Latest / Ageless and Timeless Podcast® / Reversing Alzheimer’s –The Bredesen Protocol and the Future of Brain Health

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Reversing Alzheimer’s –The Bredesen Protocol and the Future of Brain Health · Ageless and Timeless Podcast®

0:09
Speaker 1: Good morning everyone.
0:10
Speaker 2: This is Michelle Hughes from Ageless and Timeless. Today, I
0:14
Speaker 2: have a guest that I've been talking to for probably
0:17
Speaker 2: nine months, but I've known about him for a couple
0:19
Speaker 2: of years. His name is doctor Dale Gretison, and everybody
0:24
Speaker 2: that's into the ending of Alzheimer's knows him because he
0:30
Speaker 2: had a New York Times bestselling book, which I have
0:32
Speaker 2: right here, the End of Alzheimer's.
0:36
Speaker 1: And so I don't know if I'm doing this right.
0:39
Speaker 1: Is it in this? Is it in the video?
0:41
Speaker 3: A little? A little to your right, A little, yeah.
0:45
Speaker 1: The end of Alzheimer's.
0:47
Speaker 2: That is.
0:48
Speaker 1: Okay. So Dale, welcome. I'm so happy to have you here.
0:53
Speaker 2: And you know, I've been watching some of your podcasts
0:56
Speaker 2: on on the internet, and one thing I have to
1:00
Speaker 2: say right up front is you are truly on a mission,
1:05
Speaker 2: and you're one of the most dedicated and most passionate,
1:09
Speaker 2: but in a very subtle way. I mean, you don't
1:12
Speaker 2: wear it on your sleeve, but you are truly a pioneer,
1:16
Speaker 2: and you are truly doing something that is at the
1:19
Speaker 2: cutting edge. And I will tell everybody right up front,
1:23
Speaker 2: the first thing that Dale said to me after.
1:26
Speaker 1: Our get acquainted.
1:27
Speaker 2: Call that shocked me was he said, we will be Michelle,
1:33
Speaker 2: we will be the last generation of people who will
1:37
Speaker 2: look at Alzheimer's as an incurable disease. Well, that, coming
1:43
Speaker 2: from probably one of the most disastrous records in history
1:48
Speaker 2: of medicine for any disease.
1:51
Speaker 1: Is a bold statement, to say the least.
1:54
Speaker 2: So, Dale, why don't you just start off and tell
1:57
Speaker 2: us what is it that makes you so courageous to
2:02
Speaker 2: make a statement like that.
2:04
Speaker 1: Why do you think that can be?
2:07
Speaker 3: Yeah, that's a really good point, Michelle, And thanks for
2:09
Speaker 3: having me on.
2:10
Speaker 4: In fact, we have here.
2:11
Speaker 3: So here's the new book, which is called The Rain,
2:14
Speaker 3: which just became a New York Times bestseller. I agreed
2:19
Speaker 3: that I'll get you a copy of that.
2:21
Speaker 1: Thank you. Well, you know we are neighbors, so it's
2:24
Speaker 1: only a little.
2:29
Speaker 3: Right. So, what's what's changed dramatically during my career? And
2:33
Speaker 3: I've been doing this now for fifty years. I'm in
2:35
Speaker 3: my seventies, so this has been, you know, a lifelong passion.
2:39
Speaker 3: As you said, when we started out, we were told
2:43
Speaker 3: there's nothing you can do. There is nothing that will prevent,
2:47
Speaker 3: reverse or delay cognitive decline. In fact, you know some
2:51
Speaker 3: of the old work from from thousands of years ago.
2:54
Speaker 3: Pythagoras pointed out, you know, dimension what happens to people
2:59
Speaker 3: as they get old. Marcus Aurelius talked about what happens
3:03
Speaker 3: to people as they get older, and until just the
3:06
Speaker 3: work that we've been doing over the last ten years,
3:09
Speaker 3: that was the thought, there's nothing that you can do.
3:11
Speaker 3: As you get a little older, your mind slips, and
3:14
Speaker 3: for many people they can look forward to dementia. But
3:16
Speaker 3: as you pointed out, I did indeed say ours is
3:20
Speaker 3: the last generation that will fear Alzheimer's because for the
3:24
Speaker 3: younger generations, now what do they have? They have so
3:27
Speaker 3: many things that we did not have. Number one, there
3:31
Speaker 3: are new blood tests. Now there's something called brain scan
3:34
Speaker 3: which gives you a pe tow two seventeen, GFAP and NFL.
3:39
Speaker 3: That's three tests that literally look inside your brain and
3:43
Speaker 3: tell you are you on the way to that problem,
3:47
Speaker 3: and that there's a lot you can do about it.
3:49
Speaker 3: Now we have labs you can look to see what's
3:52
Speaker 3: driving it. Like never before, we can determine what is
3:56
Speaker 3: driving you or whether it's you've got a little brain fall,
4:00
Speaker 3: whether it's that you're really having trouble with your memory,
4:04
Speaker 3: or you're having trouble recognizing faces, or getting lost driving
4:08
Speaker 3: or remembering your keys, or any of these sorts of things.
4:12
Speaker 3: We can now determine what's causing that problem, and it's
4:15
Speaker 3: often multiple things. And of course COVID has been one
4:19
Speaker 3: of the things that has contributed to so many people
4:21
Speaker 3: having brain fog, but it's also the California fires, air pollution,
4:27
Speaker 3: and leaky gut changes in oral microbiome. There are dozens
4:32
Speaker 3: and dozens of things, chronic infections that people can be
4:36
Speaker 3: unaware of, exposure to various toxins that they're unaware of.
4:41
Speaker 3: We can ferret these out. We can identify and address
4:46
Speaker 3: them like never before, and we have such spectacular results
4:51
Speaker 3: with prevention and reversal of cognitive decline. We were the
4:55
Speaker 3: first to publish that back in twenty fourteen. We're now
4:58
Speaker 3: in the middle of a randomized can trolled trial at
5:01
Speaker 3: six sites around the country and this will be completed
5:04
Speaker 3: in October of this year. We have interim analysis to
5:08
Speaker 3: see where we stand here. We're now about two thirds
5:11
Speaker 3: of the way through and the results are really exciting.
5:15
Speaker 3: So we are seeing statistically significant benefits for people who
5:18
Speaker 3: are doing the right things, and the people who are
5:20
Speaker 3: on standard of care are actually going downhill instead of
5:24
Speaker 3: uphill as we know. So this really is a new
5:27
Speaker 3: era like never before. We understand, and we can do
5:30
Speaker 3: something about this so that we're getting to the point
5:33
Speaker 3: that we can tell people, look, this is really an
5:36
Speaker 3: optional problem. If you start early, get on active prevention
5:41
Speaker 3: or early treatment, you can do very, very well. And
5:44
Speaker 3: that was the point of the book The Ageless Brains
5:47
Speaker 3: for all of us, whether you're headed for Alzheimer's or not,
5:50
Speaker 3: let's optimize our performance and our protection of our brains.
5:54
Speaker 3: Because whether you're twenties or nineties or anywhere in between,
5:59
Speaker 3: your most important asset is a functional brain.
6:04
Speaker 1: You know, it's interesting because that little three pounds does
6:07
Speaker 1: the work of, like you said, two thousand computers, and
6:12
Speaker 1: people just take it for granted when they're young, and
6:14
Speaker 1: I think even as we get older. You know, we're told.
6:17
Speaker 2: To get our livid checked, we're told to get our
6:21
Speaker 2: hormones checked, you know, all these things that we have
6:24
Speaker 2: to take responsibility for, but we're never told to go.
6:28
Speaker 1: Get our brain check.
6:29
Speaker 2: So how do you make this paradigm shift to get
6:32
Speaker 2: people from being the creatures of habit, you know, and
6:36
Speaker 2: as David Promoter quoted, and I think it was originally
6:40
Speaker 2: an Einstein quoted, you know, doing the same thing over
6:43
Speaker 2: and over again and expecting different results. Well, you know,
6:46
Speaker 2: we've been led to believe that we can kind of
6:50
Speaker 2: ignore the brain until.
6:52
Speaker 1: It's too late. Yes, how do we change that paradigm?
6:56
Speaker 1: Doctor Gretison.
6:58
Speaker 3: Yeah, isn't that interesting? That's so important, And it stems
7:01
Speaker 3: from the fact that people thought there was nothing you
7:03
Speaker 3: could do about it, so they didn't bother to check.
