Latest / Resiliency Radio with Dr. Jill Carnahan, MD / 307: Resiliency Radio with Dr. Jill: Hormones, Peptides and Performance with Dr. Gordon Crozier
Transcript
- 0:01Dr. Jill Carnahan, MD: Welcome to Resiliency Radio, your go to podcast for the most cutting edge insights integrative and functional medicine.
- 0:08Dr. Jill Carnahan, MD: I'm your host, Dr. Jill and with each episode we dive into the heart of healing and personal transformation.
- 0:15Dr. Jill Carnahan, MD: Join me as I interview medical experts, innovators, worldwide thought leaders and all kinds of interesting people to help you on your journey to optimal performance and longevity.
- 0:26Dr. Jill Carnahan, MD: Today is no different.
- 0:27Dr. Jill Carnahan, MD: I'm interviewing a friend and colleague, Dr. Gordon Crozier and I will introduce him in just a moment.
- 0:33Dr. Jill Carnahan, MD: We're going to talk all things energy, vitality and yes, you've been asking for it.
- 0:37Dr. Jill Carnahan, MD: More information today about peptides, about how to get them safely, what are the best uses and how to optimize your performance and your vitality with hormones and peptides.
- 0:48Dr. Jill Carnahan, MD: So stay tuned.
- 0:49Dr. Jill Carnahan, MD: In the meantime, I just want to remind you that you can find products and services and all of the great Dr. Jill Beauty line which is clean and really works.
- 0:58Dr. Jill Carnahan, MD: I know I use it every single day in my own life.
- 1:01Dr. Jill Carnahan, MD: You can find this@doctor Jill health.com and you can get 15% off.
- 1:07Dr. Jill Carnahan, MD: Your first order just there on the website will pop right up.
- 1:10Dr. Jill Carnahan, MD: If you have not yet purchased, you can get that 15% off.
- 1:13Dr. Jill Carnahan, MD: One of my favorite things today I just wanted to remind you about that's been a top seller and were out recently.
- 1:18Dr. Jill Carnahan, MD: Back in stock is this sheer Defense SPF tinted moisturizer.
- 1:23Dr. Jill Carnahan, MD: It is my favorite go to.
- 1:25Dr. Jill Carnahan, MD: On a day when I want to go out on a hike or a run, I don't really want makeup on my face.
- 1:28Dr. Jill Carnahan, MD: I want to protect it from the sun but I want to look kind of glowy.
- 1:32Dr. Jill Carnahan, MD: This is a top seller.
- 1:33Dr. Jill Carnahan, MD: People love it.
- 1:34Dr. Jill Carnahan, MD: It goes on easy.
- 1:35Dr. Jill Carnahan, MD: It gives you a very light level of tinted moisturizer and it also protects you from the sun.
- 1:41Dr. Jill Carnahan, MD: And here in Colorado we need that because we're so close to the sun.
- 1:46Dr. Jill Carnahan, MD: Anyway.
- 1:47Dr. Jill Carnahan, MD: Okay, back to our show.
- 1:48Dr. Jill Carnahan, MD: I want to go ahead and introduce my guest now owner and medical director of Kier Clinic.
- 1:54Dr. Jill Carnahan, MD: He leads one of America's premier genetic based clinics.
- 1:57Dr. Jill Carnahan, MD: Specializes in personalized treatments using hormone optimization, IV therapy, peptides and advanced diagnostic testing.
- 2:05Dr. Jill Carnahan, MD: Today we're going to talk about peptides and vitality.
- 2:08Dr. Jill Carnahan, MD: You're going to love this episode.
- 2:10Dr. Jill Carnahan, MD: His early experience as a physician he was an assistant in neurology, neuroscience and ophthalmology providing critical insights into inform his complex clinical protocols.
- 2:19Dr. Jill Carnahan, MD: You will just love him.
- 2:21Dr. Jill Carnahan, MD: I could read the rest of the bio but I want you to meet him.
- 2:24Dr. Jill Carnahan, MD: So let's just jump on into the show and meet Dr. CR.
- 2:27Dr. Jill Carnahan, MD: Dr. CR.
- 2:28Dr. Jill Carnahan, MD: I have the deepest respect for you in the world of teaching and just even the kind of clinician you are in practice.
- 2:35Dr. Jill Carnahan, MD: We've had some deep discussions about that.
- 2:37Dr. Jill Carnahan, MD: And I'm so excited today to talk about a topic people are always asking about.
- 2:42Dr. Jill Carnahan, MD: And that's not only hormones, which has gotten a lot of rap, but peptides and performance and how someone who's kind of just not got their mojo.
- 2:50Dr. Jill Carnahan, MD: Maybe it's a man or woman listening out there that is just like, I wake up now and I just don't feel like myself.
- 2:55Dr. Jill Carnahan, MD: I don't feel like that energy and that vibrancy.
- 2:57Dr. Jill Carnahan, MD: And so we want today talk to that person who is like.
- 3:00Dr. Jill Carnahan, MD: Which is probably 90% of the people out there in this world nowadays, right?
- 3:03Dr. Jill Carnahan, MD: At least even me on some days.
- 3:05Dr. Jill Carnahan, MD: So we want to talk to them.
- 3:06Dr. Jill Carnahan, MD: But before we dive in, I always like to know the person behind all the knowledge.
- 3:10Dr. Jill Carnahan, MD: And I would love to hear a little bit about your story.
- 3:12Dr. Jill Carnahan, MD: How did you get into medicine and how did you get to where you're at with your clinic?
- 3:17Dr. Gordon Crozier: So it's a long story because I was actually fairly sick most of my life.
- 3:23Dr. Gordon Crozier: When I was in second grade, I was bit by a tick back before Lyme existed, by the way, because I am old, and so we didn't know what Lyme was back then or that it existed.
- 3:37Dr. Gordon Crozier: But I was sick from that point on.
- 3:39Dr. Gordon Crozier: I just had undulating health.
- 3:41Dr. Gordon Crozier: And then I did get better and I wanted to help people.
- 3:48Dr. Gordon Crozier: So I wanted to figure out how I could help people.
- 3:52Dr. Gordon Crozier: And eventually my uncle really talked me into going into medicine and he said, why don't you become a PA?
- 4:02Dr. Gordon Crozier: That's pretty good.
- 4:03Dr. Gordon Crozier: He says there's hardly any PAs out there because this was back when there were only two schools for.
- 4:09Dr. Gordon Crozier: For physician assistants.
- 4:11Dr. Gordon Crozier: And there were really no NPS back then, so they didn't exist.
- 4:15Dr. Gordon Crozier: And so I said, okay, I'm going to try that.
- 4:18Dr. Gordon Crozier: So I did, and sure enough, I became a physician assistant.
- 4:23Dr. Gordon Crozier: I worked in neurology and neurosurgery.
- 4:25Dr. Gordon Crozier: So I did a lot with neurological health.
- 4:28Dr. Gordon Crozier: And that's why I still do a lot with neurotoxicology.
- 4:31Dr. Gordon Crozier: I've taken a couple of courses in neurotoxicology because I really love that aspect.
- 4:38Dr. Gordon Crozier: I think that's part of what's going on with our society today.
- 4:43Dr. Gordon Crozier: And you can hear because RFK has actually said stuff about that, you know, which.
- 4:48Dr. Gordon Crozier: Whether you're for him or not for him, you know, he's brought a Lot of the toxicology stuff to the forefront.
- 4:55Dr. Gordon Crozier: And so I like that for that he's done that in.
- 4:59Dr. Gordon Crozier: And then I went back to medicine and I actually went into ob gyn because my uncle once again said, well, if you go into ob gyn, you can join our practice and we can have a whole family of nothing but ob gyns, because they were all ob gyn.
- 5:17Dr. Gordon Crozier: So I went into ob gyn.
- 5:19Dr. Gordon Crozier: So that's where I began to learn about hormones.
- 5:23Dr. Gordon Crozier: So all these.
- 5:25Dr. Gordon Crozier: All my physicians in the family.
- 5:28Dr. Gordon Crozier: My.
- 5:28Dr. Gordon Crozier: My family were.
- 5:29Dr. Gordon Crozier: There were a lot of physicians.
- 5:31Dr. Gordon Crozier: My father was not.
- 5:32Dr. Gordon Crozier: He was a minister, but.
- 5:34Dr. Gordon Crozier: But all my uncles, a lot of my uncles and cousins were all physicians.
- 5:39Dr. Gordon Crozier: And so that's how I got into where I was at.
- 5:42Dr. Gordon Crozier: And when I got into OB gyn, I realized that I started working at the university.
- 5:50Dr. Gordon Crozier: And at the university, I was always getting in trouble because I was telling women, you know, you really don't need to be maimed by a hysterectomy.
- 6:00Dr. Gordon Crozier: We can improve this in other ways.
- 6:03Dr. Gordon Crozier: Right.
- 6:03Dr. Gordon Crozier: And so I had other ways to actually help them get over what we could.
- 6:08Dr. Gordon Crozier: And back then, we didn't have as much as what we have today.
- 6:12Dr. Gordon Crozier: But I really.
- 6:14Dr. Gordon Crozier: So I was getting in trouble because they didn't make as much money if I didn't do the surgery.
- 6:18Dr. Gordon Crozier: Right.
- 6:19Dr. Jill Carnahan, MD: Right.
