Latest / The Dr. Randi Show / Your Hair Follicles Hold Stem Cells—and the Key to Regenerative Medicine — Dr. Drew Taylor / Acorn Biolabs
Transcript
- 0:03The views expressed in this podcast are for informational
- 0:06purposes only and do not constitute medical advice.
- 0:09This episode of The Doctor Randy Show is proudly sponsored by New
- 0:13Beauty, the ultimate authority in beauty and aesthetics.
- 0:16Whether you're looking for the latest innovations, expert
- 0:19insights or trusted recommendations, New Beauty is
- 0:22your go to source. Visit newbeauty.com to stay
- 0:25ahead of the trends and discover what's next in beauty.
- 0:28Now let's get into the episode. Hello everyone, and welcome to
- 0:32the Doctor Randy show, where science meets beauty, where
- 0:35innovation meets impact, and where we go beyond the surface
- 0:39to bring you the real stories driving the aesthetics, Wellness
- 0:42and medical industry forward. I'm your host, Doctor Randy
- 0:46Boya, and today's guest is about to change the way you think
- 0:50about your own biology. He played pro baseball before
- 0:54becoming a scientist. He holds a PhD in biomedical
- 0:58engineering and he's revolutionizing the future of
- 1:01anti aging one hair follicle at a time.
- 1:05Please welcome Doctor Drew Taylor, CEO of Acorn Bio Labs.
- 1:10Doctor Randy, thanks so much for having me.
- 1:12That was quite the introduction. Well, we're very glad to have
- 1:16you. And the buzz and the
- 1:18conversation is all about ACORN. So excited we got to meet at
- 1:22scale in Nashville. So excited to have you on the
- 1:26show because even myself, I want to know more about Acorn and
- 1:29what's going on. It's so unique.
- 1:32So let's start right at the top. If you don't mind, tell us about
- 1:36Acorn Bio Labs. Why is banking your own stem
- 1:40cells something people need to be thinking about in 2025?
- 1:44Yeah, absolutely. So unfortunately, every day that
- 1:47goes by, our cells are becoming less and less efficient at doing
- 1:50the things that they're supposed to do.
- 1:53And that also includes our own stem cells.
- 1:55And our stem cells are really these repositories for renewal
- 1:58and a replenishment. And so if they're failing that,
- 2:01how are they going to be able to really keep up with the demands
- 2:04of servicing and supplementing all of the cells around our
- 2:07body? And so as that goes down, we
- 2:09really want to be making sure that we're doing everything we
- 2:12can to try to stave off those effects.
- 2:15And part of one of the ultimate solutions that you can do is
- 2:19really by capturing some of your stem cells and cryogenically
- 2:23freezing them in time, which is really the only true way to
- 2:26totally stop the aging process. We freeze them down in in liquid
- 2:30nitrogen. So these are levels that are
- 2:32-310°F, so only slightly warmer than the surface of Pluto.
- 2:38And at those temperatures, the cells do not metabolize, they do
- 2:41not age. They're literally frozen in
- 2:43time. And so now you've got your own,
- 2:46your very own cells at your disposal and definitely moving
- 2:50forward from that age that you froze them down.
- 2:54Wow, that is some unique science and you are doing something
- 2:59definitely different. So I think most people have
- 3:02heard of stem cells, but using hair follicles, that's something
- 3:07new. So why that method and what are
- 3:11you actually preserving? Tell us more about that.
- 3:14Yeah. So my background was really in
- 3:16regenerating connective tissues and that included a number of
- 3:20different cell types that included things in orthopedics
- 3:23and sports medicine as well as in aesthetics and skin.
- 3:26When we kind of think back to how our approach was then is it
- 3:32was really trying to make sure that we could check a few boxes
- 3:36for a patient in preparing them for a regenerative medicine and
- 3:39and one was a source of quality cells.
- 3:42There's a few different places around the body that we can get
- 3:44very high quality cells from. But then also something that
- 3:48patients would actually do proactively and wouldn't have
- 3:51create other complications or other risk factors and wouldn't
- 3:55leave them potentially with some unsavory complications, right?
- 4:01Yes. When we think about harvesting
- 4:02cells, bone marrow has obviously been an area of focus for a long
- 4:06time. There's also stem cells that can
- 4:08be harvested in other sources and tissues, including our fat.
- 4:12They're dispersed through our fat.
- 4:14But then also we've discovered really in the last decade, these
- 4:17high concentrations of very similar stem cells in our hair
- 4:20follicles. And so both from bone marrow,
- 4:23from the adipocytes or fat as well as from the hair follicle,
- 4:26these are all mesenchymal stem cells.
- 4:29And so these are the cells that have really focused a lot of
- 4:31scientists attention on on leveraging near term
- 4:34regenerative solutions using these cells.
- 4:36They're very robust cells and they have the ability to become
- 4:40a multitude of different types of cells that are important for
- 4:43our performance in our bodies. And so targeting the hair
- 4:47follicle allows us really an Ave. to do something
- 4:50prospectively right by capturing those cells and freezing them
- 4:54without the need to engage in something that is invasive.
- 4:58And so bone marrow obviously tapping into your iliac Crest,
- 5:01harvesting that bone marrow is not a nothing procedure.