7:05
Speaker 3: So in fact, still mainstream medicine will say, don't bother
7:08
Speaker 3: to check your apoe status, your genetics, because there's nothing
7:11
Speaker 3: you can do about if you've got an increased risk
7:15
Speaker 3: for Alzheimer's, there's nothing you can do about it. Well,
7:16
Speaker 3: that's absolutely wrong, and in fact, people are doing something
7:20
Speaker 3: about it all the time. So, you know, Michelle, the
7:22
Speaker 3: very first person that I treated who got better, was
7:26
Speaker 3: in April of twenty twelve and came out from Washington,
7:31
Speaker 3: d C. She'd been having problems and she was actually
7:34
Speaker 3: considering committing suicide because her doctor had already said you've
7:37
Speaker 3: got early Alzheimer's. Her mother had died of it. She
7:40
Speaker 3: had watched her mother in the nursing home. It was
7:41
Speaker 3: really sad to see, and so she was actually saving
7:45
Speaker 3: pills to kill herself. She came out and she was
7:48
Speaker 3: sixty seven. Then she's done absolutely great. She's about to
7:52
Speaker 3: turn eighty one, and she is now starting. She's by
7:55
Speaker 3: the way, she's a brain health coach now and she
7:59
Speaker 3: is starting on April fifth, a walk across the United
8:03
Speaker 3: States to bring attention to the fact that there is
8:07
Speaker 3: a lot you can do about brain health and about
8:10
Speaker 3: prevention and reversal of cognitive decline. And she's been doing
8:13
Speaker 3: it for thirteen years now. So she's going to be walking.
8:17
Speaker 3: She's done one hundred mile bike rides and she's done marathons.
8:21
Speaker 3: She's amazing, and she's going to begin to walk from
8:24
Speaker 3: San Diego to Saint Augustine, Florida. No, it's going to
8:28
Speaker 3: be it's a long way to walk, three five hundred miles.
8:33
Speaker 1: Is this patient zero from your booth?
8:35
Speaker 3: Patient zero, Judy. And so in fact, you can look
8:38
Speaker 3: there's a website Judy Walks, and you can see you
8:43
Speaker 3: can see her where she's going and where she is
8:45
Speaker 3: at each stage of the game. I think it's a
8:48
Speaker 3: wonderful story. But as you said, you know, we need
8:51
Speaker 3: people to know about this now, We need able to
8:54
Speaker 3: understand because so many times the doctor will just say
8:58
Speaker 3: you're getting a little older. It's just what you expect,
9:01
Speaker 3: and that is absolutely wrong.
9:04
Speaker 2: Right.
9:04
Speaker 1: Well, you you're obviously at the forefront of doing that
9:08
Speaker 1: as his doctor, pearl mother being such a big believer
9:11
Speaker 1: in being also you know, an expert in brain health.
9:16
Speaker 1: So I have to tell you that although Ageless and.
9:21
Speaker 2: Times is only six years old, and that's you know,
9:24
Speaker 2: that's a pretty good run for a podcast. But I
9:27
Speaker 2: from the very beginning, had a mission to educate people
9:32
Speaker 2: about brain health. I always felt the mission was to
9:36
Speaker 2: help people generally speaking, that to you know, take charge
9:39
Speaker 2: of their health. But I always felt like the problem
9:43
Speaker 2: of seeing people, you know, to deteriorate from this horrendous disease
9:49
Speaker 2: and might And by the way, my husband.
9:51
Speaker 1: I think I told you this. My husband was a football.
9:54
Speaker 2: Player and he developed Parkinson's without any genetics and any
10:00
Speaker 2: So I'm very close to you know.
10:02
Speaker 1: This subject, and it's.
10:05
Speaker 2: Near and dear to my heart when I hear stories
10:07
Speaker 2: like Gaudy you know what she's doing.
10:09
Speaker 1: Because I think that's this is all about it.
10:13
Speaker 2: It's just like taking anything that you want to create
10:16
Speaker 2: brand awareness. This is like a brand, you know, curing
10:20
Speaker 2: Alzheimer's the end of all sider And now how do
10:23
Speaker 2: we get that awareness out to people? And it's a
10:26
Speaker 2: little it's like baby steps. You know, you don't seem
10:30
Speaker 2: to have these huge paradigms. You're certainly you and your
10:33
Speaker 2: books have helped tremendously, and all your podcast lectures and
10:37
Speaker 2: your lectures around the country, and in fact, you know,
10:41
Speaker 2: I looked at Apollo Health and and you know, Deborah
10:45
Speaker 2: Geisler's going to be on my podcast I think in
10:50
Speaker 2: two weeks or three weeks so, and she's the you know.
10:54
Speaker 1: One of the founders with you of Gray Matters. Right,
10:58
Speaker 1: So let's let's take a little.
11:01
Speaker 2: When backed up a little bit, what gives Alzheimer's? How
11:05
Speaker 2: do you differentiate Alzheimer's from these other mental brain disorders?
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12:00
Speaker 3: Is a good point. So Alzheimer's was defined as a pathology.
12:04
Speaker 3: So doctor Alzheimer way back in nineteen oh six, sover
12:08
Speaker 3: one hundred years ago, had a patient who died who
12:12
Speaker 3: actually got demented in her fifties, quite demented and passed
12:17
Speaker 3: away and looked in the brain at that time saw
12:20
Speaker 3: the hallmarks. By the way, another doctor, doctor Oscar Fisher,
12:24
Speaker 3: right around the same time, also showed the same pathology.
12:28
Speaker 3: So you know it's called Alzheimer's, it should probably be
12:31
Speaker 3: called Alzheimer's Fisher disease, because they both did a superb
12:35
Speaker 3: and very important work to define this and you could
12:39
Speaker 3: see these these amyloid plaques, so it looks a little
12:43
Speaker 3: bit like a drop of maple syrums on the brain.
12:47
Speaker 3: You see these drops around and they are outside the
12:50
Speaker 3: cells mostly. And then he saw also these shrunken neurons
12:56
Speaker 3: with these tangled structures that he called neurofiblary tangles. What
13:01
Speaker 3: they became called neurofibrillary tangles. And it's turned out that
13:05
Speaker 3: these are associated with specific proteins. So those drops of syrup,
13:10
Speaker 3: the amyloid plaques have turned out to be a little
13:15
Speaker 3: peptide called beta amyloid, and so for years it was
13:19
Speaker 3: thought that's what's causing the problem. We now know that
13:23
Speaker 3: what happens is this is your brain's response to being
13:28
Speaker 3: attacked by various microbes and various things. So what happens
13:32
Speaker 3: is you have insults to your brain and your body
13:36
Speaker 3: is trying, just as if you would get an abscess
13:39
Speaker 3: in your tooth. You've got organisms there, but your body
13:42
Speaker 3: is making all those white cells that are what's making
13:44
Speaker 3: the abscess. They're doing it because they're trying to help you.
13:48
Speaker 3: They're not trying. They're not there to hurt you. It's
13:50
Speaker 3: the same idea with the amyloid, and then the one
13:53
Speaker 3: that these neurofibrillary tangles. These are composed largely of what's
13:59
Speaker 3: called phosphtao. And this is a fascinating story because tao
14:05
Speaker 3: is a molecule that is a normal brain molecule, and
14:09
Speaker 3: what it does is it bolts down your microtubules. So
14:13
Speaker 3: you have these microtubules that are part of the structure
14:17
Speaker 3: of your brain cells. So when you're growing these things
14:20
Speaker 3: and reaching out and making new contacts and keeping memory,
14:24
Speaker 3: just like putting an addition on your house, you need
14:28
Speaker 3: to have the bolts the structure to keep that strong. Now,
14:31
Speaker 3: what we've found in the research is that your body
14:34
Speaker 3: literally just the way it goes from sleep to wakefulness
14:38
Speaker 3: and all whole sort of things change. In going from
14:41
Speaker 3: sleep to wakefulness, you also go from connection mode to
14:46
Speaker 3: protection mode. When things are good, you are putting your
14:51
Speaker 3: resources into connections, so your tao is bolting down these
14:56
Speaker 3: things you're making and keeping these structures. When you've got inflammation,
15:01
Speaker 3: when you've got organisms there, when you've got toxin exposure,
15:06
Speaker 3: all these sorts of things, your brain literally switches from
15:10
Speaker 3: connection mode to protection mode. When it does that, your
15:14
Speaker 3: tau is phosphorylated, so you add phosphorus and oxygen to
15:19
Speaker 3: your tao and what it does is it changes the
15:23
Speaker 3: charge and the shape, so it pops off. Unfortunately that
15:27
Speaker 3: allows your neurrites to collapse again, but it now goes
15:31
Speaker 3: and it kills bacteria. So it's literally becoming an antimicrobial protein.
15:38
Speaker 3: And you're by the way, your amyloid is an antimicrobial
15:41
Speaker 3: peptide short piece of a protein. So it's clear that
15:46
Speaker 3: when you get this problem, you are responding to insults.
15:50
Speaker 3: And as you imply there there is an intimate relationship
15:54
Speaker 3: between brain aging and Alzheimer's and people have always argued,
15:58
Speaker 3: you know, is it separate, is it the same? You
16:00
Speaker 3: know what's going on here? Well, it turns out it
16:02
Speaker 3: is closely related. That's why it's hard to separate the two.