- 6:21Dr. Jill Carnahan, MD: So.
- 6:21Dr. Gordon Crozier: So.
- 6:21Dr. Gordon Crozier: But I loved what I did.
- 6:24Dr. Gordon Crozier: But I got sick when I was at the university, I got so sick, and I found out that the OR I was working in because they remodeled the whole.
- 6:35Dr. Gordon Crozier: The whole university was remodeled.
- 6:37Dr. Gordon Crozier: They built a whole brand new beautiful hospital, and they were remodeling the old part.
- 6:43Dr. Gordon Crozier: And they said, hey, you know, the OR you worked in every morning where the robotics was, and you were teaching the residents that OR is full of black mold.
- 6:54Dr. Gordon Crozier: Wow.
- 6:55Dr. Gordon Crozier: And so I then realized that's why I got so sick.
- 7:01Dr. Gordon Crozier: I was so sick because I was exposed on a daily basis to mold that was driving down my immune system.
- 7:10Dr. Gordon Crozier: And I ended up with pain syndromes, all different kinds of things.
- 7:13Dr. Gordon Crozier: And as you know, those people, they have a myriad of different things that they do, but I had to learn how to treat myself and how to get myself well, because nobody knew back then, you know, that was back in the advent of it back like you.
- 7:30Dr. Gordon Crozier: And so we had to learn for ourselves from scratch, trying to read research articles and all this stuff and develop pathways to get ourselves well.
- 7:39Dr. Gordon Crozier: And that's what I did for myself and for my other people.
- 7:44Dr. Gordon Crozier: But in that advent, then I began to feel great, and then I got involved with powerlifting and other things so that I could really experience the other aspect of it all where I could enjoy exercising, hiking, biking, you know, powerlifting, all those things that are fun to do.
- 8:07Dr. Gordon Crozier: And a lot of people don't enjoy exercise.
- 8:09Dr. Gordon Crozier: But let me tell you now, I love it.
- 8:13Dr. Gordon Crozier: It's one of my favorite things, and it's a good outlet.
- 8:16Dr. Jill Carnahan, MD: What a great story.
- 8:17Dr. Jill Carnahan, MD: And it makes so much sense why you're so knowledgeable and because you have this infectious thing you dealt with and then the toxic thing you dealt with.
- 8:26Dr. Jill Carnahan, MD: And I feel like those often interplay at the core of functional and personalized medicine for the most of the complex chronic.
- 8:33Dr. Jill Carnahan, MD: So we're going to go into kind of hormone optimization and peptides and some of the really amazing tools that we now have.
- 8:40Dr. Jill Carnahan, MD: But before we do, speaking of infections, toxins, and this immune interplay, do you want to give us your framework on the complex chronic people, patients that we see?
- 8:50Dr. Jill Carnahan, MD: And I shouldn't say patients, because the disease is.
- 8:51Dr. Jill Carnahan, MD: It's not the patient.
- 8:52Dr. Jill Carnahan, MD: But the complexity and the chronicity of what we see is often related to this interplay.
- 8:58Dr. Jill Carnahan, MD: Do you want to give us your framework on kind of the majority of the really sick people you see and what might be going on that bigger level?
- 9:05Dr. Gordon Crozier: So a majority of my patients have a complex.
- 9:09Dr. Gordon Crozier: They don't have just a virus or just Lyme.
- 9:13Dr. Gordon Crozier: They have also the toxicity from mold.
- 9:17Dr. Gordon Crozier: And I see a lot of them, they have gone to other people and they've been treated for actual mold living in their body.
- 9:24Dr. Gordon Crozier: But, you know, we know from world standards, mold growing in the human being and mold actually being in the human being, is 0.3 to 1% of the world population, while mycotoxins, the toxins put off by molds.
- 9:40Dr. Gordon Crozier: And you know, there's other things, too.
- 9:41Dr. Gordon Crozier: There's a myriad of toxins, but those toxins are in anywhere from 33 to 55% of the world population.
- 9:51Dr. Gordon Crozier: That's over half of the world population that are affected by these mycotoxins.
- 9:57Dr. Gordon Crozier: That's those gases put off by molds.
- 10:00Dr. Gordon Crozier: And that's what I see in my patient population.
- 10:02Dr. Gordon Crozier: I'm in Florida.
- 10:04Dr. Gordon Crozier: But I do treat people from around the world.
- 10:06Dr. Gordon Crozier: And some of the worst of the people I've seen are actually from Scotland, Ireland and England.
- 10:14Dr. Gordon Crozier: And those people have horrible toxins that they're not even testing for in those countries.
- 10:21Dr. Gordon Crozier: But we have tested them for them because we can do that.
- 10:25Dr. Gordon Crozier: And they have been able to be relieved.
- 10:28Dr. Gordon Crozier: I do it by my complex IVs, but, you know, there's other ways to do it, too.
- 10:33Dr. Gordon Crozier: And you have to work with the individual patient, where they are, with their finances, with all those things, because each person's an individual, you know, and you have to.
- 10:45Dr. Gordon Crozier: You have to speak to their.
- 10:47Dr. Gordon Crozier: Their spirit, their rationale, their support group and everything like that, because it all plays a part.
- 10:53Dr. Gordon Crozier: Part of what happens in that person.
- 10:56Dr. Gordon Crozier: And a lot of times, the mindset of some of these people that I see that have the hardest time getting well is their mindset.
- 11:04Dr. Gordon Crozier: If they don't think they're going to be well, they're not going to be well.
- 11:08Dr. Gordon Crozier: And you have to kind of.
- 11:10Dr. Gordon Crozier: And there are ways that we can help them overcome that negative mindset.
- 11:15Dr. Gordon Crozier: So a lot of times we have to overcome their negative mindset at the same time as we're treating them, which becomes extremely complicated in these people.
- 11:24Dr. Jill Carnahan, MD: Wow.
- 11:24Dr. Jill Carnahan, MD: And I love that you mentioned that, because I have, you know, years, 20.
- 11:27Dr. Jill Carnahan, MD: I've been practicing probably as long as, you know, maybe you've been doing it longer, but I've been doing a long time, too.
- 11:32Dr. Jill Carnahan, MD: And the truth is, way back in the day, you have a thyroid issue, you have a little hormone issue, and these things are kind of straightforward, and you fix it and get better, and they don't come see you again because they're well.
- 11:40Dr. Jill Carnahan, MD: And nowadays I'm seeing probably 80% or more that are very complex and very.
- 11:46Dr. Jill Carnahan, MD: There's so many layers.
- 11:47Dr. Jill Carnahan, MD: And what I've realized this last five or ten years is like, that mindset that old trauma patterns, the identity around illness.
- 11:54Dr. Jill Carnahan, MD: What you're mentioning is maybe the most important thing that we do is bringing the awareness around, how is this illness?
- 12:00Dr. Jill Carnahan, MD: And some of you actually even ask, how is this illness benefiting you?
- 12:03Dr. Jill Carnahan, MD: And they look at you like, what?
- 12:04Dr. Jill Carnahan, MD: I don't want this.
- 12:05Dr. Jill Carnahan, MD: Right.
- 12:05Dr. Jill Carnahan, MD: But there's some subconscious pattern of maybe somehow there's a benefit they aren't aware of.
- 12:10Dr. Jill Carnahan, MD: And if they start to identify and detach from that, then they realize they can get well and they can have a life that they want with.
- 12:17Dr. Gordon Crozier: Exactly, exactly.
- 12:19Dr. Gordon Crozier: And we're all like that.
- 12:20Dr. Gordon Crozier: You know, there were things that I had to break off in myself that actually helped me create new patterns of thinking that actually improved my overall being and my overall look on life.
- 12:34Dr. Jill Carnahan, MD: Yeah, love that.
- 12:35Dr. Jill Carnahan, MD: And love talking about that, because it all works together.
- 12:39Dr. Jill Carnahan, MD: You often talk about healing one cell at a time from, like, a cellular physiological standpoint.
- 12:44Dr. Jill Carnahan, MD: What does that really mean?
- 12:45Dr. Jill Carnahan, MD: Like, how do you approach a patient?
- 12:47Dr. Jill Carnahan, MD: I loved that you said the individualized, because you and I talked one night after Lecturing at a conference.
- 12:52Dr. Jill Carnahan, MD: And just like there's no protocol, right.
- 12:54Dr. Jill Carnahan, MD: There's this very individualized approach.
- 12:56Dr. Jill Carnahan, MD: Talk a little bit about your the one cell at a time and the individualization of care.
- 13:00Dr. Gordon Crozier: So my first book that I wrote was called Healing One Cell at a Time and that has my complete story in it.
- 13:08Dr. Gordon Crozier: And but that I realized a long time ago that actually the cell is the key to what's going on.
- 13:18Dr. Gordon Crozier: And each cell communicates with the other cells.
- 13:22Dr. Gordon Crozier: When you have one cell that's miscommunicating with the other cells, you have the extracellular matrix, the intracellular matrix, those matrix begin to communicate one with another.
- 13:35Dr. Gordon Crozier: And you have to bring healing to that individual cell.
- 13:39Dr. Gordon Crozier: Part of that's genetics.
- 13:40Dr. Gordon Crozier: Because genetics play a part in our cell.
- 13:43Dr. Gordon Crozier: We know that we inherit our mitochondrial DNA from the mother.
