998-Gateways for Myeloid Cell Entry into the CNS
This review examines the anatomical gateways and molecular pathways that allow myeloid cells to enter the central nervous system (CNS). It details how the healthy brain is primarily populated by embryonically derived macrophages, such as microglia, which establish themselves during development and maintain their numbers through self-renewal. The text distinguishes these resident cells from border-associated macrophages located in the meninges and choroid plexus, explaining how these specific regions vary in their accessibility to circulating monocytes. Furthermore, the authors describe how…
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