16:07
Speaker 3: So you do get this amyloid in your towel as
16:10
Speaker 3: for many people as they age, but you may not
16:13
Speaker 3: have dementia. This is why it's so important for anyone
16:17
Speaker 3: to get for everyone to get evaluated. And by the way,
16:20
Speaker 3: I just had my own tests done so everyone should know.
16:24
Speaker 3: They're what we call brain scan. It's a blood test
16:27
Speaker 3: for p TOW for it's called PTOW two seventeen because
16:32
Speaker 3: it's the one that correlates best GFAP, which tells you
16:36
Speaker 3: whether there's inflammation in your brain, and then NFL which
16:39
Speaker 3: tells you if there's damage to your neurons. These are
16:42
Speaker 3: three complementary tests that are absolutely critical and you get
16:47
Speaker 3: the little report that will show you. So you can
16:49
Speaker 3: go to get a brain scan dot com. You can
16:51
Speaker 3: actually have it drawn. I had it drawn in my kitchen.
16:54
Speaker 3: I don't do it with mobile phlebotomy. You can do
16:56
Speaker 3: it by going to a local draw station. Lots of
16:59
Speaker 3: ways to get the done. So it's a very helpful test.
17:03
Speaker 3: And so for the first time we can look without
17:06
Speaker 3: having to get to a spinal tap. We can look
17:09
Speaker 3: inside your brain with a simple blood test, see where
17:12
Speaker 3: you stand, and then we can address the things that
17:15
Speaker 3: are actually causing the decline. So Alzheimer's is a pathology,
17:20
Speaker 3: but it's been argued about what actually causes that. When
17:24
Speaker 3: you get it, by the way, you go through four phases,
17:27
Speaker 3: so you actually have a long time where you can
17:29
Speaker 3: prevent and reverse this problem. Phase one asymptomatic. You don't
17:34
Speaker 3: know you have problems, which is why early testing is
17:36
Speaker 3: so important. Phase two sci subjective cognitive impairment. By definition,
17:42
Speaker 3: you notice something's not quite right, but you're still able
17:46
Speaker 3: to score normally on cognitive testing. Phase three is MCI
17:51
Speaker 3: mild cognitive impairment, where now you are struggling on the test,
17:56
Speaker 3: but you're still able to care for yourself. And in
17:58
Speaker 3: phase four, unfortunately, dementia, where now you're having trouble with
18:02
Speaker 3: your activities of daily living. We find that in the
18:06
Speaker 3: first two phases we can get one hundred percent of
18:08
Speaker 3: the people to do very well. Phase three, in our trial,
18:12
Speaker 3: eighty four percent of the people improved, but some of
18:14
Speaker 3: them approved a lot, some of them proved a little.
18:17
Speaker 3: And phase four, the dementia, we do see people improve,
18:20
Speaker 3: but it's hard to bring them all the way back
18:22
Speaker 3: to normal, which is why again we want people get
18:25
Speaker 3: in early, get checked early. Let's make sure you never
18:28
Speaker 3: get to those phases three and four.
18:31
Speaker 2: So do you need a doctor's prescription to get a
18:34
Speaker 2: brain skin dot com No.
18:36
Speaker 3: So one of the things that we're involved in is
18:39
Speaker 3: trying to make this war available for everybody, make it
18:42
Speaker 3: so people can get appropriate labs, and then you can
18:44
Speaker 3: get a brain health coach. You can find a doctor
18:47
Speaker 3: who's been trained. We've trained over two thousand physicians all
18:51
Speaker 3: over the world and all over the US to be
18:55
Speaker 3: able to do this, and we do see big differences
18:57
Speaker 3: between people who are trained and who know what they're
19:00
Speaker 3: doing and people who haven't been trained, so that you
19:02
Speaker 3: can get very good outcomes for many doctors. So yeah,
19:06
Speaker 3: you don't have to have your doctor do this. You
19:08
Speaker 3: can get this online easily. And so we want to
19:13
Speaker 3: make this available so everybody can have the best chance
19:17
Speaker 3: of good outcomes in their cognition.
19:19
Speaker 2: And isn't this what Gray Matters is trying to do
19:22
Speaker 2: with respect to spreading, you know, expanding into different cities
19:28
Speaker 2: so that people can actually go to a physical location.
19:34
Speaker 3: Yes, And because there are so many people that you know,
19:35
Speaker 3: they go to their doctor and the doctor says, well,
19:37
Speaker 3: I don't know about this, I don't know how to
19:39
Speaker 3: do it. I don't know what to look for. I'll
19:41
Speaker 3: just tell you the standard The standard line is, uh.
19:46
Speaker 3: You know, the party line is there's nothing you can
19:48
Speaker 3: do about it, so, you know, so they don't believe it.
19:51
Speaker 3: So Gray Matters, as you mentioned, founded by Deborah Geisler
19:56
Speaker 3: and Craig Weston and Howard Byrd and myself, UH, is
20:01
Speaker 3: to spread clinics around the country to say there is
20:03
Speaker 3: something you can do about it. We see it again
20:05
Speaker 3: and again. We've published trials showing that you can improve
20:08
Speaker 3: and everybody should have access to best cerebral care. So
20:14
Speaker 3: and and deb has been fantastic. She has a long
20:17
Speaker 3: history with healthcare at Harvard and has done a great
20:21
Speaker 3: job in setting this up.
20:23
Speaker 1: So what's stay vision is Right now, they're only in Florida, correct,
20:28
Speaker 1: and they have three.
20:31
Speaker 3: Locations right So the vision is to have clinics all
20:34
Speaker 3: around the country that will make it so that people
20:36
Speaker 3: can get on prevention and active you know, and active treatment.
20:41
Speaker 3: And you can do that today through Apollo and through
20:45
Speaker 3: getting someone who's who has been trained. That's I think
20:48
Speaker 3: the best way to go. But there's not yet these
20:52
Speaker 3: standardized clinics where you can where you can know, here's
20:54
Speaker 3: someone that's been been trained. So the best thing right
20:58
Speaker 3: now you can definitely get get the brain scan, get
21:02
Speaker 3: the blood tests and look and it will tell you,
21:04
Speaker 3: and then get a good practitioner who has been trained.
21:08
Speaker 3: We hope that there will be clinics around the country
21:10
Speaker 3: at some point.
21:13
Speaker 1: To help you do that.
21:14
Speaker 3: And now in Florida, doctor Neilds is the doctor there
21:17
Speaker 3: who's doing an excellent job with patients but the one thing,
21:22
Speaker 3: you know.
21:22
Speaker 2: If you can go get the test on your own
21:24
Speaker 2: without a doctor, but somebody has to interpret the results.
21:28
Speaker 3: So there is a report that actually interprets the results
21:31
Speaker 3: for you. And then there's also you can there's a
21:34
Speaker 3: number you can call up and you can get further discussion.
21:36
Speaker 3: You can get so all the things that you need
21:39
Speaker 3: you can get. We want to make this so it's
21:41
Speaker 3: easily available to everyone.
21:44
Speaker 2: Right, but you don't see patients, but yet you have these,
21:49
Speaker 2: you know, eighty four percent of these and those seven
21:53
Speaker 2: people that wrote the second book, so obviously you did
21:57
Speaker 2: treat you know, you've made some ecces.
22:00
Speaker 1: When do you make an exception to actually take care
22:04
Speaker 1: of a patient?
22:05
Speaker 3: Yeah, so you know I was you know, I saw
22:08
Speaker 3: patients for years and but but then I ran a
22:12
Speaker 3: laboratory for years so that we could study the basic aspect.
22:15
Speaker 3: So the idea is we went into the lab with
22:16
Speaker 3: the idea that there was nothing at that time. This
22:19
Speaker 3: has now started my first lab in nineteen eighty nine,
22:23
Speaker 3: and so there was nothing that could be offered to anybody.
22:26
Speaker 3: So I thought, it doesn't help me to tell people
22:28
Speaker 3: there's nothing that I can offer you. So the idea
22:31
Speaker 3: was to go into the lab study this at the
22:33
Speaker 3: most basic level, see if we could understand the process
22:37
Speaker 3: well enough to begin to fashion the first effective treatments.
22:42
Speaker 3: We did that, and so I actually did see patient zero,
22:45
Speaker 3: and I've seen a number of patients since then. But
22:48
Speaker 3: I'm not a I'm no longer a you know again,
22:51
Speaker 3: as I said, I'm in my seventies. Now I'm no
22:53
Speaker 3: longer a clinically practicing physician. So now I'm a teacher.
22:58
Speaker 3: So we have taught all these people how to do this,
23:00
Speaker 3: and many of them are doing a fabulous job. We're
23:03
Speaker 3: developing new tests and I'm involved with that, looking at
23:06
Speaker 3: what can we do better, how can we do it less?
23:08
Speaker 3: And basically, how can we do all the things that
23:10
Speaker 3: are needed. What are the tests that are working, what
23:13
Speaker 3: are not working, what are the treatments that are working.
23:16
Speaker 3: There's a lot of junk out there, as you know.
