107-Glioma-Neuron Interactions: Retrograde Tracing Study

Paper Talk · Sep 29, 2025 · 22m

The article describes research focused on characterizing and targeting glioblastoma (GB) neuron-tumor networks using a modified rabies virus for retrograde tracing. This technique effectively maps the brain-wide neuronal connectome of glioblastoma, revealing that the rapid integration of tumor cells into neuronal circuits promotes tumor growth and invasion. The study identifies acetylcholine-mediated tumor growth and proposes therapeutic strategies, including disconnecting these neuron-tumor networks using a combination of radiotherapy with AMPA receptor inhibition or via rabies-mediated…