- 13:47Dr. Gordon Crozier: But there's other aspects of genetics that actually play a role in cellular health and cellular healing.
- 13:55Dr. Gordon Crozier: But we also need to give the proper nutrients and we know that there's cells specific nutrients that the mitochondria needs for it to produce proper ATP and ATP production.
- 14:10Dr. Gordon Crozier: And that's what comes into sports medicine, that's what comes into overall health, to overall vitality, to all of that.
- 14:19Dr. Gordon Crozier: So I used to talk about the mitochondria before it was even popular.
- 14:24Dr. Gordon Crozier: I mean it's popular now to talk about the mitochondria.
- 14:27Dr. Gordon Crozier: Right?
- 14:27Dr. Gordon Crozier: Everybody is right.
- 14:28Dr. Gordon Crozier: But you know, before it was even popular I was talking about it.
- 14:32Dr. Gordon Crozier: Well, now we understand that mitochondria actually communicates with the nucleus that houses our DNA.
- 14:38Dr. Gordon Crozier: So it's going to interpret your DNA either correctly or incorrectly.
- 14:42Dr. Gordon Crozier: And how can you do that?
- 14:43Dr. Gordon Crozier: How can you control that?
- 14:45Dr. Gordon Crozier: Well, we can do it through peptides.
- 14:47Dr. Gordon Crozier: And now that peptides are coming back and I'm so excited for that, we can actually do that and do it legally and help these people to have more vitality and more life.
- 15:00Dr. Jill Carnahan, MD: Okay, so this is the topic we definitely wanted to get today.
- 15:03Dr. Jill Carnahan, MD: And so many people have asked me and have questions and I'm super excited to talk about peptides.
- 15:07Dr. Jill Carnahan, MD: Before we go there.
- 15:08Dr. Jill Carnahan, MD: Stay tuned.
- 15:09Dr. Jill Carnahan, MD: Let's talk about hormones because I feel like this foundation of thyroid adrenal female male hormones.
- 15:14Dr. Jill Carnahan, MD: So let's talk to the 55 year old male or female out there that feels like they're waking up and they're just not as vital as they used to be.
- 15:21Dr. Jill Carnahan, MD: Where would you start?
- 15:22Dr. Jill Carnahan, MD: In kind of a clinical workup as far as hormones and then we'll move on to peptides.
- 15:26Dr. Gordon Crozier: So you have to have a hormonal base before you can go to peptides.
- 15:30Dr. Gordon Crozier: Peptides are if you have a deficiency of either hormones and, or amino acids, because peptides are amino acids, they are not going to work.
- 15:40Dr. Gordon Crozier: So you have to look at the initial thing.
- 15:43Dr. Gordon Crozier: Is it the HPA axis, is it an adrenal issue where the adrenals, your adrenal glands are, you know, spewing out cortisol and cortisone and maybe you don't have enough.
- 15:57Dr. Gordon Crozier: Maybe you've been so stressed all your life, you've been a surgeon or you've been something, you know, you've been a high powered physician and you're just putting things out, or a high powered attorney.
- 16:07Dr. Gordon Crozier: I have these high powered attorneys around here all the time.
- 16:10Dr. Gordon Crozier: They're coming, they're worn out, their adrenals are flat, they don't have any adrenals anymore to put anything for.
- 16:19Dr. Gordon Crozier: So they're tired in the morning, they can barely function, but they're tired all day.
- 16:24Dr. Gordon Crozier: But because they're flat, they still can't go to sleep at night because they're still a little bit too high, not where they should be.
- 16:31Dr. Gordon Crozier: So then they're not getting sleep.
- 16:32Dr. Gordon Crozier: So then they're crashing their adrenal glands even more.
- 16:36Dr. Gordon Crozier: So I always look at the adrenals probably first and then I try to repair those first.
- 16:43Dr. Gordon Crozier: But I also repair at the same time any other dysfunction.
- 16:47Dr. Gordon Crozier: You know, what are their overall hormones?
- 16:50Dr. Gordon Crozier: Did, did they go through premature menopause?
- 16:52Dr. Gordon Crozier: If they went through premature menopause, we need to, in those women, we need to help them with replacement.
- 16:59Dr. Gordon Crozier: And we have new avenues now that we're not going to be put down for putting women on, you know, hormones and proper hormones.
- 17:09Dr. Gordon Crozier: And actually the studies are out there that, you know, if we have more natural type of hormones that's different than the hormones that are coming from the pharmaceutical realm.
- 17:23Dr. Gordon Crozier: Not that I'm against pharmacy altogether, but I would prefer more natural things than unnatural.
- 17:30Dr. Gordon Crozier: And for men, I'm seeing men in their 20s with zero testosterone and some of them are because they were using SARMs or something else that actually depleted their testosterone or they had toxins that depleted their testosterone.
- 17:46Dr. Gordon Crozier: And we know plastics do that in men and they cause more estrogenization in men and they'll have that belly fat around the middle.
- 17:56Dr. Gordon Crozier: So I like to address both adrenals and functional hormones.
- 18:02Dr. Gordon Crozier: Estrogens, testosterone, progesterones, you know, where are they at for these individuals?
- 18:09Dr. Gordon Crozier: I do not like to push them over the normal realm because they don't work that way.
- 18:15Dr. Gordon Crozier: You know there's a normal physiological function and number that we should not push things over.
- 18:22Dr. Gordon Crozier: I have guys come in all the time.
- 18:23Dr. Gordon Crozier: They said, I have no energy, I can't work out, I can't even get an erection anymore.
- 18:29Dr. Gordon Crozier: And.
- 18:29Dr. Gordon Crozier: And then they have testosterone that's 2000 way over what it should be.
- 18:33Dr. Gordon Crozier: And I'm going like, number one, you're too high on your testosterone.
- 18:37Dr. Gordon Crozier: Let's get it down to physiological functioning and then let's try to correct the other things along the way.
- 18:43Dr. Gordon Crozier: And a lot of times it's either adrenal issues or too high a sex hormone binding globulin.
- 18:51Dr. Gordon Crozier: So we have to look at all those things to correct everything because sex hormone binding globulin is really causing a lot of issues.
- 19:02Dr. Gordon Crozier: If you look at that and it's high, it's usually going to be your adrenals, but it can be toxins.
- 19:07Dr. Jill Carnahan, MD: Hey guys, just a quick break to remind you that at Flatiron Functional Medicine, my clinic in Louisville, Colorado, we are accepting new patients.
- 19:15Dr. Jill Carnahan, MD: If you're listening to this and want to know more about peptides, hormone optimization or you just don't feel like yourself anymore, why don't you give us a call 303-993-7910 and discuss getting scheduled with either Fawn or Hannah.
- 19:30Dr. Jill Carnahan, MD: My PA and nurse practitioner, they're both incredibly knowledgeable about all of these things and I advise them on all cases.
- 19:38Dr. Jill Carnahan, MD: So you can either give us a call 303-993-7910 for more information or you can email infoatironfunctionalmedicine.com okay, let's get back to Dr. Gordon.
- 19:51Dr. Jill Carnahan, MD: I love that you mentioned toxins because of course that's a favorite topic of mine.
- 19:55Dr. Jill Carnahan, MD: And I think even in our realm, many clinicians are not realizing the aromatization that happens, which is that conversion for men and women from testosterone to estrogen.
- 20:04Dr. Jill Carnahan, MD: And then women will have heavy, painful periods and fibroids and all those things we know associated with the estrogen dominance.
- 20:10Dr. Jill Carnahan, MD: And then men will just have the, you know, man boobs and weight gain around the waist and feeling low libido, lack of motivation.
- 20:18Dr. Jill Carnahan, MD: And it's interesting for men, I always call it like the couch test.
- 20:21Dr. Jill Carnahan, MD: If they're like, I just sit on the couch and I don't feel motivated before I even test, I'd say 95% have low testosterone.
- 20:27Dr. Jill Carnahan, MD: It's like this story that you hear, I'm sure you heard before too, where they're just like, I don't have that like get off the couch like I used to.
- 20:33Dr. Gordon Crozier: Right.
- 20:34Dr. Gordon Crozier: Yes.
- 20:35Dr. Gordon Crozier: It's so true.
- 20:36Dr. Gordon Crozier: And you can see it time and time again and it's becoming more and more prevalent all the time.
- 20:42Dr. Gordon Crozier: And you know, I think a lot of it is the toxins in our foods.
- 20:47Dr. Gordon Crozier: But you know, so many people are drinking out of plastic water bottles.
- 20:51Dr. Gordon Crozier: They're getting all these plastics.
- 20:54Dr. Gordon Crozier: We know that causes increased estrogens in men and women and we've got to help control that.
- 21:01Dr. Gordon Crozier: And people can control it.
- 21:03Dr. Gordon Crozier: And I've seen it.
- 21:04Dr. Gordon Crozier: Yeah.
- 21:04Dr. Jill Carnahan, MD: So the avoidance is the key and you have to be very deliberate because if you're not, we're all swimming in toxic soup.
- 21:10Dr. Jill Carnahan, MD: So your water filtration and your air filtration and the choices you make with fast food or with takeout containers or PFAOs or any of these things all matter.
- 21:19Dr. Jill Carnahan, MD: Which we could do a whole other episode on that.
- 21:22Dr. Gordon Crozier: That is a whole two hour conversation or longer.
