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A 40-year obstacle (nausea) kept a potentially novel psychedelic class from being tested in humans
A 40-year obstacle (nausea) kept a potentially novel psychedelic class from being tested in humans
The idea that a single side effect could block a whole line of psychedelic discovery is chilling: quipazine produced clear LSD-like signals in rodents and monkeys yet caused uncontrollable nausea in primates and humans. How did a molecule described in 1966, active at five distinct serotonin receptors, point toward psychedelic potential for forty years and still fail to open the door for human testing?
In this episode, we tell the story of quipazine from its first synthesis to the human trials…
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