23:17
Speaker 3: People will say, oh, you just take my crystal and
23:20
Speaker 3: put it on your forehead, Everything's going to be fine. No,
23:23
Speaker 3: we want to know the things that are actually scientifically
23:26
Speaker 3: validated and working. I'm not seeing many people these days.
23:33
Speaker 2: So do you have a data do you have a
23:35
Speaker 2: database of the two thousand people you've trained, so that
23:38
Speaker 2: people can look at their geographic location and find someone
23:42
Speaker 2: that's a specialist and have learned through through your training.
23:46
Speaker 3: Yeah, and in fact that you know, the easiest way
23:48
Speaker 3: to get onto that is to go to my CQ test.
23:53
Speaker 3: So CQ is cognitive quotient, So m y CQ test.
23:58
Speaker 3: That gives you a free online cognitive assessment. Yeah, and
24:02
Speaker 3: look and see where do I stand?
24:05
Speaker 1: Do I?
24:05
Speaker 3: Because this does sneak up on you as you know
24:07
Speaker 3: some changes in your cognitive abilities. You can do that
24:11
Speaker 3: and you can also will help you get the appropriate
24:13
Speaker 3: tests and tell you where are the trained practitioners.
24:18
Speaker 1: Somebody's trying to call in. So you just got into
24:22
Speaker 1: put it up into a little box. So hold on
24:24
Speaker 1: just a second. I'm sure you can come back. As
24:26
Speaker 1: soon as that call goes away. There we go. Okay,
24:29
Speaker 1: we're back. Okay, So that's really good. This is you know,
24:33
Speaker 1: one of the things I wanted to do.
24:35
Speaker 2: In today's podcast is have practical information for people to
24:40
Speaker 2: be proactive that they get inspired by what they learn,
24:45
Speaker 2: or if they.
24:45
Speaker 1: If they just read your book twenty seventeen, you know
24:49
Speaker 1: that's seven years ago, eight years ago. What has changed
24:54
Speaker 1: in the eight years that you want to share with us.
24:59
Speaker 3: Yeah, really good point. So in the eight years since
25:01
Speaker 3: the first book came out, this is why I wrote
25:04
Speaker 3: the new one, The Ageless Brain. And so number one,
25:08
Speaker 3: we've never had these blood tests before, so this is
25:10
Speaker 3: this one that I mentioned brain scan that's never been
25:13
Speaker 3: available before, so that you didn't really know. You had
25:16
Speaker 3: to have a spinal tap, or you had to have
25:18
Speaker 3: a very expensive pet scan instead of just a simple
25:21
Speaker 3: blood test. So to me, that is a huge step
25:25
Speaker 3: in the right direction, and you could also use that
25:27
Speaker 3: to follow where you stand as you get better. The
25:31
Speaker 3: second thing, when we first came out with this back
25:34
Speaker 3: in twenty seventeen, we had anecdotal improvements, but we didn't
25:38
Speaker 3: have a clinical trial. There are now three clinical trials,
25:43
Speaker 3: all showing two of them already published. The next one
25:46
Speaker 3: will be published later this year, all showing the same thing,
25:50
Speaker 3: improvement when you address these things that are driving the problem.
25:54
Speaker 3: The third thing is we understand much more now about
25:58
Speaker 3: the drivers of the disease. We had the thirty six
26:01
Speaker 3: holes before you we're looking at all these different pieces.
26:04
Speaker 3: We now know that they all come in just a
26:06
Speaker 3: couple of groups. So we can look for them better
26:09
Speaker 3: and we can address them better. We know more things
26:13
Speaker 3: like EWOT, which I didn't know about way back when,
26:16
Speaker 3: which is exercise with oxygen therapy. It's actually quite helpful
26:20
Speaker 3: for people because it gives you this double positive. You've
26:24
Speaker 3: got better blood flow with better oxygenation. We know a
26:29
Speaker 3: lot more about how to achieve best outcomes. We know
26:33
Speaker 3: more about some of the pathogens that can be involved
26:37
Speaker 3: with this, so we have a better and better chance
26:41
Speaker 3: to produce this. Also, in twenty seventeen, we didn't have
26:43
Speaker 3: any examples of long term improvement because we didn't we
26:47
Speaker 3: hadn't been doing it long enough. We've now published a
26:50
Speaker 3: paper it's freely available online that shows sustained improvement in
26:55
Speaker 3: people for over a decade. As I mentioned, first patient
26:58
Speaker 3: came in in twenty twelve, so she's now thirteen years out.
27:02
Speaker 3: She's doing great, So we now know about long term outcomes.
27:07
Speaker 3: We've now begun to modify this and use it for
27:12
Speaker 3: other neurodegenerative conditions. We have some good results with Louis
27:16
Speaker 3: body disease, which is often mistaken for Alzheimer's disease. We
27:20
Speaker 3: have some beginning good results with macular degeneration. We have
27:25
Speaker 3: some beginning results with Parkinson's, so there are other things
27:29
Speaker 3: that as we understand the process better, we can do
27:33
Speaker 3: better and better for outcomes. We now have a much
27:38
Speaker 3: bigger group of people who've been trained to do this,
27:42
Speaker 3: but there's still a lot more to do. We need
27:45
Speaker 3: to understand how to make this as simple as possible,
27:48
Speaker 3: as accessible as possible, as effective as possible. And one
27:53
Speaker 3: of the big problems has been mainstream medicine saying, hey,
27:57
Speaker 3: what are you talking about. We know you can't do that.
28:00
Speaker 3: You know, it's interesting to me when you have something
28:03
Speaker 3: that hasn't been done before. People will literally deny data.
28:08
Speaker 3: Yeah data, Well, you have to get the word out.
28:11
Speaker 1: If it makes you feel any better.
28:13
Speaker 2: I was on the board of doctor Barry Sears and
28:16
Speaker 2: doctor Stephen Sinatra.
28:18
Speaker 1: I don't know if you know them, but Barry Sears
28:20
Speaker 1: was the.
28:21
Speaker 2: Really the father of inflammation, of the concept of inflammation,
28:26
Speaker 2: and he developed the zone diet and he wanted he
28:30
Speaker 2: and doctor Sinatra, who was a big famous cardiologist, wanted
28:34
Speaker 2: to expand by creating these little zone cafes.
28:39
Speaker 1: Yeah.
28:39
Speaker 2: Interesting, And they did one prototype in Reno and it
28:44
Speaker 2: was so successful. Anyway, but the point I'm making that
28:48
Speaker 2: I was on their advisory board because I knew even
28:51
Speaker 2: a couple of the people other people that were involved,
28:54
Speaker 2: and they wanted someone with real estate and a passion
28:59
Speaker 2: for health. You couldn't find someone that fit that one
29:02
Speaker 2: as well as I could at that moment, because I
29:05
Speaker 2: was developing real estate all over the far, you know,
29:08
Speaker 2: in many locations, and some of which the locations they wanted.
29:12
Speaker 2: But I remember sitting down with doctor Sears one day
29:15
Speaker 2: and he said, it is so frustrating because I know
29:19
Speaker 2: that inflammation is the root cause of so many diseases,
29:23
Speaker 2: but I am getting so much flack from my own
29:27
Speaker 2: medical community. And now I think of you and how
29:30
Speaker 2: you said many of your friends don't even talk to
29:32
Speaker 2: you anymore.
29:34
Speaker 1: So what is it?
29:35
Speaker 2: Why is it that this disease has just basically snookered
29:41
Speaker 2: so many famous brain I mean, you know, really bright
29:45
Speaker 2: people into thinking that it's a mono cause you know, basically.
29:51
Speaker 1: Beta amyloid is the cause. They don't really.
29:56
Speaker 2: Think beyond and embrace possibility that are outside of that paradigm.
30:03
Speaker 2: So why do you think there is so much resistance
30:06
Speaker 2: to your actually very credible research and data, Like you said.
30:12
Speaker 3: Yeah, yeah, there are a lot of angry people out there.
30:15
Speaker 3: It's so funny. So, you know, two centuries ago, in
30:19
Speaker 3: the early eighteen hundreds, there was no germ theory. People
30:23
Speaker 3: didn't know about microbes, about bacteria and things like that,
30:27
Speaker 3: but they knew that women were dying. Women in Europe
30:31
Speaker 3: were dying when they after they had their babies, and
30:34
Speaker 3: they would get infections and die. They didn't realize what
30:36
Speaker 3: it was. And so a doctor, a young doctor named
30:40
Speaker 3: doctor Ignaz Semmelweiss, said, you know, there must be something
30:44
Speaker 3: associated with the fact that the medical students who were
30:47
Speaker 3: delivering the babies worked on cadavers before they would deliver
30:52
Speaker 3: the babies.
30:52
Speaker 1: Oh wow.
30:54
Speaker 3: And so, as it turned out, they were carrying infections,
30:57
Speaker 3: unfortunately from the cadavers, and so many women would die
31:00
Speaker 3: after childbirth with what they call purporle fever. So he said, look,
31:04
Speaker 3: you guys have to use this solution that he developed
31:07
Speaker 3: for cleansing your hands. And the rate of death from
31:13
Speaker 3: mothers went down. In fact, a couple of months, it
31:16
Speaker 3: was completely zero, whereas it had been up very very high.
