Latest / The Joe Rogan Experience / #2537 - David Sinclair

Transcript

#2537 - David Sinclair · The Joe Rogan Experience

• 0:03
  Speaker 1: Check it out the Joe Rogan Experience shrain My Day
• 0:06
  Speaker 1: Joe Rogan Podcast. By name All Day, mister Sinclair, good
• 0:14
  Speaker 1: to see you again, doctor Sinclair.
• 0:16
  Speaker 2: Doctor, I'm kidding.
• 0:18
  Speaker 1: Yeah, do you ever introduce yourself as doctor?
• 0:21
  Speaker 2: Never?
• 0:22
  Speaker 1: Yeah, that's a kind of a it's a weird thing
• 0:24
  Speaker 1: because you're allowed to Well.
• 0:26
  Speaker 2: I'm actually a sir, David from Australia.
• 0:28
  Speaker 1: But are you a sir?
• 0:29
  Speaker 2: Yeah, but it's kind of a joke. I don't really
• 0:31
  Speaker 2: what does that?
• 0:32
  Speaker 1: How does that work out? Did you get.
• 0:35
  Speaker 2: The representative gave me some Australian version of a knighthood?
• 0:39
  Speaker 2: But uh, I get to put AO at the end
• 0:42
  Speaker 2: of my name Ao. Yeah, Order of Australia. But it
• 0:46
  Speaker 2: actually makes no difference to my life. So it's just
• 0:49
  Speaker 2: an extra couple of letters.
• 0:50
  Speaker 1: It's kind of cool.
• 0:52
  Speaker 2: I'm honored, for sure, but uh it uh, it's just
• 0:57
  Speaker 2: a joke.
• 0:58
  Speaker 1: If you don't know, well, it's kind of anybody's sir.
• 1:00
  Speaker 1: You meet a guy at the gas station, how are
• 1:02
  Speaker 1: you doing? Sir?
• 1:03
  Speaker 2: Is that like? Wow? How does he know? Right?
• 1:06
  Speaker 1: You don't see how you're doing?
• 1:07
  Speaker 2: King?
• 1:08
  Speaker 1: Yeah?
• 1:08
  Speaker 2: Right, Well, I'm David, I'm Australian, so in Australia. If
• 1:11
  Speaker 2: you have any ego, you get beaten up in the playgrounds.
• 1:14
  Speaker 1: That is true. Australia is the land of the tall
• 1:17
  Speaker 1: poppy syndrome. They don't they don't fuck around. They don't
• 1:21
  Speaker 1: like you get in a big head in Australia.
• 1:23
  Speaker 2: That that is true. I like to go back there though,
• 1:25
  Speaker 2: because it's any level playing field, nobody cares who you are.
• 1:28
  Speaker 1: I love the people there. Australian people are some of
• 1:31
  Speaker 1: my favorite people. They're awesome. They're just They're very friendly
• 1:35
  Speaker 1: and fun. It's a great place to be. It's just
• 1:38
  Speaker 1: too far to get there. Such a haul.
• 1:40
  Speaker 2: Oh no, if you just you know, whiskey and an
• 1:42
  Speaker 2: ambient and you're.
• 1:43
  Speaker 1: There without is that what you do?
• 1:44
  Speaker 2: I used to. I've gone clean. I don't drink much
• 1:48
  Speaker 2: at all anymore.
• 1:50
  Speaker 1: How often is drink much at all?
• 1:51
  Speaker 2: Celebrator right now? No, it would be a bad look.
• 1:55
  Speaker 2: I've got the coffee that you gave me, which, yeah,
• 1:58
  Speaker 2: this is.
• 1:58
  Speaker 1: A layered superfood coffee. So Laird Hamilton has cop it's
• 2:03
  Speaker 1: black rifle coffee mixed with his superfood stuff which is
• 2:07
  Speaker 1: this one's turmeric. So it's turmeric and I think it
• 2:10
  Speaker 1: has coconut milk in it and some other jazz.
• 2:12
  Speaker 2: That's greatious, anti inflammatory.
• 2:14
  Speaker 1: Yes, they which I know you're all about.
• 2:17
  Speaker 2: Yes, as a prophet of longevity.
• 2:22
  Speaker 1: Yes, is that another title of you.
• 2:25
  Speaker 2: Yes, you can call me Sir David the Prophet.
• 2:27
  Speaker 1: How about that, Sir David the prophet, doctor, Sir David
• 2:31
  Speaker 1: the Prophet of longevity.
• 2:33
  Speaker 2: That'll do.
• 2:34
  Speaker 1: So there's a lot. Let's let's jump right into it,
• 2:36
  Speaker 1: because there is a lot going on in the longevity space.
• 2:39
  Speaker 2: I think you're having me back on it my pleasure.
• 2:41
  Speaker 2: And by the way, I also want to thank you
• 2:44
  Speaker 2: for I think this is fourth time on which is amazing.
• 2:48
  Speaker 2: Thank you, congrats on all your success.
• 2:50
  Speaker 1: It's thank you.
• 2:50
  Speaker 2: Wonderful to see. Also, the book that I wrote, which
• 2:54
  Speaker 2: you first had me on to promote, has done so well,
• 2:56
  Speaker 2: and it's really because of you and the book Lifespan
• 3:00
  Speaker 2: became a best seller. Not just that, but it's now
• 3:02
  Speaker 2: been read millions of times around the world.
• 3:04
  Speaker 1: It's in forty that's phenomenal, and it's my pleasure.
• 3:07
  Speaker 2: And that's not a promo, as you know, you don't
• 3:09
  Speaker 2: make any money from books really, but I'm just honored
• 3:11
  Speaker 2: that it was read by so many people around the
• 3:14
  Speaker 2: world because it wasn't an easy read, it was high
• 3:17
  Speaker 2: tech science.
• 3:18
  Speaker 1: Well, people are very interested, especially nowadays. I think I've
• 3:22
  Speaker 1: never I can't recall a time in my life where
• 3:28
  Speaker 1: optimizing your health and longevity has been more of a
• 3:32
  Speaker 1: subject that people are interested in.
• 3:34
  Speaker 2: Well, I think that's largely because not to keep blowing
• 3:37
  Speaker 2: smoke up your rear, but largely because of what you
• 3:41
  Speaker 2: did in the book. So the book went global, and
• 3:45
  Speaker 2: it was right in twenty nineteen and the pandemic hit,
• 3:49
  Speaker 2: and I think most people saw their own mortality at
• 3:52
  Speaker 2: that point. Most people under the age of about seventy
• 3:55
  Speaker 2: didn't even think about dying, but then pandemics Like shit,
• 3:58
  Speaker 2: I could die. I saw the book take off. You
• 4:01
  Speaker 2: launched it. But yeah, since then a lot of people
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  Speaker 2: have jumped on the bandwagon and now longevities. I hear
• 4:07
  Speaker 2: this everywhere I go.
• 4:08
  Speaker 1: It's everything. It's everywhere. People are constantly talking about different modalities.
• 4:13
  Speaker 1: How often do you cold plunge? Are you sawing it?
• 4:15
  Speaker 1: What about the red light? What do you think is
• 4:17
  Speaker 1: this legit? Is that legit? Like everybody's optimizing everything constantly
• 4:21
  Speaker 1: all the time. But the reason why it's caught on
• 4:23
  Speaker 1: is because if you do follow some of the protocols,
• 4:26
  Speaker 1: you will feel better, and so that's the ultimate goal.
• 4:30
  Speaker 1: Like longevity is wonderful, but feeling better in the moment currently,
• 4:34
  Speaker 1: like living your life should be primary longevity, I think
• 4:38
  Speaker 1: is if you're optimizing your life and you feel better,
• 4:44
  Speaker 1: you will live longer. It's like this, it's all part
• 4:46
  Speaker 1: of it. So it would follow the longevity principles and
• 4:49
  Speaker 1: the ideas behind it, you certainly will live better right now.
• 4:53
  Speaker 2: You will, And it's not even that hard. There are
• 4:55
  Speaker 2: basic things, five basic things you can do or avoid
• 4:58
  Speaker 2: and you can live another fifteen years. It's really not
• 5:00
  Speaker 2: that hard. And that's what I'm excited about telling millions
• 5:02
  Speaker 2: of people today is and maybe we can go over
• 5:05
  Speaker 2: the kind of things that people can do easily to
• 5:06
  Speaker 2: live longer.
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  Speaker 1: Well, well, I definitely want to do that, But I
• 5:09
  Speaker 1: also want to talk about, like what is the current
• 5:13
  Speaker 1: state of science as applied to longevity treatments, because I
• 5:19
  Speaker 1: know that there's some pretty groundbreaking stuff that's in the
• 5:23
  Speaker 1: pipeline right now.
• 5:25
  Speaker 2: Yeah, so since twenty nineteen, a lot of what we
• 5:29
  Speaker 2: talked about has come true, which is the amazing thing.
• 5:32
  Speaker 2: We're speculating twenty nineteen that we could potentially reverse aging,
• 5:38
  Speaker 2: and that was a sin to say that as a
• 5:40
  Speaker 2: scientist publicly in those days. I put it in the book,
• 5:44
  Speaker 2: and it's actually come true since then, certainly for the
• 5:48
  Speaker 2: lab for mice, monkeys, and now we have a human
• 5:52
  Speaker 2: clinical trial. The first potential human age reversal technology is
• 5:56
  Speaker 2: in people right now.
• 5:58
  Speaker 1: Listen. It completely seems logical. The idea that that at
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  Speaker 1: one point in time would have been heresy and science
• 6:04
  Speaker 1: to discuss it so that seems crazy, like if people
• 6:08
  Speaker 1: get old, we understand the mechanism, why couldn't we reverse it?
• 6:13
  Speaker 2: Well, I think for a long time we had to
• 6:14
  Speaker 2: accept it in the way that cancer used to be
• 6:17
  Speaker 2: accepted two hundred years ago. Probably there was nothing you
• 6:20
  Speaker 2: could do about it. And then my colleagues and I
• 6:22
  Speaker 2: found that aging has a root cause that's the same
• 6:24
  Speaker 2: in pretty much every cell in the body, and that
• 6:27
  Speaker 2: we could control that, and that there were genes that
• 6:29
  Speaker 2: not only slowed it down. But in twenty twenty we
• 6:32
  Speaker 2: had a big publication that showed we could actually safely
• 6:35
  Speaker 2: for the first time reverse that process, like reinstalling software
• 6:38
  Speaker 2: in the cell to make it work again, and so.
• 6:41
  Speaker 1: What is the is that using crisper?
• 6:44
  Speaker 2: Like what are you using to Well, we deliver genes
• 6:48
  Speaker 2: into the body like crisper. I have a little little
• 6:52
  Speaker 2: prop here and brought what is it in my pocket here?
• 6:54
  Speaker 2: This is a representation of how we deliver the age
• 6:57
  Speaker 2: reversal genes. It's a virus like captule that we make
• 7:00
  Speaker 2: in the lab and this is what's going into the
• 7:03
  Speaker 2: patients right now, into their eyes initially, and the eye
• 7:09
  Speaker 2: is a good place to start.
• 7:10
  Speaker 1: How do you pick the people to get on these tests?
• 7:12
  Speaker 2: They volunteer. I was really fortunate to see the first
• 7:18
  Speaker 2: patient get dosed earlier this year, and that person bravely
• 7:24
  Speaker 2: volunteered to be the first person to get trillions of
• 7:28
  Speaker 2: these injected into his eye to see if could cure
• 7:31
  Speaker 2: his glaucoma loss of vision.
• 7:34
  Speaker 1: And I bet if you have glaucoma, you're probably like, listen,
• 7:36
  Speaker 1: what's the worst that could happen?
• 7:38
  Speaker 2: Well, exactly, he pretty much was totally blind in one eye,
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  Speaker 2: and so there's really nothing that he has to lose.
• 7:45
  Speaker 2: There's a risk that something might go wrong, but not really.
• 7:49
  Speaker 2: He The good news is, and I can report to
• 7:52
  Speaker 2: everybody around the world that nothing's gone wrong. So far,
• 7:56
  Speaker 2: everything's proceeding according to plan, and we're at its turning
• 8:01
  Speaker 2: point potentially in human history if it works.
• 8:04
  Speaker 1: So I interrupt you, but explain this little virus.
• 8:07
  Speaker 2: Trust sure, And for those of you listening, I've got
• 8:10
  Speaker 2: a little rubber ball with spikes on it. It looks a
• 8:12
  Speaker 2: bit like COVID, but don't be scared of it. It's
• 8:14
  Speaker 2: not a pathogenic virus. It's actually a domesticated version of
• 8:18
  Speaker 2: a virus. And this little plastic ball has little adapters.
• 8:22
  Speaker 2: These red balls on the surface of the big ball
• 8:25
  Speaker 2: target it to the cells in the back of the eye,
• 8:28
  Speaker 2: and you can change the balls to target different tissues.
• 8:30
  Speaker 2: We could change that outside little spike and target it
• 8:34
  Speaker 2: to the liver, which we've done and cured mice of
• 8:36
  Speaker 2: their fatty liver disease as well. But this one's for
• 8:39
  Speaker 2: the eye. And within that big ball is a protein capsule,
• 8:43
  Speaker 2: and inside the protein capsule is our DNA special delivery,
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  Speaker 2: which we call osk or ER one hundred R one
• 8:53
  Speaker 2: hundred is epigenetic reprogramming one hundred, the drug that we
• 8:57
  Speaker 2: know when we put it into human cells, it makes
• 8:59
  Speaker 2: them younger and then they work like they were young again.
• 9:05
  Speaker 1: This sounds like the beginning of a horror movie, you
• 9:08
  Speaker 1: know what I mean, Like the scientist is on a
• 9:10
  Speaker 1: talk show and the scientist is explaining it, and everyone's
• 9:13
  Speaker 1: at home like with their coffee, Like, Wow, we're in
• 9:16
  Speaker 1: a scientist. This is wonderful. We're gonna get younger again.
• 9:19
  Speaker 2: And SCIENTII to worry, it's all gonna work.
• 9:22
  Speaker 1: Twenty eight days later, garbage in the streets, cars on fire,
• 9:26
  Speaker 1: the guy's waking up from a coma, doesn't know what happened. Yeah,
• 9:29
  Speaker 1: goes outside. These optimized humans are eating each other.
• 9:32
  Speaker 2: I admit, I admit it is science fiction, and I
• 9:35
  Speaker 2: even have to pinch myself that it's actually happening. But
• 9:38
  Speaker 2: we've done a lot of safety studies, and this trial
• 9:39
  Speaker 2: is FDA approved because they've looked at all the data.
• 9:42
  Speaker 1: Well god knows, they never fucked anything up.
• 9:44
  Speaker 2: Yeah, I figured you might say that perfect. Yeah. Well,
• 9:48
  Speaker 2: it's in the eyes. So that's why we start with
• 9:50
  Speaker 2: the eye. It's enclosed, it's not gonna spread, nobody's going
• 9:53
  Speaker 2: to grow another.
• 9:54
  Speaker 1: And so these trillions of cells that you're putting into the.
• 9:59
  Speaker 2: Eyes, the little capsule the virus tillians.
• 10:02
  Speaker 1: I shouldn't call themselves trillions of capsules that you're putting
• 10:07
  Speaker 1: into the eye. What are they doing for glaucola?
• 10:12
  Speaker 2: Well, what they're doing is that there are three genes
• 10:14
  Speaker 2: in this DNA package, and I called them OSK. OSK
• 10:20
  Speaker 2: are three special genes that we found safely reprogram cells
• 10:25
  Speaker 2: and reboot the backup copy of youth, which we now
• 10:28
  Speaker 2: believe exists in our body. That's a big deal that
• 10:32
  Speaker 2: there's a backup copy of youth. Even an old person.
• 10:34
  Speaker 2: I don't see that an old person anymore on the street.
• 10:37
  Speaker 2: I just see a person that needs to be rebooted.
• 10:39
  Speaker 2: These OSK genes you just see.
• 10:42
  Speaker 1: Hold on, when you see old people, you don't see
• 10:45
  Speaker 1: old people you think. You just say, oh, that poor
• 10:47
  Speaker 1: person needs to be rebooted. Yeah, you're doing the perfect
• 10:51
  Speaker 1: job for you, like your personality is perfectly suited for
• 10:55
  Speaker 1: your occupation. If that's how you actually look at people.
• 10:58
  Speaker 2: Well I do. And the reason is that we all,
• 11:03
  Speaker 2: we all have this backup copy that the DNA, the
• 11:07
  Speaker 2: instructions to be young that made us into who we
• 11:09
  Speaker 2: are as kids, is still in our bodies, almost largely intact.
• 11:14
  Speaker 2: You just need to read it again. And that's why
• 11:17
  Speaker 2: read installing software or I used to use the analogy
• 11:20
  Speaker 2: of a CD. Kids these days probably don't know what
• 11:24
  Speaker 2: a CD is. It's a It's a little plastic circle
• 11:26
  Speaker 2: like a record that we used to put twenty songs on.
• 11:29
  Speaker 2: It was awesome at the time. I'm kidding. I'm kidding
• 11:32
  Speaker 2: is a bit of a silly joke. When I teach
• 11:35
  Speaker 2: kids at Harvard, most of them have never held a
• 11:37
  Speaker 2: CD in that wild Yeah, though, they're not coming back,
• 11:42
  Speaker 2: but albums definitely. So think of it like an album
• 11:45
  Speaker 2: that you scratch and the scratches are like aging, and
• 11:49
  Speaker 2: we are getting rid of the scratches with these three genes,
• 11:52
  Speaker 2: as kay, So let me tell you how these three
• 11:54
  Speaker 2: genes work. We found there was a person whose name
• 11:58
  Speaker 2: is well known in science vocals called Shinya Yamanaka from Japan, obviously,
• 12:04
  Speaker 2: and he discovered that there was a set of four
• 12:07
  Speaker 2: genes that could reliably make adult cells like skin cells,
• 12:12
  Speaker 2: into stem cells, and he deservedly won the Nobel Prize
• 12:15
  Speaker 2: for that in two thousand and six. But that wouldn't
• 12:18
  Speaker 2: be useful here. If I turned you into a bunch
• 12:20
  Speaker 2: of stem cells, you'd probably die within a few minutes.
• 12:24
  Speaker 2: So we don't want to do that, and cancer is
• 12:26
  Speaker 2: also a potential. So it took us about well from
• 12:30
  Speaker 2: twenty nineteen. It took us a while to figure out
• 12:33
  Speaker 2: that if we leave out one of the Yamanaka genes
• 12:36
  Speaker 2: and just use three OSK leave out the other one
• 12:39
  Speaker 2: called M, we'd get safe age reversal about seventy five
• 12:43
  Speaker 2: eighty percent back to youth, but no further. We don't
• 12:46
  Speaker 2: go back to zero, which is what Yamanaka did, and
• 12:49
  Speaker 2: instead of cells losing their identity, which is what a
• 12:51
  Speaker 2: stem cell has no identity, we regain identity. So it's
• 12:55
  Speaker 2: actually I could draw graphs, but it doesn't really help listeners.
• 12:58
  Speaker 2: But basically old old age is losing identity of your cells,
• 13:02
  Speaker 2: so they don't work, they forget how to work. That's
• 13:04
  Speaker 2: what we think old ages in my lab and stem
• 13:07
  Speaker 2: cells have no identity. It was like a very early
• 13:09
  Speaker 2: embryo in between. We our cells have a lot of identity.
• 13:13
  Speaker 2: They function beautifully, where in our twenties we're at peak.
• 13:17
  Speaker 2: And what we've done is we've figured out how to
• 13:18
  Speaker 2: go back towards youth, get these cells to work like
• 13:23
  Speaker 2: they did again back get the backup copy somewhere. It exists.
• 13:27
  Speaker 2: We're looking for it and now cells actually behave like
• 13:30
  Speaker 2: they did when we were twenty And if it works,
• 13:33
  Speaker 2: we're going to have glaucoma patients seeing for the first time.
• 13:36
  Speaker 2: And that's the beginning of a whole cascade of drugs
• 13:39
  Speaker 2: that I want to develop for diseases of aging and
• 13:42
  Speaker 2: eventually whole body rejuvenation.
• 13:44
  Speaker 1: So the initial experiments are on glaucoma because it's a
• 13:48
  Speaker 1: contained thing. The eyeball is a contained thing, and you
• 13:52
  Speaker 1: could do it that way. Yeah.
• 13:53
  Speaker 2: My student Juan cheng Lu, who was doing this in
• 13:55
  Speaker 2: twenty seventeen, I said, let's do the liver. Let's rejuvenate
• 13:59
  Speaker 2: the liver, and he said, no, the eye is a
• 14:00
  Speaker 2: good idea, and he was right. So that's exactly why
• 14:03
  Speaker 2: we chose that first.
• 14:04
  Speaker 1: But just think about how many people have vision problems.
• 14:07
  Speaker 2: It's forty million just in the US for glaucoma. Macula
• 14:11
  Speaker 2: de generation is even more. And in the lab we
• 14:13
  Speaker 2: can cure that as well in the mice.
• 14:16
  Speaker 1: Now, macular degeneration and glaucoma, these are diseases of aging, right,
• 14:22
  Speaker 1: you would say, or gla Cooma's a disease. Oh yeah, Well,
• 14:25
  Speaker 1: what about people that have had eyeball injuries and things
• 14:29
  Speaker 1: like that. Is there a backup copy of the eyeball
• 14:31
  Speaker 1: where you could sort of reformat the eyeball structure.
• 14:35
  Speaker 2: You should come work in my lab at least come visit.
• 14:38
  Speaker 1: I would love to visit.
• 14:39
  Speaker 2: And the reason I say that is that's the exact
• 14:40
  Speaker 2: question that we're asking. We showed that even if you injure,
• 14:45
  Speaker 2: say a nerve, whether it's peripheral in your arm or
• 14:49
  Speaker 2: in your brain or in the eye like the uptic nerve,
• 14:52
  Speaker 2: we can regrow those back to where they were. And actually,
• 14:56
  Speaker 2: in twenty twenty on the cover of Nature magazine there
• 14:59
  Speaker 2: was picture of an eye and in the in the
• 15:02
  Speaker 2: paper we published, you could see the noes re growing back,
• 15:06
  Speaker 2: and so we think that injury is also treatable. Actually,
• 15:10
  Speaker 2: a group in China just took our technology, this always
• 15:13
  Speaker 2: K stuff, put it into mice that had bad joints,
• 15:16
  Speaker 2: and it regrew their muscle and their bone back to normal.
• 15:19
  Speaker 1: WHOA.
• 15:20
  Speaker 2: And so we were also looking at treating injury back
• 15:24
  Speaker 2: injury joints. What's do your arthritis?
• 15:27
  Speaker 1: That would be phenomenal because there's so many people that
• 15:31
  Speaker 1: are suffering from arthritis, and so many I know so
• 15:34
  Speaker 1: many people with injuries, like martial arts injuries. I have one.
• 15:38
  Speaker 1: My left knee is fucked up. It's annoying. I keep
• 15:41
  Speaker 1: it together. I've got it like main. I maintain it,
• 15:45
  Speaker 1: but it's always an issue. I have to stay on it.
• 15:47
  Speaker 2: And there's littally you can do, like stem cells a
• 15:49
  Speaker 2: little bit of relief.
• 15:50
  Speaker 1: But stem cells give you relief, but not when once
• 15:54
  Speaker 1: you're dealing with cartilage damage and you're dealing with the
• 15:58
  Speaker 1: I had a meniscus surgery where they out a piece
• 16:00
  Speaker 1: of my mensqs and I had my acl reconstructed on
• 16:03
  Speaker 1: that knee as well. It's it's just an issue, but
• 16:06
  Speaker 1: it works pretty good for like what it should be
• 16:09
  Speaker 1: like if we were living in the nineteen thirties, I'd
• 16:11
  Speaker 1: be a cripple.
• 16:13
  Speaker 2: You know, hang in there, because we're going to be
• 16:15
  Speaker 2: in a world where we can rebuild parts of the body,
• 16:17
  Speaker 2: including joints.
• 16:19
  Speaker 1: The problem with that is, like how does that apply
• 16:21
  Speaker 1: to athletics. We're gonna have fucking super soldiers in every sport.
• 16:26
  Speaker 1: There's gonna be people in every sport that could do
• 16:28
  Speaker 1: what Michael Jordan did and like leap from halfway across
• 16:31
  Speaker 1: the basketball court and dunk.
• 16:33
  Speaker 2: That's that's probably coming, and there may be DNA tests
• 16:36
  Speaker 2: to see if you've got these osk jeens inserted. And
• 16:39
  Speaker 2: we're working on it, working on a drink and a
• 16:41
  Speaker 2: pill as well.
• 16:42
  Speaker 1: For a drink and a pill.
• 16:43
  Speaker 2: Yeah, we're I mean we're now eight years ahead of
• 16:46
  Speaker 2: what the public realizes.
• 16:48
  Speaker 1: Really in my lab at Harvard, Yeah, a drink and
• 16:50
  Speaker 1: a pill. And what's a drink and a pill gonna
• 16:51
  Speaker 1: do well?
• 16:53
  Speaker 2: Right now? It's in mice, so we still got ways
• 16:56
  Speaker 2: to go. But when we give the drink to mice,
• 16:59
  Speaker 2: they get rejuvenated.
• 17:00
  Speaker 1: We just give it to eighty year olds. If you're
• 17:03
  Speaker 1: on the way out, like, let's fucking go, Like, give.
• 17:06
  Speaker 2: What DA is for. They forbid that.
• 17:08
  Speaker 1: Yeah, that's why we need to get rid of them,
• 17:10
  Speaker 1: get rid of the FDA, and just give it to
• 17:12
  Speaker 1: old people. If I was an old guy, yeah, i
• 17:15
  Speaker 1: was like hanging in there with her and I'm walking
• 17:18
  Speaker 1: around with it, and you're like, look, this drink and
• 17:21
  Speaker 1: a pill might kill you, or you might be like
• 17:24
  Speaker 1: a thirty year old. Again, I'm like, let fucking go.
• 17:28
  Speaker 2: A lot I've had to take my emails off public
• 17:31
  Speaker 2: access because there's a lot of people that want this. Oh,
• 17:33
  Speaker 2: I'm sure there was one guy that wouldn't leave the
• 17:36
  Speaker 2: building until he saw me, So it's getting to that point.
• 17:40
  Speaker 1: Yeah, there's a little bit of that, right, People get
• 17:42
  Speaker 1: a little selfish, like it's all about them.
• 17:44
  Speaker 2: Yeah. And actually, the US government blocked an investment from
• 17:48
  Speaker 2: a foreign country into one of my companies because they
• 17:50
  Speaker 2: were afraid of super soldiers.
• 17:53
  Speaker 1: Oh what country, Well.
• 17:54
  Speaker 2: They're afraid of the technology getting out. Which country?
• 17:58
  Speaker 1: Could I guess? China? It wasn't wasn't no Russia.
• 18:04
  Speaker 2: It was somewhere in between here and China. Oh Usha,
• 18:06
  Speaker 2: that's pretty It's it's a little sensitive, but yeah, the
• 18:12
  Speaker 2: US government does have the ability to block it for
• 18:14
  Speaker 2: an investment, and they did in this case one hundred
• 18:16
  Speaker 2: and sixty million bucks they blocked. Wow, that was a
• 18:18
  Speaker 2: painful episode.
• 18:20
  Speaker 1: So they were worried that people were going to actually
• 18:22
  Speaker 1: engineer super soldiers. This episode is brought to you by superpower.
