that's that's the most because when we were like in the savannah yeah we would walk around looking for food and we find like a bush of berries and it's like oh my god eat it eat it happy you know and then you go because that's survival yeah exactly so all these apps they hijack that system and you feel like it's exploitable this is a great video
2:08:40
SPEAKER_00: I have a zero tolerance policy for scrolling I use Instagram and these apps mainly to get the word out for the podcast or invite people
2:09:04
SPEAKER_01: but no like i'm not allowed to scroll ones good like the real that's impressive that's impressive man i had to i had to because it was i mean don't just eat through your time like but like i mean and it's just so depressing because you look around and like it's everybody it's not even just the young people it's like old people are the worst like my my uncle is at home and he's just on the tablet like for hours and hours and hours just on youtube videos and i'm like
2:09:29
SPEAKER_01: 058
2:09:57
SPEAKER_00: It is, it is.
2:09:58
SPEAKER_00: I think we will figure things out.
2:09:59
SPEAKER_00: I think we will look at this era.
2:10:01
SPEAKER_00: I mean, the internet came, what, like 30 years ago?
2:10:03
SPEAKER_00: That's true, that's true.
2:10:04
SPEAKER_01: And we were yelling at people like, ah, these people were with their books, you know, what are they doing with their heads in books?
2:10:10
SPEAKER_00: We're gonna reach a stage where we're gonna look back at this era and be like, holy shit, they gave TikTok to kids?
2:10:16
SPEAKER_00: What are they doing?
2:10:18
SPEAKER_01: And we're gonna figure it out, but it's gonna, you know, take a little while.
2:10:21
SPEAKER_01: That opium coming over.
2:10:23
SPEAKER_00: That's what they're...
2:10:25
SPEAKER_01: 058
2:10:45
SPEAKER_01: to come.
2:11:08
SPEAKER_01: like neighborhood you know and and how also people could advertise you know like would be that's gonna be the other thing is like your brain yeah it'll just be on but then you could also have like different worlds you know you're like oh I don't like you know this one's made by so-and-so and he has these advertisements you know maybe tastefully done because of you know he's getting paid for that in that sense or she's getting paid for this but then like having these augmented worlds where you put on your goggles and then all of a sudden it looks like you know
2:11:34
SPEAKER_01: to come.
2:11:47
SPEAKER_01: It's
2:12:08
SPEAKER_00: 058
2:12:26
SPEAKER_00: 058
2:12:41
SPEAKER_01: when that happens we're done that's it yeah that's a good point we need to figure out the clones that we were talking about before we figure out the virtual reality sex yeah because otherwise then it's going to be what is this uh what is the dystopian future comedy that happened a long time ago it was like uh it turned out to be a documentary rather than just a comedy but uh oh i can't remember the name of it
2:13:05
SPEAKER_00: and much more
2:13:23
SPEAKER_00: And you're on a toilet.
2:13:25
SPEAKER_00: It's a creator of Beavis and Butthead.
2:13:28
SPEAKER_01: It's so funny to watch it now, and you're like, yeah, it's not so much different.
2:13:32
SPEAKER_01: Yeah.
2:13:33
SPEAKER_01: We're kind of wrong.
2:13:34
SPEAKER_01: And it was funny because apparently like one of the little like Easter eggs to that was the knowledge that like he had people wearing Crocs in that movie.
2:13:44
SPEAKER_00: Oh, yeah.
2:13:45
SPEAKER_01: Because of the fact that he thought these were like the ugliest things possible and nobody in their right mind and now they're like super popular.
2:13:51
SPEAKER_01: Yeah.
2:13:51
SPEAKER_01: People are putting all these little
2:13:52
SPEAKER_01: 058
2:14:17
SPEAKER_00: but maybe we should start wrapping things up and do another conversation when when your book is published absolutely absolutely i will talk to you about perhaps getting some connections here of course of course i can in any way i can help awesome listen man this has been a fantastic conversation cool yeah thank you for sharing
2:14:38
SPEAKER_00: all the cool shit you do and you've done.
2:14:40
SPEAKER_01: Thank you for having me.
2:14:41
SPEAKER_01: It's been a pleasure and definitely anytime.
2:14:44
SPEAKER_01: I honestly thought like, ah, you know, I mean, just having a little caffeine before and like, I'll go with it.
2:14:49
SPEAKER_01: That's the trick.
2:14:50
SPEAKER_01: Let the ADD do the talking.
2:14:53
SPEAKER_01: Well, ADD did great.
2:14:54
SPEAKER_01: Excellent.
2:14:55
SPEAKER_01: Excellent.
2:14:55
SPEAKER_01: Thank you, man.
2:14:56
SPEAKER_01: I appreciate it.
2:14:56
SPEAKER_00: Thank you very much.
2:14:57
SPEAKER_00: And thank you to everyone listening and watching.
2:14:59
SPEAKER_00: See you next time.