31:20
Speaker 3: You know, twenty thirty thirty five percent of these people
31:23
Speaker 3: were dying. It was horrible. So he said, Okay, there's
31:27
Speaker 3: something in there. I don't know what it is yet,
31:29
Speaker 3: but this this is the beginning of what later would
31:31
Speaker 3: become germ theory and List and Pastor and all these people.
31:36
Speaker 3: At the time, the doctors who are the quote experts
31:40
Speaker 3: pushed back so hard he ended up being forced to
31:43
Speaker 3: go into an insane asylum ideas where he died of
31:48
Speaker 3: an infection. Ironically, oh, we doctors have a horrible track
31:53
Speaker 3: record of coming into the modern times. And it's because,
31:58
Speaker 3: you know, being a doctor is like being in the army.
32:01
Speaker 3: You're told if you don't do what we tell you,
32:04
Speaker 3: someone might die, just like the army, So you do
32:07
Speaker 3: what you're told, you don't ask questions. Well, when you
32:10
Speaker 3: have something like Alzheimer's where there's nothing, somebody's got to
32:14
Speaker 3: ask questions, and so you now have to start looking
32:17
Speaker 3: at what's better now. To be fair, the data that
32:20
Speaker 3: support Alzheimer's as a mediator, not the cause of the problem,
32:24
Speaker 3: but as an important mediator are pretty good. I mean
32:27
Speaker 3: they're very good, actually, and it's because people who have
32:30
Speaker 3: mutations in that gene amyloid precursor protein do go on
32:36
Speaker 3: to get Alzheimer's so there's no question you can give
32:39
Speaker 3: someone Alzheimer's, which is what they do in the mice
32:43
Speaker 3: by making a bunch of extra ameloid, but that doesn't
32:46
Speaker 3: say that that's the cause of it. Yeah, majority of people,
32:50
Speaker 3: and that's our research was over the years, what's driving
32:53
Speaker 3: this problem? And you can see that this is literally
32:57
Speaker 3: a network insufficiency. You just like a big company or
33:00
Speaker 3: a big country. You've got all these things that have
33:03
Speaker 3: to work together to get things working. And we start
33:07
Speaker 3: reducing the energy, reducing the blood flow, reducing the oxygenation,
33:12
Speaker 3: all these things. And now you add more demand, which
33:16
Speaker 3: is inflammation. Now you got to deal with infections, toxicity.
33:20
Speaker 3: Now you've got a detox. You lose that you cannot
33:23
Speaker 3: support the five hundred trillion synapses in your brain.
33:28
Speaker 2: You know, I'm so happy, Yeah, and Charity interpret and
33:32
Speaker 2: so happy you said that words because I don't know
33:35
Speaker 2: that everybody understands what a synapse is.
33:37
Speaker 1: Would you define that? Yeah?
33:39
Speaker 3: Absolutely, So. The way your brain works, it's very much
33:42
Speaker 3: like a computer where you've now got a you've got
33:46
Speaker 3: an impulse, which is going from one place to another
33:49
Speaker 3: and then basically making decisions whether you're going to basically yes,
33:54
Speaker 3: or no. So a synapse is where the brain cells connect.
33:58
Speaker 3: They come very closely, don't touch, they come very close,
34:02
Speaker 3: and then across that tiny little junction of the synapse
34:06
Speaker 3: they spray a little neurotransmitter and so then depending on
34:12
Speaker 3: the strength of the inputs you get, basically will fire
34:16
Speaker 3: the next neuron or you don't fire it. So it's
34:18
Speaker 3: essentially a way to build a computer. And as you
34:22
Speaker 3: said earlier, it's amazing. We can store in our brains
34:29
Speaker 3: over two thousand home computers worth of information. So imagine
34:35
Speaker 3: having two thousand computers in your home. All of that
34:39
Speaker 3: storage capacity is in your brain. So when you are
34:43
Speaker 3: unable to support all of that, you've got a downsize. Unfortunately,
34:48
Speaker 3: just like a company, you do not support it. And
34:51
Speaker 3: when you've got additional demands on it because of infections, inflammation, toxicity,
34:57
Speaker 3: you're also going to have to downsize. Said earlier, you're
35:00
Speaker 3: switching your resources from connection to protection. And that's what's
35:06
Speaker 3: happening in Alzheimer's. And if you don't identify it and
35:09
Speaker 3: address it, you just keep downsizing, downsizing, downsizing, till you
35:14
Speaker 3: can no longer take care of yourself. So this is
35:18
Speaker 3: a breakthrough in our understanding about what this is all about,
35:23
Speaker 3: and we got to quit saying, well, it's just amyloid. Well,
35:25
Speaker 3: the amyloid is there for a reason. So we're changing
35:29
Speaker 3: the way we think about this. From pathology amyloid how
35:34
Speaker 3: tangles things like that to physiology, what is your body
35:39
Speaker 3: doing to try to help you give it the insults
35:42
Speaker 3: it's undergoing. When you do that, it really opens things up.
35:46
Speaker 2: That is such an important statement that you just made
35:49
Speaker 2: from pathology to physiology because you know, app as you
35:54
Speaker 2: mentioned in your book, you know, they that amyloid is
35:58
Speaker 2: actually the protector and to get it so wrong, you know,
36:04
Speaker 2: the whole medical establishment has gotten it so wrong and
36:07
Speaker 2: spent how many millions or billions that have been spent
36:10
Speaker 2: on this disease.
36:12
Speaker 3: Over forty billion dollars and still no cure. That's a
36:17
Speaker 3: big mistake. That is an expensive mistake.
36:20
Speaker 2: And still no cure except the Bretison Protocol, which they're
36:24
Speaker 2: ignoring or not or not willing to embrace. So this
36:28
Speaker 2: is a sad story, and you know, it kind of
36:31
Speaker 2: reminds me a little bit of your history with the
36:33
Speaker 2: Buck Institute and where it was when I think you
36:37
Speaker 2: were probably the person that was serving because you were
36:40
Speaker 2: the founder of founding CEO, and that's when I was
36:43
Speaker 2: on their advisory board, was right.
36:46
Speaker 1: At the very beginning.
36:47
Speaker 2: So we must have known each other back then, but
36:50
Speaker 2: not really you know, remember that. But I can remember
36:54
Speaker 2: the Buckans started out being very allopathic and very much medded,
37:00
Speaker 2: wedded to the pharmaceutical industry.
37:03
Speaker 1: And I don't want to get into the.
37:04
Speaker 2: Politics, but I remember thinking very feeling very uncomfortable. And
37:09
Speaker 2: to your credit and to Lee Hood and Eric Verdon,
37:14
Speaker 2: both of whom, well, Lee was supposed to be on
37:17
Speaker 2: my podcast. He will be on, I hope next year,
37:19
Speaker 2: but Eric has already been on. Eric wants me to
37:24
Speaker 2: interview doctor Nathan Price. So I'm getting a lot of
37:27
Speaker 2: exposure to the Buck Institute for where they are today,
37:31
Speaker 2: and you were the you know, the first and foremost
37:35
Speaker 2: to really start them on that track of embracing something
37:40
Speaker 2: that now we look at with respect to a specific
37:43
Speaker 2: condition called Alzheimer's and other neuro degenerative diseases that actually
37:51
Speaker 2: embraces the very protocol and functional medicine, integrative medicine structure
38:00
Speaker 2: that the Buck Institute basically started to move towards, and
38:06
Speaker 2: over these years have gotten more and more to that
38:08
Speaker 2: level of let's call it away from pathology and more
38:15
Speaker 2: towards physiology.
38:16
Speaker 1: So that all that being said, the.
38:19
Speaker 2: Reason I'm saying it is because I want you to
38:22
Speaker 2: take a deep dive into the functional medicine protocol, which
38:26
Speaker 2: is really the Breteston protocol. So let's start with those
38:30
Speaker 2: seven pillars that are the real coustitive factors. For let's
38:36
Speaker 2: just use Alzheimer's even though it can be embracing other
38:41
Speaker 2: neurogener degenerative diseases.
38:44
Speaker 3: Yeah, and as I mentioned, we're you know, we're modifying
38:45
Speaker 3: this to take into account the special situation for each
38:48
Speaker 3: of these different networks. So whether it's Louis body related
38:52
Speaker 3: or whether it's als related or magic generation. So yeah,
38:56
Speaker 3: so we're all about best outcomes. That's that's the goal.
39:01
Speaker 3: And so it's this is why the Institute has moved
39:04
Speaker 3: toward this with people like Lee Hood and Nathan Price.
39:07
Speaker 3: They are experts in this area. So we're looking at
39:10
Speaker 3: all the things and they're they're very good with things
39:12
Speaker 3: like metabolomics and and as as Lee calls it, the theenome,
39:18
Speaker 3: we don't want to just look at the genome. We
39:20
Speaker 3: want to look at the theenome to see where things stand.