- 5:04And then not everybody is in the middle of contemplating A
- 5:08liposuction or a fat retrieval, a treatment or procedure where
- 5:12they could actually take some of that excess fat and look at the
- 5:15other interesting thing about fat though, is the stem cells
- 5:18themselves are dispersed throughout all of the regular
- 5:22dip sites, regular fat cells which are actually oil based.
- 5:25And unfortunately, all of the cryoprotectants that we have
- 5:30that have been invented are efficient at freezing cells.
- 5:34They are all water soluble. And so there's a bit of a
- 5:37conflict, whereas we're able to more effectively and efficiently
- 5:42freeze down bone marrow and hair follicle cells than fat.
- 5:46And so that really, when you think about some of the
- 5:47limitations that exist in the invasiveness and in the type of
- 5:50cell, the hair follicle has truly emerged as the ideal cell
- 5:54source to save for the future of regenerative medicine.
- 5:58Wow. Well, I think that it has been
- 6:01sort of the hype around this is the hair follicle, right?
- 6:04Because I think that's something no one else is doing.
- 6:06And so it is creating a buzz. So for our listeners and viewers
- 6:11out there, who is this really for?
- 6:14What type of future uses are we talking about?
- 6:17Is it cosmetic? Is it medical?
- 6:19Is it longevity? And what type of person should
- 6:23be doing this today? What should we be doing right
- 6:25now with our darker follicles? It's a, it's a fantastic
- 6:29question and I'm going to try to keep it a concise answer because
- 6:32honestly, there's a lot of different avenues where this is
- 6:35going to go. We've already seen the creation
- 6:38of applications using our own cryopreserved hair follicles in
- 6:42the world of aesthetic medicine. And so we recently launched and
- 6:47released the first opportunity to leverage your bank cells,
- 6:50which is actually capturing your hair follicle cells, your very
- 6:54own and growing them in our laboratory.
- 6:56And as they grow in the laboratory, we actually capture
- 6:59all of the molecules that are released from those cells as
- 7:02they're growing. And so this includes large
- 7:04matrix molecules like collagens and elastin, fibronectin and
- 7:08Agrican, as well as small growth factor proteins that are like
- 7:13PDGF, A number of factors like IGF, one can go under the very
- 7:18long list, the EGF, but ultimately the things that
- 7:21stimulate our cells to grow, divide and create matrix or the
- 7:26things that, you know, create our skin and other connective
- 7:29tissues. And then on top of that,
- 7:32exosomes themselves are released.
- 7:34So you have this entire complement, it's called the
- 7:36secret tone, where the entire secreted product from these
- 7:40cells and that can be actually collected over a period of time
- 7:43while those cells are growing. So we can collect very high
- 7:45volumes of these essential molecules and then bottle that
- 7:50essentially and deliver it back to a physician to apply for you
- 7:54alongside procedures to open up your skin and enhance absorption
- 7:58like micro needling and laser and and even just apply
- 8:01topically. And so it's a very exciting
- 8:03opportunity to get value out of your cells right away.
- 8:06But I think there's a very long future.
- 8:08And the idea is by capturing a template of yourself and
- 8:11freezing it, you can use them today already in the world of
- 8:14cosmetics and aesthetics. And then in in the future,
- 8:17you're going to be able to leverage these cells in a
- 8:19multitude of different ways. And so we've got ongoing
- 8:22research projects that have taken these cells from her hair
- 8:25follicle and turn them into cartilage, bone, fat.
- 8:29We've been able to create even pancreas, pancreas cells.
- 8:32We've been able to create natural killer cells, which is
- 8:35part of our immune system. So all of these different
- 8:39opportunities really lead to an ever expanding use cases of
- 8:44leveraging these cells for own benefit.
- 8:46And in fact, we're working on a project right now where we've
- 8:49already turned the cells into neurons and even dopaminergic
- 8:53neurons, which are the neurons we lose during Parkinson's
- 8:56disease. And so this is a joint
- 8:58collaboration with the University of Guelph right now,
- 8:59where we're actually going to be creating different types of
- 9:01neurons, all sourced from stored hair follicle stem cells.
- 9:07Unbelievable. And I think this really is the
- 9:10future and what we're going to be able to do.
- 9:13So why would you say to somebody do this today, not ten years
- 9:18from now? What are what is your advice on
- 9:20that? Because I think everybody out
- 9:22there is so curious. Stem cells, exosomes, you know,
- 9:26all of these treatments are piquing all of our interest.
- 9:28And we're just kind of curious, what are we supposed to do next?
- 9:32Yeah. I think that it's early on.
- 9:34I think in the regenerative medicine scene, you know, we
- 9:37talked a little bit about how some of these new innovative
- 9:41technologies emerge. And an analogy I usually make is
- 9:44actually to another really amazing discovery, which is
- 9:48flight. And so if you think back to the
- 9:50Wright brothers, the first time that they actually created
- 9:53flight and flew a plane, obviously it carried somebody
- 9:56that, you know, 100 feet, right? It was not exactly useful or
- 10:00delivering value to humanity. And it took another almost 40
- 10:04years, the better part of four decades, for it to actually
- 10:08deliver tangible value for people by carrying passengers
- 10:12across the Atlantic Ocean. And so it took a long time and
- 10:16revelations and new things added on to that technology.
- 10:18But then after that was accomplished, within 10 years,
- 10:22they'd achieved supersonic flight.
- 10:24And within another 10 years after that, they had landed on
- 10:26the moon. And so you start to see this
- 10:29acceleration in these technologies.
