1459-LCP2 Deficiency Drives Chemoresistance in Lymphoma

Paper Talk · Aug 19, 2026 · 22m

This research investigates the role of lymphocyte cytosolic protein 2 (LCP2) in driving chemoresistance through cellular senescence in natural killer/T-cell lymphoma (NKTCL). The study demonstrates that repeated chemotherapy triggers therapy-induced senescence, which is marked by a significant reduction in LCP2 expression in both resistant cells and patient plasma. This deficiency activates the IQGAP2/LaminA/C/SUV39H1 signaling axis, promoting an immunosuppressive microenvironment that allows cancer cells to evade treatment. Experimental results show that low levels of LCP2 correlate with…