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  Speaker 1: Your doctor spends eight minutes with you, and your insurance
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  Speaker 1: end goals. Go to superpower dot com, slash rogan and
• 19:05
  Speaker 1: take control of your health. Yeah. You know about the
• 19:10
  Speaker 1: Crussian experiments that they did during World War Two where
• 19:13
  Speaker 1: they were trying to come up with a chimpanzee human
• 19:15
  Speaker 1: hybrid tell us. Yes, so, uh, It's very difficult obviously
• 19:21
  Speaker 1: to get information out of the former Soviet Union as
• 19:24
  Speaker 1: to what their top secret programs were, but there seems
• 19:27
  Speaker 1: to be an indication that there was actual, real research
• 19:30
  Speaker 1: to try to you know, because obviously Russia lost an
• 19:34
  Speaker 1: incredible amount of people in World War two. I mean
• 19:38
  Speaker 1: tens of millions of soldiers died in World War Two
• 19:41
  Speaker 1: from Russia, and I think they said, wouldn't it be
• 19:44
  Speaker 1: great if it wasn't people? And so they were doing
• 19:48
  Speaker 1: experiments with hybridization, and they were trying to combine human
• 19:52
  Speaker 1: beings and chimpanzees to create a you know, a stable
• 19:57
  Speaker 1: of super soldiers that were like some hybrid hominin.
• 20:02
  Speaker 2: Yeah, there's a scientist in New York who does this
• 20:04
  Speaker 2: for a living. But he does that creating them. But
• 20:07
  Speaker 2: I've seen I was on stage with him. He made
• 20:10
  Speaker 2: hybrid embryos they didn't reach.
• 20:14
  Speaker 1: See. The thing is, if that guy's doing that and
• 20:16
  Speaker 1: he's ethical and he lives in America and we have
• 20:18
  Speaker 1: rules and regulations in the FDA and all that good stuff,
• 20:21
  Speaker 1: what the fuck is going on in other countries where
• 20:23
  Speaker 1: they don't have that right?
• 20:24
  Speaker 2: Right, Well, there's genetic engineering of humans already and certainly selection. Yea,
• 20:29
  Speaker 2: even parents today in the US can if they have
• 20:32
  Speaker 2: the money, they can select.
• 20:33
  Speaker 1: Well, people select. They don't tell people select for hotness,
• 20:37
  Speaker 1: they select for tallness, they select for intelligence.
• 20:40
  Speaker 2: It's like Geteka. Yes, it's a great movie. If you
• 20:43
  Speaker 2: haven't seen it.
• 20:43
  Speaker 1: It is a great movie. Yeah. So see if you
• 20:46
  Speaker 1: could find that Russian hybridization program, it's uh, it never happened.
• 20:51
  Speaker 1: I don't think. I don't think they did it. But
• 20:54
  Speaker 1: there's uh, there's actually a guy who was also involved
• 20:58
  Speaker 1: in a gigantic fertility scam, not a scam per se,
• 21:03
  Speaker 1: but he was a doctor that was supposed to be
• 21:06
  Speaker 1: doing fertility treatments with women, like you know, like if
• 21:09
  Speaker 1: you went with your wife to a doctor and said, hey,
• 21:12
  Speaker 1: we're having a hard time getting pregnant, and well, David,
• 21:15
  Speaker 1: I just need some of your sperm and i'll take
• 21:17
  Speaker 1: your wife's sag we'll make you a nice baby. And
• 21:19
  Speaker 1: he was using his sperm on everybody, on everybody, everybody
• 21:23
  Speaker 1: gets mine.
• 21:23
  Speaker 2: One of my kids' partners is from someone in the
• 21:28
  Speaker 2: US who had hundreds of babies.
• 21:30
  Speaker 1: Dude, there is a ton of those guys. As I
• 21:32
  Speaker 1: was doing research for this, I started looking up all
• 21:35
  Speaker 1: these stories and I said, wait, this is a different story,
• 21:37
  Speaker 1: the same thing. There's been a ton of these doctors
• 21:40
  Speaker 1: from fertility clinics that use their own sperm, just insane.
• 21:43
  Speaker 1: But this one doctor that did that also claimed that
• 21:47
  Speaker 1: he impregnated an orangutang. Yeah, like, how how'd you do that?
• 21:52
  Speaker 1: Soviet doctor Joseph Stalin Dictator Oh obviously wanted to rebuild
• 21:59
  Speaker 1: the Army in the mid nineteen twenties with Planet of
• 22:02
  Speaker 1: the Ape style troops by crossing humans with ape. Stalin
• 22:05
  Speaker 1: is said to have told Ivanoff, I want a new
• 22:07
  Speaker 1: invincible human being, insensitive to pain, resistant and indifferent about
• 22:11
  Speaker 1: the quality of the food they ate, which is crazy.
• 22:15
  Speaker 1: The only legitimate source of the claim comes from a
• 22:17
  Speaker 1: two thousand and two paper in the academic journal Science
• 22:20
  Speaker 1: in Context by the Russian historian of science Koreel Rasiyanov.
• 22:27
  Speaker 1: Rasianov's study follows the ill fated attempt by the Russian
• 22:31
  Speaker 1: psychologists or physiologists rather that word ilyya Ivanov, to crossbreed
• 22:37
  Speaker 1: humans with anthropoid apes. His research offers an important warning
• 22:41
  Speaker 1: about the ethical abuses. Did you do it? What happened?
• 22:48
  Speaker 1: The alleged quote from Stalin is not found in the paper,
• 22:50
  Speaker 1: and there's no evidence of Stalin ever ever made such
• 22:53
  Speaker 1: a statement. Yeah, I don't know, however, why the Soviets
• 23:00
  Speaker 1: would find such a human chimp hybridization program in the
• 23:04
  Speaker 1: first place, and what could be learned from this sorid
• 23:06
  Speaker 1: tale of ethical misconduct is an important topic and fascinating
• 23:10
  Speaker 1: in its own right. It's a that's an interesting way
• 23:12
  Speaker 1: of phrasing it, like a sorid tale of ethical misconduct. Like, however,
• 23:18
  Speaker 1: if you are going to go to war, would you
• 23:21
  Speaker 1: rather have like human made orcs fight for us? Or
• 23:26
  Speaker 1: you know Johnny Robinson who grew up down the street,
• 23:31
  Speaker 1: who's a nice kid who you know, just really wanted
• 23:34
  Speaker 1: money for college, and so he signed up for military service,
• 23:37
  Speaker 1: and you're gonna fly him over to fight this war
• 23:40
  Speaker 1: that maybe he doesn't need to die in when you
• 23:42
  Speaker 1: can have these monsters that you made in a lab
• 23:44
  Speaker 1: fight yep.
• 23:45
  Speaker 2: And and the average a can kill a human with one.
• 23:49
  Speaker 2: So there's much stronger.
• 23:50
  Speaker 1: Than we really what I'm talking about.
• 23:52
  Speaker 2: Let's go, Well, we're in the process of building, you know,
• 23:55
  Speaker 2: anthropoid robots that I think will be recruited to the army.
• 23:59
  Speaker 1: Yeah, that's gonna be weird, Like our robots beat your robots,
• 24:02
  Speaker 1: So give us your oil. How's that gonna work?
• 24:04
  Speaker 2: And if we all have one at home, what stops
• 24:06
  Speaker 2: the government recruiting them? All?
• 24:07
  Speaker 1: Right? And also means what's the real problem is gonna be?
• 24:11
  Speaker 1: We both know the real problem is gonna be Sex robots.
• 24:16
  Speaker 2: Is a problem.
• 24:16
  Speaker 1: It's gonna be a problem for people that don't have
• 24:19
  Speaker 1: a sex to leave home. It's gonna be a problem
• 24:21
  Speaker 1: with people that want a regular person and there's none
• 24:24
  Speaker 1: available because everybody's got a sex robot.
• 24:26
  Speaker 2: Yeah, that well, it comes with a few strings attests.
• 24:29
  Speaker 1: It also comes with the same problems that AI comes
• 24:31
  Speaker 1: with right where AI says, David, you're amazing. Everything you
• 24:35
  Speaker 1: do is wonderful. You should be so proud of yourself.
• 24:38
  Speaker 1: I love that, No real at all, love that. But
• 24:41
  Speaker 1: that's not healthy, right, too big. This is one of
• 24:44
  Speaker 1: the reasons, This is one of the reasons why relate, actual,
• 24:48
  Speaker 1: real relationships between human beings are good. Because you do
• 24:51
  Speaker 1: things that are annoying, you don't realize they're annoying, and
• 24:53
  Speaker 1: then your wife or your husband or whatever it is,
• 24:56
  Speaker 1: tells you, Hey, you're fucking annoying, and you're like, I'm sorry,
• 25:00
  Speaker 1: I'll fix that. I didn't mean to. I didn't That's
• 25:03
  Speaker 1: not what I was trying to exactly. I was in
• 25:05
  Speaker 1: my own head. I was thinking about myself. You're right,
• 25:06
  Speaker 1: I was selfish. You get better. It's like help people grow,
• 25:10
  Speaker 1: like relationships support to help people grow, not with AI.
• 25:13
  Speaker 1: Like you can fight in my face any day, David,
• 25:16
  Speaker 1: I don't mind at all. Your farts are amazing.
• 25:19
  Speaker 2: You know they're gonna be way smarter than us, too, right.
• 25:23
  Speaker 2: I don't know how people are gonna say, go stack
• 25:24
  Speaker 2: the dishwasher to one of these robots that's smarter than
• 25:27
  Speaker 2: all cumans combined.
• 25:28
  Speaker 1: You, But they're not gonna mind stacking that they're smart
• 25:30
  Speaker 1: enough to meet.
• 25:31
  Speaker 2: Out of hell and they're gonna beat us up.
• 25:33
  Speaker 1: They don't care. They're not going to mind doing like
• 25:36
  Speaker 1: menial tasks. But while you're doing it, you know, you
• 25:39
  Speaker 1: can go explain to me quantum entanglement, Like while I'm
• 25:46
  Speaker 1: filling up the dishwasher, they can go if you one day,
• 25:49
  Speaker 1: well if you have a particle and the particles, yeah,
• 25:53
  Speaker 1: I just right. Well, look at what it's done with mathematics, Like,
• 25:59
  Speaker 1: just over the last couple of weeks, they've solved more
• 26:03
  Speaker 1: than fifty program or fifty mathematical equations that they have
• 26:07
  Speaker 1: struggled for a decade upon decade to try to solve.
• 26:11
  Speaker 1: And a I was like, oh, I got it.
• 26:13
  Speaker 2: Yeah, well biology is a little bit more complicated, but
• 26:16
  Speaker 2: already AI is doing a lot of the science that
• 26:18
  Speaker 2: we used to do in my lab. In fact, what
• 26:20
  Speaker 2: we just recently did in a couple of months would
• 26:23
  Speaker 2: have taken about one hundred and sixty years to complete
• 26:25
  Speaker 2: what and it's only getting faster. Eventually someone came and
• 26:28
  Speaker 2: make it again two months instead of one hundred and
• 26:32
  Speaker 2: sixty years. Well, what exactly was it that you had
• 26:35
  Speaker 2: to do Oh, so this drink and the pill that
• 26:38
  Speaker 2: we're looking for. That's not easy, right, So we have
• 26:41
  Speaker 2: some candidate molecules. We have a cocktail that works. But
• 26:44
  Speaker 2: you want to see you take in stuff.
• 26:46
  Speaker 1: Not yet you're thinking about it. Yeah, I no one
• 26:50
  Speaker 1: could stop you.
• 26:51
  Speaker 2: I might. Well, that is true, that is true, But
• 26:54
  Speaker 2: it'd be a bad look if I died. So may
• 26:56
  Speaker 2: maybe I.
• 26:58
  Speaker 1: Didn't think.
• 26:59
  Speaker 2: So We've done a lot of sayfty tests and it
• 27:00
  Speaker 2: looks really safe. But I'm not going to publicly do
• 27:04
  Speaker 2: anything against the law. Of course, it'll be in private,
• 27:07
  Speaker 2: of course, of course, not publicly. No, but we I'm
• 27:10
  Speaker 2: at a stage where i have to be a good
• 27:12
  Speaker 2: boy because I've got the world watching. Yes, a lot
• 27:15
  Speaker 2: is at stake, yes, and a lot of If this
• 27:18
  Speaker 2: trial has any issues, it's not good.
• 27:20
  Speaker 1: We've got to dot your eyes and cross your t's
• 27:23
  Speaker 1: and follow every I understand that. Yeah, but please, I
• 27:26
  Speaker 1: will be rude. I interrupted you when you're telling me
• 27:29
  Speaker 1: that in two months it did something that would have
• 27:31
  Speaker 1: required one hundred and sixty years of work, Like, what
• 27:34
  Speaker 1: do you exactly mean by that?
• 27:35
  Speaker 2: And now we it would probably be impossible in thousands
• 27:40
  Speaker 2: of years because what we do is we're looking for molecules,
• 27:44
  Speaker 2: a single molecule that can replace this cocktail. So you
• 27:47
  Speaker 2: need a molecule to do three or four activities in
• 27:50
  Speaker 2: the cell. Finding one activity is what pharmaceutical companies do.
• 27:53
  Speaker 2: It takes hundreds of millions, if not billions, to make
• 27:57
  Speaker 2: a drug. We know that, right, My little of twenty
• 28:01
  Speaker 2: people and students, young kids are trying to make one
• 28:06
  Speaker 2: drug do three or four different things. That's beyond the
• 28:10
  Speaker 2: reach of pharmaceutical experience at least five years ago. So
• 28:14
  Speaker 2: what we do is we've teamed up with a group
• 28:16
  Speaker 2: at Saint Jude's Hospital where they can take it was
• 28:19
  Speaker 2: ten billion, now it's a trillion theoretical and also drug
• 28:24
  Speaker 2: known drugs. With my hands, I'm showing a big funnel and.
• 28:29
  Speaker 1: These podcasts you're like helping out the audio people and everything.
• 28:33
  Speaker 2: I relaunched my podcast that that's wow, that's why Yeah,
• 28:36
  Speaker 2: lifespan David Sinclair shameless plug. So this funnel is full
• 28:42
  Speaker 2: of a trillion molecules and we have to come down
• 28:44
  Speaker 2: to one. How do we do that? Well, we don't
• 28:46
  Speaker 2: look for a trillion molecules at the bench. That would
• 28:48
  Speaker 2: take one hundred and sixty or thousands of years, with
• 28:51
  Speaker 2: the case of a trillion molecules, even with robots, even
• 28:54
  Speaker 2: with a lot of graduate students. So we do it
• 28:57
  Speaker 2: inside the computer. We just use a lot of compute
• 29:00
  Speaker 2: and we dock each of these molecules against the enzymes
• 29:04
  Speaker 2: that we now know how they work. Thanks to Google
• 29:07
  Speaker 2: Deep Mind solve the problem of how to all our
• 29:10
  Speaker 2: proteins look twenty thousand of them and there's a lot
• 29:13
  Speaker 2: of compute. But out the other end. A couple of
• 29:15
  Speaker 2: months later, we have two I don't have two hundred fingers,
• 29:18
  Speaker 2: but two hundred molecules that we can now test in
• 29:22
  Speaker 2: the lab within a few weeks. Actually, next week, we're
• 29:26
  Speaker 2: testing these two hundred against human cells. And we've also
• 29:30
  Speaker 2: got AI helping us to tell us if the human
• 29:32
  Speaker 2: cells go from ninety two years old back to twenty.
• 29:35
  Speaker 2: We can tell that just by looking at them thanks
• 29:38
  Speaker 2: to the AI.
• 29:38
  Speaker 1: Is there a way to stop them from turning you
• 29:40
  Speaker 1: into a baby, because that's what I would worry.
• 29:42
  Speaker 2: Yes, yes, I don't want to be a baby again. Right,
• 29:46
  Speaker 2: some people are right.
• 29:47
  Speaker 1: I'd like to cut it off at like I was
• 29:49
  Speaker 1: pretty good at twenty five.
• 29:50
  Speaker 2: You know that's I'm going to get attacked for saying this,
• 29:53
  Speaker 2: But that is what we do in the lab. We
• 29:55
  Speaker 2: take ninety two year old cells and they stop at
• 29:57
  Speaker 2: twenty something.
• 29:58
  Speaker 1: Why would you get attacked for the.
• 30:01
  Speaker 2: Because on the internet people take a clip and they
• 30:03
  Speaker 2: say Sinclair says, we can all go back to being
• 30:05
  Speaker 2: twenty again. You suffer from this too, right, They take
• 30:08
  Speaker 2: a clip and it's of course it's out of context. Yeah,
• 30:12
  Speaker 2: and I'm just saying cells from humans, skin cells, we
• 30:15
  Speaker 2: take them back to twenty five. All my students can
• 30:17
  Speaker 2: do this. In fact, if you had these little genes
• 30:19
  Speaker 2: OSK in your garage, you could do this experiment. It's
• 30:22
  Speaker 2: not hard at all to reverse aging. The question is
• 30:25
  Speaker 2: how do you safely make it a drug? And that's
• 30:27
  Speaker 2: been the hard part of the last ten years.
• 30:29
  Speaker 1: So how would it be able to regulate this reduction
• 30:36
  Speaker 1: or reversal of aging and stop it at twenty something
• 30:41
  Speaker 1: years old.
• 30:42
  Speaker 2: Well that's what took so long. It wasn't obvious that
• 30:45
  Speaker 2: these three Yemenarka genes called OSK were the right cocktail.
• 30:50
  Speaker 2: My student who I mentioned one chain, he was struggling.
• 30:53
  Speaker 2: He was trying a lot of different genes, most of
• 30:56
  Speaker 2: them from embryos. Because we know embryos have to do
• 30:59
  Speaker 2: a reset in the first week of life, otherwise they
• 31:01
  Speaker 2: stay the age of the parents. And he found that
• 31:07
  Speaker 2: leaving out one of the amenarca genes was the trick.
• 31:09
  Speaker 2: And now that we know it's super easy, but in
• 31:11
  Speaker 2: those days he was ready to quit.
• 31:13
  Speaker 1: How did he find that out?
• 31:15
  Speaker 2: Well, he tried lots of different combinations, hundreds in human cells.
• 31:18
  Speaker 2: And you look at the cells to see if they
• 31:19
  Speaker 2: get younger, and then we can measure mole likely that
• 31:22
  Speaker 2: they get younger.
• 31:22
  Speaker 1: Class And now are you measuring them by the length
• 31:24
  Speaker 1: of they're telomeres? Are you?
• 31:26
  Speaker 2: Partly? But actually a better measure is the chemicals that
• 31:31
  Speaker 2: are added and subtracted off DNA itself called methyls, and
• 31:35
  Speaker 2: it's just a carbon molecule with three hydrogens, very very
• 31:39
  Speaker 2: simple molecule. But what cells do is they use these
• 31:42
  Speaker 2: methyls to tag genes to be switched off. So when
• 31:46
  Speaker 2: we're growing as an embryo, the cells that want to
• 31:49
  Speaker 2: become neurons will shut off all these other unwanted genes
• 31:53
  Speaker 2: like liver genes and skin genes, and the ones that
• 31:56
  Speaker 2: don't get this methyl chemical stay on for our life.
• 31:59
  Speaker 2: And that's how cells develop and stay healthy. But what
• 32:02
  Speaker 2: happens during aging. A friend of mine, Steve Horvath, discovered
• 32:06
  Speaker 2: that you can use this as a clock. These chemicals
• 32:08
  Speaker 2: they change over time, and we found that that happens
• 32:12
  Speaker 2: largely due to DNA damage going in the sun. These
• 32:15
  Speaker 2: kind of things. We could use this to rapidly age
• 32:17
  Speaker 2: a mouse, which we published in twenty twenty three.
• 32:21
  Speaker 1: Oh so, like maybe like some nefarious state actor, like
• 32:24
  Speaker 1: some Russian spy could like inject something in your coffee
• 32:28
  Speaker 1: and you would turn ninety nine over nine.
• 32:30
  Speaker 2: We know how to do that.
• 32:31
  Speaker 1: Whoa, Yeah, that's the dark side of this. It could
• 32:35
  Speaker 1: you could spike your husband's drink, Fuck that dude and
• 32:38
  Speaker 1: turn them into an old man. Yeah you do.
• 32:42
  Speaker 2: Yeah. Someone tweeted the other day if a ninety two
• 32:46
  Speaker 2: year old could be twenty five again, would you have
• 32:48
  Speaker 2: sex with them?
• 32:51
  Speaker 1: Yeah? Yes, imagine how much they know.
• 32:53
  Speaker 2: But would they have sex with you?
• 32:54
  Speaker 1: Right, that's the better question. That's a question they'd be
• 32:57
  Speaker 1: looking for another twenty year old, right.
• 33:00
  Speaker 2: So anyway, how do we do it? We can measure
• 33:02
  Speaker 2: those chemicals and determine how old a cell is or
• 33:05
  Speaker 2: a human. I could take your skin cells from your
• 33:07
  Speaker 2: mouth or your blood.
• 33:08
  Speaker 1: I'll tell you how old people would be so disturbed by,
• 33:11
  Speaker 1: like old rich guys dating young women. If that was
• 33:15
  Speaker 1: the case.
• 33:16
  Speaker 2: You can tell if they looked young, because people.
• 33:18
  Speaker 1: Get very mad at that. Do you ever notice, Yeah, yeah,
• 33:22
  Speaker 1: you see someone real old, decrepit dude with a hot
• 33:24
  Speaker 1: young wife, and people are like, god, damn it. They
• 33:26
  Speaker 1: get really mad right right now.
• 33:29
  Speaker 2: The best way to do that is to have a
• 33:30
  Speaker 2: big bank account. But eventually you'll likely right. But people
• 33:33
  Speaker 2: still get grossed out. I wonder if they would get
• 33:35
  Speaker 2: grossed out if you look twenty, they'd be like, he's
• 33:38
  Speaker 2: praying he has so much more years of knowledge and information.
• 33:41
  Speaker 1: I'm not fair. If he looks twenty, that's a ninety
• 33:44
  Speaker 1: nine year old man.
• 33:46
  Speaker 2: That day will come. That day will come where you
• 33:48
  Speaker 2: will not be able to tell how old somebody is
• 33:50
  Speaker 2: by looking at them. You'll have to do a test
• 33:52
  Speaker 2: for these genes.
• 33:53
  Speaker 1: Wow. I wonder if people still lie about their age
• 33:55
  Speaker 1: if that's the case. I wonder if no one will care,
• 33:58
  Speaker 1: like you would probably lie the other way, Like I'm eighty,
• 34:03
  Speaker 1: it's right to tell everybody's eighty.
• 34:05
  Speaker 2: That's right. Well, when we live for hundreds of years,
• 34:08
  Speaker 2: people will do that, they'll be proud of their age.
• 34:10
  Speaker 1: Do you know anything about ancient civilizations and some of
• 34:15
  Speaker 1: the weirdness of the records of like ancient sumer.
• 34:20
  Speaker 2: Well only really what I've learned from listening to you.
• 34:23
  Speaker 1: Well, it's there's what's really weird is that ancient kings lists,
• 34:29
  Speaker 1: because so okay, the theory, the theory among these alternative
• 34:37
  Speaker 1: archaeologist types is that there was a very advanced civilization
• 34:41
  Speaker 1: that existed on Earth tens of thousands of years ago,
• 34:45
  Speaker 1: and we were probably wiped out by common impact, and
• 34:49
  Speaker 1: what we have today is a rebuild of civilization. There's
• 34:53
  Speaker 1: not a linear progression from caveman to us, and that
• 34:56
  Speaker 1: at one point in time we had reached great heights.
• 34:58
  Speaker 1: This explains the pyramids, this explains machipichu, soakssee waman. Some
• 35:04
  Speaker 1: megalithic structures that don't make any sense. These the trilithon
• 35:08
  Speaker 1: stones and balbec lemanon that are hundreds and hundreds of
• 35:12
  Speaker 1: tons that are massive, that are you know, nine meters
• 35:16
  Speaker 1: off the ground. No one understands exactly how they place them.
• 35:20
  Speaker 1: When you look at the Sumerian kings list, it gets
• 35:24
  Speaker 1: very weird because there's kings that reigned for thousands of years,
• 35:29
  Speaker 1: and then you have the flood, and then after the flood,
• 35:33
  Speaker 1: the age of these people drops pretty dramatically, and the
• 35:38
  Speaker 1: rains are after a few hundred years become normal, become
• 35:42
  Speaker 1: like a normal person, like fifty years, thirty years like that,
• 35:45
  Speaker 1: but thousands of years before and then people are looking
• 35:49
  Speaker 1: at it like, Okay, is this just myth? Is this
• 35:52
  Speaker 1: poor record keeping? Do they have just these you know,
• 35:55
  Speaker 1: hyperbolic elevated stories about these kings they were so amazing
• 36:00
  Speaker 1: they reigned for thirty thousand years? Or had they achieved
• 36:06
  Speaker 1: not just in building, because in building we know they'd
• 36:09
  Speaker 1: achieved incredibly complex structure like the pyramid for instance, Like
• 36:14
  Speaker 1: they had insane engineering somehow or another, the ability to
• 36:18
  Speaker 1: move these five hundred ton stones from hundreds of miles away,
• 36:22
  Speaker 1: Like how did they do this? We don't really know,
• 36:24
  Speaker 1: but we know that they did it. Did they also
• 36:29
  Speaker 1: have the kind of technology that you're talking about right now,
• 36:32
  Speaker 1: Because if it's possible today and if that is a
• 36:35
  Speaker 1: I mean, it makes it very difficult because it goes
• 36:38
  Speaker 1: against what you would call like the modern narrative that
• 36:43
  Speaker 1: they're teaching in universities in terms of the timeline of
• 36:45
  Speaker 1: human history. But if that changes and we have undeniable evidence, well,
• 36:50
  Speaker 1: it looks like these people were far more advanced than
• 36:52
  Speaker 1: we thought, and there probably was some sort of a
• 36:54
  Speaker 1: reset of civilization. What else had they accomplished and had
• 36:58
  Speaker 1: they gotten involved in genetic engineering, had they figured out
• 37:02
  Speaker 1: a way to extend lifespan? And if they did, imagine
• 37:06
  Speaker 1: all the work that you've accomplished in your your fifty
• 37:10
  Speaker 1: seven now about fifty fifty seven. You look great, by
• 37:13
  Speaker 1: the way, Hey, you really do. Look your hair. It's
• 37:15
  Speaker 1: so dark, it's incredible.
• 37:17
  Speaker 2: People speculate it's old, fake, but it's actually it's not.
• 37:19
  Speaker 2: But anyway, you're at the heavy birthday too.
• 37:22
  Speaker 1: It's coming, Thank you very much. Yeah, yeah, I don't
• 37:24
  Speaker 1: look as good as you, though, yes you do. It's different.
• 37:27
  Speaker 2: Physically, you're way better than me.
• 37:29
  Speaker 1: That's different. Though my face looks older, you look you
• 37:32
  Speaker 1: look very young for your age. You know why?
• 37:34
  Speaker 2: Why Because I've spent all my time in a lab
• 37:36
  Speaker 2: and I haven't gone outdoors for a while.
• 37:38
  Speaker 1: I'm sure that helps, that does all. But my point is,
• 37:41
  Speaker 1: imagine if you had five hundred years to do research,
• 37:48
  Speaker 1: not just fifty seven years. Imagine if you could continue
• 37:52
  Speaker 1: learning and growing and they did develop some sort of
• 37:56
  Speaker 1: a life extension technology where you could not just be,
• 38:00
  Speaker 1: but be healthier than you've ever been before and live
• 38:03
  Speaker 1: for a thousand years. You would get so much done.
• 38:06
  Speaker 1: I mean, the exponential increase in technological innovation that we
• 38:10
  Speaker 1: would have in this society would be absolutely mind blown.
• 38:14
  Speaker 2: Exactly, exactly exactly.
• 38:15
  Speaker 1: This is really might be point what these alternative history
• 38:19
  Speaker 1: people think that might be what had taken place tens
• 38:22
  Speaker 1: of thousands of years ago.
• 38:23
  Speaker 2: Yeah, well, I'm a havid scientist, so I'm not going
• 38:25
  Speaker 2: to say anything that isn't.
• 38:26
  Speaker 1: Of course that's for me. Yes, that's where I live.