- 21:26Dr. Gordon Crozier: Just that alone.
- 21:28Dr. Jill Carnahan, MD: Yeah.
- 21:28Dr. Jill Carnahan, MD: Oh, goodness.
- 21:30Dr. Jill Carnahan, MD: So of the hormones, basic foundational things.
- 21:33Dr. Jill Carnahan, MD: I couldn't agree more.
- 21:34Dr. Jill Carnahan, MD: Let's shift to peptides because people are, I know, dying to hear about that.
- 21:38Dr. Jill Carnahan, MD: I know I have like 10 favorites and there's all kinds of out there, but.
- 21:41Dr. Jill Carnahan, MD: Well, let's kind of go through and talk about some of the foundation ones that maybe have the best evidence.
- 21:46Dr. Jill Carnahan, MD: Immune system energy, maybe growth hormone, maybe repair and recovery.
- 21:52Dr. Jill Carnahan, MD: And then I definitely wanted to spend a section of time talking about mitochondrial peptides.
- 21:57Dr. Jill Carnahan, MD: So whatever order you want to go, let's talk about some of your favorites.
- 22:00Dr. Gordon Crozier: Well, mitochondrial peptides are my favorite.
- 22:02Dr. Jill Carnahan, MD: Okay, let's start there.
- 22:03Dr. Jill Carnahan, MD: Let's start there.
- 22:04Dr. Jill Carnahan, MD: I agree with you 100%.
- 22:06Dr. Jill Carnahan, MD: Let's start right there.
- 22:08Dr. Gordon Crozier: So there's a plethora of mitochondrial peptides.
- 22:11Dr. Gordon Crozier: There are a few mitochondrial peptides that we can actually get and utilize.
- 22:16Dr. Gordon Crozier: Of course, SS31, that's the big one that's being utilized today, SS31, which actually helps the mitochondria in repair the mitochondria.
- 22:26Dr. Gordon Crozier: And that's why one of the pharmaceutical companies have taken that over.
- 22:29Dr. Gordon Crozier: And it's going to be a pharmaceutical pretty soon.
- 22:32Dr. Gordon Crozier: But it is a natural peptide to our body.
- 22:36Dr. Gordon Crozier: That peptide actually helps with repair of mitochondria, but it helps with balancing insulin resistance and a lot of times with insulin resistance.
- 22:49Dr. Gordon Crozier: That's what's driving men to aromatize some of their testosterone.
- 22:56Dr. Gordon Crozier: But in women it drives up their estrogens as well.
- 23:00Dr. Gordon Crozier: So if you are over aromatizing and you have too much estrogen.
- 23:04Dr. Gordon Crozier: Estrogen dominance in women, estrogen dominance in men, that can be an insulin resistance thing that actually happens from the mitochondria.
- 23:14Dr. Gordon Crozier: That's why I love SS31.
- 23:16Dr. Gordon Crozier: It's one of my favorites.
- 23:17Dr. Gordon Crozier: But I also love Mot C, which is very similar to SS31.
- 23:22Dr. Gordon Crozier: Mot C was, we had that available before we had SS31.
- 23:27Dr. Gordon Crozier: Right.
- 23:27Dr. Gordon Crozier: And then the FDA took it away.
- 23:30Dr. Gordon Crozier: MOTC is going to be coming back in the next couple weeks, so I'm excited about that.
- 23:36Dr. Gordon Crozier: MOT C C probably has the most literature on it of almost all peptides.
- 23:42Dr. Gordon Crozier: And it's one of the only ones that has a lot of literature on giving it IV wise.
- 23:49Dr. Gordon Crozier: As you know, I do a ton of IVs in my practice and I kind of individualize them according to what the patient needs and all of that.
- 23:56Dr. Gordon Crozier: What amino acids do they need, what kind of lipids do they need?
- 24:02Dr. Gordon Crozier: And then what kind of peptides do they need?
- 24:04Dr. Gordon Crozier: And can those peptides actually be given iv?
- 24:07Dr. Gordon Crozier: But MOT C has a ton of literature being given IV wise.
- 24:11Dr. Gordon Crozier: And I loved it because I could actually help my people that had a lot of toxicology at the mitochondria, right.
- 24:20Dr. Gordon Crozier: That M.O.T.
- 24:21Dr. Gordon Crozier: c helped me once I had them kind of free of those toxins to repair and restore and increase their ATP production.
- 24:31Dr. Gordon Crozier: So that's why I loved giving that one IV wise because we all want more energy, we all want that ATP production without over driving our mitochondria.
- 24:44Dr. Gordon Crozier: Because there's some things out there right now that are over driving our mitochondria.
- 24:49Dr. Gordon Crozier: But I also like huumanin and huminin is extremely hard to get, but it's one of my favorites as well because why it actually brings healing to the mitochondria and the cell as well.
- 25:00Dr. Gordon Crozier: And because of that, it's very difficult.
- 25:03Dr. Gordon Crozier: But it does come out of Israel.
- 25:05Dr. Gordon Crozier: Most of the humanin produced actually comes out of Israel.
- 25:09Dr. Gordon Crozier: And I actually happen to know a couple of the PhDs that were out there producing it.
- 25:16Dr. Gordon Crozier: And they had, you know, it's almost 100% pure humanin that they are producing, very good quality.
- 25:25Dr. Gordon Crozier: But I found that it was actually reversing some of these women in the stages where they wanted to have a baby later, it was reversing that because it was actually healing up some of the mitochondria deep within the ovum.
- 25:41Dr. Gordon Crozier: And so their ovaries were being healed and they would actually be able to produce children.
- 25:51Dr. Gordon Crozier: And I saw that time and time again and I said, okay, I might give you this human in.
- 25:55Dr. Gordon Crozier: But you, if you don't Want to have children, you know, beware.
- 26:00Dr. Gordon Crozier: We have to use precaution with it.
- 26:02Dr. Gordon Crozier: Right.
- 26:03Dr. Gordon Crozier: Well, so that was kind of cool because I had a couple Beverly Hills patients and they kind of, you know, they were in their upper 30s, low 40s, they wanted to have children and boom, they were able to have them.
- 26:14Dr. Gordon Crozier: So that was one of the cool things about that.
- 26:17Dr. Gordon Crozier: So that's one of my favorites.
- 26:18Dr. Gordon Crozier: Those are my three favorite mitochondrial peptides.
- 26:24Dr. Gordon Crozier: I have a ton of other ones like BPC is an indirect helper of the mitochondria.
- 26:32Dr. Gordon Crozier: But I love BPC both orally and injection wise.
- 26:36Dr. Gordon Crozier: Why?
- 26:37Dr. Gordon Crozier: Because bpc, a lot of the toxins that we see, they cause remodeling of some of our tissues and they cause remodeling of some of the biological pathways.
- 26:49Dr. Gordon Crozier: Well, what does BPC do?
- 26:51Dr. Gordon Crozier: It goes in and it helps that remodeled area and tissue to be corrected.
- 26:57Dr. Jill Carnahan, MD: Yeah.
- 26:58Dr. Gordon Crozier: And BPC's, there's a lot, so much literature on BPC 157.
- 27:02Dr. Gordon Crozier: I don't know why it was taken away because it has zero side effects.
- 27:07Dr. Gordon Crozier: Zero.
- 27:08Dr. Jill Carnahan, MD: That's what I always think.
- 27:09Dr. Jill Carnahan, MD: That is one of the most safe and even long term use.
- 27:12Dr. Jill Carnahan, MD: I, I have not seen any data against, you know, dangerous.
- 27:15Dr. Gordon Crozier: I know.
- 27:16Dr. Gordon Crozier: And there's been some physicians come out there and say, oh, you can't use BPC in cancer patients or anybody who had cancer.
- 27:24Dr. Gordon Crozier: That's not true.
- 27:25Dr. Gordon Crozier: There's literature and there's research articles out there that it does not increase cancer and if you've ever had cancer, it does not increase the risk of recurrence of cancer and it actually helps with those PC people.
- 27:38Dr. Gordon Crozier: So BPC is one of my favorites for overall health and resilience and it actually is a genetic modifier.
- 27:47Dr. Jill Carnahan, MD: Wow.
- 27:48Dr. Gordon Crozier: A lot of people don't know that, but BPC157 actually modulates genetic expression so you can express genes in a more correct manner.
- 27:59Dr. Gordon Crozier: And because of that, it's probably my overall favorite.
- 28:05Dr. Gordon Crozier: That's probably my overall favorite peptide.
- 28:08Dr. Gordon Crozier: And it helps with mitochondrial repair as well.
- 28:11Dr. Gordon Crozier: But it doesn't directly do that.
- 28:13Dr. Gordon Crozier: It's an indirect pattern of how it repairs mitochondria.
- 28:17Dr. Jill Carnahan, MD: Yeah, I couldn't agree more.
- 28:18Dr. Jill Carnahan, MD: And in like gut we didn't specifically talk about because of the rapid turnover of cells, a lot of microns colitis, post mold, inflammatory gut disease issues that BPC can be really helpful at healing the gut level too.
- 28:31Dr. Gordon Crozier: I know.
- 28:32Dr. Gordon Crozier: And I had a professional baseball player that actually quit professional baseball because nothing worked for him.
- 28:40Dr. Gordon Crozier: Nothing but BPC worked for him.