- 10:32And so right now, we are the youngest that we're ever going
- 10:34to be, right? The opportunity in front of us
- 10:37is immense. We already know use cases that
- 10:40are delivering value to patients from these cells today, and
- 10:43that's only going to grow and escalate really at an
- 10:46exponential scale. So the best action that that we
- 10:49can do is to make sure that the best version of our cells is
- 10:53ready and waiting and we can stop the clock so that we can
- 10:56tap into our younger, better cells to take advantage of that
- 10:59amazing bright future. Right.
- 11:01So this is the future, right? This is where the future is
- 11:04going. And I think that our listeners
- 11:07will want to know, if you don't mind, take us through what
- 11:11happens when someone signs up. Do they sign up directly through
- 11:15you? Do they have to sign up through
- 11:16a clinic? And then what is the experience
- 11:19like? So we've been really grateful
- 11:21that we're working alongside some of the top dermatologists
- 11:25and plastic surgeons and really physicians across North America.
- 11:29And so there's the opportunity for you to visit one of their
- 11:32practices. You can see a comprehensive list
- 11:34on our website at acorn dot me and you can see all the
- 11:38different amazing physicians that we're lucky to work with.
- 11:41And you can have your cells banked as well as create your
- 11:45secret tone and order your secret tone at the same time
- 11:48through any of those partners. And so I urge anybody that's
- 11:51interested to to jump online and see where the closest clinic to
- 11:53you is. I can't wait to do mine.
- 11:55I'm very excited about this because I think the future is
- 11:59bright and where this is going. So you keep them frozen for
- 12:04decades, right? Is there any exploration on that
- 12:07at all? So that's a great question and
- 12:09that's one of the limitations with some of these other cell
- 12:12types that don't work well with cryoprotectants.
- 12:14We've been very lucky that we've identified ways to cryogenically
- 12:18preserve these cells optimally. And that's really built on the
- 12:21shoulders of giants like that technology has been emerging
- 12:23since the 1960s and the way that we cryogenically free cells.
- 12:27And so there is theoretically no limit, right?
- 12:30We have data from the 60s through to today on
- 12:34cryogenically preserving cells and doing it in a way that
- 12:38allows for these adult somatic cells to be cryopreserved and
- 12:41not have that degradation over time.
- 12:43That being said, theoretically you can keep these cells banks
- 12:46for 1000 years. Wow.
- 12:49So this really, I can't wait to see what happens with all of
- 12:53this because that's a very long time.
- 12:56So let's for our viewers to kind of understand the difference,
- 13:00What is the true difference between what you're doing at
- 13:04Acorn and PRP exosomes toward blood banking?
- 13:09These are some of the buzzwords in the industry.
- 13:11Can you tell us just so people can understand the difference?
- 13:15Yeah. So what I would say is just in
- 13:17cells in general, right, If you think about some of these
- 13:20sources of different cells in general or like a mountain and
- 13:23around the bottom of that mountain are all of the cells
- 13:27that are performing a job in our body.
- 13:28They're defined, right. So our kidney or liver or skin,
- 13:32they're doing a job. Now, if we go up the mountain,
- 13:36certain faces, we've got different cell types.
- 13:38That would be like stem cells that actually have the
- 13:40opportunity to create multiple different types of cells.
- 13:44So they can actually roll down the mountain in different paths
- 13:47and create different cell types at the bottom.
- 13:50Now that magic moment when sperm meets egg, that's at the very
- 13:53top of that mountain, right? So at that point, that cell can
- 13:57roll down any face of that mountain.
- 14:00So what we're after really is anytime after that point when
- 14:04you know you're you have a human being in front of you is where
- 14:07can we access quality cells from that patient that can become a
- 14:10multitude of cells and also hold the promise of being able to be
- 14:15pushed back up to the top of that mountain.
- 14:18Not every cell does that efficiently and not every cell
- 14:21can become many other cell types.
- 14:22And so we're really looking after these pockets of stem
- 14:25cells and bone marrow has some or fat has those adipocyte stem
- 14:30cells, progenitor cells or hair follicles have it.
- 14:32And there's other areas that you can capture them like at the
- 14:35time of birth with cord blood, right?
- 14:37Or you can get in Wharton's Jelly specifically if you're
- 14:40after mesenchymal stem cells. And so these are all different
- 14:43cell types, right, that are providing opportunities to
- 14:48create different and new cells. So for us, what we focus on is
- 14:52being able to do this at any age.
- 14:55Capturing an umbilical cord has to be done in a period of time
- 14:58when you're being born. And so that's a very specific
- 15:01time you have to be ready, willing and able to do it.
- 15:04Going beyond that, when you think about a hair follicle, you
- 15:07can capture it almost any age. And so that really provides an
- 15:11opportunity for anybody, right, the entire population to engage
- 15:15in having their cells banked and be prepared for regenerative
- 15:18medicine. So we're all about access and
- 15:20we're all about really making sure that patients have an
- 15:22opportunity to engage in this bright future.
- 15:25So Speaking of access, right, that kind of brings me to my
- 15:29next question, because some people think of this as stem
- 15:34cell banking is only a luxury, right?
- 15:37That only maybe this kind of technology is only available to
- 15:41the wealthy. Do you see it becoming more
- 15:44common, almost like a necessity that something that health
- 15:47insurance might even cover at some point?