• 38:30
  Speaker 2: That's why I shut out. But you did make some
• 38:33
  Speaker 2: really important points. One is that ancient civilizations will have
• 38:36
  Speaker 2: always been way more advanced than we think. Yeah, dinosaurs
• 38:39
  Speaker 2: a lot more real than we make them. Look. We
• 38:42
  Speaker 2: always get things wrong looking back in time and looking
• 38:45
  Speaker 2: forward in time. But the other thing that you said,
• 38:47
  Speaker 2: which is really important, is that if we do have
• 38:49
  Speaker 2: extension of human life span, like the Bible and these
• 38:51
  Speaker 2: civilizations suggest, then how will you think about your life?
• 38:57
  Speaker 2: If being one hundred is you know, you're still in
• 38:59
  Speaker 2: your prime, you do things very differently. Who would you marry,
• 39:04
  Speaker 2: what career would you think about? You might have multiple lifetimes,
• 39:08
  Speaker 2: multiple marriages, multiple families, and that will happen. It's not
• 39:12
  Speaker 2: really a question of if anymore. It's like asking the
• 39:15
  Speaker 2: right brothers. Will we fly? Yeah, we built the glider,
• 39:18
  Speaker 2: We're gonna fly around. The question is will we build
• 39:21
  Speaker 2: a concorde? Will we go to space? And I think
• 39:22
  Speaker 2: that will happen.
• 39:24
  Speaker 1: Yeah, No, I think so too. I think, well, certainly.
• 39:28
  Speaker 1: One thing that we know is that there's a giant
• 39:30
  Speaker 1: difference between people who are fifty seven years old today
• 39:33
  Speaker 1: versus fifty seven years old in the nineteen thirties. It's
• 39:37
  Speaker 1: just a giant difference, a giant difference in your physical ability,
• 39:40
  Speaker 1: your health.
• 39:41
  Speaker 2: We'd be old men.
• 39:42
  Speaker 1: Yeah, we would be old men. And what I mean
• 39:45
  Speaker 1: when I was a child, I thought of people, I'm
• 39:47
  Speaker 1: almost fifty nine. I'll be fifty nine in a week.
• 39:50
  Speaker 1: I used to think of a fifty nine year old
• 39:52
  Speaker 1: as being basically dead, like you're barely getting around. You know,
• 39:58
  Speaker 1: you're probably tired all the time. Looking to retire something, Yeah,
• 40:01
  Speaker 1: looking to retire, you got no energy. I'm filled with energy.
• 40:05
  Speaker 1: I'm constantly doing how old is he sixty? Oh? No, I
• 40:09
  Speaker 1: don't know if that's accurate. That's I bet that's accurate.
• 40:12
  Speaker 1: They had no fucking vitamins. Nobody knew what like what
• 40:16
  Speaker 1: the proper nutrients you should take where nobody knew what
• 40:19
  Speaker 1: was really important in terms of like resistance training and
• 40:23
  Speaker 1: sleep and red light therapy and all that chizz.
• 40:25
  Speaker 2: And they were doing all the bad stuff like heavy smoking, drinking.
• 40:28
  Speaker 1: Yep, not sleeping a lot, yep, not sleeping a lot
• 40:31
  Speaker 1: here and who pesticides and all kinds of terrible shit.
• 40:35
  Speaker 1: Sixty year old? What that guy's sixty? No way, come on,
• 40:40
  Speaker 1: shut up. That guy's fucking twenty eight years old. There's
• 40:44
  Speaker 1: no way that guy's sixty. Is that real?
• 40:47
  Speaker 2: I doubt it. I doubt it. How about that guy
• 40:49
  Speaker 2: that looks fifteen? He says, everyone thinks I'm eighteen? Like, yeah, sure,
• 40:53
  Speaker 2: what's up. There's a guy on Instagram which I occasionally visit,
• 40:57
  Speaker 2: and he obviously looks old like he looks Oh it's crazy,
• 41:02
  Speaker 2: And he says, people think I look eighteen, are you crazy?
• 41:05
  Speaker 1: Well, there's a lot of crazy people out there, there's
• 41:07
  Speaker 1: a lot. Well, that's body dysmorphia. You know, it must
• 41:10
  Speaker 1: be bodybuilders. They think they're tiny. A lot of people
• 41:13
  Speaker 1: are crazy, Yeah, a lot of people have a distorted
• 41:15
  Speaker 1: perception of what they look like.
• 41:17
  Speaker 2: Yeah, the plastic surgery industry is massive. It's just growing
• 41:20
  Speaker 2: and growing. You can see it on the street La especially.
• 41:25
  Speaker 2: But imagine a world where if I'm successful, you can
• 41:29
  Speaker 2: take a pill, your doctor could get it, or eventually
• 41:31
  Speaker 2: it's a cream on your face and you literally get younger.
• 41:35
  Speaker 2: We do this in mice already, the mice get younger.
• 41:38
  Speaker 2: Is it going to work in humans? I think it's
• 41:39
  Speaker 2: just a matter of time.
• 41:40
  Speaker 1: So in the mice experiments, what have you achieved?
• 41:45
  Speaker 2: Well, a lot, you know, I can reveal here some
• 41:50
  Speaker 2: of it for the first time. This pill that we
• 41:54
  Speaker 2: give them to drink, actually because they can't chew. The
• 41:57
  Speaker 2: mice within four weeks with this cocktail. It has three components,
• 42:00
  Speaker 2: which a top secret my lab has sworn to secrecy.
• 42:04
  Speaker 2: They after four weeks, we give it to them three
• 42:06
  Speaker 2: days a week Monday, Wednesday, Friday, weekends off. Within those
• 42:11
  Speaker 2: four weeks they get better physically mentally. Excuse me, they uh,
• 42:16
  Speaker 2: so we put them through tests. If he just in
• 42:18
  Speaker 2: a couple of days, Oh, no, three days a week
• 42:20
  Speaker 2: for a month.
• 42:21
  Speaker 1: Oh okay, he found this guy's this is the guy
• 42:23
  Speaker 1: he went viral last year. He's being fifty nine years old?
• 42:27
  Speaker 1: What how fucking it seems so bur real?
• 42:31
  Speaker 2: He looks thirty exactly.
• 42:33
  Speaker 1: He might have just amazing genetics. Well look at Joel Romero.
• 42:38
  Speaker 1: There there are people that are freaking Singapore.
• 42:41
  Speaker 2: Yeah.
• 42:41
  Speaker 1: Wow, twondo kwondo ten and he's sixty years old.
• 42:46
  Speaker 2: Yeah, he's been going without a face lifts.
• 42:48
  Speaker 1: Yeah, I don't know. It's he certainly doesn't look like
• 42:51
  Speaker 1: he's had a facelift. Yeah right, it's fucking incredible.
• 42:54
  Speaker 2: Yeah, but he's probably never been in the sun.
• 42:56
  Speaker 1: It could be a full AI account. It's trolling everyone.
• 43:00
  Speaker 1: I don't know that's possible too. Like, look at that
• 43:03
  Speaker 1: picture right there, Like that looks a little AI ish.
• 43:05
  Speaker 1: Go back to that one again. Keep your pants on, Jamie,
• 43:08
  Speaker 1: that relax That looks very AI, doesn't it. I'm just
• 43:13
  Speaker 1: it could be it is all his fifty ninth birthday.
• 43:17
  Speaker 1: His whole thing is that he's young for eight looks
• 43:19
  Speaker 1: half his age.
• 43:21
  Speaker 2: Wow, man, this will be normal, Gues.
• 43:24
  Speaker 1: It's just twenty twenty fourst It's not this has been
• 43:26
  Speaker 1: going on for a while. Okay, so this is pre AI.
• 43:29
  Speaker 1: If it's faked, then he would have been called out now, right,
• 43:32
  Speaker 1: So he might just be a genetic free which is interesting, right,
• 43:37
  Speaker 1: Like do you guys study the different like you know,
• 43:40
  Speaker 1: unfortunately certain people that have like like pale people for instance,
• 43:44
  Speaker 1: with thin skin, they age hardcore, they.
• 43:47
  Speaker 2: Go and there are those kids that get old in
• 43:49
  Speaker 2: the teens, right, the study that as well. Yeah, ye,
• 43:54
  Speaker 2: but yeah, we do study the genetics of aging.
• 43:56
  Speaker 1: That's the real application for it where people are going
• 43:59
  Speaker 1: to be excited about it, people that have that what.
• 44:01
  Speaker 2: Is it per Jerry Jerry exactly.
• 44:03
  Speaker 1: Yeah.
• 44:04
  Speaker 2: Yeah, And so we have mice that have this same
• 44:06
  Speaker 2: gene mutation and they get old really quickly, and we're
• 44:09
  Speaker 2: giving them the drink right now.
• 44:11
  Speaker 1: And so in the drink you give it to them
• 44:13
  Speaker 1: how often and for a month.
• 44:15
  Speaker 2: It's once a day, every other day, three days a
• 44:19
  Speaker 2: week for a month. And yeah, in normal old mice,
• 44:24
  Speaker 2: we see them fitter, stronger, better memory. They run around
• 44:27
  Speaker 2: the cave in just a month. It's amazing. We only
• 44:30
  Speaker 2: did a month because it was Christmas holiday season. We
• 44:33
  Speaker 2: didn't we didn't want to go for longer, but it worked.
• 44:36
  Speaker 2: In four weeks. I'm shocked. Even these genes require six
• 44:39
  Speaker 2: to eight weeks to work for revision, recovery of vision.
• 44:44
  Speaker 1: And so this this is working on a different pathway.
• 44:47
  Speaker 2: Well, here's the cool thing. We think it's working through
• 44:50
  Speaker 2: the same mechanism, the reboot, the reinstallation of software the drink.
• 44:56
  Speaker 2: Because there are genes called TETs. There are three of
• 44:59
  Speaker 2: them in the body, and they do something spoiler t
• 45:02
  Speaker 2: ET capital t T there's one, two, three, And these
• 45:05
  Speaker 2: are genes that make enzymes that remove these methyls off
• 45:09
  Speaker 2: the DNA, so they control the clock. And if we
• 45:14
  Speaker 2: get rid of those genes, our system doesn't work. We
• 45:18
  Speaker 2: cannot restore vision, and our pill doesn't work without removing
• 45:23
  Speaker 2: and altering those chemicals. So in other words, it's not
• 45:26
  Speaker 2: just because the chemicals make the cell healthier, it's actually
• 45:29
  Speaker 2: resetting this clock on the DNA. WHOA, And that was
• 45:34
  Speaker 2: the big deal, I said, why when my student told me.
• 45:37
  Speaker 2: And that's why I think it got the cover of
• 45:38
  Speaker 2: Nature magazine, which is we're actually looking at the clock
• 45:42
  Speaker 2: of life, and we've realized that this clock that goes around,
• 45:47
  Speaker 2: this biological clock, isn't just a clock. When you move
• 45:50
  Speaker 2: the hands of the clock. Time goes backwards for the body,
• 45:55
  Speaker 2: meaning the clock is aging and aging is the clock.
• 46:00
  Speaker 1: Wow, what is it? You don't really know in terms
• 46:04
  Speaker 1: of humans. But is there any indication that improves cognitive
• 46:09
  Speaker 1: function in mice?
• 46:10
  Speaker 2: Yes, I can say without a doubt that other labs
• 46:13
  Speaker 2: and ours have shown that when you reverse the age
• 46:16
  Speaker 2: of the brain in a mouse, it gets better at learning.
• 46:19
  Speaker 2: And we even have some hints and we're going to
• 46:22
  Speaker 2: publish this that lost memories come back. WHOA. So Alzheimer's
• 46:27
  Speaker 2: patients I believe still have memories, they just cannot access them,
• 46:31
  Speaker 2: and that one day we can reverse Alzheimer's disease by
• 46:34
  Speaker 2: making the brain young, and that using that approach, making
• 46:38
  Speaker 2: the whole body young, we can cure diseases that are
• 46:41
  Speaker 2: currently incurable. Holy shit, Well young people don't get Alzheimer's
• 46:47
  Speaker 2: Why because the body can tackle the problem. The young
• 46:51
  Speaker 2: body can heal itself. So my approach is make the
• 46:53
  Speaker 2: body young, it'll heal itself in every way.
• 46:57
  Speaker 1: Well do you have children three? Yeah. One of the
• 47:00
  Speaker 1: that's just phenomenal is watching them heal.
• 47:04
  Speaker 2: Yeah.
• 47:04
  Speaker 1: I'm like it is so uh, it's so wild. But
• 47:08
  Speaker 1: also you envy them so much because they get cut
• 47:12
  Speaker 1: and it's like two days later, like, where's your cut?
• 47:14
  Speaker 1: It's fucking gone, Like that's crazy. My daughter had a cutter.
• 47:18
  Speaker 1: She fell and knocked her head and she had this
• 47:21
  Speaker 1: like dark spot on her head like where she got injured.
• 47:24
  Speaker 1: It was like four or five days it was gone,
• 47:26
  Speaker 1: and I was like, that fucking thing would be with
• 47:28
  Speaker 1: me for four months.
• 47:29
  Speaker 2: Yeah. And the good thing is if we rub our
• 47:31
  Speaker 2: cocktail on the skin of the mice, they heal like
• 47:34
  Speaker 2: the young again.
• 47:35
  Speaker 1: Oh so that would be like a great application for
• 47:37
  Speaker 1: ladies who want the beauty treatment on the face, right,
• 47:40
  Speaker 1: because that was just.
• 47:41
  Speaker 2: Way waheaded whoa, yeah, yeah, And we're working on hair.
• 47:45
  Speaker 2: We can grow human hair on mice now. Really that
• 47:47
  Speaker 2: took a few years and now we can check if
• 47:49
  Speaker 2: we can regrow hair and make it dark again.
• 47:52
  Speaker 1: You can grow human hair on mice.
• 47:54
  Speaker 2: Yeah, I'm not alawd to. Actually did post it on
• 47:56
  Speaker 2: Instagram and the university said, get that down. It exists.
• 48:01
  Speaker 2: We grow it from stem cells, from human stem cells.
• 48:04
  Speaker 2: We make little bowls of hair. It takes a few months.
• 48:07
  Speaker 2: We open up the ball to make a flat piece
• 48:09
  Speaker 2: of skin, human skin, and we put that in the
• 48:12
  Speaker 2: back of a mouse that can accept human skin and
• 48:15
  Speaker 2: then you get black tufts of hair from humans.
• 48:17
  Speaker 1: Can you get any kind of hair? Like, could I
• 48:19
  Speaker 1: get an afro? I just want to get one to
• 48:20
  Speaker 1: piss people off. Oh, we'd love an afro, like a
• 48:23
  Speaker 1: Colin Kaepernick type, just a big crazy one.
• 48:26
  Speaker 2: Yeah. We can grow hair. We can do that. We
• 48:29
  Speaker 2: were on at a few leves that can grow this hair.
• 48:31
  Speaker 2: So I thought about doing that for a company, but
• 48:33
  Speaker 2: I think hair transplants would just be easier.
• 48:36
  Speaker 1: Oh right, so you would grow hair in a lab
• 48:38
  Speaker 1: and then transplant those hairs.
• 48:39
  Speaker 2: We can do that.
• 48:40
  Speaker 1: Yeah, Oh well that's the thing, because I got a
• 48:42
  Speaker 1: hair transplant. But the way I describe it is like
• 48:45
  Speaker 1: your take. It's like taking people that are really healthy
• 48:49
  Speaker 1: and moving them into a town where everyone's dying. Because
• 48:52
  Speaker 1: like you take taking hair from back here where it's
• 48:56
  Speaker 1: gonna stay, and you put it up here where it's
• 48:58
  Speaker 1: all falling out.
• 48:59
  Speaker 2: It didn't thrive. What's up It doesn't thrive if you
• 49:01
  Speaker 2: move it.
• 49:02
  Speaker 1: Oh, it thrives, but everybody else dies. You know. You
• 49:05
  Speaker 1: can only take so much from the back of your
• 49:07
  Speaker 1: head and move it to the top of your head.
• 49:09
  Speaker 1: That's why a lot of guys with hair transplants look
• 49:11
  Speaker 1: goofy because you have like this strong hairline in the
• 49:14
  Speaker 1: front and it goes back like that and then everything
• 49:17
  Speaker 1: else looks like chaos.
• 49:18
  Speaker 2: Oh that sucks. You know what I take from my hair?
• 49:20
  Speaker 1: What do you take?
• 49:21
  Speaker 2: Among other things? Uh? Viagra?
• 49:25
  Speaker 1: Viagra?
• 49:26
  Speaker 2: Yeah, actually I shouldn't say the brand name.
• 49:28
  Speaker 1: That's actually I take it.
• 49:30
  Speaker 2: That's what I tell everybody. That is true. It's low dose,
• 49:33
  Speaker 2: seven milligrams a day to delafill, and it's good for
• 49:37
  Speaker 2: a lot of things.
• 49:38
  Speaker 1: I know it's good for endurance. Yeah, yeah, because I
• 49:41
  Speaker 1: know athletes who take it for endurance, they probably take
• 49:45
  Speaker 1: it to fuck too. Let's not kid ourselves.
• 49:48
  Speaker 2: Well, it's a nice it's a nice benefit. When a
• 49:52
  Speaker 2: sign a paper just came out about its role in
• 49:55
  Speaker 2: preventing cancer, I tweeted what's not to love? People love
• 49:59
  Speaker 2: that tweet. But the point is, actually last week they
• 50:02
  Speaker 2: found that these drugs in mice and seemingly in people
• 50:07
  Speaker 2: who take these drugs are actually resistant to can certain
• 50:10
  Speaker 2: types of cancers like head and neck cancer. So interested
• 50:13
  Speaker 2: turning out.
• 50:14
  Speaker 1: To be really important. Blow well, two.
• 50:16
  Speaker 2: Reasons that are not related to blood flow, but they're
• 50:19
  Speaker 2: related to what's called nitric oxide signaling, which is what
• 50:22
  Speaker 2: helps dilate blood vessels in all your body, including your penis.
• 50:26
  Speaker 2: The other two mechanisms, one showed that to dalaphil is
• 50:30
  Speaker 2: good for exposing the tumor to the immune system. There
• 50:34
  Speaker 2: are certain cells are called mdsc's that protect the tumor
• 50:39
  Speaker 2: from getting attacked, and the drug stops that. So now
• 50:43
  Speaker 2: the tumors shrink in mice and seemingly in people in tumors.
• 50:48
  Speaker 2: And then the second mechanism is really interesting. It seems
• 50:51
  Speaker 2: too this was sidanaphil, So this is now viagra. Found
• 50:54
  Speaker 2: that the cancer is a lot of cancers thrive on cholesterol,
• 51:00
  Speaker 2: and this blocks the ability of cancer cells to use cholesterol.
• 51:03
  Speaker 1: I thought they thrived on glucose.
• 51:04
  Speaker 2: That too, exactly right. So you want to be in
• 51:07
  Speaker 2: katosis if you've got the tumor in general, so fasting
• 51:12
  Speaker 2: is good, but now it looks like these ed drugs
• 51:16
  Speaker 2: might be good for it as well.
• 51:18
  Speaker 1: Fascinating. And it wasn't I think viagra was a It
• 51:25
  Speaker 1: was an accident, right, wasn't Wasn't it a blood pressure medication?
• 51:28
  Speaker 2: It's a good story. It was for angina, Right was
• 51:30
  Speaker 2: for your heart. But the story goes that women especially
• 51:35
  Speaker 2: and the men didn't want to give up the drugs
• 51:37
  Speaker 2: that they had left over. It was amazing. It was
• 51:41
  Speaker 2: I think it was seventy five percent had a positive
• 51:43
  Speaker 2: reaction for erections and without it twenty two. So it's
• 51:47
  Speaker 2: it's very clear that it was working.
• 51:50
  Speaker 1: Interesting and so so how does it help hair?
• 51:55
  Speaker 2: Well, we don't know for sure, but there's a lot
• 51:57
  Speaker 2: of evidence that part of the reason hair dies out
• 52:00
  Speaker 2: and stops growing is lack of blood flow, and the
• 52:03
  Speaker 2: monoxidol that people put on their hair helps with.
• 52:05
  Speaker 1: That, right. Interesting, and then DHT inhibitors exactly.
• 52:11
  Speaker 2: Also, i'd be do test ride people can take orally.
• 52:15
  Speaker 1: The problem with that is my friend had severe depression
• 52:18
  Speaker 1: when he took that. Yeah, it really fucked him up,
• 52:22
  Speaker 1: and he didn't realize because he didn't understand that that
• 52:25
  Speaker 1: was He was like, what is wrong with me? And
• 52:27
  Speaker 1: he was getting suicidal and then he got off of
• 52:30
  Speaker 1: it and it just went away. And he's like, oh
• 52:31
  Speaker 1: my god, I can't believe that this episode is sponsored
• 52:34
  Speaker 1: by Better Help. You've probably heard about Better Help before,
• 52:38
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• 53:20
  Speaker 2: Yeah, well, I'm taking it for a number of reasons,
• 53:25
  Speaker 2: including my hair and my prostate. See if I can
• 53:28
  Speaker 2: keep it from growing. But unfortunately I haven't had that
• 53:31
  Speaker 2: side effect.
• 53:32
  Speaker 1: But everything depends, right, It varies biologically depending on the person.
• 53:35
  Speaker 2: Yeah, it's important when either of us says that drug's
• 53:38
  Speaker 2: good that drug's bad, right, people realize that you have
• 53:41
  Speaker 2: to test it, see and with doctors supervision.
• 53:44
  Speaker 1: Yeah, that was where I was going to get to.
• 53:46
  Speaker 1: Was like, because different medications have different reactions or different
• 53:50
  Speaker 1: people's reactions to medications, they vary quite wildly, so like
• 53:54
  Speaker 1: before you make this public. I mean, like, how do
• 53:59
  Speaker 1: you determin whether or not this is going to be
• 54:02
  Speaker 1: safe for a wide variety of people to reverse aging?
• 54:06
  Speaker 2: Oh, my drug, our drug that we're making, Well, we
• 54:10
  Speaker 2: will test it on a lot of people before it
• 54:13
  Speaker 2: goes out into the wide world.
• 54:15
  Speaker 1: And you've started testing it on people so far.
• 54:17
  Speaker 2: Yeah, there are people right now who have this these
• 54:20
  Speaker 2: genes in their eye.
• 54:21
  Speaker 1: And how's it going.
• 54:23
  Speaker 2: I'm not allowed to say.
• 54:24
  Speaker 1: But can you wink twice? If it's great?
• 54:27
  Speaker 2: Um, I would say that everything's on target. Okay, it's
• 54:33
  Speaker 2: good to hear. Nothing bad to report, nothing bad to report.
• 54:36
  Speaker 2: I think those might be the words I'm allowed to say.
• 54:38
  Speaker 1: And is that the only clinical trials you've used with
• 54:40
  Speaker 1: any of these applications for humans so far?
• 54:43
  Speaker 2: That was the first glaucoma And also sudden blindness it's
• 54:47
  Speaker 2: called nyon, which is now twice as more prevalent because
• 54:51
  Speaker 2: of the JLP one drugs. Really, it's not well known obviously,
• 54:56
  Speaker 2: companies don't want to talk about it, but yes, blindness
• 55:00
  Speaker 2: has doubled seemingly because of these meds.
• 55:03
  Speaker 1: You have to Holy shit, sudden blindness has doubled because
• 55:08
  Speaker 1: of GLP one's.
• 55:09
  Speaker 2: Do you deny on? Which is like a stroke in
• 55:11
  Speaker 2: your eye and then your other eye can go, which
• 55:14
  Speaker 2: is pretty scary and there's nothing you can do about it. Hopefully,
• 55:17
  Speaker 2: How drug does work for those people?
• 55:20
  Speaker 1: And I'll well, obviously correlation does not equal causation, but
• 55:25
  Speaker 1: it seems to be.
• 55:27
  Speaker 2: Yeah, there's a scientist at Harvard, you could look up
• 55:30
  Speaker 2: his work, Joe Rizzeau. It looks like it's repeatable across
• 55:34
  Speaker 2: the planet.
• 55:35
  Speaker 1: Wow, that's terrible because there's so many people out there
• 55:38
  Speaker 1: that are just telling everyone they should get on GLP ones.
• 55:41
  Speaker 2: Yeah, I've we've.
• 55:42
  Speaker 1: Seen that, like by online people, like online podcasters saying
• 55:47
  Speaker 1: everyone should get on GLP one's. It's a groundbreaking technology.
• 55:50
  Speaker 1: This is amazing, it's going to transform society. I'm like,
• 55:54
  Speaker 1: we just started taking these. The fuck are you saying?
• 55:58
  Speaker 2: Yeah, it's not risk free? Same with eight D drugs.
• 56:00
  Speaker 1: Here goes. Recent studies suggests that a potential rare link
• 56:04
  Speaker 1: between GLP one receptor agonist medication such as zempeg, wagovi
• 56:09
  Speaker 1: blah blah blah, and a condition called non artytic anterior
• 56:15
  Speaker 1: what's that word, ischemic ischemic optic neuropathy an eye stroke
• 56:21
  Speaker 1: can cause sudden, painless loss of vision in one eye.
• 56:24
  Speaker 1: Why absolute risk remains very low. Anyone experienced sudden vision change,
• 56:28
  Speaker 1: you should seek emergency metal medical evaluation immediately. Well, very
• 56:32
  Speaker 1: low is like, it's still what does that mean?
• 56:35
  Speaker 2: People?
• 56:36
  Speaker 1: One in ten thousand? Yeah, yeah, that's a total of
• 56:39
  Speaker 1: ten thousand, oh total of ten thousand so far for
• 56:42
  Speaker 1: how much you were taking this. I think it's pretty
• 56:45
  Speaker 1: The drugs were sixty eight point six times more likely
• 56:50
  Speaker 1: to develop this and eight times more likely to develop
• 56:53
  Speaker 1: diabetic What is that we only got the blurb? Oh
• 57:01
  Speaker 1: my god? Then wow? Yeah, man, these things are just
• 57:09
  Speaker 1: they're just rolling out and the people that are like
• 57:12
  Speaker 1: super enthusiastic, and also they have some sort of a
• 57:16
  Speaker 1: financial interest in promoting these things, which oftentimes does seem
• 57:19
  Speaker 1: to be the case with a lot of these people.
• 57:21
  Speaker 1: They have either stock in these companies or some sort
• 57:24
  Speaker 1: of a stake in them. Uh.
• 57:26
  Speaker 2: Yeah, it's true, though, I will I will say to
• 57:28
  Speaker 2: counter that that JLP one drugs have probably saved millions
• 57:31
  Speaker 2: of lives already, and they're pretty common. At least ten
• 57:33
  Speaker 2: percent of people are trying them in twenty five percent
• 57:36
  Speaker 2: one to two.
• 57:36
  Speaker 1: Yeah, I mean they don't work for everybody. I have
• 57:38
  Speaker 1: a good friend of mine that had a terrible reaction
• 57:40
  Speaker 1: from it and he was hospitalized. But I know other
• 57:44
  Speaker 1: people where it's completely transformed their life and they've lost
• 57:47
  Speaker 1: a ton of weight, and particularly people that just for
• 57:50
  Speaker 1: whatever reason, the food addiction was so incredibly strong that
• 57:54
  Speaker 1: whatever their constitution, the way they're the way they're designed,
• 57:58
  Speaker 1: the way they're built, the way they've as a human being,
• 58:01
  Speaker 1: they weren't capable of overcoming it. They take the GLP
• 58:04
  Speaker 1: ones and then they sort of start getting moving and
• 58:08
  Speaker 1: then they lose all the weight, they start feeling better,
• 58:10
  Speaker 1: they start making a lot of other positive changes. You
• 58:13
  Speaker 1: get that momentum, which I always talk about, is which
• 58:15
  Speaker 1: is one of the most important things for transforming your life.
• 58:18
  Speaker 1: Everyone wants to talk about discipline. I think discipline is
• 58:21
  Speaker 1: the primary, that's the main engine, but one of the
• 58:25
  Speaker 1: things that comes along with any kind of an exercise
• 58:28
  Speaker 1: program or changing your life program where you start getting
• 58:31
  Speaker 1: positive results is momentum. And momentum is absolutely huge, thank you,
• 58:35
  Speaker 1: because then you start feeling that's so important, this is good.
