1706-Splenic Extramedullary Hematopoiesis in Myelofibrosis

Paper Talk · Oct 25, 2026 · 23m

The research investigates the molecular and cellular mechanisms driving advanced myelofibrosis, a progressive blood disorder marked by severe bone marrow scarring. By performing single-cell transcriptomic and epigenetic profiling on surgically removed spleens, the authors reveal that neoplastic extramedullary hematopoiesis in the spleen is characterized by a significant expansion of hematopoietic stem and progenitor cells. The findings demonstrate that these abnormal progenitor cells show a strong bias toward erythroid and megakaryocytic differentiation alongside heightened inflammatory…