- 15:50I do believe that absolutely at one point having access to your
- 15:54own cells cryogenically preserved will be a standard of
- 15:56care, right? And it won't be a luxury item.
- 15:59In fact, we very much are trying to drive that opportunity
- 16:02already. Stem cells traditionally have
- 16:04been an expensive yet experimental opportunities for
- 16:08patients to to engage with and often have to go outside of the
- 16:12United States or Canada to, to actually access that right,
- 16:16going to countries where the regulations aren't as severe and
- 16:19the protections and safety measures aren't as developed.
- 16:23So for us, we want to make sure that we're operating within
- 16:26those parameters right, so that you can have access to this in
- 16:29your own country and don't have to travel for it.
- 16:31And then also have all the safety measures are surrounding
- 16:34you that we think are super necessary.
- 16:36But we also want to democratize it to really make sure that
- 16:40anybody can access it, not just those can fly somewhere and pay,
- 16:44pay high fees. This is an opportunity for, I
- 16:47think you know, really if you look at our costs annually,
- 16:51right, our cost to keep sales banked are cheaper than a
- 16:54Netflix account. So it really is trying to make
- 16:56sure that people can engage with this and make it a very easy
- 16:59decision. Yeah, it sounds like it could
- 17:02fit. I remember when the whole
- 17:04concept of freezing women's eggs became accessible to all, and it
- 17:10was still like, people thought it was almost like science
- 17:12fiction when that happened. And everybody was like, Oh no,
- 17:16that's scary. But now, like so many people are
- 17:19doing it because it becomes more accepted, right?
- 17:22So on that, I guess on that mindset, what do you think the
- 17:26biggest mental shift is that people need to make in order to
- 17:30understand the future of regenerative medicine?
- 17:34I, I think people are making it right.
- 17:36And I think that the fertility industry and the opportunity
- 17:39that it provided for women to cryogenically preserve eggs is
- 17:44the massive step forward and a tremendous opportunity.
- 17:46And I'm grateful for the people that worked so hard to do that.
- 17:49And I'm lucky to have to be friends with some great
- 17:52physicians in that industry that were pioneers in giving access
- 17:56to that, like Doctor Bob Casper here in Toronto as an example.
- 18:00So I think there's some amazing people out there that that
- 18:02provided that opportunity. We would like to do the same
- 18:04thing and in making sure that, you know, we're following those
- 18:07footsteps and making sure that patients have an opportunity to
- 18:10bank their own cells outside of obviously fertility, but for
- 18:14healthcare needs and regenerative medicine needs.
- 18:18And that starts our beachhead is in regenerative aesthetics, but
- 18:21I think it goes well beyond that into too many other areas of
- 18:25medicine as we talked about. So thinking the 10 year game, if
- 18:30people are banking themselves today, what's your hope of what
- 18:33they'll be able to do within 10 years at least?
- 18:36Yeah. Well, we're already seeing
- 18:37patients receive benefit from using their cells in
- 18:40regenerative statics, which is phenomenal.
- 18:42I think the next wave of things is going to be increasingly more
- 18:45complex and in forms of delivery.
- 18:47We already have studies that are going on right now evaluating
- 18:51our approach in orthopedics and sports medicine and we have
- 18:55preclinical studies going on in areas of internal medicine
- 18:58obviously been creating pancreatic cells, neurons and K
- 19:02cells and the like, right. So some really long term settler
- 19:05approaches. So I think that patients are
- 19:08already receiving benefit from it.
- 19:09In the next 10 years we're going to see an ever expanding
- 19:11opportunity of different ways that they'll receive benefit
- 19:14from them. And I think a really exciting
- 19:17moment for us will be, you know, seeing that first patient that
- 19:20might have gotten exposed to ACORN by banking their cells for
- 19:23skin care needs or they're a set of considerations and then maybe
- 19:27years down the road receiving benefit from those cells that
- 19:30may even save their life one day.
- 19:32I think that's going to be really exciting moment.
- 19:34That has to be super exhilarating.
- 19:37Have you seen any same mind blowing clinical use cases that
- 19:41are coming down the pipeline sooner than you thought?
- 19:45Yeah. I think the opportunity to
- 19:46create neurons on demand is an exceptionally promising
- 19:49opportunity. The NK cells is a very exciting
- 19:52opportunity. I mean, these are immune cells
- 19:54that are part of our bodies that recognize our own cells.
- 19:58And so they go around and they look for either precancerous or
- 20:02cancerous cells before they start to grow and divide and
- 20:05become a tumor or our own cells that have become senescent.
- 20:09Right. And that's a big word in
- 20:10longevity right now of our own cells that unfortunately aren't
- 20:13performing that well and then become senescence.
- 20:15Now there's a very complex definition of what senescence
- 20:18is, but essentially think of cells that really are exhausted,
- 20:22not performing very well and need to be cleared really to
- 20:25make way because their presence is negative at that point.
- 20:30And so these NK cells do a really efficient job of that.
- 20:33Fortunately, they drop rapidly due to age and so for us, the
- 20:39opportunity to create a patient's own NK cells that can
- 20:44be delivered back to them as they age.
- 20:47I think it's a very exciting prospect of fighting off some
- 20:50of, you know, some terrible things like senescence and the
- 20:54acceleration of age-related conditions, but on top of that,
- 20:58thinking about things like cancer, right?
