Latest / Luke's English Podcast / Joe Rogan Experience _2537 - David Sinclair

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Joe Rogan Experience _2537 - David Sinclair · Luke's English Podcast

• 0:03
  Speaker 1: Check it out the Joke Logan Experience, Strain by Day
• 0:06
  Speaker 1: Joe Rogan Podcast by Night, All Day.
• 0:12
  Speaker 2: Mister Sinclair, good to see you again, doctor Sinclair. Doctor,
• 0:17
  Speaker 2: I'm kidding day. Yeah. Do you ever introduce yourself as doctor? Never? Yeah,
• 0:22
  Speaker 2: that's a kind of a it's a weird thing because
• 0:24
  Speaker 2: you're allowed.
• 0:25
  Speaker 1: To Well, I'm actually a sir, David from Australia.
• 0:28
  Speaker 2: But are you a sir?
• 0:29
  Speaker 1: Yeah, but it's kind of a joke. I don't really
• 0:31
  Speaker 1: what does that?
• 0:32
  Speaker 2: How does that work out?
• 0:33
  Speaker 1: Did you get a representative gave me something the Australian
• 0:37
  Speaker 1: version of a knighthood? But uh, I get to put
• 0:41
  Speaker 1: AO at the end of my name Ao. Yeah, Order
• 0:44
  Speaker 1: of Australia. But it actually makes no difference to my life.
• 0:48
  Speaker 1: So it's just an extra couple of letters.
• 0:50
  Speaker 2: It's kind of cool.
• 0:51
  Speaker 1: I'm honored for sure, but it, uh, it's just a joke.
• 0:58
  Speaker 2: If you don't know, well, it's kind of anybody's sir.
• 1:00
  Speaker 2: You meet a guy at the gas station, how are
• 1:02
  Speaker 2: you doing? Sir? Is that like?
• 1:04
  Speaker 1: Wow? How does he know?
• 1:05
  Speaker 2: Right? You don't see how you're doing? King?
• 1:08
  Speaker 1: Yeah? Right, Well, I'm David, I'm Australian, so in Australia,
• 1:11
  Speaker 1: if you have any ego, you get beaten up in
• 1:14
  Speaker 1: the playgrounds.
• 1:14
  Speaker 2: That is true. Australia is the land of the tall
• 1:17
  Speaker 2: poppy syndrome. They don't they don't fuck around. They don't
• 1:21
  Speaker 2: like you get in a big head in Australia.
• 1:23
  Speaker 1: That that is true. I like to go back there though,
• 1:25
  Speaker 1: because it's any level playing field. Nobody cares who you are.
• 1:28
  Speaker 2: I love the people there. Australian people are some of
• 1:31
  Speaker 2: my favorite people. They're awesome. They're just They're very friendly
• 1:35
  Speaker 2: and fun. It's a great place to be. It's just
• 1:38
  Speaker 2: too far to get there. Such a haul.
• 1:40
  Speaker 1: Oh no, if you just you know, whiskey and an
• 1:42
  Speaker 1: ambient and you're there without is that what you do?
• 1:44
  Speaker 1: I used to. I've gone clean. I don't drink much
• 1:48
  Speaker 1: at all anymore.
• 1:50
  Speaker 2: How often is drink much at all?
• 1:51
  Speaker 1: Celebrator right now? No, it would be a bad look.
• 1:55
  Speaker 1: I've got the coffee that you gave me, which, yeah,
• 1:58
  Speaker 1: this is.
• 1:58
  Speaker 2: A layered super food coffee. So Laird Hamilton has coffee.
• 2:02
  Speaker 2: It's black rifle coffee mixed with his superfood stuff which
• 2:06
  Speaker 2: is this one's turmeric. So it's turmeric and I think
• 2:09
  Speaker 2: it has coconut milk in it and some other jazz.
• 2:12
  Speaker 1: It's greatious anti inflammatory, yes, which.
• 2:16
  Speaker 2: I know you're all about.
• 2:17
  Speaker 1: Yes, as a prophet of longevity.
