422-Profile Neural Organoid Response to Morphogens

Paper Talk · Jan 23, 2026 · 18m

This research study presents a systematic single-cell transcriptomic atlas designed to understand how various morphogens direct the regional patterning of the human central nervous system in vitro. By analyzing over 100,000 cells across multiple human pluripotent stem cell lines, the authors examined how the timing and concentration of signaling molecules like SHH, FGF8, and RA influence the emergence of specific brain identities. The data reveal that specific gene regulatory networks, or regulons, respond uniquely to these chemical cues, allowing for the targeted activation of developmental…