- 21:02Right, right. I think the future is very
- 21:05bright. I think that you're going to and
- 21:07I think it's probably exciting for you as the CEO to wake up
- 21:11every morning and and decide, hey, you know, where, where are
- 21:15we going to take science today? And I guess that's, that leads
- 21:19me into my next question, which what was the moment where you
- 21:22knew Acorn could actually work, not just scientifically, but
- 21:27commercially, and then getting a set of clinics to accept it and
- 21:31dive in. How did all that take place for
- 21:33you? Yeah.
- 21:35I mean that's, I think that's a whole podcast episode on its own
- 21:37on the business development side, right.
- 21:39I think for us, we wanted to really share our goals at a with
- 21:46a small group of physicians initially to really test the
- 21:49waters with understanding how something like ACORN can
- 21:52integrate in with their practice.
- 21:54And so we're really grateful to have a phenomenal group of
- 21:56medical advisors that helped us to understand the inner workings
- 22:00of aesthetic practices and how our product would be positioned
- 22:04within them. It was growing our team and
- 22:06including people that have long great careers in aesthetic
- 22:09medicine and understanding how they've worked to bring new
- 22:12products to market. So we're really lucky to have a
- 22:17fantastic team and a fantastic group of doctors that are
- 22:20working with us. And that's grown, right.
- 22:22So from those humble beginnings, we've been able to amass more
- 22:26and more physicians that are excited about offering this next
- 22:29generation of healthcare to their patients.
- 22:31And so we've seen a growing list of amazing clinics that we're
- 22:35lucky to work with, that it's increasing every month.
- 22:39How many clinics so far on board?
- 22:41Well, it's growing fast. I'd have to look, but I know
- 22:44that we are available and well over 100 practices now across
- 22:48what's the US and Canada. Congratulations, that's great.
- 22:51And it's unchartered territory, right.
- 22:53So I'm sure toughest part about building a company in this space
- 22:57is getting people to adopt it, understand it, right and being
- 23:01that first case scenario, right, so.
- 23:05Yeah, exactly. It is.
- 23:07You have to have people that are really passionate about what
- 23:09you're trying to build. And I think part of my gratitude
- 23:12around that was we really had a group of core physicians that
- 23:16were working with us. They understood the vision of
- 23:20what Acorn was trying to be, right?
- 23:22Like this really is a platform, an opportunity to lock in the
- 23:26best cellular content from a patient that can benefit them
- 23:29today in the world of aesthetic medicine, but really can drive
- 23:33forward their healthcare needs in the future regenerative, you
- 23:36know, in cellular medicine. So that was a big step forward
- 23:39and kind of assembling a group of people that saw that vision
- 23:41and wanted to help us test this out and how this would be
- 23:44commercially viable. So do you deal with ethical
- 23:49concerns at all? Do people bring that up?
- 23:52How do you stay grounded as the science advances and you know,
- 23:56the critics and whatnot? How does?
- 23:58How does that go for you? So we're, we're pretty lucky
- 24:00because we're fairly agnostic until a lot of the ethical
- 24:03issues that come up with with some of the cellular medicine,
- 24:08right? And I think it's important to
- 24:12understand what are our ethical considerations and then what
- 24:17might be best practices or safety considerations.
- 24:21And I think that for us, we look at both of those two areas.
- 24:24We look at those as being massive areas where we thrive
- 24:28and we have a great benefit on the ethical side.
- 24:31Procurement of cells is a question, right?
- 24:35So where are you getting these cells from?
- 24:38And from a company perspective, from a treatment perspective, it
- 24:42then starts to think about, well, some of these things are
- 24:45experimental and do you and if you don't understand where those
- 24:48cells came from a healthcare perspective, applying those
- 24:51cells to the patient can do more harm than good.
- 24:55And so these are the areas that for us, we are that patient's
- 24:59very own cells. And so they're from that
- 25:01patient, We're delivering them back to that patient.
- 25:04And so we know where they're procured.
- 25:05We know that there's consent and we know that the patient knows
- 25:08exactly how those cells are going to be used on the other
- 25:12side, from a safety perspective, I think that there is a number
- 25:17of different avenues right now where we are testing out
- 25:20regenerative medicine in aesthetics topically.
- 25:24And so you have different sources of where you get these
- 25:27cells from. And it can be things that are
- 25:29fairly benign like plants all the way through to different
- 25:34animals and into donor humans. And so the questions now across
- 25:38that entire chain or what are the implications on having
- 25:41things that are taken from an animal?
- 25:44Is there disease transference or are those cells even accepted by
- 25:48our cells? What are the differences from
- 25:50recognizing those cells as foreign?
- 25:52And and those same things then end up extending into cells from
- 25:56other patients, right. So what diseases could be
- 26:00transferred? What pieces of mRNA are encoding
- 26:04things that you may not want to deliver to that patient, Right?
- 26:08We're very unique beings. We're very different.
- 26:10And so taking something from somebody else and put it into
- 26:14ourselves is not always a good idea.
- 26:16And so there's a lot of limitations and how we can
- 26:18leverage regenerative medicine in a Safeway right now where
- 26:22we're testing out the waters or a lot of groups are testing out
- 26:24the waters topically. And that is what we kind of see
- 26:27right now in this world of topical regenerative aesthetics.