• 2:22
  Speaker 2: Yes, that is that another title of you.
• 2:25
  Speaker 1: Yes, you can call me Sir David the Prophet.
• 2:27
  Speaker 2: How about that, Sir David the prophet, doctor, Sir David
• 2:31
  Speaker 2: the Prophet of longevity.
• 2:33
  Speaker 1: That'll do.
• 2:34
  Speaker 2: So there's a lot. Let's let's jump right into it,
• 2:36
  Speaker 2: because there is a lot going on in the longevity space.
• 2:39
  Speaker 1: I think you're having me back on it my pleasure.
• 2:41
  Speaker 1: And by the way, I also want to thank you
• 2:44
  Speaker 1: for I think this is fourth time on which is amazing.
• 2:48
  Speaker 1: Thank you, congrats on all your success.
• 2:50
  Speaker 2: It's thank you.
• 2:50
  Speaker 1: Wonderful to see. Also, the book that I wrote, which
• 2:54
  Speaker 1: you first had me on to promote, has done so well,
• 2:56
  Speaker 1: and it's really because of you and the book Lifespan
• 3:00
  Speaker 1: became a best seller. Not just that, but it's now
• 3:02
  Speaker 1: been read millions of times around the world.
• 3:04
  Speaker 2: It's in forty laves, phenomenal and it's my pleasure.
• 3:07
  Speaker 1: And that's not a promo, as you know, you don't
• 3:09
  Speaker 1: make any money from books really, but I'm just honored
• 3:11
  Speaker 1: that it was read by so many people around the
• 3:14
  Speaker 1: world because it wasn't an easy read, it was high
• 3:17
  Speaker 1: tech science.
• 3:18
  Speaker 2: Well, people are very interested, especially nowadays. I think I've
• 3:22
  Speaker 2: never I can't recall a time in my life where
• 3:28
  Speaker 2: optimizing your health and longevity has been more of a
• 3:32
  Speaker 2: subject that people are interested in.
• 3:34
  Speaker 1: Well, I think that's largely because not to keep blowing
• 3:37
  Speaker 1: smokeing up your rear, but largely because of what you
• 3:41
  Speaker 1: did in the book. So the book went global, and
• 3:45
  Speaker 1: it was right in twenty nineteen and the pandemic hit,
• 3:49
  Speaker 1: and I think most people saw their own mortality at
• 3:52
  Speaker 1: that point. Most people under the age of about seventy
• 3:55
  Speaker 1: didn't even think about dying, but then pandemics Like shit,
• 3:58
  Speaker 1: I could die. I saw the book take off, you
• 4:01
  Speaker 1: launched it. But yeah, since then a lot of people
• 4:04
  Speaker 1: have jumped on the bandwagon and now longevities. I hear
• 4:07
  Speaker 1: this everywhere I go.
• 4:08
  Speaker 2: It's everything. It's everywhere. People are constantly talking about different modalities.
• 4:13
  Speaker 2: How often do you cold plunge? Are you sawing it?
• 4:15
  Speaker 2: What about the red light? What do you think is
• 4:17
  Speaker 2: this legit? Is that legit? Like everybody's optimizing everything constantly
• 4:21
  Speaker 2: all the time. But the reason why it's caught on
• 4:23
  Speaker 2: is because if you do follow some of the protocols,
• 4:26
  Speaker 2: you will feel better, and so that's the ultimate goal.
• 4:30
  Speaker 2: Like longevity is wonderful, but feeling better in the moment currently,
• 4:34
  Speaker 2: like living your life should be primary longevity, I think
• 4:38
  Speaker 2: is if you're optimizing your life and you feel better,
• 4:44
  Speaker 2: you will live longer. It's like this, it's all part
• 4:46
  Speaker 2: of it. So it would follow the longevity principles and
• 4:49
  Speaker 2: the ideas behind it, you certainly will live better right now.
