1299-Transcriptomic Landscape of Neocortical Development

Paper Talk · Jul 18, 2026 · 23m

The paper introduces NeMO Analytics, a specialized digital platform designed to help researchers explore the complex genetic landscape of neocortical development. By compiling transcriptomic data from approximately 200 distinct studies, the resource allows scientists to simultaneously analyze gene expression across humans, macaques, and mice. The authors utilized joint matrix decomposition to identify shared biological programs that govern how brain cells transition from early progenitors to mature neurons. Their findings reveal critical evolutionary differences in cell behavior and highlight…