• 58:37
  Speaker 1: So I think golp ones are fantastic for getting people going.
• 58:41
  Speaker 2: Yes, everybody should hear this. It's really important. I'll give
• 58:45
  Speaker 2: you my example. It's a classic case. I couldn't fast
• 58:49
  Speaker 2: for more than about a day. I want to do more.
• 58:53
  Speaker 2: I know that three days fasting is good, A week
• 58:54
  Speaker 2: can be even better, but I couldn't do it. I
• 58:57
  Speaker 2: don't have a lot of willpower when it comes to
• 58:58
  Speaker 2: this kind of stuff. I tried a jolpy one receptor agonist.
• 59:03
  Speaker 2: I gave it and it was easy. I didn't even
• 59:05
  Speaker 2: feel like I needed to snack at night, which is
• 59:07
  Speaker 2: one of the things that I and many people suffer from.
• 59:09
  Speaker 2: But the fact that I could do it, I went
• 59:12
  Speaker 2: off the drug. I didn't need it. But now I
• 59:15
  Speaker 2: can fast for I went for two weeks in a
• 59:18
  Speaker 2: couple of months ago. Well it's easy now now that
• 59:21
  Speaker 2: I know that I can do it. Mentally, it's not
• 59:23
  Speaker 2: hard at all. The momentum exactly, I know what's possible.
• 59:27
  Speaker 1: Yeah, Yeah, that's fascinating. You are you still on a
• 59:33
  Speaker 1: plant based diet?
• 59:34
  Speaker 2: Mostly?
• 59:35
  Speaker 1: Yeah, what I had. I just had a conversation with
• 59:39
  Speaker 1: a friend of mine about this. I don't know how
• 59:41
  Speaker 1: much of the information that he was telling me it
• 59:42
  Speaker 1: was totally accurate, but what he was saying was that
• 59:46
  Speaker 1: he was told before he did fasting that one of
• 59:50
  Speaker 1: the best because he's a runner. He said, one of
• 59:53
  Speaker 1: the best ways to get into fasting is to get
• 59:57
  Speaker 1: your body into kittosis first, he said. And what he
• 1:00:01
  Speaker 1: thinks is that a carnivore based diet and what he
• 1:00:04
  Speaker 1: was told was a good way. If you could do
• 1:00:06
  Speaker 1: that for a few weeks, it mitigates your appetite. Like
• 1:00:09
  Speaker 1: one of the things that happens with a lot of
• 1:00:11
  Speaker 1: these diets that regulate insolent resistance is that when you
• 1:00:17
  Speaker 1: get used to consuming just fats and protein, you don't
• 1:00:21
  Speaker 1: have the kind of hunger pangs that you have with carbohydrates.
• 1:00:25
  Speaker 1: Like when I if I go in a bad streak
• 1:00:27
  Speaker 1: and I'm eating pizza and pasta, and I've done that
• 1:00:31
  Speaker 1: in the past, I don't really do that much in
• 1:00:33
  Speaker 1: a less I'm on vacation. In the past, though, what
• 1:00:37
  Speaker 1: I would get hungry, I would get crazy hungry, like
• 1:00:40
  Speaker 1: I've got to eat. Now, I don't get that at
• 1:00:43
  Speaker 1: all anymore because I'm mostly on a carnivore based diet.
• 1:00:46
  Speaker 1: Mostly what I eat the like you look the bulk
• 1:00:49
  Speaker 1: of my diet, it's meat and fermented vegetables, it's meat
• 1:00:53
  Speaker 1: and like kimchi and sauer kraut and stuff along those lines.
• 1:00:57
  Speaker 1: And when I eat like that, my hunger is very
• 1:01:00
  Speaker 1: easy to control. And I've gone twenty four hours like
• 1:01:04
  Speaker 1: it's nothing, not eating, it's like not a problem at all.
• 1:01:07
  Speaker 1: But that's the most I've ever fasted. It's twenty four hours.
• 1:01:09
  Speaker 2: Okay, well see if you can go for three, it's
• 1:01:12
  Speaker 2: really worth it. You feel really great, Katosa's.
• 1:01:15
  Speaker 1: Well that's what everybody says. Yeah.
• 1:01:16
  Speaker 2: Yeah, And you go into what's called deep cleansing. It's
• 1:01:19
  Speaker 2: called chaperone mediated ortopogy or CMA, and a friend of
• 1:01:23
  Speaker 2: mine in New York, Maria Corvo, studies this and it
• 1:01:27
  Speaker 2: cleans out a lot of the old proteins in your body.
• 1:01:30
  Speaker 2: So katosis doesn't just make you feel good, You're actually
• 1:01:33
  Speaker 2: renewing your protein in your body and rebuilding it. And
• 1:01:36
  Speaker 2: so I do that as a as an anti aging thing.
• 1:01:38
  Speaker 1: Is what I find is the biggest benefit is mental acuity.
• 1:01:43
  Speaker 1: It's a giant It has a giant impact when I
• 1:01:45
  Speaker 1: stick to the diet in terms of my ability to
• 1:01:49
  Speaker 1: form sentences, like recall information and just be present in podcasts.
• 1:01:55
  Speaker 2: Yeah, so in my podcast, what you do is really
• 1:01:59
  Speaker 2: quite difficult. You make it look easy. So when I'm
• 1:02:02
  Speaker 2: when I'm doing my podcast, and often it's solo, so
• 1:02:05
  Speaker 2: it's challenging. I forget things. I have to remember hundreds
• 1:02:08
  Speaker 2: of papers for these things. They quite hard. Either I'm
• 1:02:11
  Speaker 2: gonna fast and if I don't remember to fast, I
• 1:02:14
  Speaker 2: didn't experiment. I took some keytones. You can drink these things, right,
• 1:02:18
  Speaker 2: So yeah, there's the one, the little drink I think.
• 1:02:20
  Speaker 1: With fantastic stuff.
• 1:02:23
  Speaker 2: Yeah, yeah, I use that.
• 1:02:24
  Speaker 1: I love that stuff. I do that. I take that
• 1:02:25
  Speaker 1: before I do UFC broadcasts a lot of the time. Yeah, yeah,
• 1:02:29
  Speaker 1: I actually took some before because one that's great before
• 1:02:32
  Speaker 1: podcasts as well. Well. The one and one of more
• 1:02:34
  Speaker 1: difficult things that I do is the UFC commentary because
• 1:02:37
  Speaker 1: it's six hours, six hours of talking on air live yeah,
• 1:02:42
  Speaker 1: and about fights, and I'm also recalling fights and I'm
• 1:02:45
  Speaker 1: also I'm seeing positions, so I have to remember in
• 1:02:48
  Speaker 1: my mind how this is finished, because like in jiu jitsu,
• 1:02:52
  Speaker 1: there might be I don't know how many positions there are,
• 1:02:54
  Speaker 1: there thousands, and there's moves where I'm like, what is
• 1:02:57
  Speaker 1: he doing? What's he doing? Oh? Oh, that's that that's
• 1:02:59
  Speaker 1: the prova. Next. Hi, I'm looking at his arms like
• 1:03:02
  Speaker 1: your brain is. I am exhausted at the end of
• 1:03:05
  Speaker 1: six hours and fucking starving, Like after the UFC is over,
• 1:03:09
  Speaker 1: I can eat so much food. It's I'm so hungry.
• 1:03:12
  Speaker 1: But you take a little drink or take a little keytone,
• 1:03:14
  Speaker 1: little keytone IQ. I take nootropics. I drink this stuff.
• 1:03:18
  Speaker 1: My friend Derek makes this his Gorilla mind. It says
• 1:03:22
  Speaker 1: a nootropicotropic cocktail with caffeineuf's really good for a podcast.
• 1:03:29
  Speaker 1: I also take alpha brain. Alpha Brain Black labels phenomenal
• 1:03:33
  Speaker 1: for that. There's a bunch of different ones that I take.
• 1:03:36
  Speaker 1: The gum neurogum neurogum is excellent for that too. But
• 1:03:39
  Speaker 1: I just do fucking everything I can to maximize.
• 1:03:42
  Speaker 2: That's how you do it, all right. Yes, secret is
• 1:03:44
  Speaker 2: now out, all right, But what you do is amazing.
• 1:03:46
  Speaker 2: And I thought you were on mendafanol or something. No.
• 1:03:49
  Speaker 1: I've taken that before in the past. But the problem
• 1:03:52
  Speaker 1: with that stuff is I think I like it too
• 1:03:55
  Speaker 1: much and I want to take it all the time.
• 1:03:57
  Speaker 1: You know, when I used to take that, if I
• 1:03:58
  Speaker 1: had a gig in San Diego and I drive home
• 1:04:02
  Speaker 1: after the gig, and it was like, you know, one
• 1:04:04
  Speaker 1: o'clock in the morning when I'm done, and then I'm like, ah,
• 1:04:07
  Speaker 1: I'll just go home. It's only two and a half hours.
• 1:04:09
  Speaker 1: And I start making the drive and you just get
• 1:04:12
  Speaker 1: so tired. But if I take new Vigil or Provigil
• 1:04:16
  Speaker 1: before I do that, I would be able to drive
• 1:04:17
  Speaker 1: no problem.
• 1:04:18
  Speaker 2: Put can you sleep after that? Dome?
• 1:04:21
  Speaker 1: Oh yeah, yeah. It doesn't seem to affect your ability
• 1:04:24
  Speaker 1: to sleep, which is really interesting. It's not like caffeine.
• 1:04:27
  Speaker 1: Do you do it? Do you take it at all?
• 1:04:29
  Speaker 2: Arm adafinil for tulks when I'm traveling?
• 1:04:32
  Speaker 1: Does it help you?
• 1:04:34
  Speaker 2: Definitely? Like in what way it gets rid of my
• 1:04:38
  Speaker 2: jet lag? And I can focus. My brain often is
• 1:04:42
  Speaker 2: either scattered or filled with facts that I pauses me
• 1:04:45
  Speaker 2: like now to not be able to talk properly. But
• 1:04:47
  Speaker 2: if I'm on it, in which I'm not, I'm on
• 1:04:50
  Speaker 2: point every time.
• 1:04:52
  Speaker 1: For me, the best thing for jet lag is exercise.
• 1:04:55
  Speaker 1: There's something about rigorous exercise. It doesn't even have to
• 1:04:59
  Speaker 1: be long, it just has to be where my heart
• 1:05:02
  Speaker 1: break gets really elevated, like above one hundred and fifty
• 1:05:05
  Speaker 1: bats per minute for fifteen twenty minutes, Like I have
• 1:05:08
  Speaker 1: to really go hard where I'm sweaty and breathing heavy,
• 1:05:13
  Speaker 1: you know, especially if like jacket up to like one
• 1:05:15
  Speaker 1: eighty one ninety like I'm doing like Tabata sprints on
• 1:05:17
  Speaker 1: an air dine bike. That kind of stuff completely resets me. Yeah,
• 1:05:21
  Speaker 1: hard kettlebell workouts like I'll do like a hard series
• 1:05:25
  Speaker 1: where a minimum amount of rest in between, So I'm
• 1:05:27
  Speaker 1: really pushing it. Once I relax, I'm back, It's like
• 1:05:31
  Speaker 1: it whatever it is where your body just needs to
• 1:05:34
  Speaker 1: like shake it up and like get all of it
• 1:05:36
  Speaker 1: out of your system. It's like now I feel completely normal.
• 1:05:39
  Speaker 2: Yeah, well you might remember last time we talked about hormesis. Yeah,
• 1:05:43
  Speaker 2: what doesn't kill you makes you stronger, And that's what
• 1:05:45
  Speaker 2: you're doing. You're putting your body into survival mode. So
• 1:05:48
  Speaker 2: one of the reasons I mostly plants, why I take
• 1:05:52
  Speaker 2: and a man and these other molecules, is to mimic
• 1:05:55
  Speaker 2: that I don't work out like you do. I should,
• 1:05:58
  Speaker 2: but I don't and don't you.
• 1:06:01
  Speaker 1: Uh.
• 1:06:01
  Speaker 2: I think partly because I tell myself I'm too busy,
• 1:06:06
  Speaker 2: which is bullshit. Uh. I need I need a partner
• 1:06:11
  Speaker 2: who will motivate me. I think that would help.
• 1:06:13
  Speaker 1: Maybe just get a trainer.
• 1:06:15
  Speaker 2: That's that's a solution.
• 1:06:16
  Speaker 1: You get some chadder, get a trainer.
• 1:06:19
  Speaker 2: I got some chad. Is that my money?
• 1:06:20
  Speaker 1: Yeah?
• 1:06:21
  Speaker 2: No, I can definitely fold one. Uh yeah, you know
• 1:06:24
  Speaker 2: it's on me. I actually I will own that that
• 1:06:27
  Speaker 2: I get it.
• 1:06:28
  Speaker 1: I just was explaining this to my friend last night.
• 1:06:30
  Speaker 1: It was like, I gotta start working. I'm like, just
• 1:06:31
  Speaker 1: get a trainer. Get a trainer, someone who's good, and
• 1:06:34
  Speaker 1: that way, they'll develop a program for you. All you
• 1:06:37
  Speaker 1: have to do is just show up and do what
• 1:06:39
  Speaker 1: they tell you to do. Just do it and it's mindless.
• 1:06:42
  Speaker 1: You could just like just go through what they tell
• 1:06:44
  Speaker 1: you to do and you'll just trust the process. You'll
• 1:06:48
  Speaker 1: improve radically.
• 1:06:49
  Speaker 2: All right, all right, here, here's what we're gonna do. Okay,
• 1:06:52
  Speaker 2: I'm gonna take years.
• 1:06:54
  Speaker 1: What we're gonna do. You're gonna get me a jug
• 1:06:55
  Speaker 1: of that fucking.
• 1:06:56
  Speaker 2: Juice will swamp, all right, and you'll be my train.
• 1:07:00
  Speaker 1: I'll be a well I will. I've done that before
• 1:07:03
  Speaker 1: with my comedian friends.
• 1:07:05
  Speaker 2: Really sure.
• 1:07:06
  Speaker 1: Yeah, I'll do it the right way where I take
• 1:07:09
  Speaker 1: them through it very easy. I don't have them worked
• 1:07:12
  Speaker 1: out hard at all, especially in the beginning, everything is
• 1:07:15
  Speaker 1: like nice and easy. It's like a little bit of strained.
• 1:07:18
  Speaker 1: You're not gonna be exhausted afterwards, and we build you up.
• 1:07:22
  Speaker 1: I'm a bil' I'm a firm believer and not over
• 1:07:26
  Speaker 1: taxing the system on people that are sedentary. I really
• 1:07:29
  Speaker 1: think it's a slow, gradual process. I think you have
• 1:07:32
  Speaker 1: to get better the same way you got sick over time. Okay,
• 1:07:36
  Speaker 1: you to make radical changes in a short period of time,
• 1:07:38
  Speaker 1: don't get me wrong. And even just a little bit
• 1:07:41
  Speaker 1: of you know, moderately rigorous exercise a few days a week, well,
• 1:07:47
  Speaker 1: a few days a week will give you great improvements.
• 1:07:49
  Speaker 1: But I'm not one of those guys. Is like, you know,
• 1:07:52
  Speaker 1: we're gonna do two hours today and you're gonna go
• 1:07:54
  Speaker 1: to failure and you're gonna be throwing up in a
• 1:07:56
  Speaker 1: garbage pan. You're not gonna do that again the next day.
• 1:07:58
  Speaker 1: I want you to do it again the next time.
• 1:08:00
  Speaker 1: I want you to have a nice workout where you
• 1:08:03
  Speaker 1: know you're doing like ten push ups and ten sit
• 1:08:06
  Speaker 1: ups and ten body weight squads, and then we're gonna
• 1:08:08
  Speaker 1: do some of these kettlebell cleans and kettlebell and nothing hard,
• 1:08:12
  Speaker 1: like everything's gonna be like, oh, okay, you put it down,
• 1:08:15
  Speaker 1: You're fine, and I want you to leave rejuvenated, like
• 1:08:18
  Speaker 1: you feel like, oh that was like exhilarating, nothing crazy,
• 1:08:22
  Speaker 1: and then we'll slowly start to add a little bit
• 1:08:24
  Speaker 1: over time. That's what I think the right thing to
• 1:08:27
  Speaker 1: do With people who don't work out all the time.
• 1:08:29
  Speaker 1: You can't just jump in and you know, it's like
• 1:08:32
  Speaker 1: worsting and skipping meals.
• 1:08:34
  Speaker 2: You just can't do a day or three without practicing.
• 1:08:36
  Speaker 1: Well. It's also you're gonna get injured. And this is
• 1:08:39
  Speaker 1: one of the main things that happens to people that
• 1:08:41
  Speaker 1: dive right into the deep end of the pool when
• 1:08:42
  Speaker 1: they start working out, is they get hurt, they get
• 1:08:44
  Speaker 1: muscle polls, they get back aches, they got all these
• 1:08:47
  Speaker 1: different things that happen because I think you just pushed
• 1:08:49
  Speaker 1: your body too quickly. You know, it's like you're in
• 1:08:52
  Speaker 1: boot camp, Like, well, you don't have to be in
• 1:08:54
  Speaker 1: boot camp. This is not the way to do it.
• 1:08:56
  Speaker 1: The way to do it is like slowly build up
• 1:08:59
  Speaker 1: and trust the process. Slowly start by. If you're overweight,
• 1:09:03
  Speaker 1: like my friend Jelly Roll, he lost two hundred and
• 1:09:05
  Speaker 1: fifty pounds, what did he do? Started walking? Just start walking,
• 1:09:09
  Speaker 1: walking around the neighborhood, walk around the block, walk upstairs,
• 1:09:12
  Speaker 1: just slowly, and then change the diet and then add
• 1:09:15
  Speaker 1: some stuff and next thing you know, you're doing this
• 1:09:18
  Speaker 1: and write it all down to that's the other thing.
• 1:09:20
  Speaker 1: Write down what you're gonna do, and write down how
• 1:09:23
  Speaker 1: you feel, and then keep doing that. And if you
• 1:09:25
  Speaker 1: could do that all the time, you'll start developing this
• 1:09:27
  Speaker 1: like momentum that we were talking about, right, Like, Okay,
• 1:09:30
  Speaker 1: I'm on the course, I'm on a process. But it
• 1:09:33
  Speaker 1: doesn't have to be like you you're exhausted and then
• 1:09:35
  Speaker 1: you go to the lab and you're like, I can't
• 1:09:37
  Speaker 1: even fucking concentrate. You know, I was doing tabata sprints
• 1:09:41
  Speaker 1: on the airdime machine Like this is crazy.
• 1:09:43
  Speaker 2: Well that's it's really good advice, and I'm going to
• 1:09:46
  Speaker 2: take you up on it. So let's say I'm lucky
• 1:09:48
  Speaker 2: enough to come on the show again. Yeah, I'll wear
• 1:09:50
  Speaker 2: a tight T shirt.
• 1:09:51
  Speaker 1: Let's go.
• 1:09:52
  Speaker 2: Right, So twenty million people have to.
• 1:09:54
  Speaker 1: Get on the fucking goofy plant based diet.
• 1:09:57
  Speaker 2: Well, start speak about that, because that's one of the
• 1:09:59
  Speaker 2: things disagree on. I'm on a plant based diet because
• 1:10:03
  Speaker 2: I've seen a lot of work on animals, at least
• 1:10:06
  Speaker 2: that plants promote longevity. I eat a lot of protein.
• 1:10:10
  Speaker 1: It's interesting because you're not an animal. You know that right.
• 1:10:12
  Speaker 1: I'm not a mouse. I'm definitely an animal. Human. Meat
• 1:10:17
  Speaker 1: is the most nutrient dense food it is, it's available.
• 1:10:20
  Speaker 2: I love meat.
• 1:10:21
  Speaker 1: I love me.
• 1:10:24
  Speaker 2: I believe that there are there are two states that
• 1:10:26
  Speaker 2: we can be in. I should try meat, and then
• 1:10:31
  Speaker 2: you can see because I've been measuring myself with rings
• 1:10:35
  Speaker 2: and blood tests for the last twenty years.
• 1:10:37
  Speaker 1: You should try elk. I'll get you an elk steak.
• 1:10:40
  Speaker 2: I'd love to try it. Sounds fair. I'm not against me.
• 1:10:42
  Speaker 2: I will eat it and you'll be like whoa, yeah,
• 1:10:45
  Speaker 2: don't get me addicted to me.
• 1:10:46
  Speaker 1: I feel it right away, like oh, you're sitting out
• 1:10:50
  Speaker 1: to start firing. Your body starts like yes, this is
• 1:10:53
  Speaker 1: what we wanted to David.
• 1:10:55
  Speaker 2: Well, here's some science, which is what I do. There
• 1:10:59
  Speaker 2: are two states, this is my theory. There's the abundance mode,
• 1:11:03
  Speaker 2: which is very good for health. You'll build muscle, you'll
• 1:11:05
  Speaker 2: heal better. That's meat kill a mammoth. There's adversity mode,
• 1:11:11
  Speaker 2: which is we're out of meat. We got to eat
• 1:11:13
  Speaker 2: roots and berries. That's adversity. We've got to run, running, exercise,
• 1:11:18
  Speaker 2: eating less, that's adversity. Both are good for you. This
• 1:11:22
  Speaker 2: one is pro survival. This one is pro growth. This
• 1:11:25
  Speaker 2: one is longevity. This one is you're going to be
• 1:11:28
  Speaker 2: stronger fitting.
• 1:11:29
  Speaker 1: How do you determine that though, in terms of like
• 1:11:31
  Speaker 1: what is longevity versus what is just like health and vitality.
• 1:11:35
  Speaker 2: Currently, Well, it's based on the last thirty years of
• 1:11:38
  Speaker 2: research in a variety of animals.
• 1:11:40
  Speaker 1: And she just doesn't have to do with the blue zones,
• 1:11:42
  Speaker 1: does it?
• 1:11:43
  Speaker 2: Nor I read that recently.
• 1:11:47
  Speaker 1: Yeah, isn't that nuts a fraud?
• 1:11:51
  Speaker 2: Well, records are hard.
• 1:11:53
  Speaker 1: Well, it's not just hard. A lot of it is
• 1:11:55
  Speaker 1: actual fraud where people are getting checks for their grandpa
• 1:11:58
  Speaker 1: and grandpa was dead, so they weren't writing it into
• 1:12:01
  Speaker 1: the government. They didn't expose like this was the problem
• 1:12:04
  Speaker 1: with Okinawa in particular, is that they would have to
• 1:12:07
  Speaker 1: in order for these people to get taken off the list,
• 1:12:10
  Speaker 1: they would have to inform the government if this person died,
• 1:12:13
  Speaker 1: and they just didn't do it. And so they had
• 1:12:16
  Speaker 1: this list of people that they were counting in their
• 1:12:18
  Speaker 1: census that were like soul really, like, this is crazy.
• 1:12:21
  Speaker 1: What are you people doing? Even the oldest one hundred.
• 1:12:23
  Speaker 2: Years old, the oldest person in the world apparently one
• 1:12:25
  Speaker 2: hundred and twenty two. There's a theory, not proven, that
• 1:12:29
  Speaker 2: the oldest person in the world was actually the daughter
• 1:12:31
  Speaker 2: who was faking it to get taxes or avoid taxes.
• 1:12:36
  Speaker 2: I think it was in France. I hope that that's
• 1:12:38
  Speaker 2: not true.
• 1:12:38
  Speaker 1: I bet it's true. People are full of shit.
• 1:12:41
  Speaker 2: Well either way. The maximum uman life spent's around one
• 1:12:43
  Speaker 2: hundred and seventeen eighteen, which is still a lot more
• 1:12:46
  Speaker 2: than we live.
• 1:12:47
  Speaker 1: And what's really crazy is none of those people are
• 1:12:49
  Speaker 1: doing everything right exactly. They're all smoking cigarettes and drinking
• 1:12:53
  Speaker 1: wine and having a good time. And that's a factor
• 1:12:56
  Speaker 1: that we really need to take into consideration. Loneliness and
• 1:13:00
  Speaker 1: isolation and sadness are one of the greatest contributors to
• 1:13:06
  Speaker 1: poor health outcomes. Number one, is it really Yeah?
• 1:13:08
  Speaker 2: Robert Voldinger at Harvard had a study for I think
• 1:13:11
  Speaker 2: it was forty years World War two vets. They looked
• 1:13:14
  Speaker 2: at everything blood pressure, cholesterol. The number one thing that
• 1:13:17
  Speaker 2: predicted longevity in those men was having a reliable partner.
• 1:13:21
  Speaker 1: Hmmm.
• 1:13:23
  Speaker 2: Yeah, So not just.
• 1:13:24
  Speaker 1: A reliable partner, someone that you love, that's true, someone
• 1:13:28
  Speaker 1: that you want to be around all the time. You
• 1:13:31
  Speaker 1: enjoy them, You still enjoy their company, which is possible.
• 1:13:35
  Speaker 1: Most people don't believe that's possible. Well, your role model
• 1:13:38
  Speaker 1: is that I love my wife. I have fun with her,
• 1:13:42
  Speaker 1: like we I've been with her for a while, I've
• 1:13:43
  Speaker 1: been married for seventeen years. I enjoy her, I enjoy
• 1:13:46
  Speaker 1: hanging out with her. She's cool. Yeah, Like she's a
• 1:13:49
  Speaker 1: fun And I have friends that aren't in situations like that,
• 1:13:53
  Speaker 1: and it's it's so bad when you're like, I have
• 1:13:57
  Speaker 1: a friend who just we're actually talking last night. He
• 1:14:00
  Speaker 1: just got out of a crazy relationship where he's dating
• 1:14:04
  Speaker 1: this girl for seven years. Was chaos and this and that.
• 1:14:06
  Speaker 1: And I said to him and he was like, he's forty,
• 1:14:10
  Speaker 1: and he goes, I don't think I'm ever gonna have
• 1:14:12
  Speaker 1: a relationship again. He goes, it was so bad. He goes,
• 1:14:15
  Speaker 1: being single feels so good. And I said, there's an
• 1:14:18
  Speaker 1: old saying it's so much better to be alone than
• 1:14:21
  Speaker 1: to wish you were alone. And he's like, yeah, that's
• 1:14:25
  Speaker 1: it because he was like with this crazy lady and
• 1:14:28
  Speaker 1: he was like I just wish I was and he
• 1:14:30
  Speaker 1: finally got free and now he's like, I think I'm ruined,
• 1:14:33
  Speaker 1: and I'm like, it doesn't have to be like that.
• 1:14:35
  Speaker 1: You can find someone that you actually love and you
• 1:14:38
  Speaker 1: really enjoy their time, you enjoy being with them. It's possible.
• 1:14:42
  Speaker 1: There's good people out there, but you gotta also be
• 1:14:45
  Speaker 1: someone that that kind of person wants to be with.
• 1:14:47
  Speaker 1: That's the other thing for sure.
• 1:14:49
  Speaker 2: And stress of relationship. We've seen and studies that clock
• 1:14:53
  Speaker 2: with those chemicals on the DNA, it accelerates when you're
• 1:14:55
  Speaker 2: on distress. We'll go going through a breakup.
• 1:14:58
  Speaker 1: Oh yeah, oh see it. Oh I've seen people going
• 1:15:01
  Speaker 1: through divorces and it's just like it takes decades off
• 1:15:03
  Speaker 1: of their life. They just look wrecked and it takes
• 1:15:06
  Speaker 1: a year or two for them to like achieve equilibrium. Again.
• 1:15:10
  Speaker 1: It's hard.
• 1:15:11
  Speaker 2: It is, it is. I went through that actually just
• 1:15:14
  Speaker 2: during COVID when our family got shoved in a house together,
• 1:15:18
  Speaker 2: and yeah, it was brutal.
• 1:15:20
  Speaker 1: It was unexpected to Wow, that's the stress test, right, it.