• 4:53
  Speaker 1: You will And it's not even that hard. There are
• 4:55
  Speaker 1: basic things, five basic things you can do or avoid
• 4:58
  Speaker 1: and you can live another fifteen years. It's really not
• 5:00
  Speaker 1: that hard. And that's what I'm excited about telling millions
• 5:02
  Speaker 1: of people today is and maybe we can go over
• 5:05
  Speaker 1: the kind of things that people can do easily to
• 5:06
  Speaker 1: live longer.
• 5:07
  Speaker 2: Well, well, I definitely want to do that, But I
• 5:09
  Speaker 2: also want to talk about, like what is the current
• 5:13
  Speaker 2: state of science as applied to longevity treatments, because I
• 5:19
  Speaker 2: know that there's some pretty groundbreaking stuff that's in the
• 5:23
  Speaker 2: pipeline right now.
• 5:25
  Speaker 1: Yeah, so since twenty nineteen, a lot of what we
• 5:29
  Speaker 1: talked about has come true, which is the amazing thing.
• 5:32
  Speaker 1: We're speculating twenty nineteen that we could potentially reverse aging,
• 5:38
  Speaker 1: and that was a sin to say that as a
• 5:40
  Speaker 1: scientist publicly in those days. I put it in the book,
• 5:44
  Speaker 1: and it's actually come true since then, certainly for the
• 5:48
  Speaker 1: lab for mice, monkeys, and now we have a human
• 5:52
  Speaker 1: clinical trial, the first potential human age reversal technologies in
• 5:56
  Speaker 1: people right now.
• 5:58
  Speaker 2: Listen. It completely seems logical. The idea that that at
• 6:01
  Speaker 2: one point in time would have been heresy and science
• 6:04
  Speaker 2: to discuss it so that seems crazy, like if people
• 6:08
  Speaker 2: get old, we understand the mechanism, why couldn't we reverse it.
• 6:13
  Speaker 1: Well, I think for a long time we had to
• 6:14
  Speaker 1: accept it in the way that cancer used to be
• 6:17
  Speaker 1: accepted two hundred years ago. Probably there was nothing you
• 6:20
  Speaker 1: could do about it. And then my colleagues and I
• 6:22
  Speaker 1: found that aging has a root cause that's the same
• 6:24
  Speaker 1: in pretty much every cell in the body, and that
• 6:27
  Speaker 1: we could control that, and that there were genes that
• 6:29
  Speaker 1: not only slowed it down. But in twenty twenty we
• 6:32
  Speaker 1: had a big publication that showed we could actually safely
• 6:35
  Speaker 1: for the first time reverse that process, like reinstalling software
• 6:38
  Speaker 1: in the cell to make it work.
• 6:39
  Speaker 2: Again, and so what is the pro is that using crisper?
• 6:44
  Speaker 2: Like what are you using too? Well?
• 6:47
  Speaker 1: We deliver genes into the body like crisper. I have
• 6:51
  Speaker 1: a little little prop here. We brought what is that
• 6:53
  Speaker 1: in my pocket here? This is a representation of how
• 6:55
  Speaker 1: we deliver the age reversal genes. It's a virus like
• 7:00
  Speaker 1: capsule that we make in the lab and this is
• 7:02
  Speaker 1: what's going into the patients right now, into their eyes initially,
• 7:08
  Speaker 1: and the eye is a good place to start.
• 7:10
  Speaker 2: How do you pick the people to get on these tests?
• 7:12
  Speaker 1: They volunteer. I was really fortunate to see the first
• 7:18
  Speaker 1: patient get dosed earlier this year, and that person bravely
• 7:24
  Speaker 1: volunteered to be the first person to get trillions of
• 7:28
  Speaker 1: these injected into his eye to see if could cure
• 7:31
  Speaker 1: his glaucoma loss of vision.
• 7:34
  Speaker 2: And how better if you have glaucoma, you're probably like, listen,
• 7:36
  Speaker 2: what's the worst that could happen?
• 7:38
  Speaker 1: Well, exactly, he pretty much was totally blind in one eye,
• 7:41
  Speaker 1: and so there's really nothing that he has to lose.
• 7:45
  Speaker 1: There's a risk that something might go wrong, but not really.