- 26:30I think that as we progress into more and more invasive ways of
- 26:35delivering cells, it is going to be more and more important to
- 26:40understand where those cells were derived from and, and
- 26:43ensuring that those patient is not going to react negatively to
- 26:46those cells. The two big ways that we can do
- 26:49that is 1, make sure that they're from that patient
- 26:51themselves. And then two, make sure that
- 26:54those cells have been treated well when they're being
- 26:57prepared. That's an era that I think is
- 27:00going to get more and more focus here because it's largely been
- 27:03not addressed with a lot of detail.
- 27:06When we take cells from a donor, not only are there questions,
- 27:09but where they came from and all of these things, but often
- 27:12they're used to try to treat many patients.
- 27:15And so if you think about taking a sample from a patient and then
- 27:20our source and then growing those cells up to fill 10,000
- 27:25vials to sit on shelves and doctors offices across the
- 27:28country, the dilution effect and the changes that those cells
- 27:33would have endured during that culture step can vastly impact
- 27:36the product. And there's been some fantastic
- 27:39studies by Patella Del and Hartman ET al.
- 27:41In the last five years that have demonstrated really the
- 27:45detrimental things that happen to cells when they are overgrown
- 27:49in the lab. And on top of that the
- 27:53diminishment of the value of some of those cellular things
- 27:56that are released like EXO cells when those cells are over
- 28:00divided. Well, I think what you said
- 28:03about it being like this almost like a clean option, right,
- 28:07because it's not coming from some foreign matter.
- 28:11I think that's the most appealing piece of all of it
- 28:15right to the outside, right. So the non scientists or I think
- 28:19that. To scientists as well.
- 28:20I mean, like all of the reasons that we just talked about,
- 28:24right, scientifically I think are fantastic reasons for us to
- 28:27have our own cells. But just on principle alone,
- 28:29understanding that if I'm going to receive regenerative
- 28:33medicine, I'm going to get exosomes, I'm going to get
- 28:34growth factors, knowing that they came from me is essential.
- 28:38Yes, and I've heard some stories of where these come from and it
- 28:41is scary. So now I'm going to rush to have
- 28:44my collection done because I'm very excited, so very pumped to
- 28:49get that done. So Doctor Drew, changing gears
- 28:51for just a minute. So it is intriguing about your
- 28:55background that you were a professional baseball player.
- 28:58How do you think that's affected your mindset and how does that
- 29:02translate into the lab and the business world?
- 29:06My husband is an ex pro baseball player and I see how it affects
- 29:10our lives so I'm curious how it affects yours.
- 29:13Yeah, well, I come from a baseball and healthcare family,
- 29:15so it was always kind of dual focus.
- 29:17My dad happened to be a professional baseball player and
- 29:19a doctor as well, and I get a phenomenal career.
- 29:23So for me, I think baseball has influenced my life in a lot of
- 29:27positive ways. I didn't have the longest career
- 29:30in the world. I actually had an injury.
- 29:31So that going through that injury and that experiences a
- 29:34patient and that uncertainty helped put me in the chair of
- 29:38somebody that is in need and looking to healthcare for
- 29:41solutions. And so I think that was a very
- 29:43valuable experience at a young age to go through and have that
- 29:47perspective. Secondly, baseball is a sport
- 29:51where you have a team, right? Is a team sport, but every
- 29:55player in the team has vastly different skill sets, right?
- 29:59So it is no myth that the first baseman in the pitcher, in the
- 30:03catcher in the outfield are all even different body makeups and
- 30:06abilities and different talents. And so understanding that it
- 30:09takes a team to accomplish your goal and finding the right
- 30:13people for the job, I think is something that was a very good
- 30:16lesson for me to carry over into business.
- 30:18And so as a matter of principle, we at Acorn try to find when we
- 30:23hire somebody, we're trying to hire somebody that is better at
- 30:26something than anybody else in the company.
- 30:28And if we can find out, that's really exciting.
- 30:31And then trust them to do that job that they're more skilled at
- 30:34than us. So that's been wonderful.
- 30:36And I think, you know, baseball is as a long road.
- 30:39And I took it as far as I could. Unfortunately, I had an injury
- 30:41and I didn't get to that last last level or, or, or have a
- 30:45long career. But you know, it's a game where
- 30:48you have a game almost every day, right?
- 30:51And so you're going to lose. And the best teams lose barely
- 30:55or win barely more than half their games.
- 30:57They lose just under half their games.
- 30:59And you have to figure out how to kind of show up the next day
- 31:03ready to give it another shot and give the best of your
- 31:06ability. And so that's nasty, I think is
- 31:09super important in business and then bringing something new for
- 31:12entrepreneurs. And so I'm pretty grateful for
- 31:15all those lessons learned. Sure.
- 31:17I think it's a test of discipline, right?
- 31:19I think it's less than 1% of the population maybe makes it to
- 31:25that pro level. And I think it it says something
- 31:28about who makes it there because the amount of discipline that
- 31:32goes into getting there is the kind of discipline that the rest
- 31:36of us were not born with, right? So, you know, it's a different
- 31:39level and it's also a resilience that you all have, right?
- 31:44Because that you know, as I'm sure you are too.
- 31:48My husband on any given day weekend, I mean, we have many
- 31:52TV's going in one room at the same time, 5 sometimes going 5
- 31:56different games. And I watch like the losers, the
- 32:00losing team has to walk off hanging their heads.