39:23
Speaker 3: So we we are we start with, you know where
39:26
Speaker 3: the brain scan that I mentioned earlier, you were going
39:28
Speaker 3: to get that and look at what's the status of
39:30
Speaker 3: your brain. Then we look at the future where are
39:32
Speaker 3: you headed? And that includes things like your homocysteine and
39:36
Speaker 3: your hsc RP and your various tocsin burden, all these
39:40
Speaker 3: sorts of things. And then we can fashion a personalized
39:44
Speaker 3: precision medicine protocol for you which addresses these various things.
39:49
Speaker 3: And as you said, there are seven basics and there
39:52
Speaker 3: are two specifics. And the way this works is the
39:56
Speaker 3: basic things support everybody the specific things. Then say you
40:00
Speaker 3: have additional things we need to look at. So seven
40:02
Speaker 3: basics are this so interestingly your diet. You know everyone
40:06
Speaker 3: thinks diet is not very important, doesn't really matter what
40:09
Speaker 3: you eat. As an I was taught, diet's not that important.
40:13
Speaker 3: Have to be very incorrect. So much that can be done.
40:18
Speaker 3: So a plant rich, mildly ketogenic diet with high fiber,
40:22
Speaker 3: high phyto nutrients very very important. Arguably the most important
40:27
Speaker 3: of all these things. Healing your gut, making sure that
40:30
Speaker 3: your gut microbiome is good, having enough prebiotic fiber, all
40:34
Speaker 3: this sort of stuff. Exercise, and there's some great things
40:38
Speaker 3: like ewat that I mentioned, Katsu bands hit this high
40:44
Speaker 3: intensity increases your BDNF, which we know supports synapse formation
40:49
Speaker 3: and has an anti Alzheimer effect. It's a very good one.
40:53
Speaker 3: And then the third one is sleep and I tract
40:56
Speaker 3: mine every night. It's an idea. You want to have
41:00
Speaker 3: sleep each night, at least seven hours of sleep, at
41:03
Speaker 3: least an hour and a half of rem at least
41:06
Speaker 3: one hour of deep sleep, and at least ninety four
41:09
Speaker 3: percent oxygen saturation. Those are parameters critical and having good
41:15
Speaker 3: you know sleep hygiene is helpful and things like this.
41:18
Speaker 3: And then the fifth thing is brain stimulation. And as
41:22
Speaker 3: you are supporting your brain, you want to stimulate it
41:25
Speaker 3: a little bit too, and that's with brain training, it
41:28
Speaker 3: can be with photobiomodulation, you know, red light therapy, things
41:32
Speaker 3: like that very helpful. And then detox some basic detox
41:37
Speaker 3: for all of us, sauna sweating, non toxic soaps to
41:41
Speaker 3: get rid of that sweat afterwards, basic detox, clean water,
41:46
Speaker 3: you know, filtered water. These are all very helpful and
41:48
Speaker 3: as you know, one of the big things that is
41:51
Speaker 3: coming up now is the microplastics. Can't ignore these anymore.
41:57
Speaker 3: It turns out they do collect your brain more than
42:01
Speaker 3: your liver. They concentrate in your brain more, deliver more
42:05
Speaker 3: than your kidney, and they are associated. We don't know
42:09
Speaker 3: yet whether it's causal, but they are clearly associated epidemiologically
42:15
Speaker 3: with cognitive decline. Now you can reduce these with things
42:19
Speaker 3: like plasma exchange. That's expensive and like somebody going to
42:24
Speaker 3: have to undergo plasma exchange, we've got to look at
42:27
Speaker 3: better and better ways to minimize the microplastics in our brain.
42:32
Speaker 1: Right classmic exchange.
42:33
Speaker 2: If you go to doctor dog Schawan Shaw nextl it's
42:37
Speaker 2: like eighteen thousand dollars. If you go to doctor Kurita
42:41
Speaker 2: in Florida, he's a lot less, but it's like four
42:44
Speaker 2: or five thousand. At the A four m oh No
42:47
Speaker 2: at Radfest they were doing actually had someone right on
42:50
Speaker 2: the floor that was doing it, set up their booth
42:53
Speaker 2: and everything, and that was going to be about six thousand.
42:56
Speaker 1: So this is not affordable for everybody, but it is you.
42:59
Speaker 2: Know, certainly if you can afford it to take four
43:03
Speaker 2: or five meters of your blood out of you and
43:07
Speaker 2: basically reconstitute it with oxygenation, taking out all the toxicity,
43:14
Speaker 2: and they even show.
43:15
Speaker 1: You the blood is the color of the blood and
43:17
Speaker 1: how it changes. It's something it's really quite fascinating.
43:21
Speaker 2: But not everybody, not for everybody, so that I love
43:24
Speaker 2: what you're saying, but I would say that's kind of
43:26
Speaker 2: like for one percent of the population.
43:29
Speaker 3: That's the issue. And by the way, one of the
43:31
Speaker 3: world's experts on this who is ahead of all those
43:34
Speaker 3: guys you mentioned is doctor delbry Kiproff, who is right
43:37
Speaker 3: here in Marin County, right in Mill Valley. He and
43:41
Speaker 3: I were both together years ago at uc San Francisco
43:44
Speaker 3: in our training, So he's been doing this for a
43:47
Speaker 3: long time and is very successful and has shown there's
43:50
Speaker 3: some improvement in cognition as well. So these are you know,
43:54
Speaker 3: this is another issue, so detox and then the final
43:57
Speaker 3: one is some targeted supplements. These can help to reduce
44:00
Speaker 3: the inflammation you were talking about earlier. And I have
44:04
Speaker 3: met doctor Stephen Sinatra, so I know his work.
44:08
Speaker 1: Did you know that he passed away.
44:10
Speaker 3: I had no because I haven't seen him in several years.
44:14
Speaker 3: I've interacted with his son as well. Yeah, yeah, I
44:19
Speaker 3: met him late in his career obviously, so, but I
44:23
Speaker 3: think you know what what he's done and his son
44:25
Speaker 3: has done very important. We always say, well, you've got
44:29
Speaker 3: to find out also what's causing the inflammation, because you
44:32
Speaker 3: don't want to just reduce the inflammation without knowing what
44:35
Speaker 3: it's doing. It's there for just like the amyloid, it's
44:39
Speaker 3: there for a reason.
44:41
Speaker 2: Well, you didn't say the vascular part, but that certainly,
44:45
Speaker 2: and you did say the gut, the big green gut,
44:48
Speaker 2: access to the microbios But what about the vascular and
44:52
Speaker 2: what about the genetics and what about the hormones. This
44:56
Speaker 2: seems like there's so many potential causative fact but you
45:01
Speaker 2: talked about those for a moment.
45:03
Speaker 1: Yeah.
45:04
Speaker 3: So when I said, remember and energetics, inflammation and toxicity, Yeah,
45:09
Speaker 3: so the vascular is absolutely part of the energetics. So
45:13
Speaker 3: I mentioned you have to have good blood flow, oxygenation,
45:16
Speaker 3: mitochondrial function, and that's where ketone level turns out to
45:19
Speaker 3: be important as well, and insulin sensitivity. Metabolic flexibility. As
45:24
Speaker 3: my wife taught me many years ago, she's an outstanding
45:27
Speaker 3: integrated physician. As she taught me many years ago, metabolic
45:31
Speaker 3: flexibility is very important, So the ability to go seamlessly
45:36
Speaker 3: back and forth between utilizing glucose and utilizing keytones. You know,
45:40
Speaker 3: our brains are like a prius, they are like a hybrid.
45:43
Speaker 3: They only come on two things. They run on glucose,
45:46
Speaker 3: they run on keytones. So you have insulin resistance, you
45:50
Speaker 3: lose both of those. A high insulin, you're not using
45:54
Speaker 3: your glucose well and you're not able to make keytones.
45:57
Speaker 3: Now you mentioned hormones, Optimizing your whole hormones also helps
46:01
Speaker 3: that energetic support helps support the neuronal structure in your brain.
46:08
Speaker 3: So absolutely these are important as well, so the function dale.
46:14
Speaker 2: Are there any specific hormones that you would list as
46:17
Speaker 2: the most important for brain health?
46:21
Speaker 3: Yes, so there are several. Now, as you know, there's
46:24
Speaker 3: a controversy about BHRT bioidentical hormone replacement therapy, but there
46:30
Speaker 3: are repeated studies coming out showing they do improve brain health.
46:36
Speaker 3: And you talk to an expert like doctor Ann Hathaway
46:40
Speaker 3: or doctor Prudence Hall or doctor Felice Gersh, there are
46:44
Speaker 3: numerous experts, Doctor Robert of Diaz, Brenton, all of these
46:49
Speaker 3: people will tell you these do support brain health and
46:53
Speaker 3: so estradol, progesterone, testosterone, pregnenolone. These are all important. Thyroid
47:02
Speaker 3: is another important one to have optimal thyroids. So many
47:05
Speaker 3: of us have low thyroid and have some degree of hushamotives.