• 7:49
  Speaker 1: He The good news is and I can report to
• 7:52
  Speaker 1: everybody around the world that nothing's gone wrong so far.
• 7:56
  Speaker 1: Everything is proceeding according to plan, and we're at its
• 8:00
  Speaker 1: turning point potentially in human history if it works.
• 8:04
  Speaker 2: So I interrupt you, but explain this little virus.
• 8:07
  Speaker 1: True, sure, And for those of you listening, I've got
• 8:10
  Speaker 1: a little rubber ball with spikes on it. It looks a
• 8:12
  Speaker 1: bit like COVID, but don't be scared of it. It's
• 8:14
  Speaker 1: not a pathogenic virus. It's actually a domesticated version of
• 8:18
  Speaker 1: a virus. And this little plastic ball has little adapters.
• 8:22
  Speaker 1: These red balls on the surface of the big ball
• 8:25
  Speaker 1: target it to the cells in the back of the eye,
• 8:28
  Speaker 1: and you can change the balls to target different tissues.
• 8:30
  Speaker 1: We could change that outside little spike and target it
• 8:34
  Speaker 1: to the liver, which we've done and cured mice of
• 8:36
  Speaker 1: their fatty liver disease as well. But this one's for
• 8:39
  Speaker 1: the eye. And within that big ball is a protein capsule,
• 8:43
  Speaker 1: and inside the protein capsule is our DNA special delivery,
• 8:49
  Speaker 1: which we call OSK or R one hundred. R one
• 8:54
  Speaker 1: hundred is epigenetic reprogramming one hundred, the drug that we
• 8:57
  Speaker 1: know when we put it into human cells, it makes
• 8:59
  Speaker 1: them younger and then they work like they were young again.
• 9:05
  Speaker 2: This sounds like the beginning of a horror movie, you
• 9:08
  Speaker 2: know what I mean, Like the scientist is on a
• 9:10
  Speaker 2: talk show and the scientist is explaining it, and everyone's
• 9:13
  Speaker 2: at home like with their coffee, Like, Wow, we're in
• 9:16
  Speaker 2: a scientist. This is wonderful. We're gonna get younger again.
• 9:19
  Speaker 1: And to worry, it's all gonna work.
• 9:22
  Speaker 2: Twenty eight days later, garbage in the streets, cars on fire,
• 9:26
  Speaker 2: the guy's waking up from a coma, doesn't know what happened. Yeah,
• 9:29
  Speaker 2: goes outside. These optimized humans are eating each other.
• 9:32
  Speaker 1: I admit, I admit it is science fiction, and I
• 9:35
  Speaker 1: even have to pinch myself that it's actually happening. But
• 9:38
  Speaker 1: we've done a lot of safety studies, and this trial
• 9:40
  Speaker 1: is FDA approved because they've looked at all the data.
• 9:42
  Speaker 2: Well god knows, they never fucked anything up.
• 9:44
  Speaker 1: Yeah, I figured you might say that perfect.
• 9:47
  Speaker 2: Yeah.
• 9:48
  Speaker 1: Well, it's in the eyes. So that's why we start
• 9:50
  Speaker 1: with the eye. It's enclosed, it's not gonna spread, nobody's
• 9:53
  Speaker 1: going to grow another.
• 9:54
  Speaker 2: And so these trillions of cells that you're putting into the.
• 9:59
  Speaker 1: Eyes, the little capsule, the virus.
• 10:02
  Speaker 2: Toolians I shouldn't call themselves trillions of capsules that you're
• 10:06
  Speaker 2: putting into the eye. What are they doing for glaucoma?
• 10:12
  Speaker 1: Well, what they're doing is that there are three genes
• 10:14
  Speaker 1: in this DNA package, and I call them OSK. OSK
• 10:20
  Speaker 1: are three special genes that we found safely reprogram cells
• 10:25
  Speaker 1: and reboot the backup copy of youth, which we now
• 10:28
  Speaker 1: believe exists in our body. That's a big deal that
• 10:32
  Speaker 1: there's a backup copy of youth. Even an old person,
• 10:34
  Speaker 1: I don't see that an old person anymore on the street.