- 32:03And then I think about, you know, I always ask him like,
- 32:06what was it like to have to come back the next day and put it all
- 32:10back together again? So that resilience of taking
- 32:13that beating and then coming back in again the next day, I
- 32:16think it says a lot about who you are, right.
- 32:20So and then it shows up in business as well for.
- 32:23Sure. And you know, I think it was a
- 32:24better scientist than baseball players.
- 32:26So everything worked out. But I got a chance to learn a
- 32:29lot of those lessons. Yes.
- 32:32Well, it definitely toughens you up, right.
- 32:34So, yeah, definitely. So if we had to, first of all,
- 32:39if there's anything else, you know, you want our viewers or
- 32:42listeners to know about Acorn, but I was going to ask you, in
- 32:4610 years, what do you want people to say Acorn Bio Labs
- 32:51made possible? What would that be?
- 32:53Yeah. So I think there's a lot of ways
- 32:56to answer that question. And I think that ultimately, I
- 33:00want people that bank themselves to sit back and say, I'm really
- 33:04glad I did that, right? And the way that we can make
- 33:08sure that that said is that we've delivered value to them in
- 33:11a number of different ways, right?
- 33:13We delivered value to them in the world of aesthetics, helping
- 33:17them accomplish their goals with their skin or their hair, right?
- 33:20Or it can be all the way through to some of the opportunities
- 33:23that we're exploring and regenerating neurons on demand
- 33:27to stave off diseases like Parkinson's, right?
- 33:30There's a lot of different categories.
- 33:31But if they walk away and saying I'm really glad I banked myself
- 33:34with Acorn, then I think we've done our job.
- 33:37I think you have too, and I think you've started something
- 33:40so completely different in you. And I'm excited to bring this
- 33:44podcast episode to the public, to the consumer so that they
- 33:48understand because I'm in the industry for a long time.
- 33:53And I was still like, wait, what are they doing with the hair?
- 33:56You know, what are they doing? So I think that making people
- 34:00aware of what you're doing, it is so critical.
- 34:02I would say that maybe a very small, maybe that's small amount
- 34:06of the population. Maybe that's same thing that
- 34:08gets the pro level sports understands this right now.
- 34:11So our job is to make sure that people know about it, right?
- 34:14Because this is a change for their health.
- 34:17Absolutely. I'm super grateful for the
- 34:19opportunity to share a message with your audience.
- 34:22We've worked really hard in the lab behind closed doors, and I
- 34:25think we've created something that is has the potential to
- 34:28deliver a lot of value to a lot of people, but it won't be
- 34:31unless people hear about it and then go ask their physician
- 34:34about it and then engage with it.
- 34:36And so this really is the opportunity for us to reach a
- 34:39lot more people so we can try to help them.
- 34:42Well, I'm excited for you and I can't wait to hear more.
- 34:44So I think that we should probably have you back on the
- 34:47show in about 6 months and hear what's happened, what any new
- 34:51developments, because this really is the future and I'm
- 34:54excited to see what you're doing.
- 34:55So if you don't mind sticking around, we'd love to to take you
- 34:59through our speed round and get to know you just a little bit
- 35:02better. Doctor Drew, is that OK?
- 35:03Let's. Do it.
- 35:05All right, Ready. OK.
- 35:07How many people on your team report directly to you?
- 35:11Oh my gosh, that's interesting. 1234 right now.
- 35:15OK, how many hours of sleep do you get per night?
- 35:19That varies greatly and especially running a startup and
- 35:23especially with with our busy schedules and the fact that my
- 35:26wife and I still have three young boys at home, it's pretty,
- 35:30pretty variable. Somewhere between 6:00 and 7:00
- 35:33is probably normal. That's pretty good.
- 35:35Not bad. When is the last time you took a
- 35:38full day off? Before I started ACORN.
- 35:43That and how many years is that? It's been what, 7 years?
- 35:46Yeah, that sounds. About.
- 35:48Right, it's been a while. No, there's time.
- 35:50So we do a my wife and I try to do a trip once a year, just the
- 35:54two of us, to do a bit of a getaway and connect without
- 35:57distractions. And I'm really lucky.
- 35:59I've got some awesome people on my team that let me do that and
- 36:02only harass me if absolutely necessary.
- 36:04So I get it. Yeah, what's the first thing you
- 36:07do when you wake up? First thing I do when I wake up
- 36:12is I go start the coffee machine.
- 36:16OK, fair enough. And what's the last thing you do
- 36:19before you go to bed? Say goodnight to my wife.
- 36:22Aw, OK. Do you answer all of your emails
- 36:26yourself? Emails.
- 36:27Yes, right now. And would you say you're a quick
- 36:32responder to text messages? No I'm not.
- 36:36I am bad at responding to text fast because I'll put my phone
- 36:40down and then often times I'll have to get caught back up.
- 36:44That's OK, I that's where that mark is.
- 36:46Unread button works really well and you can make sure to catch
- 36:51up on those. Do you remember every person's
- 36:54name on your payroll? Do you know everybody in your
- 36:57payroll? OK, good.
- 36:58Ignoring your phone for an hour? Easy or painful?
- 37:02Depends on what's going on, right?
- 37:03There's waves where it's painful and then there's moments where
- 37:06it's OK. Do you take business calls on
- 37:09the weekends? When necessary, yeah.
- 37:12Do you use ChatGPT at work? Not very often.