- 28:43Dr. Gordon Crozier: He was a UC Patient and ulcerative colitis patient that nothing worked for him, but BPC did.
- 28:49Dr. Jill Carnahan, MD: Yeah.
- 28:50Dr. Gordon Crozier: And you weren't allowed to be on BPC and be in professional athletes, so.
- 28:54Dr. Gordon Crozier: Because they test for it.
- 28:56Dr. Jill Carnahan, MD: Oh, wow.
- 28:56Dr. Gordon Crozier: So he quit.
- 28:58Dr. Gordon Crozier: Now he's doing coaching.
- 29:00Dr. Gordon Crozier: Yeah, he's doing coaching and he's doing other things and he's excited and he loves it.
- 29:04Dr. Gordon Crozier: So now I'm trying to get his wife better because she does the Olympics.
- 29:10Dr. Jill Carnahan, MD: Amazing.
- 29:10Dr. Jill Carnahan, MD: Yeah.
- 29:10Dr. Jill Carnahan, MD: All these amazing athletes.
- 29:12Dr. Jill Carnahan, MD: So let's talk thymus and alpha one has been around a long time, and in Europe, there's incredible studies antiviral into cancer.
- 29:18Dr. Jill Carnahan, MD: Talk a little bit about that one.
- 29:21Dr. Gordon Crozier: So that was one of my favorite ones.
- 29:22Dr. Gordon Crozier: And I talked about it in the beginning of COVID The FDA came in and raided everything because of that.
- 29:32Dr. Gordon Crozier: But I never said it cured Covid.
- 29:34Dr. Gordon Crozier: I never said that at all.
- 29:36Dr. Gordon Crozier: But they still kind of got on me a little bit.
- 29:38Dr. Gordon Crozier: But I never said that.
- 29:40Dr. Gordon Crozier: But what I will say is there's so much literature on Thymos and Alpha 1, what it does for antiviral anti properties and immune modulation.
- 29:50Dr. Gordon Crozier: So it will not overdrive your immunity.
- 29:53Dr. Gordon Crozier: It modulates it.
- 29:55Dr. Gordon Crozier: So I like Thymosin Alpha 1 for people that have high bacterial vaginosis.
- 30:02Dr. Gordon Crozier: It works for those people that have recurrence and recurrence.
- 30:06Dr. Gordon Crozier: And you treat them and then they still get it back.
- 30:09Dr. Gordon Crozier: This will help them so that they don't get that recurrence anymore.
- 30:14Dr. Gordon Crozier: That one along.
- 30:16Dr. Gordon Crozier: In those people, I kind of combine thymosin alpha 1 and LL37.
- 30:20Dr. Gordon Crozier: I combine those two because they kind of work synergistically to help with those people, but also people with Epstein Barr.
- 30:29Dr. Gordon Crozier: I love it with those people with Epstein Barr because I think it really helps with their immune system.
- 30:34Dr. Gordon Crozier: Really helps to clear out some of that old Epstein Barr for them, that Thymus and Alpha 1.
- 30:41Dr. Gordon Crozier: But because it is immune modulation, I love it in my patients that have been battling mycotoxins and the mycotoxin, it helps them because their immune system is so hit that it helps to modulate that and begin to build their immune system so they can fight the other things.
- 31:02Dr. Gordon Crozier: Because remember, chronic disease is the layered effect.
- 31:06Dr. Gordon Crozier: Right.
- 31:07Dr. Gordon Crozier: So thymos and alpha one has so much literature on it.
- 31:11Dr. Gordon Crozier: And I can't wait for it to come back because it has been one of the ones that was my cornerstone back in the day to help with things.
- 31:21Dr. Gordon Crozier: When I knew that they were going to be taking all those away, I bought up a bunch of it and I stored it at my House because I wanted it from my family.
- 31:30Dr. Gordon Crozier: And for me too.
- 31:33Dr. Gordon Crozier: Anytime were going to get sick, I was going to be injecting Thymos and Alpha 1.
- 31:38Dr. Gordon Crozier: And now it's coming back and I'm out of my old state wars.
- 31:41Dr. Jill Carnahan, MD: So perfect timing.
- 31:42Dr. Jill Carnahan, MD: I could not agree more.
- 31:44Dr. Jill Carnahan, MD: I've been on that forever, since my cancer and as immune.
- 31:47Dr. Jill Carnahan, MD: I actually have an immune deficiency.
- 31:48Dr. Jill Carnahan, MD: It's been a game changer for me personally and recently.
- 31:51Dr. Jill Carnahan, MD: Interesting.
- 31:52Dr. Jill Carnahan, MD: You'll get this.
- 31:52Dr. Jill Carnahan, MD: In January, I had a tooth infection, so I was going to get it extracted.
- 31:56Dr. Jill Carnahan, MD: But the weekend, it was January 1st through the 4th, which of course, no dentist is around.
- 32:00Dr. Jill Carnahan, MD: And if anyone's ever had that infection, it's painful, it's.
- 32:04Dr. Jill Carnahan, MD: I had a fever.
- 32:05Dr. Jill Carnahan, MD: I mean, I was very.
- 32:06Dr. Jill Carnahan, MD: Almost septic from it.
- 32:08Dr. Jill Carnahan, MD: But what I did is I had LL37 and thymosin alpha 1.
- 32:12Dr. Jill Carnahan, MD: And I was able to, until I was able to get that extracted, really control that infection with those two peptides.
- 32:18Dr. Jill Carnahan, MD: Because the antibacterial.
- 32:20Dr. Jill Carnahan, MD: And it was just profound to me because we know these work.
- 32:23Dr. Jill Carnahan, MD: And I remembered I had some of that in my fridge and I'm like, I'm going to try this.
- 32:26Dr. Jill Carnahan, MD: And that was my way of getting around until I could get it extracted.
- 32:29Dr. Jill Carnahan, MD: And I just find long Covid.
- 32:32Dr. Jill Carnahan, MD: There's been some papers recently published by Dr. Vojdani and others around this chronic reactivation of HHV6, HV7 and Epstein Barr in lung.
- 32:44Dr. Jill Carnahan, MD: And so those are great patients too, that are suffering from long Covid because, you know, their T cell function is diminished and they're having the activation of viruses.
- 32:51Dr. Jill Carnahan, MD: And those could be that one I give subcutaneously.
- 32:54Dr. Jill Carnahan, MD: Is it possible to give it iv?
- 32:55Dr. Jill Carnahan, MD: I think there were some studies, yes,
- 32:57Dr. Gordon Crozier: you can give it iv.
- 32:58Dr. Gordon Crozier: I've given it IV in the past when we had it available.
- 33:01Dr. Gordon Crozier: Now we're going to have it available again.
- 33:04Dr. Gordon Crozier: I would not give any of these black market things.
- 33:08Dr. Jill Carnahan, MD: contaminant.
- 33:09Dr. Jill Carnahan, MD: Actually, let's pause right there, because what happened is when the FDA regulated some of these that are now coming back, there was a huge black market.
- 33:17Dr. Jill Carnahan, MD: And that black market often is contaminated, where you're literally injecting something with.
- 33:22Dr. Jill Carnahan, MD: Talk a little bit about that.
- 33:25Dr. Gordon Crozier: Yeah.
- 33:26Dr. Gordon Crozier: So the black market peptides are really dangerous for people to do.
- 33:30Dr. Gordon Crozier: And.
- 33:31Dr. Gordon Crozier: And I have seen in my practice a plethora of people buying them off the Internet because they're available.
- 33:37Dr. Gordon Crozier: They constantly are there.
- 33:39Dr. Gordon Crozier: I see it.
- 33:39Dr. Gordon Crozier: If I ever look at Facebook, boom, it's there.
- 33:42Dr. Gordon Crozier: If I'm looking on, you know, all These ads for these black market peptides are there.
- 33:48Dr. Gordon Crozier: They have a lot of mycotoxins in them, believe it or not, because a lot of peptides have mycotoxins in them, which is.
- 33:55Dr. Gordon Crozier: That's the number one contaminant.
- 33:57Dr. Gordon Crozier: But they have preservatives and some other things that are really can be very deadly, especially in the wrong hands and the wrong people.
- 34:08Dr. Gordon Crozier: So if you have anybody that's immune compromised and they use some of those.
- 34:13Dr. Gordon Crozier: Because we know.
- 34:13Dr. Gordon Crozier: We know what happened.
- 34:14Dr. Gordon Crozier: A couple years ago.
- 34:15Dr. Gordon Crozier: They had a peptide thing.
- 34:17Dr. Gordon Crozier: A couple years ago in Las Vegas.
- 34:20Dr. Gordon Crozier: Somebody injected these people.
- 34:23Dr. Gordon Crozier: Two women ended up in the ICU because they were black market peptides and they were peptides that weren't legal at the present time.
- 34:32Dr. Gordon Crozier: And this doctor, he said he wasn't the one that gave him.
- 34:36Dr. Gordon Crozier: Somebody else gave him.
- 34:37Dr. Gordon Crozier: But who knows?
- 34:38Dr. Gordon Crozier: He was in charge of that, Booth.
- 34:40Dr. Gordon Crozier: So he shouldn't allow that to happen.
- 34:43Dr. Gordon Crozier: So.
- 34:43Dr. Gordon Crozier: But you know, we.