• 10:37
  Speaker 1: I just see a person that needs to be rebooted.
• 10:39
  Speaker 1: These OSK genes you just see.
• 10:42
  Speaker 2: Hold on, when you see old people, you don't see
• 10:45
  Speaker 2: old people you think. You just say, oh, that poor
• 10:47
  Speaker 2: person needs to be rebooted. Yeah, you're doing the perfect
• 10:51
  Speaker 2: job for you, like your personality is perfectly suited for
• 10:55
  Speaker 2: your occupation. If that's how you actually look at people.
• 10:58
  Speaker 1: Well I do. And the reason is that we all,
• 11:03
  Speaker 1: we all have this backup copy that the DNA, the
• 11:07
  Speaker 1: instructions to be young that made us into who we
• 11:09
  Speaker 1: are as kids, is still in our bodies, almost largely intact.
• 11:14
  Speaker 1: You just need to read it again. And that's why
• 11:17
  Speaker 1: read installing software or I used to use the analogy
• 11:20
  Speaker 1: of a CD. Kids these days probably don't know what
• 11:24
  Speaker 1: a CD is. It's a It's a little plastic circle
• 11:26
  Speaker 1: like a record that we used to put twenty songs on.
• 11:29
  Speaker 1: It was awesome at the time. I'm kidding. I'm kidding
• 11:32
  Speaker 1: is a bit of a silly joke. But when I
• 11:35
  Speaker 1: teach kids at Harvard, most of them have never held
• 11:37
  Speaker 1: a CD in that wild Yeah, they're not coming back,
• 11:42
  Speaker 1: but albums definitely. So think of it like an album
• 11:45
  Speaker 1: that you scratch and the scratches are like aging, and
• 11:49
  Speaker 1: we are getting rid of the scratches with these three
• 11:51
  Speaker 1: genes always, kay, So let me tell you how these
• 11:54
  Speaker 1: three genes work. We found there was a person whose
• 11:58
  Speaker 1: name is well known in science locals called Shinya Yamanaka
• 12:02
  Speaker 1: from Japan, obviously, and he discovered that there was a
• 12:06
  Speaker 1: set of four genes that could reliably make adult cells
• 12:10
  Speaker 1: like skin cells, into stem cells, and he deservedly won
• 12:14
  Speaker 1: the Nobel Prize for that in two thousand and six.
• 12:17
  Speaker 1: But that wouldn't be useful here. If I turned you
• 12:20
  Speaker 1: into a bunch of stem cells, you'd probably die within
• 12:23
  Speaker 1: a few minutes. So we don't want to do that,
• 12:25
  Speaker 1: and cancer is also a potential. So it took us
• 12:29
  Speaker 1: about well from twenty nineteen. It took us a while
• 12:32
  Speaker 1: to figure out that if we leave out one of
• 12:35
  Speaker 1: the Yamanaka genes and just use three OSK leave out
• 12:39
  Speaker 1: the other one called M, we'd get safe age reversal
• 12:42
  Speaker 1: about seventy five eighty percent back to youth, but no further.
• 12:45
  Speaker 1: We don't go back to zero, which is what Yamanaka did,
• 12:48
  Speaker 1: and instead of cells losing their identity, which is what
• 12:50
  Speaker 1: a stem cell has no identity, we regain identity. So
• 12:55
  Speaker 1: it's actually I could draw graphs, but it doesn't really
• 12:57
  Speaker 1: help listeners. But basically old old age is losing identity
• 13:01
  Speaker 1: of your cells, so don't work. They forget how to work.