- 37:16Do you check LinkedIn every day? No your goal for the company
- 37:22exit or legacy. Oh, that's a good question.
- 37:26I think whatever helps allow us to drive more value to patients.
- 37:29I'm open to all. I love what I do, so I can do it
- 37:31forever. But I think that there's some
- 37:33amazing partners could join our team or us join them and take
- 37:36this to the next level. One word that describes your
- 37:40leadership style. Trusting.
- 37:43When are you at your best? Morning or night?
- 37:45I've had to make some adjustments with three kids in
- 37:47the house, but I would say I'm normally default a night owl.
- 37:52Same. OK, what is the first app that
- 37:56you open every morning on your phone?
- 37:59E-mail. When you hear the word no, what
- 38:03is your first thought? When I hear the word no, what
- 38:08did the dog do? It's good.
- 38:13What's your biggest current time waster?
- 38:16Something that drives you crazy that you spend time on.
- 38:20I would I it's probably have a love hate relationship with
- 38:24social media. Yeah.
- 38:26Yeah, it's a very powerful tool and can be an enormous suck of
- 38:30time if it takes your attention in the wrong direction.
- 38:32Sure, absolutely. How often do you?
- 38:35Are you texting your team after hours?
- 38:38I try to be respectful and, you know, I think they know my style
- 38:41so that if I do message them, it's because it's on my mind
- 38:44right now and we have a system where I can do it so that I can
- 38:47do that. Not in text that bothers them.
- 38:50They'll see it when they're back online and can react to it.
- 38:54If you lost everything tomorrow, what would be the first thing
- 38:57you would do? Lost everything.
- 39:00Yes, business wise. Business wise, if I lost
- 39:04everything business wise, the first thing that I would do the
- 39:07next day is contemplate probably what learnings there were from
- 39:14whatever went wrong to make sure that I embraced where mistakes
- 39:19were made. I always say I would just start,
- 39:22I'd start all over again. So right.
- 39:23I mean, we're, we're like that. May not be the next day, maybe
- 39:28the. Day after yes.
- 39:30Do you believe in more of a five year plan or a 90 day Sprint?
- 39:34Both and you have to believe in both.
- 39:36Yes, agreed. How fast can you make the big
- 39:40decisions? Minutes, hours or days?
- 39:43So this is something I think is one of my skill sets.
- 39:46I'm very comfortable making a decision quickly.
- 39:51And what's one thing that your team knows never to do around
- 39:55you? Probably ignore our customers.
- 39:59OK, Yeah, that's that's a good one.
- 40:01That's a good one. OK.
- 40:02What's more pressure, pitching in a stadium or pitching to
- 40:05investors? It's really interesting.
- 40:09I've had some moments where I feel the sense of the weight of
- 40:14what we're trying to accomplish and build and the opportunity in
- 40:16front of us and it can be in front of one person and I feel
- 40:20more sense of urgency and more stress or or that acute need
- 40:27then when I was itching in front of 25,000 people.
- 40:31So I would say that, yeah, I had a comfort on the mound at all,
- 40:35although there's stressful moments.
- 40:36But I would say that there's just a heightened level of
- 40:39importance sometimes when you're talking about people's
- 40:41healthcare. Yeah.
- 40:43One-on-one would be just as stressful.
- 40:45How competitive are you on a scale of 1 to 10?
- 40:49I'm pretty competitive, I would say.
- 40:51Yeah, I think Jen would say I'm pretty competitive.
- 40:53I don't know 9. What's your real life?
- 40:57I can't believe I pulled that off moment.
- 41:00So probably playing professional baseball and getting my PhD at
- 41:05the same time that that took some discipline.
- 41:09And there's a couple of crazy moments of me.
- 41:12Like one time I flew from Chicago to Toronto to write an
- 41:14exam and I flew out on like the last flight out.
- 41:18And then I wrote the exam and I flew back and ended up pitching
- 41:23that night. So I wrote an exam in the
- 41:25morning in Toronto and then pitched in Chicago later that
- 41:29day. Wow, I love that.
- 41:32Good for you. That is some discipline.
- 41:34OK, and one last question. If someone shadowed you for a
- 41:38day, what would surprise them most about you?
- 41:41How often I forget to eat? Anytime I'm spending like long
- 41:47periods of time with one person, they're always the one says can
- 41:51we just stop and get something to eat?
- 41:55And you don't carry snacks I'm assuming?
- 41:58No, no, I I'm an unintentional faster.
- 42:02So that's all right. That's OK.
- 42:04That's good for your health. Yeah.
- 42:06Well, thank you so much for joining us today, Doctor Drew.
- 42:08It's been an amazing episode. I think that the listeners, the
- 42:12viewers, everybody will be finding out more about what goes
- 42:16on at ACORN and banking their cells.
- 42:18So thank you for taking the time with us today.
- 42:21No, Doctor Randy, thank you so much for the tremendous
- 42:22opportunity to join you. I really appreciate it and thank
- 42:25you for helping get our our goal and our message out there.
- 42:28I really appreciate it. Absolutely.
- 42:31Thanks everyone. Doctor Randy Boyett holds a PhD
- 42:34and is a recognized leader in the aesthetics and medical
- 42:37industry. She is not a licensed medical
- 42:39doctor. All commentary and product
- 42:42recommendations are based on industry expertise and are
- 42:45provided for informational purposes only.