- 34:45Dr. Gordon Crozier: So those black market peptides can be extremely deadly.
- 34:49Dr. Gordon Crozier: I tell anybody if you're going to do black market peptides, I'm not going to tell you anything about them and you're on your own.
- 34:57Dr. Jill Carnahan, MD: Yeah, yeah.
- 34:58Dr. Jill Carnahan, MD: Because that's safety and that's basics.
- 34:59Dr. Jill Carnahan, MD: And I'm actually glad we're talking about that because there's a lot of people getting them from very irreputable sources.
- 35:05Dr. Gordon Crozier: Yeah.
- 35:06Dr. Jill Carnahan, MD: Let's talk a little bit about the growth hormone GnRHS, the CJC, epimoral intestine world in that class.
- 35:13Dr. Jill Carnahan, MD: Where would you use those?
- 35:14Dr. Jill Carnahan, MD: I think there's some more consideration for safety with those.
- 35:17Dr. Jill Carnahan, MD: Maybe talk about that.
- 35:19Dr. Gordon Crozier: So semorelin is legal right now, and it has been.
- 35:23Dr. Gordon Crozier: It's never gone off.
- 35:24Dr. Gordon Crozier: It's probably.
- 35:25Dr. Gordon Crozier: I just taught this.
- 35:28Dr. Jill Carnahan, MD: weekend.
- 35:29Dr. Gordon Crozier: I just taught this last weekend to all the physicians.
- 35:33Dr. Gordon Crozier: So Cimmerelin is probably one of the safest.
- 35:35Dr. Gordon Crozier: It's kind of my.
- 35:37Dr. Gordon Crozier: Go to very few complications with it now.
- 35:41Dr. Gordon Crozier: However, you can have a little bit of swelling and edema with it.
- 35:46Dr. Gordon Crozier: So you can get a little bit.
- 35:48Dr. Gordon Crozier: If you know, your legs or ankles are swelling a little bit, then I take people off of it and we'll switch to something else.
- 35:54Dr. Gordon Crozier: But cimmerelin is legal and I love it because it increases your metabolism a little bit.
- 36:02Dr. Gordon Crozier: It helps to maintain muscle mass at the same time.
- 36:07Dr. Gordon Crozier: Same time.
- 36:07Dr. Gordon Crozier: It's going to help you to get rid of some fat.
- 36:10Dr. Gordon Crozier: So if you're a skinny fat person and you're wanting to maintain and build muscle, but get rid of that fat, that's still there, you know, you have to really look and see.
- 36:19Dr. Gordon Crozier: See what?
- 36:20Dr. Gordon Crozier: What does your DEXA scan say?
- 36:22Dr. Gordon Crozier: How does it, you know, what's your muscle mass to fat ratio?
- 36:26Dr. Gordon Crozier: All of those, but those are the ones I like to use.
- 36:29Dr. Gordon Crozier: So Semorelin I love to use because of how it does increase.
- 36:33Dr. Gordon Crozier: Now it does increase your growth hormone, but it does not overly increase your growth hormone.
- 36:38Dr. Gordon Crozier: So it doesn't put it to astronomically high amounts of growth hormone.
- 36:43Dr. Gordon Crozier: And that's the key for that one, for all of those.
- 36:46Dr. Gordon Crozier: Because you don't want to push your growth hormone too high.
- 36:50Dr. Gordon Crozier: Because, yeah, there could be a possible risk for cancer if you push it too high.
- 36:56Dr. Gordon Crozier: But semirelin seems to be one of the ones that's the safest in previous cancer patients.
- 37:02Dr. Gordon Crozier: So there's some literature on that as well that it is safe for previous cancer patients.
- 37:08Dr. Gordon Crozier: Now, if that one doesn't work, I go a lot of times to Tesmorellon, which is going to be coming back as well.
- 37:15Dr. Gordon Crozier: So Tesmorellon is actually a little bit longer half life in the length that it works over Semorelin.
- 37:24Dr. Gordon Crozier: I have.
- 37:24Dr. Gordon Crozier: Women tend to like that one better than semorelin.
- 37:28Dr. Gordon Crozier: I don't know why I haven't figured it out.
- 37:31Dr. Gordon Crozier: But in women in my practice, they seem to like it better for weight loss, for not necessarily weight loss, but maintaining muscle mass, but getting rid of fat.
- 37:43Dr. Gordon Crozier: And they notice it more around the middle.
- 37:46Dr. Gordon Crozier: So if you know, you do your DEXA scans and you see or you do an ultrasound or I don't care what way you do electrical impedance.
- 37:54Dr. Gordon Crozier: There's a multiple ways to measure fat versus muscle mass and all that.
- 38:00Dr. Gordon Crozier: Which ones do you use?
- 38:02Dr. Jill Carnahan, MD: Yeah, Tessa, Morlin is actually a favorite among my patients.
- 38:05Dr. Jill Carnahan, MD: And like you said, what we can get.
- 38:07Dr. Jill Carnahan, MD: Cjc, Epimoren's been out for a while, right.
- 38:09Dr. Jill Carnahan, MD: As far as.
- 38:10Dr. Gordon Crozier: Yeah, cjc, Empamorelin, I love too.
- 38:12Dr. Jill Carnahan, MD: Yeah, I actually liked that the best.
- 38:14Dr. Jill Carnahan, MD: Harder to get.
- 38:15Dr. Gordon Crozier: Legally, it's harder to get, but it won't be.
- 38:17Dr. Gordon Crozier: Give it.
- 38:18Dr. Gordon Crozier: Give it three more weeks.
- 38:19Dr. Jill Carnahan, MD: That's my favorite combo.
- 38:22Dr. Gordon Crozier: That was my favorite combo too, because that favorite combo, you had a longer half life, better safety.
- 38:30Dr. Gordon Crozier: So it did not push your growth hormone to astronomically high levels either.
- 38:35Dr. Gordon Crozier: You really, with those three cjc, empiramorelin, Tesmorelin, and semirelin were all ones that do not push, according to all the literature, your growth hormone too high.
- 38:50Dr. Gordon Crozier: Some of the other ones that have been taken off, you know, they.
- 38:54Dr. Gordon Crozier: They do push it to astronomically high levels.
- 38:58Dr. Gordon Crozier: What's interesting about those three also is they do not cause prostatic hypertrophy and prostatic growth.
- 39:05Dr. Jill Carnahan, MD: Excellent.
- 39:06Dr. Gordon Crozier: Very good for men to know.
- 39:08Dr. Jill Carnahan, MD: Yes.
- 39:09Dr. Gordon Crozier: I'm going to be 69 this summer.
- 39:12Dr. Gordon Crozier: So, you know, as you age, you don't want that to happen.
- 39:17Dr. Gordon Crozier: But, you know, if that's going to happen in a male, what's it doing in a female?
- 39:20Dr. Jill Carnahan, MD: Right, right.
- 39:21Dr. Jill Carnahan, MD: And, and breast and prostate are very similar in how they react to the environmental endogenous endocrine disruptors.
- 39:29Dr. Jill Carnahan, MD: So.
- 39:29Dr. Gordon Crozier: Exactly.
- 39:30Dr. Gordon Crozier: So what I, so I don't see any breast engorgement, breast pain or any of those things from those three.
- 39:39Dr. Gordon Crozier: Now the other ones I did in the past and so I just, you know, stopped using them because they would say, oh, my breasts are really tender.
- 39:47Dr. Gordon Crozier: If your breasts are tender, you need to reevaluate and stop and reevaluate what's going on and change things up.
- 39:55Dr. Gordon Crozier: And that's my first clue as an OB gyn.
- 39:58Dr. Gordon Crozier: I'm like always looking, okay, what are we doing here?
- 40:01Dr. Gordon Crozier: What are we doing there?
- 40:02Dr. Gordon Crozier: And so I'm always looking to be as careful and as safe as we can for these women because, you know, they're left out there to hang and dry.
- 40:12Dr. Gordon Crozier: And as you know, you are a woman in medicine, you know.
- 40:17Dr. Jill Carnahan, MD: Yes.
- 40:17Dr. Jill Carnahan, MD: It's so important.
- 40:18Dr. Jill Carnahan, MD: So a couple of caveats I love that you mentioned with that class.
- 40:21Dr. Jill Carnahan, MD: That is the only class that I've seen where people could get a little Hyvie reaction or a little tiny bit of in duration at the site.
- 40:28Dr. Jill Carnahan, MD: And I did have two patients that over time developed a little bit more severe allergic reaction.
- 40:33Dr. Jill Carnahan, MD: We obviously stopped them.
- 40:34Dr. Jill Carnahan, MD: They're never going to use that class again.
- 40:36Dr. Jill Carnahan, MD: But I looked in the deep literature and with Ipamorelin, Semarlin and Tessamorelin, there is a slight increase in histamine in some people.
- 40:45Dr. Jill Carnahan, MD: So I would say that people with mast cell activation in that realm, I'd be very cautious.
- 40:49Dr. Jill Carnahan, MD: If you're getting that from your physician.
- 40:50Dr. Jill Carnahan, MD: Just.
- 40:51Dr. Jill Carnahan, MD: That's probably a no.
- 40:51Dr. Jill Carnahan, MD: No.
- 40:52Dr. Jill Carnahan, MD: If you're super reactive to histamine, really.
- 40:55Dr. Gordon Crozier: and you know, you kind of know already.
