Semaglutide vs Tirzepatide (Ozempic vs Zepbound): Key Differences for Weight Loss & Blood Sugar

The Vagina Doctor Podcast w/ Duncan Turner M.D. · Mar 12, 2026 · 3m

The Vagina Doctor Podcast with Duncan Turner MD

Sophie, a nurse practitioner at Turner Medical Arts, explains two main GLP-1 medications—semaglutide and tirzepatide—and how they differ. She describes semaglutide (Ozempic) as a GLP-1–only medication that slows gastric emptying to help people feel full faster, can cause constipation and nausea, and improves metabolic function by lowering blood sugars gradually, making it helpful for people with diabetes and weight to lose. She then outlines why tirzepatide (Zepbound) is her preferred option: it combines GLP-1 and GIP, with GIP receptors on fat…