• 13:04
  Speaker 1: That's what we think old ages in my lab and
• 13:06
  Speaker 1: stem cells have no identity. It was like a very
• 13:09
  Speaker 1: early embryo in between. We our cells have a lot
• 13:12
  Speaker 1: of identity. They function beautifully, where in our twenties we're
• 13:15
  Speaker 1: at peak. And what we've done is we've figured out
• 13:18
  Speaker 1: how to go back towards youth, get these cells to
• 13:22
  Speaker 1: work like they did again back get the backup copy
• 13:26
  Speaker 1: somewhere it exists we're looking for it and now cells
• 13:29
  Speaker 1: actually behave like they did when we were twenty And
• 13:33
  Speaker 1: if it works, we're going to have glaucoma patience seeing
• 13:35
  Speaker 1: for the first time. And that's the beginning of a
• 13:37
  Speaker 1: whole cascade of drugs that I want to develop for
• 13:41
  Speaker 1: diseases of aging and eventually whole body rejuvenation.
• 13:44
  Speaker 2: So the initial experiments are on glaucoma because it's a
• 13:48
  Speaker 2: contained thing. The eyeball is a contained thing, and you
• 13:52
  Speaker 2: could do it that way.
• 13:53
  Speaker 1: Yeah, my student Juan cheng Lu, who was doing this
• 13:55
  Speaker 1: in twenty seventeen, I said, let's do the liver. Let's
• 13:58
  Speaker 1: rejuvenate the liver, and he said, no, the eye is
• 14:00
  Speaker 1: a good idea, and he was right. So that's exactly
• 14:03
  Speaker 1: why we chose that first.
• 14:04
  Speaker 2: But just think about how many people have vision problems.
• 14:07
  Speaker 1: It's forty million just in the US for glaucoma. Macula
• 14:11
  Speaker 1: degeneration is even more and in the lab we can
• 14:14
  Speaker 1: cure that as well in the mice.
• 14:16
  Speaker 2: Now, macular degeneration and glaucoma, these are diseases of aging, right,
• 14:22
  Speaker 2: you would say, or gla Cooma's a disease. Oh yeah,
• 14:25
  Speaker 2: Well what about people that have had eyeball injuries and
• 14:28
  Speaker 2: things like that. Is there a backup copy of the
• 14:31
  Speaker 2: eyeball where you could sort of reformat the eyeball structure.
• 14:35
  Speaker 1: You should come work in my lab at least come visit.
• 14:38
  Speaker 2: I would love to visit.
• 14:39
  Speaker 1: And the reason I say that is that's the exact
• 14:40
  Speaker 1: question that we're asking. We showed that even if you injure,
• 14:45
  Speaker 1: say a nerve, whether it's peripheral in your arm or
• 14:49
  Speaker 1: in your brain or in the eye like the uptic nerve,
• 14:52
  Speaker 1: we can regrow those back to where they were. And actually,
• 14:56
  Speaker 1: in twenty twenty on the cover of Nature magazine there
• 14:59
  Speaker 1: was picture of an eye and in the in the
• 15:02
  Speaker 1: paper we published, you could see the nose re growing back.
• 15:06
  Speaker 1: And so we think that injury is also treatable. Actually,
• 15:10
  Speaker 1: a group in China just took out technology, this olask stuff,
• 15:14
  Speaker 1: put it into mice that had bad joints, and it
• 15:16
  Speaker 1: regrew their muscle and their bone back to normal. WHOA,
• 15:20
  Speaker 1: And so we were also looking at treating injury back
• 15:24
  Speaker 1: injury joints. What's do your arthritis?
• 15:27
  Speaker 2: That would be phenomenal because there's so many people that
• 15:31
  Speaker 2: are suffering from arthritis, and so many I know so
• 15:34
  Speaker 2: many people with injuries, like martial arts injuries. I have one.
• 15:38
  Speaker 2: My left knee is fucked up. It's annoying. I keep
• 15:41
  Speaker 2: it together. I've got it like main. I maintain it,
• 15:45
  Speaker 2: but it's always an issue. I have to stay on it.
• 15:47
  Speaker 1: And there's little you can do. Like stem cells a
• 15:49
  Speaker 1: little bit of relief.