- 40:59Dr. Gordon Crozier: I always look, I look at all my.
- 41:01Dr. Gordon Crozier: So I look at my eosinophil counts first.
- 41:04Dr. Jill Carnahan, MD: Exactly.
- 41:05Dr. Gordon Crozier: So on just a simple differential, if they have a high eosinophil count, I'm not going to give them those because they are going to end up eventually with a reaction and I don't want that for them.
- 41:18Dr. Gordon Crozier: So if they have a high eosinophil count, then I'm Going to say, hey, we probably need to look further in depth to see if you have mast cell syndrome activation.
- 41:28Dr. Gordon Crozier: You know, do you have this going on?
- 41:31Dr. Gordon Crozier: Because it's something that is going to lead to other issues later on and there are things we can do to help navigate that and bring it down.
- 41:40Dr. Jill Carnahan, MD: Absolutely.
- 41:40Dr. Jill Carnahan, MD: So I love mentioning that for those who are maybe, you know, talking to their doctors about this.
- 41:45Dr. Jill Carnahan, MD: So one of the things that, you know, 20 years ago we had access to growth hormone, but I was never a doc, even though I did cutting edge things, I didn't like to prescribe that and I rarely, except in extremely unique situations, did, because it'll stop production, it has the feedback loop, whereas these peptides don't have the same.
- 42:02Dr. Jill Carnahan, MD: Do you want to talk just a little about the difference?
- 42:03Dr. Jill Carnahan, MD: And I'd love to know your opinion on growth hormone itself, like giving growth hormone.
- 42:08Dr. Gordon Crozier: So I don't give much growth hormone.
- 42:11Dr. Jill Carnahan, MD: Yeah, agreed, agreed.
- 42:13Dr. Gordon Crozier: I didn't even back in the day I, Because I had some young girls with Turner syndrome and I did give growth hormone in those cases.
- 42:25Dr. Jill Carnahan, MD: Exactly.
- 42:25Dr. Gordon Crozier: Because I was at a university.
- 42:27Dr. Gordon Crozier: You know, you see really complicated cases working at the university.
- 42:33Dr. Gordon Crozier: So I did give growth hormone there.
- 42:35Dr. Gordon Crozier: But you're right, you do have the negative feedback and you are going to turn off your own natural growth hormone.
- 42:41Dr. Gordon Crozier: Have I seen that in some of these athletes?
- 42:45Dr. Gordon Crozier: I have.
- 42:46Dr. Gordon Crozier: And how do you undo that?
- 42:48Dr. Gordon Crozier: Well, you can't totally.
- 42:50Dr. Gordon Crozier: I mean, it's hard to really reverse that completely, right?
- 42:53Dr. Jill Carnahan, MD: Yeah.
- 42:54Dr. Gordon Crozier: But we can help them with Semorelin, cjc, some of these other ones that actually will help boost them.
- 43:03Dr. Gordon Crozier: But I've seen that actually we can help turn that back on where they are producing their own again, because that doesn't have that negative feedback effect.
- 43:14Dr. Gordon Crozier: And then your body recognizes, hey, I need this, let me produce it.
- 43:20Dr. Gordon Crozier: And then it begins to produce it.
- 43:22Dr. Gordon Crozier: So I don't use that alone in trying to bring back their ability to produce their own natural growth hormone.
- 43:28Dr. Gordon Crozier: I also use some other peptides like BPC because that's been known to help with that along with Thymos and Alpha one, by the way.
- 43:37Dr. Gordon Crozier: So Thymos and Alpha one has some literature.
- 43:40Dr. Gordon Crozier: It comes out of.
- 43:42Dr. Gordon Crozier: Oh gosh, what country now I forget which country the literature comes out of where Thymosin Alpha 1 will help with some of that in reclaiming your growth hormone.
- 43:52Dr. Gordon Crozier: But that's.
- 43:53Dr. Gordon Crozier: So those two in tandem with either CJC or Tesmorelin, I've found, actually helps those people that have been damaged by growth Hormone.
- 44:04Dr. Gordon Crozier: We had an issue back in the day with growth hormone.
- 44:09Dr. Gordon Crozier: You know, athletes were using it in high quantities, trying to really push it up.
- 44:15Dr. Gordon Crozier: And so when you have natural growth, when you have real growth hormone, you can end up with acromegaly.
- 44:22Dr. Gordon Crozier: You know, you can grow your organs, you can have cardiomegaly, your heart grows too big.
- 44:28Dr. Gordon Crozier: That does not happen with either semirelin, Tesmorelin, or CJC and ipamorelin.
- 44:34Dr. Gordon Crozier: So it doesn't happen with those combinations.
- 44:37Dr. Gordon Crozier: You don't have acromegaly, you don't have that.
- 44:41Dr. Gordon Crozier: And you can see some of the people that were big in athletics and they were, you know, some of the power lifters, they had that turtle appearance, they had that big gut.
- 44:51Dr. Gordon Crozier: Why?
- 44:51Dr. Gordon Crozier: Because growth hormone in itself makes your organs keep growing.
- 44:56Dr. Gordon Crozier: And they would have intestinal growth, so their intestines were still growing.
- 45:00Dr. Gordon Crozier: And then they had this big turtle in their gut.
- 45:03Dr. Gordon Crozier: You know, there was no fat there.
- 45:04Dr. Gordon Crozier: It was just organs that were there.
- 45:08Dr. Jill Carnahan, MD: Oh, gosh.
- 45:09Dr. Jill Carnahan, MD: Well, that's.
- 45:09Dr. Jill Carnahan, MD: And that's another question, because out there, if you're not doing this under the physician supervision, it can be very dangerous what you do.
- 45:15Dr. Jill Carnahan, MD: And some of it can be irreversible.
- 45:17Dr. Jill Carnahan, MD: Even though now what to do.
- 45:19Dr. Gordon Crozier: You know, there's.
- 45:20Dr. Gordon Crozier: There's things we can.
- 45:21Dr. Gordon Crozier: We have learned over the time on how to reverse some of it, but there's so many people out there doing it on their own.
- 45:27Dr. Gordon Crozier: And I have so many people coming to me that are doing all these crazy things, and I'm going, like, where did you hear that?
- 45:36Dr. Gordon Crozier: From this biohacker.
- 45:37Dr. Gordon Crozier: And, you know, not that all biohackers are bad.
- 45:40Dr. Gordon Crozier: There's some really good biohackers out there, but there's also some bad ones.
- 45:44Dr. Jill Carnahan, MD: Right.
- 45:44Dr. Jill Carnahan, MD: There's some bad advice being given out there, and it is kind of scary.
- 45:48Dr. Gordon Crozier: Yeah.
- 45:49Dr. Jill Carnahan, MD: Speaking of the growth hormone versus, like, testosterone, one thing I want to talk about.
- 45:53Dr. Jill Carnahan, MD: This isn't a peptide, but a lot of times we're using enclomiphen and clomiphen.
- 45:57Dr. Jill Carnahan, MD: And I'd love to just hear your perspective on men who are very low in testosterone and which populations you choose.
- 46:03Dr. Jill Carnahan, MD: Something like clomiphen versus testosterone.
- 46:06Dr. Gordon Crozier: Okay.
- 46:07Dr. Gordon Crozier: So my young guys that have low testosterone, we don't want to give them a bunch of testosterone.
- 46:14Dr. Gordon Crozier: Why?
- 46:14Dr. Gordon Crozier: Because they need to maintain their fertility.
- 46:17Dr. Gordon Crozier: Correct?
- 46:17Dr. Jill Carnahan, MD: Yes.
- 46:18Dr. Gordon Crozier: So if we give them testosterone at too young of an age, that is going to affect their fertility.
- 46:25Dr. Gordon Crozier: So I give either m. Clofamine or clomid, either one.
- 46:29Dr. Gordon Crozier: And I will pulse that and see how we're doing with that to bring back their testosterone levels.
- 46:37Dr. Gordon Crozier: Back in the day, we had Kisspeptin.
- 46:40Dr. Gordon Crozier: I think that might be one of the ones coming back, I'm not sure.
- 46:43Dr. Gordon Crozier: But kisspeptin in combination with EM clofamine worked really well to really redo their ability to produce testosterone.
- 46:56Dr. Gordon Crozier: If that wasn't enough, I would use Foxo 4.
- 47:02Dr. Gordon Crozier: Foxo 4.
- 47:02Dr. Gordon Crozier: A lot of people say that's a senolytic peptide.
- 47:05Dr. Gordon Crozier: That's a senolytic peptide.
- 47:06Dr. Gordon Crozier: Why are you using that?
- 47:07Dr. Gordon Crozier: Well, because the senolytic peptides work.
- 47:11Dr. Gordon Crozier: There's literature on it working at the epididymis for helping to restore testosterone levels.
- 47:18Dr. Gordon Crozier: So that was.
- 47:19Dr. Gordon Crozier: That comes out of Austria.
- 47:21Dr. Gordon Crozier: Literature out of Austria.
- 47:23Dr. Gordon Crozier: But how it works, how Foxo4 really works in restoring and getting rid of some of those senolytic cells in the epididymis and then you can restore what you have.
- 47:36Dr. Gordon Crozier: So testosterone, I don't like to use it on my younger guys, my older guys that might be in their 40s, but younger than 40, I still like to use EM Clofamine and other forms to try to build up their own natural testosterone.