47:10
Speaker 3: So all of these things are helpful in optimizing our
47:14
Speaker 3: brain health.
47:15
Speaker 1: And data because of the adrenas.
47:18
Speaker 3: That's another one that stress stress, Yes, and you know,
47:22
Speaker 3: part of the when we look at the seven basics
47:26
Speaker 3: and before we do the two specifics of infections and toxins,
47:29
Speaker 3: the seven specifics do include managing stress. You know, we
47:35
Speaker 3: were meant to be able to survive periods of brief
47:38
Speaker 3: periods of stress with resolution. The problem is chronic, unremitting
47:43
Speaker 3: stress and that is associated with brain shrinkage, associated with
47:48
Speaker 3: cognitive decline. So we want to avoid that ongoing, which
47:52
Speaker 3: is why again good thing. Check your heart rate variability
47:56
Speaker 3: and you can improve. There's so many things you can
47:58
Speaker 3: do to address stress us, everything from meditation to yoga
48:04
Speaker 3: to you know, dealing with the issues in your life,
48:07
Speaker 3: to uh, you know, to things like shinrin yoku that's
48:10
Speaker 3: so called forest bathing, bio feedback. They're all these things
48:15
Speaker 3: and there's no question they can be very helpful and just.
48:18
Speaker 2: Just walking out your front door to if you're able to,
48:21
Speaker 2: and like we are in California most of the year
48:24
Speaker 2: and taking a walk in nature is one of the
48:28
Speaker 2: most incredibly mindful activities.
48:32
Speaker 1: Plus you're getting good exercise exactly.
48:36
Speaker 2: Yeah, So okay, Dale, these are there's a lot here,
48:41
Speaker 2: as you know, and you know, I'm sure you understand
48:44
Speaker 2: that most people who have been not have not been
48:47
Speaker 2: open minded because their physicians haven't been open minded to
48:52
Speaker 2: taking these steps. But you are really embracing the integrated
48:55
Speaker 2: medicine model, which is look for the root cause, don't
49:00
Speaker 2: try to just treat a symptom with a drug. So
49:04
Speaker 2: I mean, if I could summarize what integrative medicine and
49:08
Speaker 2: functional medicine is compared to allopathic that would be the
49:12
Speaker 2: first one. You said physiology to I mean, from pathology
49:17
Speaker 2: to physiologists, very similar saying for similar things. But you
49:21
Speaker 2: are embracing so many aspects. So break it down a
49:25
Speaker 2: little bit further for us is how do you determine when.
49:30
Speaker 1: You have a patient, which of all these.
49:34
Speaker 2: Issues that you've just mentioned are the cause of their
49:38
Speaker 2: particular condition, and how do you then how do you
49:41
Speaker 2: find how do you be a detective and find the
49:44
Speaker 2: root cause.
49:46
Speaker 3: Yeah, great point. And you know, we would recommend just
49:48
Speaker 3: take it at your own pace. If you can just
49:50
Speaker 3: begin with a couple of things, you'll notice improvements over time.
49:55
Speaker 3: But to get an optimal outcome, you want to just
49:57
Speaker 3: keep on at your own pace, adding things. Working with
50:00
Speaker 3: a brain health coach really helpful. They can help you
50:03
Speaker 3: stay on track. So the way we figure out what's
50:06
Speaker 3: wrong is the blood test that I mentioned. So there's
50:09
Speaker 3: the first one that tells you where you stand currently,
50:11
Speaker 3: that's brain scan. We could get a brain scan dot com.
50:15
Speaker 3: Then there's the one that says where are you headed
50:18
Speaker 3: and what's driving it? And that Those are so called
50:21
Speaker 3: recode labs and you can also get those online. You
50:24
Speaker 3: can also get them at a local drawstation. It's very easy.
50:28
Speaker 3: And then from that we generate. We have a computer
50:32
Speaker 3: based algorithm that goes through all the things. That used
50:35
Speaker 3: to take me about two and a half hours per
50:38
Speaker 3: patient to go through every single thing and figure out, okay,
50:42
Speaker 3: here's an optimal plan for you. Now the computer does that,
50:45
Speaker 3: you know, in a few microseconds, so much much faster.
50:49
Speaker 3: So that's why we made this whole algorithm so that
50:51
Speaker 3: you can now see what to do here and it'll
50:55
Speaker 3: tell you base not only on your blood test, but
50:58
Speaker 3: also on some of your symptoms. So, for example, people
51:01
Speaker 3: who begin their cognitive change with depression and we hear
51:04
Speaker 3: this all the time, and they more likely have toxicity
51:10
Speaker 3: as one of the important contributors to their cognitive change,
51:14
Speaker 3: whereas people who begin it with an amnestic you know,
51:18
Speaker 3: with a memory issues, tend often to be more on
51:21
Speaker 3: the metabolic and inflammatory side. That that's one of hundreds
51:25
Speaker 3: of variables. So looking at all these different blood tests,
51:29
Speaker 3: we put the whole thing together, the computer crunches it
51:32
Speaker 3: and then says, Okay, here's what's most likely for you,
51:34
Speaker 3: and that's what's gotten the best outcomes.
51:38
Speaker 1: So, if you were to take a.
51:43
Speaker 2: History of your journey of thirty years, this is thirty
51:47
Speaker 2: years right that you've dedicated yourself. Who has been the
51:52
Speaker 2: person that is most affected your outcome as to where
51:58
Speaker 2: you are today?
51:58
Speaker 1: Who has been your.
52:02
Speaker 3: Well you mean in terms of teachers, Yeah.
52:04
Speaker 2: Teachers or PATRII individual can be anybody you know who
52:07
Speaker 2: has influenced.
52:08
Speaker 1: You to be who you are today in the most
52:11
Speaker 1: to be who you are today.
52:13
Speaker 3: Yeah, Well, when it comes to uh, you know, teaching
52:16
Speaker 3: and uh, you know my role model, my my hero
52:19
Speaker 3: is Lee Hood. He was a professor at cal Tech
52:24
Speaker 3: when I was an undergrad at cal Tech. He was
52:27
Speaker 3: the one thinking about the future of biology. He's the
52:30
Speaker 3: one that developed the DNA sequencer. He's the one that
52:33
Speaker 3: developed the peptide sequencer, uh, and developed the peptide and
52:37
Speaker 3: oligo synthesizers. He's always been and I mentioned this in
52:41
Speaker 3: the new book. He's always been a step ahead of
52:43
Speaker 3: everybody else. And so we fashion what we're doing based
52:49
Speaker 3: on what Lee taught taught me over the years. And
52:52
Speaker 3: then of course he Bill Gates attracted Lee to come
52:55
Speaker 3: up to Washington and he ultimately set up his own institute,
52:59
Speaker 3: Institute for Systems Biology, and he's he's always been looking
53:04
Speaker 3: at the future. Now he's more on the research side.
53:08
Speaker 3: We've tried to take that research into the clinic and said, Okay,
53:13
Speaker 3: if this research is correct, we should be able to
53:16
Speaker 3: heal people's brains fantastically and so exciting to see. Yes,
53:21
Speaker 3: we see it again and again and again. We've had
53:25
Speaker 3: thousands now, we've treated over over ten thousand patients. So
53:29
Speaker 3: we've got a lot of wonderful outcomes, and we still
53:32
Speaker 3: want to understand. There are others that don't get good outcomes,
53:36
Speaker 3: and we want to understand why did they miss something?
53:39
Speaker 3: Did we miss something, or did they not do the
53:42
Speaker 3: right things? Were there additional things that we're driving this
53:45
Speaker 3: did we get into late? Are these are a toxin
53:48
Speaker 3: we didn't recognize? You know, many many issues. But the
53:52
Speaker 3: good news is, as I mentioned in our trial, the
53:54
Speaker 3: vast majority of people do very well. And the earlier
53:57
Speaker 3: you start, the easier it is.
53:59
Speaker 2: You know, I would almost guarantee you that the ones
54:01
Speaker 2: that don't do well are not as compliant with with
54:05
Speaker 2: the daunting task of changing their habits. Yeah, and there
54:09
Speaker 2: are some people who just you know, I hate to
54:12
Speaker 2: say it, but they're just lazy about I mean, they
54:15
Speaker 2: know they have a condition, but they don't have that
54:19
Speaker 2: motivation like the like.
54:20
Speaker 1: Like Judy does or did motivating you know.
54:24
Speaker 2: To really embrace the challenge and to rise rise to
54:30
Speaker 2: the opportunity to you know, improve their lives.
54:33
Speaker 1: And so I would I would bet you that it's
54:36
Speaker 1: more of that, like you know, just diet alone. Look
54:39
Speaker 1: at the creatures of habit and you know, with with
54:42
Speaker 1: nutrition and people just have trouble making those changes. And you,
54:47
Speaker 1: by the way, I meant to ask you. You mentioned key.