• 1:15:24
  Speaker 2: Was super stress. It was super stress. It's funny that
• 1:15:27
  Speaker 2: without the pandemic we might have been able to make it,
• 1:15:29
  Speaker 2: but forcing us all to be in one little house
• 1:15:32
  Speaker 2: with no internet working. Well, it was tough, but in any case,
• 1:15:36
  Speaker 2: I'm great now, I'm very happy. So but I do
• 1:15:40
  Speaker 2: know how bad it can get, and it's brutal.
• 1:15:42
  Speaker 1: Yeah, bad relationships can fucking wreck people. I mean it
• 1:15:46
  Speaker 1: can wreck your health. But also it's not just relationships
• 1:15:49
  Speaker 1: in terms of your significant other, husband, wife, partner, whatever
• 1:15:52
  Speaker 1: you want to call it, but also bad relationships at work,
• 1:15:56
  Speaker 1: Like if you have a tyrant for a boss, and
• 1:15:59
  Speaker 1: you know every day you're getting you're you're working over
• 1:16:02
  Speaker 1: time and you're getting yelled at, and you're you're on
• 1:16:04
  Speaker 1: the phone, and you're you're at home trying to keep
• 1:16:06
  Speaker 1: up with work, and you never get like that that
• 1:16:09
  Speaker 1: kind of relationship. Well, you have like this, like antagonistic
• 1:16:13
  Speaker 1: terrible relationship with people that you work with. That's bad too.
• 1:16:16
  Speaker 1: Oh for sure, your body doesn't differentiate between romantic relationships
• 1:16:20
  Speaker 1: and those kind of relationships are almost equally bad.
• 1:16:23
  Speaker 2: The cortosol will be high. This will accelerate here. I
• 1:16:26
  Speaker 2: used to keep fish. I was one of those people
• 1:16:29
  Speaker 2: at school, and the fish that got picked on by
• 1:16:31
  Speaker 2: the dominant fish was small, like color lived short. It's
• 1:16:36
  Speaker 2: it's biology. If you're picked on and you're stressed, you're
• 1:16:38
  Speaker 2: going to age faster. Fortunately, I think you're probably the same.
• 1:16:42
  Speaker 2: At my age. I've managed to weed out most of
• 1:16:45
  Speaker 2: the jerks, and I don't work with them at all.
• 1:16:47
  Speaker 2: I've got a great partner who we have a hobby
• 1:16:49
  Speaker 2: of longevity together, so that I'm not lucky in that regard.
• 1:16:52
  Speaker 1: Now we found a new one.
• 1:16:54
  Speaker 2: Yeah, longevity specialist, imagine that.
• 1:16:56
  Speaker 1: Congratulations. Well that's nice too, right, I find someone who
• 1:16:59
  Speaker 1: just like thinks that you think and has similar likes,
• 1:17:03
  Speaker 1: like you say, Yeah, that definitely can help. Yeah. I
• 1:17:05
  Speaker 1: know a lot of my friends that are really good relationships.
• 1:17:08
  Speaker 1: Their significant other has the same hobby as them, you know,
• 1:17:13
  Speaker 1: like whatever it is they both like to climb mountains
• 1:17:16
  Speaker 1: or whatever the fuck it is. Find a thing. But
• 1:17:18
  Speaker 1: that helps too. Well, so you actually enjoy spending time
• 1:17:21
  Speaker 1: together doing something that you're both really excited about.
• 1:17:23
  Speaker 2: That helps to So relationships is one and the other
• 1:17:26
  Speaker 2: four major ones from that study were don't smoke, don't drink,
• 1:17:30
  Speaker 2: get enough rest, and get exercise. And that was enough
• 1:17:34
  Speaker 2: to extend by fifteen years.
• 1:17:36
  Speaker 1: But what about those old people that live forever and
• 1:17:39
  Speaker 1: do smoke and drink because that's kind of weird.
• 1:17:41
  Speaker 2: Well, they're a point zero one percent. They're not examples
• 1:17:43
  Speaker 2: of what is that?
• 1:17:44
  Speaker 1: Really?
• 1:17:44
  Speaker 2: What it is? Yeah, it's just.
• 1:17:46
  Speaker 1: So the majority of people who get old and live
• 1:17:49
  Speaker 1: to like centenarians, Like, what are the common things that
• 1:17:53
  Speaker 1: they have?
• 1:17:55
  Speaker 2: The big one is that they don't stress a lot.
• 1:17:57
  Speaker 2: They usually have a good sense of humor.
• 1:18:00
  Speaker 1: Mm.
• 1:18:00
  Speaker 2: Interesting, right, they haven't been overweight, and they say that
• 1:18:05
  Speaker 2: they typically couldn't remember when they lost got sick.
• 1:18:08
  Speaker 1: I wonder how much time Twitter takes off your life.
• 1:18:13
  Speaker 2: Yeah, we should study that. It's already taken a lot off.
• 1:18:17
  Speaker 1: Mind.
• 1:18:18
  Speaker 2: It does, and if you read the comments even.
• 1:18:20
  Speaker 1: Yep, exactly, I'm so much happier since I swore off
• 1:18:25
  Speaker 1: of all that stuff. So it's just not good for you.
• 1:18:27
  Speaker 1: It's really really bad for you. It's also you're constantly
• 1:18:31
  Speaker 1: dealing with the problems of the whole world, which I
• 1:18:33
  Speaker 1: think is a lot for a human being that lives
• 1:18:37
  Speaker 1: in a community, in a neighborhood. It's that shit that's
• 1:18:40
  Speaker 1: happening over there really shouldn't be a primary focus of
• 1:18:44
  Speaker 1: your life, like where you're in the moment actually doing
• 1:18:48
  Speaker 1: your life. It's not the same. You're not in the
• 1:18:51
  Speaker 1: same area as this problem, but yet this problem is overwhelming.
• 1:18:55
  Speaker 1: You're all day long life.
• 1:18:57
  Speaker 2: And you're in fital flight constant today all day.
• 1:19:00
  Speaker 1: Yeah, and you're worried about the climate. Oh my god,
• 1:19:03
  Speaker 1: Like there's so much. There's so much that freaks people
• 1:19:06
  Speaker 1: out that really shouldn't be affecting you at.
• 1:19:08
  Speaker 2: All, exactly, And actually the world doesn't change if you
• 1:19:11
  Speaker 2: don't read it.
• 1:19:11
  Speaker 1: So it's that's that's key, that's the key. But then
• 1:19:15
  Speaker 1: you're like, well, you need you're passing off the responsibility
• 1:19:17
  Speaker 1: to other people. You should get involved, Like, eh, you
• 1:19:20
  Speaker 1: should get involved. I'm going to be over here.
• 1:19:23
  Speaker 2: That's right. Well, if you focus on doing something good
• 1:19:26
  Speaker 2: and you're good at it, yes, like yourself, I think
• 1:19:28
  Speaker 2: that you don't need to be doing more than that.
• 1:19:30
  Speaker 1: You can't focus on everything, and anybody who tells you
• 1:19:33
  Speaker 1: can is a fool, or anybody who tells you what
• 1:19:36
  Speaker 1: you should or shouldn't be focusing on is a fool. Yeah.
• 1:19:38
  Speaker 2: A few years ago, someone at a talk that I
• 1:19:40
  Speaker 2: gave said you should be working on climate change. Fuck,
• 1:19:43
  Speaker 2: I said, after I cure aging, I'll get to climate change.
• 1:19:47
  Speaker 1: Yeah, once you go to China and tell them stop
• 1:19:49
  Speaker 1: making coal factory. Shut the fuck up, just shut up,
• 1:19:52
  Speaker 1: you No, you're not going to fix it. Yeah, yeah,
• 1:19:57
  Speaker 1: somebody is. Somebody's working on it, and that's their going.
• 1:20:00
  Speaker 1: God bless them, good luck.
• 1:20:02
  Speaker 2: Yeah. Well, what I try to spend my day is
• 1:20:04
  Speaker 2: efficiently helping the world so that people ask me why
• 1:20:07
  Speaker 2: do I study aging in the first place, And it
• 1:20:09
  Speaker 2: really is that I'm trying to please my grandmother. Like
• 1:20:13
  Speaker 2: some of else, she was the one that told me
• 1:20:15
  Speaker 2: that I need to make the world a better place.
• 1:20:17
  Speaker 2: And she's gone. That's what she said when I was four,
• 1:20:22
  Speaker 2: been that ever since. She told me two things. Humans
• 1:20:25
  Speaker 2: are evil. She lived through World War two in Hungary
• 1:20:27
  Speaker 2: and oh wow, the Russians came in and raped everybody,
• 1:20:31
  Speaker 2: she said, and then so she escaped to Australia. And
• 1:20:34
  Speaker 2: then she said that the other issue is that we
• 1:20:39
  Speaker 2: don't do enough as humans to better the world, and
• 1:20:42
  Speaker 2: so I had that stuck in my mind. She also,
• 1:20:45
  Speaker 2: by the way, said oh, we all die, and I
• 1:20:47
  Speaker 2: thought that that's not really fair, is it? And that
• 1:20:51
  Speaker 2: set me on this path make.
• 1:20:53
  Speaker 1: The world a better place and we all die, And
• 1:20:56
  Speaker 1: you're like, ah, and.
• 1:20:58
  Speaker 2: What I've noticed with my kids. Is that even if
• 1:21:01
  Speaker 2: you tell them that, they forget about it because it's
• 1:21:03
  Speaker 2: brutal to think about death every day. Yeah, but for
• 1:21:06
  Speaker 2: some reason, it's just stuck in my head and every
• 1:21:09
  Speaker 2: day I'm like, another one hundred and fifty thousand people
• 1:21:11
  Speaker 2: are going to die today due to aging related diseases.
• 1:21:15
  Speaker 2: So my lab is mission oriented. If we are day
• 1:21:17
  Speaker 2: late with something, it's a lot of people that are
• 1:21:20
  Speaker 2: suffering potentially avoidable diseases.
• 1:21:23
  Speaker 1: That's why it's sort of understandable that people like show
• 1:21:25
  Speaker 1: up outside of your lab and like like I need
• 1:21:28
  Speaker 1: to talk to you. Ah, I need this.
• 1:21:31
  Speaker 2: Yeah, blind people want to get in the trials. It's big,
• 1:21:34
  Speaker 2: and I think if the trial works, going to be
• 1:21:36
  Speaker 2: a very strange world, especially for my lab and for me.
• 1:21:40
  Speaker 2: But we'll see and even if it doesn't work this time,
• 1:21:43
  Speaker 2: the science is strong enough that will figure it out.
• 1:21:46
  Speaker 2: We will do this. It's just a question of when.
• 1:21:48
  Speaker 1: And so do you think that AI is going to
• 1:21:50
  Speaker 1: have a significant impact on the kind of improvements that
• 1:21:53
  Speaker 1: you're able to.
• 1:21:54
  Speaker 2: It already is we're going super fast and AI has
• 1:21:57
  Speaker 2: revolutionized biology. It's revolutionary everything, of course, but particularly in biology,
• 1:22:02
  Speaker 2: where we used to have to read fifteen papers a day.
• 1:22:06
  Speaker 2: Now we can read a million if we want. It's
• 1:22:08
  Speaker 2: totally different. Wow, yeah, it's super brain. A nineteen year
• 1:22:15
  Speaker 2: old came to my lab this summer and the lab
• 1:22:17
  Speaker 2: grows from twenty to forty people. And we're trying to
• 1:22:20
  Speaker 2: figure out how do these three genes reset the cell?
• 1:22:23
  Speaker 2: How does the cell remember what it was thirty forty
• 1:22:26
  Speaker 2: years ago? Where's that information stored in the cell? And
• 1:22:30
  Speaker 2: I've got this theory that there's some new biology. There's
• 1:22:34
  Speaker 2: a record in the DNA somewhere. And I gave him
• 1:22:37
  Speaker 2: that task. I said, can you just go to the
• 1:22:40
  Speaker 2: databases of the whole world look at all the data
• 1:22:43
  Speaker 2: that's there, is exobites of data, and see if my
• 1:22:46
  Speaker 2: prediction is true, or at least you can get evidence
• 1:22:49
  Speaker 2: for it. Two weeks later he came back and the
• 1:22:52
  Speaker 2: whole team, not the whole ting, but five other people
• 1:22:54
  Speaker 2: were smiling. We have to show you something. David right,
• 1:22:57
  Speaker 2: come in to my office. We sat down. He shows
• 1:22:59
  Speaker 2: up on the board on this LCD screen. I think
• 1:23:03
  Speaker 2: we found the smoking gun for what your theory suggests.
• 1:23:06
  Speaker 2: And he used AI to process all that data and
• 1:23:09
  Speaker 2: the AI came back and said, yeah, you're probably right.
• 1:23:12
  Speaker 2: And it's a nineteen year old straight out of high
• 1:23:14
  Speaker 2: school who did this, that did something that the whole
• 1:23:17
  Speaker 2: field and all these professors and all these fancy serves
• 1:23:20
  Speaker 2: could not figure out until now.
• 1:23:24
  Speaker 1: That is phenomenal. That's so promising, it's so exciting. It is.
• 1:23:29
  Speaker 2: I mean, the future really does belong to people who
• 1:23:31
  Speaker 2: can wrangle AI even on their phone. I think people
• 1:23:34
  Speaker 2: on their phones are going to be making medicines or
• 1:23:36
  Speaker 2: at least designing them, or bombs. That's the problem. And bioweapons, right,
• 1:23:41
  Speaker 2: I mean you recently had, was it Anna on the
• 1:23:44
  Speaker 2: show to talk about bio weapons and this kind of stuff.
• 1:23:47
  Speaker 2: That is a big worry. I actually had to disclose
• 1:23:50
  Speaker 2: to the US government when I first got here that
• 1:23:51
  Speaker 2: I did have the capability of making a bioweapon.
• 1:23:54
  Speaker 1: The Anna Jacobsen episode that we just did on bioweapons
• 1:23:58
  Speaker 1: was absolutely terrifying. She's you know, I mean, she scared
• 1:24:02
  Speaker 1: the shit out of the world with her nuclear war book,
• 1:24:04
  Speaker 1: and now she's scaring everybody with her bioweapons book. Yeah, yeah,
• 1:24:08
  Speaker 1: that's scary. It is.
• 1:24:10
  Speaker 2: What I've got is a database of all known pathogens
• 1:24:13
  Speaker 2: and new ones that could come so I'm trying to
• 1:24:15
  Speaker 2: do my bit there to help the world if it
• 1:24:17
  Speaker 2: happens again pandemic or something unnatural.
• 1:24:21
  Speaker 1: Yeah, well that would be I mean, when you think
• 1:24:24
  Speaker 1: about diseases that people get that just like wreck their
• 1:24:28
  Speaker 1: entire body. If you really do have an original copy
• 1:24:32
  Speaker 1: somewhere in their genome of what they look like as
• 1:24:35
  Speaker 1: a healthy person, and you could switch that back on
• 1:24:38
  Speaker 1: with a factory reboot, I mean, we could potentially get
• 1:24:43
  Speaker 1: rid of all diseases, which is just bananas.
• 1:24:47
  Speaker 2: And injuries, fixed injuries, grown new limbs, potentially. There's a
• 1:24:52
  Speaker 2: new paper that just came out a few days ago
• 1:24:54
  Speaker 2: that showed that the tips of the fingers of baby
• 1:24:56
  Speaker 2: mice can be coaxed once they've healed over as a
• 1:25:00
  Speaker 2: stub to regrow part of the finger.
• 1:25:03
  Speaker 1: Haven't people done that before?
• 1:25:05
  Speaker 2: Yeah, they found just two factors were enough, so it's
• 1:25:08
  Speaker 2: not that hard. The point is we've got the instructions
• 1:25:12
  Speaker 2: to be young and to regrow body parts in our body,
• 1:25:15
  Speaker 2: we just don't use them.
• 1:25:17
  Speaker 1: That's nuts. So like a salamander can grow an extra
• 1:25:20
  Speaker 1: leg or a leg that gets chopped off.
• 1:25:22
  Speaker 2: Yeah, I believe we still have that capability. We just
• 1:25:24
  Speaker 2: don't use it. It just didn't make sense to regrow
• 1:25:27
  Speaker 2: a limbit was quicker and safe to just heal it
• 1:25:29
  Speaker 2: over as a stub and move on. But salamanders, which
• 1:25:32
  Speaker 2: get their limbs presumably eaten, pretty often maintain that ability.
• 1:25:37
  Speaker 2: So give us. You know, I wouldn't say that we
• 1:25:40
  Speaker 2: could evolve this, but I think using a combination of
• 1:25:43
  Speaker 2: our technology plus this new technology that we're seeing come out,
• 1:25:46
  Speaker 2: where these two factors can grow new limbs. I don't
• 1:25:48
  Speaker 2: see a reason why we can't become like a deadpool
• 1:25:51
  Speaker 2: where injury doesn't hurt us, aging can't hurt us, and
• 1:25:55
  Speaker 2: we can regrow body parts.
• 1:25:56
  Speaker 1: How far do you think we are away from being
• 1:25:58
  Speaker 1: able to regrow body parts? Oh?
• 1:26:01
  Speaker 2: I mean, realistically, probably a couple of decades. But I've
• 1:26:04
  Speaker 2: seen enough that's not that far. I've seen enough to
• 1:26:06
  Speaker 2: know that it's doable.
• 1:26:07
  Speaker 1: A couple of decades ago was two thousand and six.
• 1:26:10
  Speaker 2: Well, things are going super fast. I mean ten years
• 1:26:12
  Speaker 2: ago we didn't even know aging was reversible, and now
• 1:26:14
  Speaker 2: it's in humans.
• 1:26:17
  Speaker 1: That's nuts. Think of that. Well, two thousand and there
• 1:26:22
  Speaker 1: was no AI.
• 1:26:23
  Speaker 2: Right in twenty nineteen, it was an idea that we
• 1:26:26
  Speaker 2: had just got the result in mice, and I divulged
• 1:26:29
  Speaker 2: that to the world. Then it was published, and then
• 1:26:32
  Speaker 2: we're in humans now. So if it works, then you
• 1:26:35
  Speaker 2: know it's going to be a very.
• 1:26:36
  Speaker 1: Different world, and you're you feel very confidently that some
• 1:26:41
  Speaker 1: of this stuff is going to work.
• 1:26:43
  Speaker 2: Well, it's going to work. I don't know if this
• 1:26:46
  Speaker 2: trial is going to be successful, but there's going to
• 1:26:48
  Speaker 2: be a lot of people doing these trials. I have
• 1:26:50
  Speaker 2: some competition, now, do you know about that? No, So
• 1:26:54
  Speaker 2: since I started my company Life Biosciences, which is doing
• 1:26:57
  Speaker 2: the trials with ERA one hundred, others have John joined
• 1:27:00
  Speaker 2: in and the party so Jeff Bezos and others have
• 1:27:04
  Speaker 2: started Alto's Farmer. They are based in three cities around
• 1:27:09
  Speaker 2: the world. They have a few billion dollars to catch up.
• 1:27:13
  Speaker 2: Sam Oltman has retro Bio, and let's see Brian Armstrong
• 1:27:19
  Speaker 2: from Coinbase, the CEO, started one called New Limit and
• 1:27:23
  Speaker 2: they've got a lot of money, all billions.
• 1:27:27
  Speaker 1: Do you think it's good that there's all these people
• 1:27:28
  Speaker 1: involved in this.
• 1:27:29
  Speaker 2: Ill's good?
• 1:27:30
  Speaker 1: Yeah? Competition, yeah yeah.
• 1:27:31
  Speaker 2: I'm not doing this for my own personal benefit. I
• 1:27:34
  Speaker 2: want humanity to be changed the way it could.
• 1:27:36
  Speaker 1: Be, and the more people like Jeff Bezos. The more
• 1:27:39
  Speaker 1: people with a large bank account that are invested in this,
• 1:27:41
  Speaker 1: the better fantastic. And of course a guy like Bezos,
• 1:27:44
  Speaker 1: he's balling out of control. Why wouldn't you want to
• 1:27:45
  Speaker 1: live forever?
• 1:27:46
  Speaker 2: Well, what's left if you've got everything else? You know?
• 1:27:49
  Speaker 1: Well, also it's like it's like if you've got the
• 1:27:51
  Speaker 1: amount of money that he has, and you can tackle
• 1:27:54
  Speaker 1: all these different issues, you know, like his space program
• 1:27:57
  Speaker 1: that he's working on, all these different things, Like of course,
• 1:27:59
  Speaker 1: why would you want to do cool things? Like what's
• 1:28:01
  Speaker 1: cooler than being able to grow limbs?
• 1:28:03
  Speaker 2: Yeah?
• 1:28:04
  Speaker 1: Yeah, you know what's cooler than being able to cure
• 1:28:06
  Speaker 1: all diseases and reverse aging?
• 1:28:08
  Speaker 2: Well there's I don't think there's much cooler. That's why
• 1:28:11
  Speaker 2: I'm doing it, because that I think can be the
• 1:28:13
  Speaker 2: biggest gift to humanity is what you just said. So
• 1:28:16
  Speaker 2: I don't know if I'll achieve it, probably not in
• 1:28:18
  Speaker 2: my lifetime, but at least I've moved the needl and
• 1:28:20
  Speaker 2: pushed the ball globally in that direction.
• 1:28:24
  Speaker 1: I wonder if we're going to get to a point
• 1:28:25
  Speaker 1: in time where we can engineer consciousness in terms of
• 1:28:29
  Speaker 1: like find out like you find out someone's a sociopath,
• 1:28:33
  Speaker 1: you find out someone's a kleptomaniac, or someone's an arsonist,
• 1:28:37
  Speaker 1: like whatever it is. Like if you could figure out
• 1:28:40
  Speaker 1: like what these little flaws are in the way the
• 1:28:43
  Speaker 1: mind works, if you can completely map it out and go, oh,
• 1:28:48
  Speaker 1: this is the error, this is where you're not making
• 1:28:50
  Speaker 1: these two connections.
• 1:28:51
  Speaker 2: Of course, they'll just biology and engineering. There's nothing that
• 1:28:54
  Speaker 2: stops us. And this is the century that we are
• 1:28:57
  Speaker 2: able to control our own biology, starting with cancer, heart disease,
• 1:29:02
  Speaker 2: and aging.
• 1:29:03
  Speaker 1: A true utopian world of peaceful people. We peace harmony,
• 1:29:07
  Speaker 1: but healthy, not peaceful.
• 1:29:09
  Speaker 2: I don't think world peace. I think curing aging is
• 1:29:11
  Speaker 2: easier than world peace.
• 1:29:13
  Speaker 1: Well, if everybody achieved a state of consciousness that allowed
• 1:29:17
  Speaker 1: them to understand that we're all in this together.
• 1:29:21
  Speaker 2: Yeah, how do we do that?
• 1:29:22
  Speaker 1: Mushrooms?
• 1:29:23
  Speaker 2: Yeah? Yeah, Well there are certain companies working on this.
• 1:29:27
  Speaker 1: I know. That's what's interesting, right, Like Eli Lilly is
• 1:29:30
  Speaker 1: involved in pharmaceuticals. Well, the pharmaceutical company rather is involved
• 1:29:34
  Speaker 1: in psychloalics.
• 1:29:35
  Speaker 2: They just bought a tie I think it was.
• 1:29:37
  Speaker 1: Like three point eight billion dollars, so they're all in
• 1:29:39
  Speaker 1: with real capital. Yeah, I love it.
• 1:29:42
  Speaker 2: Yeah, me too.
• 1:29:43
  Speaker 1: That's great.
• 1:29:43
  Speaker 2: I love that they're doing that. We need more of that.
• 1:29:45
  Speaker 2: There's too much depression on anxiety.
• 1:29:47
  Speaker 1: In the world and drug addiction. I mean, that's why
• 1:29:50
  Speaker 1: I went to the White House and got the President
• 1:29:53
  Speaker 1: to get involved in this executive order on fiber gain. Yes,
• 1:29:56
  Speaker 1: because I've talked to so many people that have had
• 1:30:00
  Speaker 1: their life completely turned around with IBA gain, so many
• 1:30:03
  Speaker 1: people that were opioid addiction and also brain injuries oddly enough,
• 1:30:09
  Speaker 1: brain injuries, all sorts of TBI and CTE that they've
• 1:30:14
  Speaker 1: had like phenomenal results from this ebogatry, you know, which
• 1:30:19
  Speaker 1: is so crazy that this thing had been around for
• 1:30:22
  Speaker 1: so long and is a Schedule one substance in the
• 1:30:25
  Speaker 1: United States for no reason whatsoever. There's no risk of addiction,
• 1:30:30
  Speaker 1: there is no recreational use of it. It's a horrible experience.
• 1:30:33
  Speaker 1: I've not done it, but apparently it's fucking terrible and
• 1:30:36
  Speaker 1: it lasts for like twenty four hours. Like no one's
• 1:30:38
  Speaker 1: going to be doing that for funzies, right.
• 1:30:40
  Speaker 2: Well, The question I think that comes up with all
• 1:30:43
  Speaker 2: of these drugs is do you have to have the
• 1:30:44
  Speaker 2: trip and experience the craziness to get the better to
• 1:30:48
  Speaker 2: get the benefit, and I don't think so. I think
• 1:30:50
  Speaker 2: you should be able to separate.
• 1:30:51
  Speaker 1: Well, you know they've actually figured this out with LSD. Yeah, right,
• 1:30:55
  Speaker 1: do you know about this? Okay, So they've engineered a
• 1:30:59
  Speaker 1: different version of LSD that doesn't give you the hallucinogenic effects,
• 1:31:04
  Speaker 1: but does give you the benefits in terms of like
• 1:31:08
  Speaker 1: the cognitive effects.
• 1:31:09
  Speaker 2: I tie you, guys or someone else.
• 1:31:11
  Speaker 1: I don't know what company has done this, So if
• 1:31:14
  Speaker 1: you can find that, jam, I.
• 1:31:15
  Speaker 2: Think it might be a time.
• 1:31:16
  Speaker 1: But what they've they've essentially done, and I think it's
• 1:31:19
  Speaker 1: it's basically in the lab work stage right now. I
• 1:31:22
  Speaker 1: don't think that's applied to humans yet. But what they've
• 1:31:25
  Speaker 1: done is engineered a version of LSD that has all
• 1:31:29
  Speaker 1: the positive effects that LSD has in terms of like introspection,
• 1:31:35
  Speaker 1: being able to rethink and remap and reset the way
• 1:31:38
  Speaker 1: you view things, but without like watching people's face melt
• 1:31:43
  Speaker 1: and thinking the demons are eating you, and all the
• 1:31:46
  Speaker 1: weird stuff that comes outstanding.
• 1:31:48
  Speaker 2: It should happen with psychedelics the way it's happened with
• 1:31:51
  Speaker 2: all medicines.
• 1:31:52
  Speaker 1: Right.
• 1:31:52
  Speaker 2: We start with yes, something from the bark of a
• 1:31:55
  Speaker 2: willow tree, and then we have espirin, right, not eating
• 1:31:58
  Speaker 2: bark anymore, right.
• 1:32:00
  Speaker 1: But sometimes the bark is the really way the way
• 1:32:03
  Speaker 1: to go right. Unfortunately, sometimes that's the part of the
• 1:32:06
  Speaker 1: problem is these pharmaceutical drug companies they patent these natural
• 1:32:11
  Speaker 1: compounds and you know, use petroleum based synthetic methods of
• 1:32:16
  Speaker 1: creating these medications now that they can sell and profit
• 1:32:20
  Speaker 1: wildly off of, whereas really the best way to do
• 1:32:23
  Speaker 1: it is actually to get the plant.
• 1:32:25
  Speaker 2: It's true that there's the whole issue though that if
• 1:32:28
  Speaker 2: it's not approved, then it's the wild West. You don't
• 1:32:31
  Speaker 2: know what you're getting, right, That's true too. We need
• 1:32:34
  Speaker 2: a middle ground. We need something you can get faster
• 1:32:36
  Speaker 2: in the market that's known to be safe.