- 47:55Dr. Gordon Crozier: One of my guys that he works for a big company in out in California, and he comes out because his parents live here, so he comes out to me and he does not want to do testosterone.
- 48:09Dr. Gordon Crozier: And he's in his older 30s, but, you know, he's still wanting to think about, you know, fertility into his 40s, because he doesn't have that significant other yet.
- 48:19Dr. Gordon Crozier: He doesn't have that.
- 48:21Dr. Gordon Crozier: But, you know, but.
- 48:22Dr. Gordon Crozier: So we've been doing EM Clofamine.
- 48:24Dr. Gordon Crozier: We've been doing kisspeptin.
- 48:26Dr. Gordon Crozier: Not lately.
- 48:27Dr. Gordon Crozier: Kiss Peptin.
- 48:28Dr. Gordon Crozier: But we did.
- 48:28Dr. Gordon Crozier: Still doing EM Clofamine, but we've done Foxo 4 as well.
- 48:33Dr. Gordon Crozier: His testosterone levels came from 300 and went up to 800.
- 48:37Dr. Gordon Crozier: So 800 is a really good functioning for him.
- 48:40Dr. Gordon Crozier: He says, I feel better, I have more energy, I can go to the gym.
- 48:43Dr. Gordon Crozier: I'm not a couch potato anymore.
- 48:46Dr. Gordon Crozier: I've gotten rid of my belly fat.
- 48:48Dr. Gordon Crozier: He's excited.
- 48:50Dr. Gordon Crozier: So I've been treating him for quite some time now.
- 48:52Dr. Gordon Crozier: And we do measure his testosterone levels every six months.
- 48:57Dr. Gordon Crozier: I make sure I'm kind of a little bit over the top and measuring everybody's hormones and their levels and where are we going with this?
- 49:05Dr. Gordon Crozier: So, you know, if you're stable, then it's every six months, but if you're not, then it's going to be a lot sooner.
- 49:12Dr. Jill Carnahan, MD: I couldn't agree more, but I think that's the safety of doing this is like really modulating in a safe way and optimizing back to our title, you know, vitality and performance and just feeling great.
- 49:21Dr. Jill Carnahan, MD: And the beautiful thing is we have these tools and anyone can.
- 49:25Dr. Jill Carnahan, MD: And I don't want to ever ignore the exercise, the diet, the avoiding toxins.
- 49:29Dr. Jill Carnahan, MD: Those are all foundational, which I know you start there, but then over the top of that, it's like icing on the cake.
- 49:34Dr. Jill Carnahan, MD: These things can be incredibly powerful at taking someone to the next level.
- 49:38Dr. Gordon Crozier: Yes, I agree with you 100%.
- 49:41Dr. Gordon Crozier: And I know, you know, we've talked, we do medicine a lot alike.
- 49:45Dr. Gordon Crozier: There's so many things that I'm like, oh my gosh, I found somebody that actually I know because they're not out there very often.
- 49:53Dr. Jill Carnahan, MD: You know, I remember when we first met, we actually met in Switzerland.
- 49:55Dr. Jill Carnahan, MD: Now we've known about each other for a time long, a long time.
- 49:57Dr. Jill Carnahan, MD: But we sat down to dinner, you and your wife, and it was such a pleasure because it was like I had found my tribe.
- 50:03Dr. Jill Carnahan, MD: Right.
- 50:03Dr. Jill Carnahan, MD: It's just this beautiful.
- 50:04Dr. Gordon Crozier: Right, Exactly.
- 50:06Dr. Jill Carnahan, MD: Yeah.
- 50:07Dr. Jill Carnahan, MD: Well, as we end, I want to make sure people know where to find you.
- 50:10Dr. Jill Carnahan, MD: But before we do, is there any up and coming peptides or longevity things that you think might be the next big thing that you know about?
- 50:20Dr. Gordon Crozier: So while everybody's talking about Ratatou tried already, it's not out yet, but Ratatou tried.
- 50:26Dr. Gordon Crozier: Everybody is really talking about that.
- 50:29Dr. Gordon Crozier: The other thing that a lot of people are talking about, which will become more available is OSO1.
- 50:35Dr. Gordon Crozier: It's a muscle OSO1.
- 50:37Dr. Gordon Crozier: So it has been available some, but because of the hindrance, but it's going to become more available.
- 50:45Dr. Gordon Crozier: Oso1.
- 50:46Dr. Gordon Crozier: And I like that for our elderly people or maybe somebody like me, I don't consider myself elderly yet, but people say, hey, you're almost elderly.
- 50:56Dr. Gordon Crozier: And I'm like, no, I'm not.
- 51:00Dr. Gordon Crozier: But really for muscle mass maintenance, because muscle is the currency of aging.
- 51:06Dr. Gordon Crozier: I like some of these ones for maintaining muscle mass because we really have to maintain our muscle mass in a good way, but a safe way.
- 51:18Dr. Gordon Crozier: You know, don't go to all these things online.
- 51:21Dr. Gordon Crozier: Really get a physician who is, who knows and is trained and knows this field well.
- 51:29Dr. Gordon Crozier: You do?
- 51:30Dr. Gordon Crozier: I do.
- 51:31Dr. Gordon Crozier: There's a few others I know.
- 51:33Dr. Jill Carnahan, MD: I couldn't agree more.
- 51:34Dr. Jill Carnahan, MD: It's so important and it's.
- 51:35Dr. Jill Carnahan, MD: And that's why we're out in the world teaching too, because I want the more doctors we get on board, the more people can get that help from even their general.
- 51:42Dr. Jill Carnahan, MD: Hopefully someday the primary care doctor will know this as standard.
- 51:45Dr. Jill Carnahan, MD: Like this will be the standard of care was my really.
- 51:48Dr. Gordon Crozier: I'm hoping for that.
- 51:49Dr. Gordon Crozier: I'm really hoping for that.
- 51:51Dr. Gordon Crozier: You know, we're seeing a kind of a change where a lot more people are wanting to avoid the toxins in their foods.
- 52:00Dr. Gordon Crozier: You know, let's eat organic as much as possible.
- 52:02Dr. Gordon Crozier: Let's have pure, clean water as much as possible.
- 52:05Dr. Gordon Crozier: Those are two key things.
- 52:06Dr. Gordon Crozier: And then your air, you know what about the air in your house or your work environment?
- 52:11Dr. Gordon Crozier: You know, we test here at our clinic.
- 52:14Dr. Gordon Crozier: We test, we have machines to filter the air and clean the air.
- 52:18Dr. Gordon Crozier: You know, those things are kind of key things that you really have to start with.
- 52:23Dr. Gordon Crozier: And then the fundamentals of what nutrients am I missing in my body?
- 52:28Dr. Gordon Crozier: You know, what amino acids.
- 52:29Dr. Gordon Crozier: Because you can give yourself peptides, but if you're deficient of some amino acids, theirs are going to break down and they're going to use those amino acids to do whatever they need to.
- 52:41Dr. Gordon Crozier: They're not going to do the intended product of what you want them to do.
- 52:46Dr. Jill Carnahan, MD: I couldn't agree more.
- 52:47Dr. Jill Carnahan, MD: As always, it's such a pleasure if people want to know about more about your clinic, where you teach, where can they find that information?
- 52:54Dr. Gordon Crozier: So my website is.
- 52:58Dr. Gordon Crozier: What is my Crozier Clinic?
- 53:00Dr. Gordon Crozier: Crozier Clinic, I forgot.
- 53:01Dr. Gordon Crozier: We changed it a while ago so it's crozier clinic.com.
- 53:06Dr. Jill Carnahan, MD: awesome.
- 53:06Dr. Jill Carnahan, MD: We'll be sure and put that in the show notes if you're driving or walking or with your loved ones.
- 53:11Dr. Jill Carnahan, MD: Dr. Crozier, it is always a pleasure.
- 53:13Dr. Jill Carnahan, MD: Thank you so much for sharing your knowledge today.
- 53:15Dr. Jill Carnahan, MD: Hey guys, hope you enjoyed that amazing episode on Peptides.
- 53:19Dr. Jill Carnahan, MD: I know a lot of you've been asking for more information and Dr. Crozier is one of the leading experts.
- 53:25Dr. Jill Carnahan, MD: He teaches for a 4M and as you can tell, incredibly knowledgeable.
- 53:28Dr. Jill Carnahan, MD: But what you may or may not have noticed in the interview is he has the biggest heart, just an incredible person, incredible human with his family and also incredible person, physician, and also one of the leading educators for some of the groups out there.
- 53:43Dr. Jill Carnahan, MD: So I hope you enjoyed that interview.
- 53:45Dr. Jill Carnahan, MD: And just a reminder, if you haven't yet hit the subscribe Button, we're reaching 850,000 subscribers on YouTube and if you're listening somewhere else, Spotify, itunes or wherever you listen to podcasts, would you please stop by, leave us a review.
- 53:58Dr. Jill Carnahan, MD: It helps us to reach more people.
- 54:00Dr. Jill Carnahan, MD: And as always, we will have new episodes out every week.
- 54:03Dr. Jill Carnahan, MD: So I look forward to seeing you again next week on another episode of Resiliency Radio.
- 54:08Dr. Jill Carnahan, MD: Until then, have a great day.