54:50
Speaker 2: Tones, and I want to be sure our viewers understand
54:53
Speaker 2: what a key tone is.
54:54
Speaker 1: Can you just take a moment.
54:56
Speaker 2: I know we're going to have to end soon, but
54:58
Speaker 2: I don't want to miss that because everybody, you know,
55:01
Speaker 2: misunderstands when you're on the Keto diet.
55:03
Speaker 1: They think you're eating butter and steak and day and bacon,
55:07
Speaker 1: and that's not what.
55:09
Speaker 2: You're talking about. I don't want people to go away
55:11
Speaker 2: being thinking that's what they should go to the grocery
55:14
Speaker 2: store start buying all these very bad processed food.
55:18
Speaker 1: So could you just take a second to define a
55:20
Speaker 1: key too.
55:21
Speaker 3: Yeah, So, as you said, the diet is plant rich,
55:26
Speaker 3: mildly ketogenic.
55:28
Speaker 1: Yes.
55:29
Speaker 3: Have wild caught fish, yes, have some pastured chicken, yes,
55:33
Speaker 3: have some grass fed beef. Those are all great. Yes,
55:35
Speaker 3: have some pastured eggs great. But it's a plant rich
55:39
Speaker 3: You want to have big, big vegetables, big salads, these sorts,
55:43
Speaker 3: eat the rainbow sort of things, and so many things
55:46
Speaker 3: that are helpful there.
55:47
Speaker 2: And you know you didn't Another thing we didn't talk
55:49
Speaker 2: about is intermittent fasting, which I know you and I
55:52
Speaker 2: are both doing that. I usually I usually end my
55:56
Speaker 2: meal my last meal, around seven, and then I don't
55:59
Speaker 2: eat again. I'll eat when we get off this podcast,
56:02
Speaker 2: and it'll be about let's say.
56:04
Speaker 1: New So you know, I know you'd say twelve to
56:07
Speaker 1: fourteen if you're a.
56:08
Speaker 2: Poeple will talk about the genes and real quickly in
56:12
Speaker 2: a moment. But so, so, I think that's an important
56:16
Speaker 2: thing for people to know that intermittent fast and produces
56:20
Speaker 2: the autophogy, which really is a way to get your
56:24
Speaker 2: blood sugar, your metabolic in your insulin levels under control.
56:28
Speaker 2: So I wanted to be sure that that you know,
56:31
Speaker 2: we included that is another way that you can not
56:34
Speaker 2: only lose weight or.
56:36
Speaker 1: At least keep your current way stable. But anyway, go ahead,
56:40
Speaker 1: I'm sorry.
56:41
Speaker 3: So you're right, So you want to become insulin sensitive.
56:43
Speaker 3: As I mentioned earlier, you know, your brain only functions
56:45
Speaker 3: on those two things, glucose or keytones. So keytones are
56:48
Speaker 3: made by your liver. It's a way for your liver
56:53
Speaker 3: to export energy to your brain. So it takes literally
56:59
Speaker 3: biochemical energy in the form of acetyl CoA that uses
57:05
Speaker 3: it to produce ketones, which then travel through your blood
57:09
Speaker 3: up to your brain and other organs and then they
57:12
Speaker 3: are turned back into the energy and they are burned
57:15
Speaker 3: and burned with your mitochondria. And so it's a way
57:18
Speaker 3: to export and utilize energy. And so when you are
57:23
Speaker 3: when you don't have enough glucose, when you are when
57:27
Speaker 3: you are low, you're not eating, for example, you're sleeping,
57:30
Speaker 3: you will now make these things. And the problem is
57:34
Speaker 3: if you don't have the glucose and you don't have
57:36
Speaker 3: the keytones, then your brain is sputtering. It's like a
57:40
Speaker 3: prius that has no electricity and no fuel just can't go.
57:45
Speaker 3: And that's what we see with so many people who
57:48
Speaker 3: have cognitive changes. It's because they cannot utilize and make
57:52
Speaker 3: that energy. So we recommend, just at the beginning, just
57:55
Speaker 3: take some exogynous keytones while we're getting you into this
57:58
Speaker 3: metabolic flexibility. Yeah, people will notice when they get into it,
58:02
Speaker 3: oh my gosh, my brain is working so much better
58:05
Speaker 3: and I've got more energy than before. That's the key.
58:09
Speaker 1: And add to that list of you know, first cold
58:12
Speaker 1: press organic olive oil, avocados, you know, things that are
58:16
Speaker 1: healthy fats.
58:17
Speaker 2: Take out get rid of those seed oils which are
58:19
Speaker 2: really maybe six is our killers to Yeah, there's so
58:23
Speaker 2: much you know what I was thinking with gray matters,
58:25
Speaker 2: it might be good to affiliate with some nutritional coaches
58:30
Speaker 2: that can take people right to the grocery store and.
58:34
Speaker 4: Help them, you know, really physically buy the right things
58:37
Speaker 4: instead of all being tempted by what typical grocery stores do,
58:42
Speaker 4: which is to tempt you into buying things that are
58:44
Speaker 4: not good for you.
58:45
Speaker 1: Well, I know they're going to end this.
58:47
Speaker 2: I mean they're going to want me to end this now,
58:48
Speaker 2: but I want to be sure to say one last
58:51
Speaker 2: thing about the.
58:51
Speaker 1: Apoe gene apo E four.
58:54
Speaker 2: Can you just quickly tell us what is the what
58:56
Speaker 2: are the percentages of people that have apo E four
59:00
Speaker 2: positive negative? Is that is the main genetics that kind
59:05
Speaker 2: of predisposes to you to Alzheimer's.
59:07
Speaker 3: Yes, there are one hundred different genes, but Apoi is
59:09
Speaker 3: the common one, and so there is So if you
59:13
Speaker 3: have zero copies, and that's three quarters of our population,
59:16
Speaker 3: your lifetime risk for Alzheimer's is nine percent. So I'm
59:20
Speaker 3: an apoe three to three for example, I have an
59:22
Speaker 3: apo E four negative. Yeah, it's not zero, by the way, Great,
59:27
Speaker 3: good to know. Yeah, then if you have a single copy.
59:29
Speaker 3: That's seventy five million Americans, most of whom don't know it.
59:34
Speaker 3: Your lifetime risk is thirty percent, So please check it out.
59:38
Speaker 3: Get on active prevention. If you have two copies, and
59:41
Speaker 3: that's seven million Americans, most of whom don't know it,
59:45
Speaker 3: your chance is about ninety percent most likely you will
59:49
Speaker 3: develop Alzheimer's, so again, find it. Julie G who's APO
59:53
Speaker 3: E four to four had symptoms back in her late forties,
59:56
Speaker 3: is now in her sixties. She's been on a protocol
59:58
Speaker 3: for a long time. She's doing absolutely great. There's a
1:00:01
Speaker 3: wonderful website APOE four dot info where you can have
1:00:05
Speaker 3: sorts of information. Most of the people on there are
1:00:08
Speaker 3: on some version of our protocol and doing very well.
1:00:12
Speaker 1: Oh wow.
1:00:12
Speaker 3: That's a critical gene for all of us to find out.
1:00:14
Speaker 3: And by the way, it is in those recode labs
1:00:17
Speaker 3: that I mentioned earlier. You'll know your APOE status and
1:00:19
Speaker 3: you can do something about it.
1:00:21
Speaker 1: Yeah.
1:00:21
Speaker 2: So the recode every for everybody that's listening and watching
1:00:24
Speaker 2: the recode is your protocol.
1:00:27
Speaker 1: That's what you.
1:00:28
Speaker 2: Developed out of all of this, and that's really what
1:00:31
Speaker 2: the sumptions of what we've been talking about today. The
1:00:34
Speaker 2: causes of Alzheimer's and the protocol that will help to
1:00:38
Speaker 2: reverse Alzheimer's. So I just want to end on that
1:00:42
Speaker 2: note to say, you know, you are a pioneer and
1:00:46
Speaker 2: there are very few people that would have the courage
1:00:48
Speaker 2: to do what you've done, which is to embrace a
1:00:52
Speaker 2: system that is basically against you.
1:00:54
Speaker 1: But you're a fighter. You're like a David and Goliath.
1:00:58
Speaker 1: That's the metaphor. I want to just applaud all your
1:01:02
Speaker 1: efforts and never give up. Right, You're you're never going
1:01:06
Speaker 1: to not after thirty years, they're certainly not going to
1:01:08
Speaker 1: go backward, and you know that the results are there.
1:01:11
Speaker 1: So thank you so much, Dale for being with us
1:01:14
Speaker 1: today and sharing all this information. We could have talked
1:01:18
Speaker 1: for another hour, but I maybe we'll have you back
1:01:21
Speaker 1: next year for round two.
1:01:24
Speaker 3: Thank you, Michelle.
1:01:25
Speaker 1: Okay, you take care. Bye bye bye bye Okay bye