• 1:32:38
  Speaker 1: So what we're gonna need is mind reading, because we
• 1:32:42
  Speaker 1: need to know if people are full shit. That's we're
• 1:32:44
  Speaker 1: gonna need. We're gonna need.
• 1:32:45
  Speaker 2: Gotta work on that.
• 1:32:46
  Speaker 1: Yes, I think that's that's gonna change humanity more than anything.
• 1:32:50
  Speaker 2: I think you've got a good bullshit detector.
• 1:32:52
  Speaker 1: It's okay. There's a few people that have snuck through. Unfortunately,
• 1:32:56
  Speaker 1: you know some people they get through and they're like
• 1:32:58
  Speaker 1: it takes a while, and you're like, ah, ah shit,
• 1:33:01
  Speaker 1: they they have coming back on the show. Yeah, well,
• 1:33:03
  Speaker 1: there's that. It's the show. You know, you learn a
• 1:33:07
  Speaker 1: lot from a person in about three hours. You know,
• 1:33:09
  Speaker 1: you can kind of after a while, you can kind
• 1:33:12
  Speaker 1: of see little things, and you have to be forgiving,
• 1:33:15
  Speaker 1: and you know, you have to be charitable. And some
• 1:33:17
  Speaker 1: people are just nervous and they mistate things, or they
• 1:33:21
  Speaker 1: exaggerate things, or they forget something, they get it wrong.
• 1:33:24
  Speaker 1: But then there's people that are just essentially they really
• 1:33:28
  Speaker 1: don't care about anybody but themselves. And some of those
• 1:33:32
  Speaker 1: people are really good at pretending to be people. They're
• 1:33:34
  Speaker 1: really good at pretending, you know, they're really good at
• 1:33:37
  Speaker 1: pretending to be like a normal person. Oh here's the
• 1:33:40
  Speaker 1: LSG thing LSD thing. Roight Research is recently engineered an
• 1:33:44
  Speaker 1: LSD analog called how do you say plus minus JRT
• 1:33:49
  Speaker 1: that appears to keep many of the LSD's brain beneficial
• 1:33:52
  Speaker 1: and cognitive effects while dramatically reducing and possibly eliminating it's
• 1:33:56
  Speaker 1: hallucinogenic trip in animal studies. So it's almost the same
• 1:34:00
  Speaker 1: molecule as LSD, but scientists swap the positions of just
• 1:34:04
  Speaker 1: two atoms in the structure. The subtle change makes JRT
• 1:34:08
  Speaker 1: bind more selectively to serotonin receptors in a way that
• 1:34:11
  Speaker 1: promotes neuroplasticity growth through a pair of synapses but minimizes
• 1:34:15
  Speaker 1: hallucinogenic signaling. That is, that's incredible antidepressant. Look at this
• 1:34:22
  Speaker 1: strong antidepressant effects. That DOS is reported to be around
• 1:34:25
  Speaker 1: one hundred times more potent than KETABE in standard rodent tests.
• 1:34:30
  Speaker 1: Cognitive benefits, improved cognitive flexibility and performance in tasks modeling
• 1:34:36
  Speaker 1: the negative and cognitive symptoms of schizophrenia. Holy shit, that's incredible.
• 1:34:43
  Speaker 2: When, when and where do we get it?
• 1:34:45
  Speaker 1: Well, I think it's fairly recent. You se Davis study,
• 1:34:49
  Speaker 1: they just developed it. Shout out to our AI sponsor,
• 1:34:52
  Speaker 1: Perplexity for providing us with this information. So this is
• 1:34:55
  Speaker 1: again I mean, like we could just get this information
• 1:34:57
  Speaker 1: now through AI. Like I mean this that AI for
• 1:35:01
  Speaker 1: our show has been gigantic. I mean just the ability
• 1:35:03
  Speaker 1: to just ask it a question instead of Google searching
• 1:35:07
  Speaker 1: and have to go through all these different fucking articles.
• 1:35:09
  Speaker 1: What does it say? What is that? Who's right? What's
• 1:35:11
  Speaker 1: this one? What's the website? You just ask AI and
• 1:35:15
  Speaker 1: Perplexity just gives us all the information. So proceedings from
• 1:35:19
  Speaker 1: National Academy of Science Research is that California of San
• 1:35:22
  Speaker 1: Diego Davis, excuse me, University of California Davis reported the
• 1:35:28
  Speaker 1: creation of JRT chemically modified first of LSD. So this
• 1:35:32
  Speaker 1: is like what year, so twenty twenty five, so last year,
• 1:35:38
  Speaker 1: So it's exciting. Yeah, you're right that the timeline.
• 1:35:43
  Speaker 2: At a minimum usually takes that long. But that's exciting.
• 1:35:46
  Speaker 2: At least the participle is there that you don't need
• 1:35:47
  Speaker 2: to lose.
• 1:35:48
  Speaker 1: Well, how about for schizophrenia. Yeah, that's incredible thing. Yeah,
• 1:35:51
  Speaker 1: I mean that that is incredible because that is one
• 1:35:53
  Speaker 1: of the saddest things to watch somebody fall into the
• 1:35:55
  Speaker 1: grips of schizophrenia.
• 1:35:57
  Speaker 2: Yeah.
• 1:35:57
  Speaker 1: I've seen people fall in and come out, which is interesting, huh.
• 1:36:01
  Speaker 2: I thought for the Bullshit Detective, we could have an
• 1:36:03
  Speaker 2: AI that either dings or has a green or a
• 1:36:06
  Speaker 2: red on your forehead.
• 1:36:07
  Speaker 1: I'm pretty good at it, but I think no one's
• 1:36:10
  Speaker 1: perfect at it. And I think ultimately, if we get
• 1:36:13
  Speaker 1: to a place, whether it's a technological innovation or what
• 1:36:18
  Speaker 1: have you, where we can actually read the contents of
• 1:36:21
  Speaker 1: someone's thoughts, I don't think that's outside the realm of possibility.
• 1:36:26
  Speaker 2: You'd need an implant, I think.
• 1:36:28
  Speaker 1: But Elon says, the neuralink is going to be able
• 1:36:30
  Speaker 1: to pull that off. Yeah, well you're going to be
• 1:36:32
  Speaker 1: able to talk without using words, and they're like what.
• 1:36:36
  Speaker 1: I think he's right though. I think if we all
• 1:36:39
  Speaker 1: like lock into a hive mind, and then if we develop,
• 1:36:45
  Speaker 1: like through AI, if we develop a universal language worldwide.
• 1:36:51
  Speaker 2: Well we already have that.
• 1:36:53
  Speaker 1: What do we have?
• 1:36:54
  Speaker 2: Well, the new headphones from a big company that I
• 1:36:56
  Speaker 2: won't name, you can.
• 1:36:57
  Speaker 1: Translate translate, yes, but it's translating into English. If we
• 1:37:02
  Speaker 1: just all the problem with that is there's context, There's
• 1:37:05
  Speaker 1: all sorts of different things that other cultures, different languages.
• 1:37:09
  Speaker 1: When it's deciphered and changed and translated into English, you
• 1:37:12
  Speaker 1: lose a lot of the meaning and the context is weird.
• 1:37:16
  Speaker 1: If we develop a universal language.
• 1:37:19
  Speaker 2: That'd be ideal. English is a good substitute. I was shocked.
• 1:37:23
  Speaker 2: I'm always shocked traveling globally, how many people can just
• 1:37:25
  Speaker 2: speak English now.
• 1:37:26
  Speaker 1: Yeah, it's pretty amazing. It's because America rules you're welcome.
• 1:37:31
  Speaker 2: Well we have to thank Britain for that. America should
• 1:37:34
  Speaker 2: say you're welcome.
• 1:37:35
  Speaker 1: Yeah, they're they're cute. They did a good job. Starting out,
• 1:37:38
  Speaker 1: but we took the ball.
• 1:37:39
  Speaker 2: And that so who's next? Chin?
• 1:37:43
  Speaker 1: God, No, I don't want to learn Chinese. It's too hard.
• 1:37:45
  Speaker 1: It's all the fucking characters. That's ridiculous. Even people that
• 1:37:48
  Speaker 1: I know they could speak Mandarin, they can't write it,
• 1:37:51
  Speaker 1: you know, to like to get to that level. I
• 1:37:53
  Speaker 1: have a couple friends that speak fluent Mandarin and they
• 1:37:56
  Speaker 1: can't write it. Writing. Yeah.
• 1:37:59
  Speaker 2: Well, the students in my lab who come from China,
• 1:38:01
  Speaker 2: they're being picked on by the immigration, but they don't
• 1:38:05
  Speaker 2: want to go home.
• 1:38:06
  Speaker 1: They love it here, I'm sure because they're stealing all
• 1:38:08
  Speaker 1: your secrets and I bring it back.
• 1:38:09
  Speaker 2: Then there's a lot of regulation on that.
• 1:38:11
  Speaker 1: Now. As a scientist, oh ye oh, I can imagine. Yeah,
• 1:38:14
  Speaker 1: I'm into to be because that is an actual, real
• 1:38:17
  Speaker 1: threat exactly. So the people that come through my lab
• 1:38:20
  Speaker 1: have to be vetted now, right. But the people that
• 1:38:22
  Speaker 1: come over here and experience the kind of freedom that
• 1:38:24
  Speaker 1: you have in America, oh yeah.
• 1:38:26
  Speaker 2: I came here from Australia. Australia is pretty free, but
• 1:38:28
  Speaker 2: compared to Australia, America is so different. I can't go back.
• 1:38:33
  Speaker 2: What's the big difference that I feel I can do
• 1:38:36
  Speaker 2: anything I want if I just put my mind to it.
• 1:38:39
  Speaker 2: There's not social barriers. There's not monetary barriers, at least
• 1:38:42
  Speaker 2: for a white male like me who's got a degree.
• 1:38:45
  Speaker 2: I know it's not for everybody, but I feel like,
• 1:38:48
  Speaker 2: if I want to start a company, i've got a
• 1:38:50
  Speaker 2: great idea, I can do that here. Fat chance you'll
• 1:38:53
  Speaker 2: do that in Australia. People aren't willing to invest in
• 1:38:55
  Speaker 2: great ideas down there. Not often.
• 1:38:58
  Speaker 1: That's a bummer. Do you think that changes anytime soon?
• 1:39:01
  Speaker 2: No, US is so unique. There's a lot of money flowing.
• 1:39:05
  Speaker 2: People are willing to place a bet and even lose
• 1:39:07
  Speaker 2: the money. That's rare Australians. Most of the world, if
• 1:39:11
  Speaker 2: not all, people are scared to lose their money if
• 1:39:13
  Speaker 2: they have it. Here, it's like, Okay, I risked it.
• 1:39:16
  Speaker 2: I help the world. I feel good. It's a very
• 1:39:18
  Speaker 2: generous country, very and I love it here. It's when
• 1:39:22
  Speaker 2: I arrived here, I just felt I'm home.
• 1:39:24
  Speaker 1: I love hearing that from people that have come from
• 1:39:26
  Speaker 1: somewhere else because it kind of reaffirms why people in
• 1:39:30
  Speaker 1: America are so proud of what this country is should be. Yeah,
• 1:39:34
  Speaker 1: and that's why it bumps me out. Where people are
• 1:39:36
  Speaker 1: so mad at America in terms of I get look
• 1:39:39
  Speaker 1: in terms of foreign policy and some of the things
• 1:39:41
  Speaker 1: that are wrong with America, but just in overall, this
• 1:39:44
  Speaker 1: experiment in self government is pretty remarkable.
• 1:39:47
  Speaker 2: Yeah, I watched the TV show was it? The American
• 1:39:50
  Speaker 2: Experiment came out for the anniversary fiftieth.
• 1:39:54
  Speaker 1: I haven't seen it.
• 1:39:55
  Speaker 2: You got to see it?
• 1:39:56
  Speaker 1: Well, what's it? Right?
• 1:39:57
  Speaker 2: It's the founding fathers and their lives and how they
• 1:40:00
  Speaker 2: were fighting and what was going on behind the scenes.
• 1:40:03
  Speaker 2: They were just young kids. They were in their twenties, thirties.
• 1:40:05
  Speaker 1: I know that nuts.
• 1:40:06
  Speaker 2: Yeah, just Benjamin Franklin was the old dude. But they
• 1:40:09
  Speaker 2: were so young. But they were they were in the
• 1:40:12
  Speaker 2: middle of it. They kind of realized they were making history.
• 1:40:15
  Speaker 2: But so many things could have gone wrong. We would
• 1:40:18
  Speaker 2: not have had the United States if just a few
• 1:40:20
  Speaker 2: votes went one way or the other.
• 1:40:22
  Speaker 1: A few wars, yeah, all.
• 1:40:25
  Speaker 2: The battles that exactly the US was losing the war
• 1:40:28
  Speaker 2: Agon's Britain badly. Yeah, yeah, yeah, we don't think the
• 1:40:33
  Speaker 2: French enough.
• 1:40:34
  Speaker 1: Actually, I know, right, somehow they became our enemy. Remember
• 1:40:38
  Speaker 1: during the Gulf War, they turned French fries into freedom
• 1:40:42
  Speaker 1: Fries because people hated the French.
• 1:40:43
  Speaker 2: Yeah, but everyone hates the French because they're so arrogant. Sorry,
• 1:40:47
  Speaker 2: French have some friends who are good friends who are French.
• 1:40:50
  Speaker 1: I think generally when people are arrogant, it's because they
• 1:40:52
  Speaker 1: did something fucking awesome.
• 1:40:54
  Speaker 2: Well, in the eighteen hundreds they did they conquered Europe.
• 1:40:58
  Speaker 2: I'm not sure if that's awesome. Here's a fun perplexia
• 1:41:01
  Speaker 2: search I just did.
• 1:41:01
  Speaker 1: I said to Americans have a risk gene. A risk gene.
• 1:41:05
  Speaker 2: Yeah.
• 1:41:05
  Speaker 1: One of the best studied variants in the dopamine receptor
• 1:41:08
  Speaker 1: gene d r D four, specifically, the seven repeat seven
• 1:41:12
  Speaker 1: R version, is associated in some studies with novelty seeking, impulsivity,
• 1:41:17
  Speaker 1: and higher financial or social risk taking. I wonder if
• 1:41:21
  Speaker 1: I have that gene for sure? This seven probably not?
• 1:41:24
  Speaker 1: Who knows. The seven R variant is unevenly distributed around
• 1:41:29
  Speaker 1: the world. It's populations in populations across the America, as
• 1:41:32
  Speaker 1: it shows up in roughly forty eight percent of chromosomes studied,
• 1:41:34
  Speaker 1: while in East Asia it's found in only about two percent. Wow, WHOA,
• 1:41:39
  Speaker 1: that's crazy.
• 1:41:41
  Speaker 2: It'll come down to genetics.
• 1:41:43
  Speaker 1: Evolutionary work suggest it became more common in groups that
• 1:41:45
  Speaker 1: migrated further after leaving Africa, and those lineages are strongly
• 1:41:50
  Speaker 1: represented in the Americas today. That that actually makes I
• 1:41:55
  Speaker 1: was thinking of the people that you have the balls
• 1:41:57
  Speaker 1: to fucking come here. Yeah, were your balls. You don't
• 1:41:59
  Speaker 1: have to do that much, but you can still have
• 1:42:02
  Speaker 1: balls to gamble, and yes.
• 1:42:04
  Speaker 2: That must be a but then Australian should have it.
• 1:42:07
  Speaker 1: That completely meant well, sort of, you guys got forced there.
• 1:42:10
  Speaker 1: They moved everybody over there because they were criminals.
• 1:42:12
  Speaker 2: Right, This this d d R gene that you just saw,
• 1:42:16
  Speaker 2: that was it, d R four. I know a bit
• 1:42:19
  Speaker 2: about it because I'm writing it in my next book,
• 1:42:22
  Speaker 2: d R D four, Thanks Jamie. I call this the
• 1:42:24
  Speaker 2: f U gene because I'm trying to figure out what
• 1:42:27
  Speaker 2: makes humans special over other animals, and this is one
• 1:42:31
  Speaker 2: of them that we are seekers of explorers, and it's
• 1:42:36
  Speaker 2: it turns out it turns out that this gene is
• 1:42:38
  Speaker 2: turned on in teenagers. It gets eventually switched off, not totally,
• 1:42:43
  Speaker 2: but that might be why teenagers say f you to
• 1:42:46
  Speaker 2: their parents. But it's a way genetically to get them
• 1:42:49
  Speaker 2: out of the nest, like, oh, I can't stand these parents.
• 1:42:51
  Speaker 2: They suck they're idiots. I'm out of here. That's in
• 1:42:54
  Speaker 2: this in this gene.
• 1:42:57
  Speaker 1: Well, it's also I, as a parent, have been very
• 1:43:03
  Speaker 1: aware of not doing that to my kids, like not
• 1:43:06
  Speaker 1: forcing them into something that they don't want to do,
• 1:43:09
  Speaker 1: or pushing them in any general direction, but rather encouraging
• 1:43:12
  Speaker 1: them to seek out their interests and encouraging them to
• 1:43:16
  Speaker 1: just like take chance. And if I ever correct them,
• 1:43:19
  Speaker 1: if I ever get upset about something, one of the
• 1:43:21
  Speaker 1: first things that I tell them is, I've done all
• 1:43:23
  Speaker 1: everything that you've done. I've made every mistake, I've fucked up.
• 1:43:27
  Speaker 1: You're smarter than me. I've fucked up everything. I've lied
• 1:43:31
  Speaker 1: to my parents, I lied to teachers. I've done everything
• 1:43:35
  Speaker 1: that you're doing. So it's this is not a unique thing.
• 1:43:38
  Speaker 1: I'm just telling you from my own personal experience, in
• 1:43:41
  Speaker 1: my perspective. This is why I think because I love
• 1:43:44
  Speaker 1: you and I want you to do well in life,
• 1:43:45
  Speaker 1: and I just want you to recognize this. And that's
• 1:43:48
  Speaker 1: how I correct my kids. It's never like you listen
• 1:43:52
  Speaker 1: to me because I'm your father.
• 1:43:53
  Speaker 2: Yeah, yeah, the way we will raise it doesn't work.
• 1:43:57
  Speaker 1: No, and it makes you resentment, but also probably makes
• 1:44:00
  Speaker 1: you want to do better than your parents, So like
• 1:44:03
  Speaker 1: motivates you in a certain way. Like my parents were
• 1:44:05
  Speaker 1: not risk takers at all, and my whole life I've
• 1:44:08
  Speaker 1: been like a wild risk taker.
• 1:44:10
  Speaker 2: That's really same. Yeah, I was resentful that my father
• 1:44:13
  Speaker 2: didn't have enough ambition. Now he's a great guy. We're
• 1:44:16
  Speaker 2: best friends. Actually it's been the greatest thing for me.
• 1:44:19
  Speaker 2: But one of the things I did with my kids
• 1:44:20
  Speaker 2: you reminded me is he's nineteen. He's a well built guy.
• 1:44:24
  Speaker 2: Because we were going to the gym for a number
• 1:44:26
  Speaker 2: of years. I've tried to train him in health, but
• 1:44:29
  Speaker 2: he spent the summer with me. He's literally still working
• 1:44:32
  Speaker 2: for me this summer to help with the podcast and
• 1:44:35
  Speaker 2: the magazine we're about to launch. And Benjamin's his name.
• 1:44:38
  Speaker 2: He's the best kid. But he slacked off. He was like,
• 1:44:42
  Speaker 2: ben I put you in charge of social media. You
• 1:44:43
  Speaker 2: haven't posted in a week. What's going on? Well, you know,
• 1:44:46
  Speaker 2: I slept in. So I had to think, am I
• 1:44:48
  Speaker 2: gonna get mad at him like I would a normal employee,
• 1:44:51
  Speaker 2: or do I treat him differently? And I decided to
• 1:44:54
  Speaker 2: treat him differently, probably because he's my son. But I
• 1:44:57
  Speaker 2: didn't want to ruin the relationship. But what I did was,
• 1:45:00
  Speaker 2: as I said, you know, I really think you can
• 1:45:04
  Speaker 2: do better. I think everything you've done, the weightlifting, the calculus,
• 1:45:09
  Speaker 2: you're amazing, But in this you're not. So what's going on?
• 1:45:14
  Speaker 2: And it worked. We become closer. He's really into it,
• 1:45:18
  Speaker 2: he's doing a good job.
• 1:45:19
  Speaker 1: That's great.
• 1:45:19
  Speaker 2: So that's the way to do it. I think you
• 1:45:21
  Speaker 2: can't be too hot on them. Can say you've fucked up.
• 1:45:24
  Speaker 1: Yeah, I mean that kind of can work, but it's
• 1:45:26
  Speaker 1: a blunt instrument and it doesn't work on everybody, and
• 1:45:30
  Speaker 1: it also develops resentment, and they also they miss out
• 1:45:34
  Speaker 1: on experiencing your perspective as a like for them to
• 1:45:40
  Speaker 1: understand that you are just a person who's lived longer
• 1:45:43
  Speaker 1: than them and that you can help them navigate this road.
• 1:45:47
  Speaker 2: Yeah, so you don't have to make the stay the
• 1:45:48
  Speaker 2: same mistakes.
• 1:45:49
  Speaker 1: Yeah, that's why you're helping them. You're talking to them
• 1:45:54
  Speaker 1: about this, not because you're just a mean dad who
• 1:45:58
  Speaker 1: likes to fucking tell the kids what to do. Because
• 1:46:00
  Speaker 1: we've all experienced that. I mean I had friends grown
• 1:46:02
  Speaker 1: up as fathers will fucking scream at them and throw
• 1:46:05
  Speaker 1: things and beat them, and it's like God, and then
• 1:46:09
  Speaker 1: you just grow up fucking traumatized and always resentful and
• 1:46:13
  Speaker 1: angry instead of just recognizing that, like, oh, I'm so
• 1:46:19
  Speaker 1: fortunate that my parents have this perspective where they can
• 1:46:23
  Speaker 1: explain to me why I'm going through what I'm going
• 1:46:26
  Speaker 1: through and how they got through it.
• 1:46:28
  Speaker 2: Like a mentor. You're not the best friend, you're the mentor. Yes,
• 1:46:31
  Speaker 2: my best friend doesn't work either.
• 1:46:33
  Speaker 1: No, that doesn't work either, because that just allows too
• 1:46:36
  Speaker 1: much shenanigans. You know, you have to have some rules,
• 1:46:38
  Speaker 1: you know, you have to have some some sort of regulations,
• 1:46:41
  Speaker 1: but you also.
• 1:46:42
  Speaker 2: Kids turned out?
• 1:46:43
  Speaker 1: Well, what's that?
• 1:46:44
  Speaker 2: How do your kids turn?
• 1:46:46
  Speaker 1: I'm so so lucky, so fucking lucky. I mean, I
• 1:46:49
  Speaker 1: feel so fortunate. They're so smart and ambitious and driven
• 1:46:53
  Speaker 1: and so it's wild. It's wild to watch, you know,
• 1:46:55
  Speaker 1: and talented. And it's and also like we never went
• 1:47:00
  Speaker 1: through that period where they hit teenage yeers and they
• 1:47:04
  Speaker 1: hate you like that. God, that's so nice. I mean,
• 1:47:09
  Speaker 1: my youngest shud get upset at me sometimes about certain things,
• 1:47:12
  Speaker 1: but she bounces back quickly. It's never like some kids
• 1:47:15
  Speaker 1: where they just grow to hate their parents.
• 1:47:18
  Speaker 2: Like forgen maybe they don't have strong one.
• 1:47:21
  Speaker 1: I don't know about that. I think it's how you
• 1:47:24
  Speaker 1: communicate with them. I really do. I think that's a
• 1:47:27
  Speaker 1: big factor. You have to communicate with them like you
• 1:47:31
  Speaker 1: truly care about their development. And the most important thing.
• 1:47:35
  Speaker 1: I think. The most important thing I think is that
• 1:47:37
  Speaker 1: I always tell them, whatever you've done, whatever mistake you've made,
• 1:47:41
  Speaker 1: I made way worse mistakes. It's like, I am not
• 1:47:43
  Speaker 1: coming at you from a flawless person. You know, I'm
• 1:47:46
  Speaker 1: not coming at you from the perspective of someone who
• 1:47:49
  Speaker 1: like you're an idiot. I figure that out. You should
• 1:47:52
  Speaker 1: figure it out. Like no. I whenever they from the
• 1:47:56
  Speaker 1: time they were really little, anytime I had a correct them,
• 1:47:58
  Speaker 1: I said, I did everything that you're doing. Everything.
• 1:48:03
  Speaker 2: I threw my food on the floor too.
• 1:48:05
  Speaker 1: Yes, all the above, every whatever fucking stupid thing you've
• 1:48:09
  Speaker 1: done as a kid. I guarantee you.
• 1:48:11
  Speaker 2: That is great advice, really great advice. So I hope
• 1:48:14
  Speaker 2: everyone listening heres that because I actually had to learn
• 1:48:17
  Speaker 2: the hard way my first kid. I did what my
• 1:48:19
  Speaker 2: parents did, which was you can't say that. Yeah, and
• 1:48:23
  Speaker 2: my first is a lot more rebellious and distant than
• 1:48:25
  Speaker 2: my third.
• 1:48:26
  Speaker 1: That is interesting.
• 1:48:27
  Speaker 2: Yeah, it actually is really true. I've seen it.
• 1:48:30
  Speaker 1: Yeah, and I thought I was gonna kill their motivation,
• 1:48:32
  Speaker 1: but it doesn't at all. Well, I thought, like, you know,
• 1:48:35
  Speaker 1: making things easy for them and not being strict, Like,
• 1:48:38
  Speaker 1: maybe it's good to be strict because then you just
• 1:48:40
  Speaker 1: have this determination. I'll show everybody. I don't think that
• 1:48:43
  Speaker 1: was my thing as a child, Like I'll fucking show you.
• 1:48:47
  Speaker 1: But I don't think everybody needs that. I think you're
• 1:48:50
  Speaker 1: much better off having a healthy relationship with ambition, where
• 1:48:55
  Speaker 1: you're excited about things because you're passionate about them and
• 1:48:58
  Speaker 1: you find great reward in being creative or being enthusiastic
• 1:49:04
  Speaker 1: about something exactly.
• 1:49:06
  Speaker 2: And open their eyes to the world that exists. Yes,
• 1:49:09
  Speaker 2: we used to do work experience. You go and do
• 1:49:11
  Speaker 2: a job and that's your work experience. The reason I
• 1:49:13
  Speaker 2: wanted my son Ben to work with me is he
• 1:49:15
  Speaker 2: can see how what it's like to be an entrepreneur
• 1:49:17
  Speaker 2: and build something and be excited and work is super fun.
• 1:49:21
  Speaker 2: It's I think a lot of kids just don't get
• 1:49:24
  Speaker 2: that experience. They don't know what's possible, right, and just
• 1:49:26
  Speaker 2: showing them the world is what we can do as parents.
• 1:49:29
  Speaker 1: That's awesome. Yeah, and you know, I mean, some people
• 1:49:34
  Speaker 1: don't have that at home, unfortunately. But that's one of
• 1:49:37
  Speaker 1: the cool things about the world that we live in
• 1:49:40
  Speaker 1: is that kids today have access to so many different
• 1:49:43
  Speaker 1: perspectives now because of the Internet. There's so many different
• 1:49:48
  Speaker 1: podcasts and YouTube conversations and different things where they can
• 1:49:52
  Speaker 1: just take a little tool from that, just take a
• 1:49:55
  Speaker 1: little peace from that and apply it to the way
• 1:49:57
  Speaker 1: they interact with the world.
• 1:50:01
  Speaker 2: For sure. And I would encourage parents to give their
• 1:50:04
  Speaker 2: kids stuff to read. And we talked about social media,
• 1:50:08
  Speaker 2: how that's just addictive. I saw how my kids wanted
• 1:50:11
  Speaker 2: to just scroll through their phones then read. And if
• 1:50:14
  Speaker 2: they can't read a book, give them a magazine. I'd
• 1:50:17
  Speaker 2: subscribe to not Geo National Geographic for my kids, And
• 1:50:22
  Speaker 2: I think get them used to reading. It's going to
• 1:50:25
  Speaker 2: be a lost art if we don't know.
