1419-EFHD2 Drives DNA Repair in Radioresistant Cancer
This research identifies a critical regulatory axis involving hsa-let-7b-5p, the protein EFHD2, and lactate metabolism that drives radioresistance and immune evasion in colorectal cancer. The study demonstrates that EFHD2 facilitates DNA damage repair and promotes an immunosuppressive tumor microenvironment by enhancing lactate production and stabilizing HIF-1α. Specifically, lactylation of EFHD2 at the K9 site is essential for its role in maintaining homologous recombination and helping cancer cells survive radiation. Furthermore, the accumulation of lactate reshapes the immune landscape by…
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