452-Distinct of glia in the enteric nervous system
This research identifies transcriptionally and functionally distinct subtypes of glia within the enteric nervous system (ENS), challenging the traditional view of these cells as a uniform population. By utilizing bulk and single-cell RNA sequencing, the authors mapped specific genetic signatures to the established spatial-morphological classifications of mucosal and muscularis glia. A central discovery is the NKB-TACR3 signaling axis, which uniquely identifies intraganglionic glia and serves as a critical regulator of intestinal motility and postnatal glial development. Experimental…
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