• 1:50:27
  Speaker 1: Is that nuts? I maybe read ten percent of the
• 1:50:31
  Speaker 1: things that I consume. I consume so much in audio
• 1:50:35
  Speaker 1: just for time reasons, because there's so much There's so
• 1:50:39
  Speaker 1: much time where I'm driving my car, or I'm working out,
• 1:50:42
  Speaker 1: or I'm in the sauna, or I'm in the hyperbaric chamber,
• 1:50:46
  Speaker 1: or I'm in the red light therapy.
• 1:50:47
  Speaker 2: That's reading three res.
• 1:50:48
  Speaker 1: It is similar, but I think it's only like seventy
• 1:50:52
  Speaker 1: percent of reading. I don't think it's one hundred percent.
• 1:50:55
  Speaker 1: I don't think you get the full effect. But it's
• 1:50:56
  Speaker 1: still way better than not doing it, you know. But
• 1:50:59
  Speaker 1: I'm aware that like sitting there concentrating, actually reading a
• 1:51:03
  Speaker 1: book without hearing another person's voice talking, there's another mechanism,
• 1:51:07
  Speaker 1: there's another thing that's going on. That's it's a different
• 1:51:11
  Speaker 1: way you interact with the material, whether it's non fiction
• 1:51:13
  Speaker 1: or fiction. Yeah.
• 1:51:15
  Speaker 2: I like the fact that I can listen to you
• 1:51:16
  Speaker 2: and i'm doing something else. I have to sit down,
• 1:51:19
  Speaker 2: can move, go for a walk.
• 1:51:20
  Speaker 1: Yeah, that's for me. It's it's just I'm I have
• 1:51:24
  Speaker 1: too many interests. I have way too many things that
• 1:51:26
  Speaker 1: I do, and so it's very hard for me to
• 1:51:29
  Speaker 1: just allocate a certain amount of time to sit there
• 1:51:31
  Speaker 1: in silence and read. Yeah.
• 1:51:33
  Speaker 2: I use reading to fall asleep. That's a good way.
• 1:51:35
  Speaker 1: It does do that, right, It's kind of nuts how
• 1:51:37
  Speaker 1: well it does that.
• 1:51:38
  Speaker 2: Yeah, although I'm finding it's harder to read now that
• 1:51:41
  Speaker 2: my eyes on young need some of my gas. I've
• 1:51:46
  Speaker 2: tried that. Does it work for you?
• 1:51:47
  Speaker 1: Oh yeah? Oh, I mean, people are skeptical about this
• 1:51:52
  Speaker 1: and they think I'm full shit. No, I don't need
• 1:51:54
  Speaker 1: reading glasses anymore. Really, yes, I had reading I always
• 1:51:58
  Speaker 1: have these fucking things laying around. I don't even use
• 1:52:00
  Speaker 1: them anymore.
• 1:52:01
  Speaker 2: It's awesome. Yeah, there's a lot of signs now. The
• 1:52:03
  Speaker 2: red light it's real.
• 1:52:05
  Speaker 1: I can tell you as a regular user for multiple years.
• 1:52:09
  Speaker 1: It took a while. It took like I was waiting
• 1:52:12
  Speaker 1: for it in the beginning, like what the fuck in In fact,
• 1:52:14
  Speaker 1: and not only that, in the beginning, because I don't
• 1:52:17
  Speaker 1: close my eyes in the red light bed, I thought
• 1:52:19
  Speaker 1: it was making things blurrier. I was like, oh my god,
• 1:52:22
  Speaker 1: am I fucking up my eyesight like listening to these assholes.
• 1:52:25
  Speaker 1: But no, it just took a while, and then over
• 1:52:29
  Speaker 1: the course of like many months, I started seeing some
• 1:52:32
  Speaker 1: small improvements, and then I started seeing some pretty big
• 1:52:35
  Speaker 1: improvements over the course of about a year. Whereas now
• 1:52:40
  Speaker 1: it's not my eyes aren't perfect. They aren't like they
• 1:52:43
  Speaker 1: were when I was twenty, but they are way better
• 1:52:45
  Speaker 1: than they were when I was fifty.
• 1:52:47
  Speaker 2: Oh often did you have to do that?
• 1:52:49
  Speaker 1: I do it three times a week minimum. That's what
• 1:52:51
  Speaker 1: I try to do. But sometimes I'll do it five
• 1:52:53
  Speaker 1: days a week. Well, I just get in there and
• 1:52:55
  Speaker 1: it's twenty minutes. I lay in a light bed, close
• 1:52:57
  Speaker 1: my eyes, open my eyes whatever. It seems to work
• 1:53:00
  Speaker 1: on your vision, even if you wear a blindfold.
• 1:53:03
  Speaker 2: What about people that kind of a bed can you
• 1:53:05
  Speaker 2: get a little Yes.
• 1:53:06
  Speaker 1: You can get. Well, there's a company called it's called
• 1:53:09
  Speaker 1: Jewve right j u u V is that the name
• 1:53:12
  Speaker 1: of the company. They were our sponsor at one point
• 1:53:15
  Speaker 1: in time. That's how I started it. They had it's
• 1:53:18
  Speaker 1: just a light panel that you stand in front of
• 1:53:22
  Speaker 1: h and that that works too. That but this one,
• 1:53:26
  Speaker 1: the one that I got a red and near infrared
• 1:53:29
  Speaker 1: light therapy devices juve joo vv medical grade light therapy devices.
• 1:53:36
  Speaker 1: I had one of those and that's when I started
• 1:53:38
  Speaker 1: seeing benefits. But the the big one that I got,
• 1:53:42
  Speaker 1: I got from Gary Breca from his company, and it's
• 1:53:45
  Speaker 1: it's a like a fucking tanning bed and you lie
• 1:53:47
  Speaker 1: in it. And that one's amazing. But that's expensive. But
• 1:53:50
  Speaker 1: I don't think you have to have that for those
• 1:53:52
  Speaker 1: kind of improvements. Also improves collagen your skin, makes you
• 1:53:55
  Speaker 1: look better and the But for me, the most obvious
• 1:54:00
  Speaker 1: and profound was the improvement in my vision?
• 1:54:03
  Speaker 2: Well, it makes sense. The signs behind red light wasn't
• 1:54:06
  Speaker 2: there ten years ago and people were questioning it. But
• 1:54:08
  Speaker 2: now we know if you shine certain wavelengths like nearing
• 1:54:12
  Speaker 2: for red on cells the mitochondria, which are important for
• 1:54:16
  Speaker 2: reversing aging or slowing it get redd up. It's actually
• 1:54:19
  Speaker 2: related to viagra. Long story, but viagra and red light
• 1:54:24
  Speaker 2: if something is in common, and it does help mitochondria,
• 1:54:27
  Speaker 2: and that's very important for the eye, that mighty chondria
• 1:54:29
  Speaker 2: actually the most important in any part of your body.
• 1:54:32
  Speaker 2: The eye is the most important part. And part of
• 1:54:35
  Speaker 2: the reason we lose our vision is the mitochondria don't
• 1:54:37
  Speaker 2: make enough energy.
• 1:54:38
  Speaker 1: For the How come you haven't done red light therapy before.
• 1:54:41
  Speaker 2: Then, Well, I do, but not routinely. So I have
• 1:54:46
  Speaker 2: one of those bricks that I turn on while I'm
• 1:54:48
  Speaker 2: in the shower, and I have a red light cap
• 1:54:50
  Speaker 2: for my hair, which there's some evidence.
• 1:54:54
  Speaker 1: Alien.
• 1:54:55
  Speaker 2: But what I do is I, yeah, it does. It
• 1:54:57
  Speaker 2: looks a little bit silly. I don't wor it in public.
• 1:55:00
  Speaker 2: I do lower it and I look at it and
• 1:55:02
  Speaker 2: it shines in my eyes and on my face in
• 1:55:04
  Speaker 2: the hopes that it might help you.
• 1:55:06
  Speaker 1: Yeah, they have one that you wear like doctor Doom.
• 1:55:08
  Speaker 1: It fits over your face and blast red light and
• 1:55:10
  Speaker 1: your whole face.
• 1:55:11
  Speaker 2: I definitely feel a bit weird afterwards, and I can
• 1:55:14
  Speaker 2: see speckles. But I think the science says that it
• 1:55:17
  Speaker 2: can help.
• 1:55:18
  Speaker 1: Well, all I know is my own anecdotal experience, and
• 1:55:22
  Speaker 1: for me, it has radically improved my vision.
• 1:55:26
  Speaker 2: That's a good tip.
• 1:55:27
  Speaker 1: Yeah, it stopped. It was my vision was degrading. Like
• 1:55:32
  Speaker 1: it was. It was pretty odd. Like I first started
• 1:55:35
  Speaker 1: using like reading glasses like a one x like it
• 1:55:38
  Speaker 1: made it a little better. I'm like, oh, this a
• 1:55:39
  Speaker 1: little better, makes it clearer. And then I went to
• 1:55:41
  Speaker 1: two and then I was using two point five and
• 1:55:44
  Speaker 1: it made it better, but it was like, God, this
• 1:55:46
  Speaker 1: is annoying. And then if I would try to read
• 1:55:49
  Speaker 1: an email and I didn't have my reading glasses, I
• 1:55:52
  Speaker 1: couldn't read shit. Now crystal clear, Yeah, no problem at all.
• 1:55:57
  Speaker 2: Well, so my latest show is about the eye and
• 1:55:59
  Speaker 2: how to take the eye's health, and so there's a
• 1:56:03
  Speaker 2: lot you can do, actually, supplements, red light, other things.
• 1:56:07
  Speaker 1: I take supplements for it too. I should mention that
• 1:56:09
  Speaker 1: I take No, I have no affiliation with these people
• 1:56:12
  Speaker 1: with pure encapsulations. Makes a supplement called macular support, and
• 1:56:17
  Speaker 1: I take that and it's a combination of lutine and
• 1:56:20
  Speaker 1: a few other things.
• 1:56:21
  Speaker 2: Yeah, there was a trial a while ago that showed
• 1:56:25
  Speaker 2: that taking xanthine and others as to xanthine, lute lutine,
• 1:56:31
  Speaker 2: they're good for the eye. So you can get products
• 1:56:33
  Speaker 2: like that.
• 1:56:34
  Speaker 1: Do you take it?
• 1:56:35
  Speaker 2: Not that brand, but yes, I take something similar.
• 1:56:37
  Speaker 1: And has it helped you at all?
• 1:56:40
  Speaker 2: I don't know. I haven't done an experiment.
• 1:56:41
  Speaker 1: Right, Well, if you weren't taking it, maybe you would
• 1:56:44
  Speaker 1: have more degeneration. Yeah.
• 1:56:45
  Speaker 2: Well, you know I've got neoperfect vision.
• 1:56:48
  Speaker 1: I don't need glasses, do you really?
• 1:56:50
  Speaker 2: Yeah? Near perfect, neoperfect. I mean I think low light.
• 1:56:54
  Speaker 1: Low light is with me. Yeah, where I'll go to
• 1:56:56
  Speaker 1: a restaurant with my kids and they can read the
• 1:56:58
  Speaker 1: menu and I'm like, that is so embarrassing. You can
• 1:57:01
  Speaker 1: read that. How do you read that? I can't read shit?
• 1:57:04
  Speaker 2: I don't know why?
• 1:57:05
  Speaker 1: Why?
• 1:57:06
  Speaker 2: Well, this is what I think. So we know from
• 1:57:09
  Speaker 2: my lab's work that the retina, because it has tens
• 1:57:12
  Speaker 2: of thousands of endings that pick up the light. As
• 1:57:16
  Speaker 2: you get older, those nerves lose their identity and they're
• 1:57:19
  Speaker 2: not working as well. And what we do is with
• 1:57:22
  Speaker 2: our therapy, we can restore those nerves back to being
• 1:57:27
  Speaker 2: functional nerves. And that's why mice and monkeys that lose
• 1:57:32
  Speaker 2: their retinal function get their perfect vision back again. We're
• 1:57:37
  Speaker 2: reminding those cells that have forgotten how to work. So
• 1:57:40
  Speaker 2: in your eye and my eye were twenty two months apart,
• 1:57:43
  Speaker 2: that those nerves, about half of them have forgotten how
• 1:57:46
  Speaker 2: to work properly. So we want to fix that and
• 1:57:48
  Speaker 2: go back to being young. It's not that our nerves
• 1:57:50
  Speaker 2: are gone. They're not dead. They're right there and we
• 1:57:52
  Speaker 2: can restore them. And that's going to be true for
• 1:57:54
  Speaker 2: a lot of organs. Is that the cells are still there.
• 1:57:57
  Speaker 2: They just need to be reminded how to work again.
• 1:58:00
  Speaker 1: What are the potential negative consequences of this kind of
• 1:58:03
  Speaker 1: work when you sit up at night and you worry,
• 1:58:06
  Speaker 1: I hope it doesn't do this. Is it cancer? Is
• 1:58:09
  Speaker 1: that the big one? Yeah?
• 1:58:11
  Speaker 2: It's though we've done a lot of work to ally
• 1:58:14
  Speaker 2: real fears. It is possible that if we go too young,
• 1:58:19
  Speaker 2: we can cause displasia, which is cells doing what they shouldn't,
• 1:58:22
  Speaker 2: or if they multiply and spread that would because if you.
• 1:58:25
  Speaker 1: Make the cells too young, like what I was saying
• 1:58:27
  Speaker 1: before about don't turn me into a baby.
• 1:58:28
  Speaker 2: Right, we don't want to go there. That's what Yamanaka
• 1:58:31
  Speaker 2: did and got the Nobell for it. But that's not
• 1:58:33
  Speaker 2: good here. But we never see our cells turn into
• 1:58:37
  Speaker 2: stem cells again, we can't. We had mice that we
• 1:58:40
  Speaker 2: left it, left the gene therapy on for twenty one
• 1:58:43
  Speaker 2: months in the eye and nineteen months in the whole
• 1:58:45
  Speaker 2: body of the animal, and if anything, they had less
• 1:58:48
  Speaker 2: tumors than the ones that didn't get treated. And we
• 1:58:51
  Speaker 2: actually know from a wonderful student in my lab and
• 1:58:55
  Speaker 2: a lot she's a PhD student. She found that when
• 1:58:57
  Speaker 2: you turn on these three same genes not in the
• 1:59:00
  Speaker 2: I but in cancer cells and tumors growing in mice,
• 1:59:03
  Speaker 2: human cancers growing in mice, they shrink. So we think
• 1:59:07
  Speaker 2: it might actually help for cancer as well, which was
• 1:59:09
  Speaker 2: a nice surprise.
• 1:59:10
  Speaker 1: Wow, that's incredible.
• 1:59:12
  Speaker 2: It makes sense. Right if you wake up a cancer
• 1:59:14
  Speaker 2: cell and it says, crap, I shouldn't be growing. I
• 1:59:18
  Speaker 2: should be a you know, a liver cell or something similar.
• 1:59:24
  Speaker 2: Now it kills itself. So we see that the cells
• 1:59:26
  Speaker 2: wake up, they realize what they were thirty years ago
• 1:59:29
  Speaker 2: and then they killed themselves.
• 1:59:32
  Speaker 1: What is on the horizon in terms of like what
• 1:59:34
  Speaker 1: would you like to accomplish or would you like to
• 1:59:37
  Speaker 1: work on that you can't do currently?
• 1:59:40
  Speaker 2: Well, lots lots. You know, funding in my lab got
• 1:59:43
  Speaker 2: completely cut last year and we've managed to survive through donations.
• 1:59:49
  Speaker 1: We why the funding get cut? Was it a USAID thing?
• 1:59:52
  Speaker 2: You remember there was a spat between Harvard and the
• 1:59:55
  Speaker 2: federal government. All of the funding to Harvard Medical School
• 1:59:58
  Speaker 2: got cut.
• 1:59:58
  Speaker 1: Was that during the time where the president was defending
• 2:00:02
  Speaker 1: those anti semitic comments on campuses.
• 2:00:07
  Speaker 2: Yeah, well allegedly. I'm not getting into the politics.
• 2:00:10
  Speaker 1: No, you need to get into politics. But during that
• 2:00:12
  Speaker 1: whole thing, Yeah.
• 2:00:13
  Speaker 2: Yeah, so what I almost had to fire most of
• 2:00:17
  Speaker 2: the people in my lab during that episode was quite scary,
• 2:00:20
  Speaker 2: but I raised so now my lab survives on donations,
• 2:00:25
  Speaker 2: not on federal government money. Thank you, friends, thank you,
• 2:00:29
  Speaker 2: thank you.
• 2:00:30
  Speaker 1: Well, the thing is you've accomplished enough where people like
• 2:00:33
  Speaker 1: I think he's onto something and I don't want to
• 2:00:35
  Speaker 1: live forever.
• 2:00:36
  Speaker 2: Well, I'm lucky. Most scientists can't raise money like that,
• 2:00:39
  Speaker 2: So really, really it's a blessing. And now I'm raising
• 2:00:41
  Speaker 2: money through a foundation to help other scientists survive. But yeah,
• 2:00:46
  Speaker 2: it's been a blessing. But your question was what do
• 2:00:50
  Speaker 2: I wish I could do? Yeah, I wish I could
• 2:00:52
  Speaker 2: go faster. I wish I could try multiple approaches so
• 2:00:55
  Speaker 2: we don't used to have one shot on goal. It's
• 2:00:58
  Speaker 2: going slower than I would want. With a big injection
• 2:01:01
  Speaker 2: of cash, we could do a lot of trials, a
• 2:01:03
  Speaker 2: lot of different tissues. We could do a whole body
• 2:01:07
  Speaker 2: rejuvenation as well.
• 2:01:07
  Speaker 1: Do you have a website where people can donate?
• 2:01:11
  Speaker 2: I do. It's lifespan dot com.
• 2:01:14
  Speaker 1: So if you go to lifespan dot com. Yeah, there's
• 2:01:17
  Speaker 1: a link there.
• 2:01:18
  Speaker 2: Yeah, you can do it. A foundation and we're raising
• 2:01:20
  Speaker 2: money for this type of research.
• 2:01:22
  Speaker 1: Is it tax deductible.
• 2:01:24
  Speaker 2: Depends on how big the donation is. For ten dollars,
• 2:01:28
  Speaker 2: you get the new magazine that we're putting out and
• 2:01:30
  Speaker 2: you learn all about how to live longer building. I'm
• 2:01:34
  Speaker 2: hoping to build the world's largest longevity community of millions
• 2:01:36
  Speaker 2: of people who can learn how to really live longer
• 2:01:39
  Speaker 2: and build healthcare from the ground up because top down
• 2:01:41
  Speaker 2: from the government hasn't worked. Yeah. Actually, I have a
• 2:01:44
  Speaker 2: gift for you where you are. I made something for
• 2:01:48
  Speaker 2: you that's unique. This is for you, Joe, as a
• 2:01:54
  Speaker 2: thanks it's all the support you've given me and the science.
• 2:01:57
  Speaker 1: Over the years. First edition Lifespan Magazine. Ladies and gentlemen,
• 2:02:02
  Speaker 1: look at that.
• 2:02:03
  Speaker 2: It's written by scientists.
• 2:02:04
  Speaker 1: So it's cover. It's like a velvet cover. What is this?
• 2:02:07
  Speaker 2: I figured it might like that. Inside is the magazine?
• 2:02:10
  Speaker 1: Is this material? It's beautiful lure of course.
• 2:02:15
  Speaker 2: A great expense. No, the magazine doesn't come with the lore.
• 2:02:17
  Speaker 2: That's just special for Joe as a thank you, President,
• 2:02:21
  Speaker 2: Thank you very much. Most most science out there is
• 2:02:24
  Speaker 2: written by reporters who don't know what they're talking about,
• 2:02:27
  Speaker 2: and so we want we wrote this for the public
• 2:02:30
  Speaker 2: and you can believe whatever you read in there.
• 2:02:32
  Speaker 1: All right, beautiful, so you have to trust it.
• 2:02:36
  Speaker 2: So that's at lifespan dot com. You can subscribe get
• 2:02:39
  Speaker 2: that every month just for ten bucks.
• 2:02:41
  Speaker 1: I like to take at the bottom, life's too short.
• 2:02:44
  Speaker 1: Let's fix that.
• 2:02:45
  Speaker 2: That's our slogan.
• 2:02:46
  Speaker 1: That's life slogan. Yeah, it's an awesome slogan.
• 2:02:50
  Speaker 2: So it's it's a it's a community. It's the show.
• 2:02:52
  Speaker 2: My show is also called Lifespan on YouTube. But the
• 2:02:55
  Speaker 2: magazine is a passion project. I want to put out
• 2:02:57
  Speaker 2: something that people love. It's beautiful, all right, it's like
• 2:03:02
  Speaker 2: National Geographic. By the way, just today, this is no joke.
• 2:03:07
  Speaker 2: It seems crazy, but my labs research is on the
• 2:03:10
  Speaker 2: cover of National Geographic.
• 2:03:12
  Speaker 1: Oh that's awesome.
• 2:03:13
  Speaker 2: That just came out today. They heard, by the way,
• 2:03:15
  Speaker 2: at that geo. They said, you're going on Joe Rogan.
• 2:03:18
  Speaker 2: I went yeah, they goes, all right, we'll put it
• 2:03:20
  Speaker 2: out early so you can now read about my lab's
• 2:03:23
  Speaker 2: research on that geo as well today.
• 2:03:24
  Speaker 1: That's very cool. That's very cool. So you would just
• 2:03:28
  Speaker 1: like to do more, have more funding, do more. That's
• 2:03:32
  Speaker 1: the thing that you wish it could be working on now,
• 2:03:34
  Speaker 1: just having more different, more different studies and tests running concurrently.
• 2:03:39
  Speaker 2: We could go so fast with AI because it's spitting
• 2:03:42
  Speaker 2: out new drug candidates all the time that we can't test.
• 2:03:44
  Speaker 2: It takes years to get through. So with money, we
• 2:03:47
  Speaker 2: could do a lot more trials and put these through
• 2:03:50
  Speaker 2: different diseases much faster.
• 2:03:51
  Speaker 1: If you had no regulations, like an Island of Doctor
• 2:03:54
  Speaker 1: Moreau type deal.
• 2:03:55
  Speaker 2: Yeah, well, you know, well, at the risk of getting
• 2:03:58
  Speaker 2: kicked out of my universe. Theoretically, we could very safely
• 2:04:05
  Speaker 2: do more animal studies and with those best candidates put
• 2:04:09
  Speaker 2: them into humans quicker. Right now, it takes years. It's
• 2:04:12
  Speaker 2: taken us close to ten years to go from the
• 2:04:15
  Speaker 2: first discovery in my lab in Nature magazine to now.
• 2:04:19
  Speaker 2: But that's too slow. People dying one hundred and fifty
• 2:04:22
  Speaker 2: thousand a day on this planet. It's terrible. So I
• 2:04:25
  Speaker 2: would love to have the resources, you know, like Jeff
• 2:04:28
  Speaker 2: Bezos and others. Yeah, my company, by the way, even
• 2:04:31
  Speaker 2: though we lead the pack of all these guys, we're
• 2:04:34
  Speaker 2: really small. We're a pretty small little outfit in Boston.
• 2:04:40
  Speaker 2: We've raised a lot less money, but we're because I
• 2:04:42
  Speaker 2: think we're focused. We have and we started earlier. We're
• 2:04:45
  Speaker 2: doing pretty well.
• 2:04:46
  Speaker 1: That's the big one. You started earlier, you have a
• 2:04:48
  Speaker 1: lot of momentum on your side.
• 2:04:50
  Speaker 2: But I think we we could have a big impact
• 2:04:54
  Speaker 2: on aging in our lifetime with more money directed in
• 2:04:58
  Speaker 2: general at the field, not just me, but spread it.
• 2:05:01
  Speaker 2: And so the money that we raise from the magazine
• 2:05:03
  Speaker 2: is going to support other labs as well and students
• 2:05:08
  Speaker 2: who can find these medicines quicker.
• 2:05:10
  Speaker 1: So if you in a perfect world and you had
• 2:05:13
  Speaker 1: unlimited resources. You would just run a bunch of different
• 2:05:18
  Speaker 1: clinical trials and studies concurrently.
• 2:05:21
  Speaker 2: Yeah, AI is feeding us molecules, We put them into mice,
• 2:05:23
  Speaker 2: we go to monkeys, we go to humans, and it'll
• 2:05:25
  Speaker 2: just be fast. One of my friends, Alex Zakkarnkov, he
• 2:05:30
  Speaker 2: has a similar company, but not on exactly what we do,
• 2:05:34
  Speaker 2: not on reprogramming, but he's able to think. He's on
• 2:05:37
  Speaker 2: his thirty fifth drug. But he's driven by AI and robots.
• 2:05:43
  Speaker 2: His whole lab is robots at least he says they are,
• 2:05:46
  Speaker 2: and then goes into humans, and his company is worth billions.
• 2:05:51
  Speaker 2: That approach applied to what we do would be incredible.
• 2:05:54
  Speaker 1: Hmmm, that's best case scenario. That would be incredible. Well,
• 2:06:00
  Speaker 1: I'm hoping through this conversation that people are going to
• 2:06:03
  Speaker 1: reach out, and I'm hoping through this conversation that people
• 2:06:05
  Speaker 1: realizing like, oh, well, so much work has been done
• 2:06:09
  Speaker 1: and so many breakthroughs have been made. If they had
• 2:06:12
  Speaker 1: more access to resources, more access to different whatever you need,
• 2:06:18
  Speaker 1: you know, and that you could run all these different studies,
• 2:06:21
  Speaker 1: we could.
• 2:06:22
  Speaker 2: We were Our budget in my lab is only it's
• 2:06:25
  Speaker 2: almost three three and a bit millions, not much, right,
• 2:06:28
  Speaker 2: compared to what impact it could have on the planet,
• 2:06:30
  Speaker 2: which is trillions of dollars saved just in the US alone.
• 2:06:34
  Speaker 2: So it's a little bit of donation or getting a magazine,
• 2:06:39
  Speaker 2: the impact would be life changing for all of us.
• 2:06:43
  Speaker 2: Who doesn't age, who doesn't get.
• 2:06:44
  Speaker 1: Diseases, right, who doesn't want to feel better?
• 2:06:47
  Speaker 2: Yeah, it's also.
• 2:06:48
  Speaker 1: Like so much you can get so much more done
• 2:06:51
  Speaker 1: if you feel better.
• 2:06:53
  Speaker 2: Well, we take it for granted until we feel sick,
• 2:06:56
  Speaker 2: and it's like, oh right, I forgot what it's like
• 2:06:57
  Speaker 2: to feel well.
• 2:06:58
  Speaker 1: Exactly exactly. I had a day a week and a
• 2:07:02
  Speaker 1: half ago where I came back from Italy. I was
• 2:07:06
  Speaker 1: a little jet lagged, I didn't sleep right, and I
• 2:07:09
  Speaker 1: worked out really hard a bunch of days in a row,
• 2:07:11
  Speaker 1: and I was working constantly, and then I had one
• 2:07:13
  Speaker 1: day I was like, I kind of feel like shit,
• 2:07:16
  Speaker 1: Like I better not do anything today, and I, you know,
• 2:07:20
  Speaker 1: after I was on work, I just watched TV and relaxed.
• 2:07:24
  Speaker 1: I went and I was like, I can't wait to
• 2:07:27
  Speaker 1: feel better again.
• 2:07:28
  Speaker 2: Well, imagine what it's like being old, yes and frail.
• 2:07:31
  Speaker 2: That's every day or sick and right now you can't
• 2:07:34
  Speaker 2: do anything about it.
• 2:07:35
  Speaker 1: Yes, yeah, and while you're healthy, you take it for granted,
• 2:07:40
  Speaker 1: and that's the real sin. Like you're like, ah, I'm fine,
• 2:07:44
  Speaker 1: I'm great. I mean, this is what people do when
• 2:07:46
  Speaker 1: they go out drinking, right, They take advantage of the
• 2:07:49
  Speaker 1: fact that it's worth it for a good time. Just
• 2:07:51
  Speaker 1: poison myself for a night.
• 2:07:53
  Speaker 2: Well, it's not worth it because that also accelerates aging
• 2:07:56
  Speaker 2: a big time, Right, is what I tell my kids
• 2:07:58
  Speaker 2: who like alcohol. Like my kids, you know, you might
• 2:08:02
  Speaker 2: feel better in a few days, but the memory of
• 2:08:04
  Speaker 2: that is going to be in your body. Yeah, I
• 2:08:07
  Speaker 2: think you can drink. It's you know, it's fine to
• 2:08:09
  Speaker 2: get drunk once in a while, but not a lot,
• 2:08:11
  Speaker 2: not constantly. I used to drink once a day, and
• 2:08:14
  Speaker 2: I do not do that anymore because the date is
• 2:08:16
  Speaker 2: incontrovertible that it affects the brain, even the size of
• 2:08:19
  Speaker 2: the brain, if you drink constantly consisting.
• 2:08:21
  Speaker 1: I took eight months off of no alcohol at all,
• 2:08:24
  Speaker 1: and I felt a lot better.
• 2:08:25
  Speaker 2: Exactly.
• 2:08:26
  Speaker 1: I started drinking again one night. I went to dinner
• 2:08:28
  Speaker 1: with my wife and had a margarite, and I was like,
• 2:08:30
  Speaker 1: I think I'm back.
• 2:08:32
  Speaker 2: Ah, really, well, I saw I drink.
• 2:08:35
  Speaker 1: Now I do not get drunk. I haven't gotten drunk.
• 2:08:38
  Speaker 1: This was over a year ago. It was when I
• 2:08:40
  Speaker 1: had a drink again, I think I think it was
• 2:08:42
  Speaker 1: a year I'm not sure, but point is I have
• 2:08:45
  Speaker 1: not been drunk since then.
• 2:08:46
  Speaker 2: Yeah.
• 2:08:47
  Speaker 1: I will have a glass of wine with dinner, or
• 2:08:49
  Speaker 1: I will have a like a shot of whiskey before
• 2:08:53
  Speaker 1: I go on stage, like a little bit. But I
• 2:08:56
  Speaker 1: do not get drunk anymore. It's just not worth it
• 2:08:58
  Speaker 1: for me, the feeling after, or it's just so terrible
• 2:09:01
  Speaker 1: the morning, and especially for me because I work out
• 2:09:04
  Speaker 1: so much. When I wake up, it's like that workout's
• 2:09:07
  Speaker 1: gonna get done, okay, whether I feel like shit or not,
• 2:09:09
  Speaker 1: that workout is gonna get done. And this is gonna
• 2:09:11
  Speaker 1: be rough.
• 2:09:12
  Speaker 2: And then you got the sweats, it's all right.
• 2:09:14
  Speaker 1: Versus when I feel great, I love the workout. I'm excited,
• 2:09:18
  Speaker 1: like I look forward to it, even when it's hard.
• 2:09:21
  Speaker 1: When it's over, I'm like, whoo, all right, let's see,
• 2:09:23
  Speaker 1: and I don't feel bad. I feel good, And it's like,
• 2:09:27
  Speaker 1: why am I giving up that for a few hours
• 2:09:30
  Speaker 1: of a You know, it's just not worth it. It's not
• 2:09:34
  Speaker 1: worth it.
• 2:09:34
  Speaker 2: Yeah, Well, you're funny even without alcohol. But I'm not
• 2:09:37
  Speaker 2: so I've lost a lot of my humor. But there's
• 2:09:41
  Speaker 2: nothing better than feeling great right. Yes, and you can
• 2:09:43
  Speaker 2: make it your hobby of working on your health and
• 2:09:47
  Speaker 2: your longevity. Yeah, you'll enjoy it. Yes, it shouldn't be
• 2:09:50
  Speaker 2: a chore.
• 2:09:51
  Speaker 1: It'll also directly affect the other things that you love
• 2:09:55
  Speaker 1: because you will have more energy your life. Energy, your
• 2:09:58
  Speaker 1: vitality is so important for anything you're doing, whether it's
• 2:10:02
  Speaker 1: a creative thing or an intellectual thing, like anything that
• 2:10:06
  Speaker 1: you're doing, if you have more energy, you'll be able
• 2:10:08
  Speaker 1: to apply more energy to that thing. It's that simple.
• 2:10:11
  Speaker 1: You're building a bigger gas tank for yourself. You're building
• 2:10:15
  Speaker 1: a larger engine, and that's what you're.
• 2:10:17
  Speaker 2: Doing exactly mentally, physically, you can do so much. When
• 2:10:20
  Speaker 2: you feel good, you jump out of bed. If you
• 2:10:22
  Speaker 2: wake up and you're tired, woozy, you know your eyes
• 2:10:25
  Speaker 2: are puffy, that's not how it should be when you
• 2:10:28
  Speaker 2: wake up. If you're getting and sleep is important for longevity.
• 2:10:31
  Speaker 2: Of course, if you're getting good deep sleep, then you
• 2:10:33
  Speaker 2: should wake up and you feel great. Yes, yes, you
• 2:10:36
  Speaker 2: don't even necessarily need a cup of coffee, but it's
• 2:10:39
  Speaker 2: not bad. If you have one.
• 2:10:40
  Speaker 1: I like coffee. I'm not gonna stop drinking it now.
• 2:10:43
  Speaker 1: I'll give a fuck what anybody says.
• 2:10:44
  Speaker 2: Right, it's good.
• 2:10:45
  Speaker 1: And it's also like conflicting information. Some people say it's
• 2:10:48
  Speaker 1: good for you, there's benefits.
• 2:10:50
  Speaker 2: It's good for you. Come on, that's what I say. Oh,
• 2:10:52
  Speaker 2: it really is. Anyone that says it's not doesn't read
• 2:10:55
  Speaker 2: the well.
• 2:10:55
  Speaker 1: I would imagine. An over abundance of caffeine is not good.
• 2:11:01
  Speaker 1: Too much is not good.
• 2:11:02
  Speaker 2: But that's true for everything.
• 2:11:03
  Speaker 1: Too much salt of killer, Yeah, exact pound of salt,
• 2:11:06
  Speaker 1: You'll be dead in an hour.
• 2:11:07
  Speaker 2: Right, You can get away with very little sleep, actually
• 2:11:09
  Speaker 2: as long as a deep sleep, because what it's doing
• 2:11:12
  Speaker 2: is clearing out the misfolded proteins in your brain and
• 2:11:15
  Speaker 2: the toxins. We know this the glymphatic system. And if
• 2:11:18
  Speaker 2: you get deep sleep for you know, an hour, you're
• 2:11:22
  Speaker 2: actually going to wake up much cleaner, healthier. And what
• 2:11:27
  Speaker 2: I've been able to do with some work is figure
• 2:11:30
  Speaker 2: out how to get deep sleep every night. Efficiency on
• 2:11:34
  Speaker 2: these rings that say but above ninety Sometimes I like.
• 2:11:36
  Speaker 1: You say rings because you're wearing two Aura rings or okay,
• 2:11:42
  Speaker 1: why do you wear two different rings.
• 2:11:48
  Speaker 2: Because when I've got to neither of them is correct.
• 2:11:51
  Speaker 2: Now that the truth is some of them, some of
• 2:11:55
  Speaker 2: them are really good for sleep. The others are good
• 2:11:57
  Speaker 2: for a heart. And so I've this one's my heart,
• 2:12:00
  Speaker 2: this is my sleep.
• 2:12:01
  Speaker 1: What is the difference in the companies? Which one's which?
• 2:12:04
  Speaker 2: Um uh, you don't mind me saying who they are?
• 2:12:07
  Speaker 2: This is an aura, the one right, and then the
• 2:12:09
  Speaker 2: thinner one is called ultra human ultra human?
• 2:12:13
  Speaker 1: And which one is good for what? Well?
• 2:12:14
  Speaker 2: I find aura really good for sleep, that's their specialty,
• 2:12:18
  Speaker 2: and then the heart for ultra human my cardiac age.
• 2:12:22
  Speaker 1: Okay, So it's just like giving you data all the time.
• 2:12:26
  Speaker 2: Yeah, and they're getting even better because they I don't
• 2:12:28
  Speaker 2: get paid by these companies, but I do like that
• 2:12:31
  Speaker 2: they pop up with AI information. Now have you noticed
• 2:12:34
  Speaker 2: that data? Da Or I noticed that you ate a
• 2:12:37
  Speaker 2: meal last night that spiked your glucose? You know? And
• 2:12:41
  Speaker 2: this one I have a monitor on right now so
• 2:12:43
  Speaker 2: I can see what's going on anyway. But yeah, they're becoming.
• 2:12:45
  Speaker 1: Like a fucking monitored bro. I am two rings and
• 2:12:49
  Speaker 1: a patch.
• 2:12:50
  Speaker 2: It's a it's a hobby. It's a hobby, but you
• 2:12:53
  Speaker 2: learn a lot and I put one of these on
• 2:12:54
  Speaker 2: my son, and he stopped eating bad food for.
• 2:12:57
  Speaker 1: A long while, really, because he was just recked the impact.
• 2:13:00
  Speaker 2: Of the it's good for kids. Now. I wouldn't say
• 2:13:03
  Speaker 2: slap it on a kid without pediatrician recommendation, but it
• 2:13:08
  Speaker 2: was amazing what happened when he could see the crap
• 2:13:11
  Speaker 2: that was going in his.
• 2:13:12
  Speaker 1: Mouth was doing to his blood sugar.
• 2:13:14
  Speaker 2: Really, it was amazing. I think it's a great loaraning tool,
• 2:13:16
  Speaker 2: if nothing else.
• 2:13:18
  Speaker 1: Right, just to have actual data. I know a lot
• 2:13:20
  Speaker 1: of people it's changed their opinion on alcohol, particularly the
• 2:13:24
  Speaker 1: or ring when they look at their sleep, because even
• 2:13:27
  Speaker 1: just a couple of drinks before you go to bed,
• 2:13:29
  Speaker 1: like a couple of drinks at dinner, and then you
• 2:13:32
  Speaker 1: realize like, oh god, my sleep was all fucked up
• 2:13:35
  Speaker 1: because of those drinks.
• 2:13:37
  Speaker 2: Yeah, lay off the medafinil too for me anyway.
• 2:13:40
  Speaker 1: Yeah, yeah, some medafenol fucks with your sleep as well.
• 2:13:43
  Speaker 2: Yeah. I have to work really hard to sleep. Well,
• 2:13:46
  Speaker 2: there's quiet time, there's relaxation, the lights are dimmed. I
• 2:13:51
  Speaker 2: think about a happy place rather than work. I had
• 2:13:55
  Speaker 2: to do that because for fifty years I was burning
• 2:13:56
  Speaker 2: the candle at all ends. I was really burnt out.
• 2:14:00
  Speaker 2: So I've fixed that now I don't worry.
• 2:14:01
  Speaker 1: So are you one of those guys that like dims
• 2:14:04
  Speaker 1: the lights in your house a couple hours before you
• 2:14:06
  Speaker 1: go to bed and prepare it. Stay off your phone? Yeah,
• 2:14:09
  Speaker 1: all that stuff.
• 2:14:10
  Speaker 2: Well, I don't stay off my phone as much as
• 2:14:12
  Speaker 2: I want to.
• 2:14:13
  Speaker 1: But to wear red light glasses or anything like blockers
• 2:14:16
  Speaker 1: I used to.
• 2:14:17
  Speaker 2: I haven't found a big difference for myself. But interesting
• 2:14:21
  Speaker 2: fact that isn't well known if you block blue light
• 2:14:24
  Speaker 2: during the day or just stay indoors. There's a guy
• 2:14:27
  Speaker 2: in Japan who says that what happens is you get
• 2:14:31
  Speaker 2: short sightedness, and because the mice that lack the ability
• 2:14:37
  Speaker 2: to sense violet light get myopia short sighted and he's
• 2:14:41
  Speaker 2: got a device that indoors you can shineess But our
• 2:14:44
  Speaker 2: modern world, the LEDs and being indoors means we barely
• 2:14:48
  Speaker 2: get violet light. And that would be that would be
• 2:14:50
  Speaker 2: so interesting if that's what's causing last half I have
• 2:14:53
  Speaker 2: to wear glasses.
• 2:14:54
  Speaker 1: Wow.
• 2:14:55
  Speaker 2: And he claims that people that live out in the
• 2:14:57
  Speaker 2: countryside that see blue light all the time because they
• 2:14:59
  Speaker 2: go out, don't have as much need for glasses.
• 2:15:02
  Speaker 1: That actually makes sense well, particularly artificial light, and then
• 2:15:06
  Speaker 1: also light that's from a close source. Like one of
• 2:15:10
  Speaker 1: the things that if I do, if I'm tired and
• 2:15:14
  Speaker 1: I lay in bed and I try to read something
• 2:15:16
  Speaker 1: online on my phone, it hurts my eyes. The room's dark,
• 2:15:20
  Speaker 1: and it's like it irritates my eyes, where it never
• 2:15:22
  Speaker 1: irritates my eyes normally, but it's like at the end
• 2:15:25
  Speaker 1: of the day, you know, I guess I'm more fatigued
• 2:15:28
  Speaker 1: and so.
• 2:15:28
  Speaker 2: Then and you're trying to focus on yeh.
• 2:15:30
  Speaker 1: So like, now, think about that when people are doing
• 2:15:33
  Speaker 1: it all day long. Maybe you're doing it at work
• 2:15:34
  Speaker 1: where you have to start at a computer monitor from
• 2:15:37
  Speaker 1: three feet away or closer, and then you're looking at
• 2:15:40
  Speaker 1: your phone all the time, where you're working from a
• 2:15:41
  Speaker 1: tablet or you're watching television. It's like you're constantly staring
• 2:15:45
  Speaker 1: at these light sources that are artificial.
• 2:15:48
  Speaker 2: Yeah, and also keep in mind that the muscles have
• 2:15:51
  Speaker 2: to focus. It's not naturally you don't naturally look this far.
• 2:15:54
  Speaker 2: Naturally you relax you see out there right to look here,
• 2:15:57
  Speaker 2: your muscles here have to be straining for hours and
• 2:16:00
  Speaker 2: they get very tired, and I guess eventually they age.
• 2:16:03
  Speaker 2: To a point where you cannot keep it up. And
• 2:16:06
  Speaker 2: sometimes I do this to see better though.
• 2:16:10
  Speaker 1: Well, it all makes sense if you think about it,
• 2:16:13
  Speaker 1: particularly like if your eyes are accustomed to only focusing
• 2:16:16
  Speaker 1: on things that are close. I mean, that was what
• 2:16:18
  Speaker 1: they would say about reading when people would have glasses, Oh,
• 2:16:20
  Speaker 1: you fucked up your vision reading, which I used to
• 2:16:23
  Speaker 1: think was nonsense, but I'm like, well, kind of makes
• 2:16:26
  Speaker 1: sense if you spend all day long focus even though
• 2:16:29
  Speaker 1: it's on a screen, You're spending all day long focusing
• 2:16:31
  Speaker 1: on a book that's only a foot from your face.
• 2:16:33
  Speaker 2: Yeah, it does make sense, and the lens gets really inflexible, right,
• 2:16:37
  Speaker 2: And I'm seeing this with my father. He's otherwise in
• 2:16:39
  Speaker 2: perfect health at eighty seven, which is amazing, but it's
• 2:16:42
  Speaker 2: his eyes that are failing him.
• 2:16:44
  Speaker 1: Maybe should get him a red light bed.
• 2:16:46
  Speaker 2: That's a great idea. Yeah, I'm gonna do that. He's
• 2:16:49
  Speaker 2: arriving tonight actually from Sydney.
• 2:16:52
  Speaker 1: He's uh, he's gonna get him a red light bed, man,
• 2:16:54
  Speaker 1: Because I'm telling you, there's not a thing that I've
• 2:16:56
  Speaker 1: done that's impacted me in a more obvious way than that,
• 2:17:01
  Speaker 1: in terms of like something that's hugely.
• 2:17:02
  Speaker 2: Yeah, I'm going to do it. And I mean he's
• 2:17:05
  Speaker 2: into science. He's been taking an aman resveratrol mid foreman exercising.
• 2:17:10
  Speaker 2: He goes to the gym two or three.
• 2:17:11
  Speaker 1: Times a week six months.
• 2:17:14
  Speaker 2: He's a role model at eighty seven, with no diseases,
• 2:17:17
  Speaker 2: no aches or pains. He's struggling the world. He was
• 2:17:20
  Speaker 2: in Japan two weeks ago. Wow, coming to the Boston.
• 2:17:23
  Speaker 1: That's so cool. I love hearing about people that are
• 2:17:27
  Speaker 1: older that just keep on top of it and stay
• 2:17:29
  Speaker 1: active and stay alive and enjoy life.
• 2:17:31
  Speaker 2: Yeah, exactly. He's a great role model. And what it
• 2:17:34
  Speaker 2: shows is he was an average guy till he was
• 2:17:36
  Speaker 2: in his sixties, and he figured he was going to
• 2:17:39
  Speaker 2: die in his seventies, probably because everyone in my family
• 2:17:41
  Speaker 2: dies young because we've got pretty bad jeans. But he's
• 2:17:44
  Speaker 2: just taken life by the horns and just is running
• 2:17:47
  Speaker 2: with it and has not physically aged except for his
• 2:17:51
  Speaker 2: eyes in the last twenty years. And that's not an exaggeration.
• 2:17:55
  Speaker 2: Anyone who's seen him knows he walks, he moves, he travels,
• 2:17:58
  Speaker 2: he does everything he was when he was forty.
• 2:18:01
  Speaker 1: That's where were things like resistance exercises are so important.
• 2:18:05
  Speaker 1: Because it maintains bone density, maintains muscle mass, maintains your
• 2:18:09
  Speaker 1: ability to just get around and do things.
• 2:18:11
  Speaker 2: That's the other reason to do that. I mean, you're
• 2:18:14
  Speaker 2: going to be really strong when you're older, and you
• 2:18:16
  Speaker 2: won't fall, and if you do fall, you'll bounce, you
• 2:18:18
  Speaker 2: won't break a bone. And he's like that. He's been
• 2:18:21
  Speaker 2: working out at the gym, mostly strength training, but balance
• 2:18:24
  Speaker 2: as well. It's very important to maintain balance. He's better
• 2:18:27
  Speaker 2: at the gym than me at eighty seven.
• 2:18:29
  Speaker 1: That's incredible.
• 2:18:29
  Speaker 2: That just shows how Yeah, I got to go to
• 2:18:34
  Speaker 2: the gym. How about next time if you have me on, you're.
• 2:18:37
  Speaker 1: Going to be buff. Do you get your trainer. You're
• 2:18:40
  Speaker 1: in Massachusetts. There's a ton of trainers out there.
• 2:18:42
  Speaker 2: Great, it's a deal.
• 2:18:45
  Speaker 1: We'll find you someone. We'll find you someone. Three days
• 2:18:47
  Speaker 1: a week. That's all you need. The other days you
• 2:18:49
  Speaker 1: could do stuff elective, do stuff that you want, you know,
• 2:18:54
  Speaker 1: but three days a week, get a personal trainer and
• 2:18:56
  Speaker 1: work out with them. Right, you're on, all right?
• 2:18:59
  Speaker 2: Will you know when it's going or you help me?
• 2:19:02
  Speaker 2: I can hear though that. There's probably a few million
• 2:19:04
  Speaker 2: people right now screaming David, just go to the lab.
• 2:19:07
  Speaker 2: Forget about the gym.
• 2:19:08
  Speaker 1: You need to help your stop work. It'll help everything.
• 2:19:11
  Speaker 1: It'll help the amount of research you're able to do.
• 2:19:13
  Speaker 1: You'll have more energy, you'll be more excited about things.
• 2:19:16
  Speaker 1: I'm sure you've seen those MRI cross sections of people's
• 2:19:19
  Speaker 1: tissue where they take like a seven year old man
• 2:19:22
  Speaker 1: who's sedentary versus seven year old man who's a marathon runner.
• 2:19:26
  Speaker 1: It's fucking extraordinary.
• 2:19:28
  Speaker 2: I've seen my own. There's there's too much fat in
• 2:19:31
  Speaker 2: the muscle. Got to get rid of it.
• 2:19:32
  Speaker 1: Yeah, yeah, it's really extraordinary when you see those images
• 2:19:36
  Speaker 1: like those really bring it home.
• 2:19:37
  Speaker 2: And the bone changes bone, t's fat too parts of
• 2:19:41
  Speaker 2: the bones. So, yes, you got to have the strength
• 2:19:44
  Speaker 2: training for sure.
• 2:19:46
  Speaker 1: Yeah. One hundred percent strength training is that's mandatory.
• 2:19:51
  Speaker 2: Yeah, and then do you do a lot of aerobic exercises?
• 2:19:53
  Speaker 1: Yes?
• 2:19:54
  Speaker 2: Good, Yeah, I saw the training bike.
• 2:19:56
  Speaker 1: Oh yeah, well you saw my hypoxia machines and he
• 2:19:59
  Speaker 1: just got all today. Yeah. The hypoxia thing. What it
• 2:20:05
  Speaker 1: does is it replicates fourteen thousand feet above sea level
• 2:20:10
  Speaker 1: and you train in it. And it also has a
• 2:20:12
  Speaker 1: heat element, so you could ramp the heat up to
• 2:20:15
  Speaker 1: one hundred and fifteen degrees, so one hundred and fifteen
• 2:20:17
  Speaker 1: degrees and fourteen thousand feet a kind of stuff. Yeah,
• 2:20:22
  Speaker 1: you're going to hell, that's what it is. Straight to
• 2:20:25
  Speaker 1: feel like it, but it shouldn't work right. Yeah.
• 2:20:28
  Speaker 2: POxy is great for muscle.
• 2:20:29
  Speaker 1: Yes, and for adaptation, that's the big thing. And my
• 2:20:32
  Speaker 1: friend Roman who installed it, who's owns one of the
• 2:20:35
  Speaker 1: guys from the company, it's a very they're very specific
• 2:20:39
  Speaker 1: with this protocol in terms of monitoring your heart rate,
• 2:20:42
  Speaker 1: when to do it, when to push, how much time
• 2:20:45
  Speaker 1: to spend, and how you do it. And it's very
• 2:20:47
  Speaker 1: scientific in terms of the application on athletes and that's
• 2:20:51
  Speaker 1: a My friend Adam Greentree turned me onto it, fellow Australian,
• 2:20:57
  Speaker 1: and he's a big hunter and does a lot of
• 2:21:01
  Speaker 1: mountain hunting and he said there's nothing he's ever done
• 2:21:04
  Speaker 1: that's had more of an impact on his cardio. So
• 2:21:06
  Speaker 1: it's been phenomenal.
• 2:21:07
  Speaker 2: Sounds wonderful. Actually, there's a lot of science behind that.
• 2:21:11
  Speaker 2: You probably know it. The best results are when people
• 2:21:16
  Speaker 2: are either having too much oxygen or not enough. And
• 2:21:20
  Speaker 2: you might say, well that's weird, why does it matter. Well,
• 2:21:23
  Speaker 2: you got to get out of the comfort zone hormesis
• 2:21:26
  Speaker 2: we keep talking about, and there's a big study in
• 2:21:30
  Speaker 2: Israel where they put people in these hyperbaric chambers.
• 2:21:33
  Speaker 1: I've done that protocol. Yeah yeah, sixty sessions of ninety
• 2:21:37
  Speaker 1: minutes over ninety days. Yeah yeah, yeah, I have one
• 2:21:40
  Speaker 1: a loss, you do, Yeah, because the.
• 2:21:43
  Speaker 2: Data's incontrovertible, better wound healing, better memory.
• 2:21:46
  Speaker 1: Increase in telemar length.
• 2:21:47
  Speaker 2: Yeah, I saw that one. That's the Israel's study.
• 2:21:50
  Speaker 1: Yes.
• 2:21:51
  Speaker 2: What I thought was interesting was when I went over
• 2:21:53
  Speaker 2: there myself and sat in that thing. They made a
• 2:21:57
  Speaker 2: joke over there in Israel. By the way, they said,
• 2:21:59
  Speaker 2: this gas chamber that were you going into, made by Germans.
• 2:22:02
  Speaker 2: I thought, that's not a funny joke. Don't say that again. Anyway,
• 2:22:06
  Speaker 2: I probably shouldn't have shared that. I did go into
• 2:22:09
  Speaker 2: the chamber. And what I found out and was that
• 2:22:13
  Speaker 2: they believe what I believe, which is it's not so
• 2:22:15
  Speaker 2: much the high pressure that's good for you. It's the
• 2:22:18
  Speaker 2: coming down that mimics hypoxia, which your room will mimic.
• 2:22:22
  Speaker 2: So the lack of oxygen, or the perceived lack of
• 2:22:24
  Speaker 2: oxygen from a high state is the benefit. Interesting and
• 2:22:28
  Speaker 2: that makes a lot of sense. You're going to grow
• 2:22:29
  Speaker 2: new blood vessels, just like viagra is going to open
• 2:22:33
  Speaker 2: things up. We actually had a paper two thousand and
• 2:22:36
  Speaker 2: twelve that found that one of the supplements that I take,
• 2:22:39
  Speaker 2: which everyone knows about, Niman, could allow animals to grow
• 2:22:44
  Speaker 2: new blood vessels by getting rid of a protein that
• 2:22:48
  Speaker 2: accumulates with aging. The bottom line is we could mimic
• 2:22:53
  Speaker 2: this lack of blood vessels with this pill, but by
• 2:22:56
  Speaker 2: exercising it's the same. What I really believe is barely
• 2:23:03
  Speaker 2: talked about in the medical establishment is that a major
• 2:23:05
  Speaker 2: reason we get sick when we get older is lack
• 2:23:08
  Speaker 2: of blood flow. It's really talked about, right, Vascular dementia
• 2:23:12
  Speaker 2: second largest cause of dementia in the world. Blood flow,
• 2:23:17
  Speaker 2: and it's the easiest to reverse. You just do exercise,
• 2:23:20
  Speaker 2: or take one of these PD five inhibitors viagra, or
• 2:23:25
  Speaker 2: you take my stuff which is an a man which
• 2:23:27
  Speaker 2: we think also works, or all.
• 2:23:28
  Speaker 1: The above, which is probably the best approach.
• 2:23:31
  Speaker 2: I'm two out of three, hopefully soon three out of three.
• 2:23:36
  Speaker 2: But yeah, you know, to protect your brain, which is
• 2:23:39
  Speaker 2: the most important because you don't want to be old
• 2:23:40
  Speaker 2: and demented. That's worse than anything. Keep the blood flowing
• 2:23:44
  Speaker 2: in your body. Remember that blood flowing is important.
• 2:23:47
  Speaker 1: Yes, couldn't agree more. David, You're a treasure. I really
• 2:23:51
  Speaker 1: appreciate you. Thank you for being here.
• 2:23:53
  Speaker 2: You've been so kind, and thank you for getting the
• 2:23:55
  Speaker 2: word out here about the great science that's going on.
• 2:23:57
  Speaker 1: Oh my pleasure, dude. I'm so happy that someone like
• 2:24:00
  Speaker 1: you out there doing this. I mean it's it's such
• 2:24:03
  Speaker 1: an enormous benefit to people that are listening to the
• 2:24:06
  Speaker 1: world and you're doing you're literally doing God's.
• 2:24:09
  Speaker 2: Work and we'll try to do more.
• 2:24:10
  Speaker 1: Thank you very much. Lifespan dot com is the website.
• 2:24:15
  Speaker 1: Please folks, if you're you're so inclined, go donate. It'll
• 2:24:19
  Speaker 1: really help will change the world. David, I love you
• 2:24:22
  Speaker 1: to Thank you by everybody.