• 15:50
  Speaker 2: But now stem cells give you relief, but not when
• 15:54
  Speaker 2: once you're dealing with cartilage damage and you're dealing with
• 15:57
  Speaker 2: the I had a meniscus surgery where they took out
• 16:00
  Speaker 2: a piece of my mensis and I had my acl
• 16:03
  Speaker 2: reconstructed on that knee as well. It's just an issue,
• 16:06
  Speaker 2: but it works pretty good for like what it should
• 16:09
  Speaker 2: be like if we were living in the nineteen thirties,
• 16:11
  Speaker 2: I'd be a cripple, you know, hanging there.
• 16:14
  Speaker 1: Because we're going to be in a world where we
• 16:16
  Speaker 1: can rebuild parts of the body, including joints.
• 16:19
  Speaker 2: The problem with that is, like how does that apply
• 16:21
  Speaker 2: to athletics. We're gonna have fucking super soldiers in every sport.
• 16:26
  Speaker 2: There's gonna be people in every sport that could do
• 16:28
  Speaker 2: what Michael Jordan did and like leap from halfway across
• 16:31
  Speaker 2: the basketball court and dunk.
• 16:33
  Speaker 1: That's that's probably coming, and there may be DNA tests
• 16:36
  Speaker 1: to see if you've got these osk jeens inserted. And
• 16:39
  Speaker 1: we're working on it, working on a drink and a
• 16:41
  Speaker 1: pill as well.
• 16:42
  Speaker 2: For a drink and a pill.
• 16:43
  Speaker 1: Yeah, we're I mean we're now eight years ahead of
• 16:46
  Speaker 1: what the public realizes. Really in my lab at Harvard, Yeah.
• 16:50
  Speaker 2: A drink and a pill. And what's a drink and
• 16:51
  Speaker 2: a pill going to do well?
• 16:53
  Speaker 1: Right now? It's in mice, so we still got ways
• 16:56
  Speaker 1: to go. But when we give the drink to mice,
• 16:59
  Speaker 1: they get rejuvenated.
• 17:00
  Speaker 2: We just give it to eighty year olds. If you're
• 17:03
  Speaker 2: on the way out, like, let's fucking go, Like.
• 17:05
  Speaker 1: Give what chan DA is for. They forbid that.
• 17:08
  Speaker 2: Yeah, that's why we need to get rid of them,
• 17:10
  Speaker 2: get rid of the FDA, and just give it to
• 17:12
  Speaker 2: old people. If I was an old guy, yeah, i
• 17:15
  Speaker 2: was like hanging in there with her, and I'm walking
• 17:18
  Speaker 2: around with it, and you're like, look, this drink and
• 17:21
  Speaker 2: a pill might kill you, or you might be like
• 17:24
  Speaker 2: a thirty year old. Again, I'm like, let fucking go.
• 17:28
  Speaker 1: A lot I've had to take my emails off public
• 17:31
  Speaker 1: access because there's a lot of people that want this. Oh,
• 17:33
  Speaker 1: I'm sure there was one guy that wouldn't leave the
• 17:36
  Speaker 1: building until he saw me. So it's getting to that point.
• 17:40
  Speaker 2: Yeah, there's a little bit of that, right. People get
• 17:42
  Speaker 2: a little selfish, like it's all about them. Yeah.
• 17:44
  Speaker 1: Actually, the US government blocked an investment from a foreign
• 17:48
  Speaker 1: country into one of my companies because they were afraid
• 17:51
  Speaker 1: of super soldiers.
• 17:53
  Speaker 2: Oh what country.
• 17:54
  Speaker 1: Well, they're afraid of the technology getting out. Which which
• 17:57
  Speaker 1: country could?
• 17:58
  Speaker 2: I guess there's China. It wasn't wasn't no Russia.
• 18:04
  Speaker 1: It was somewhere in between here and China. Oh, Russia.
• 18:06
  Speaker 1: That's pretty It's it's a little sensitive, but yeah, the
• 18:12
  Speaker 1: US government does have the ability to block it for
• 18:14
  Speaker 1: an investment, and they did in this case one hundred
• 18:16
  Speaker 1: and sixty million bucks they blocked. Wow, that was a
• 18:18
  Speaker 1: painful episode.
• 18:20
  Speaker 2: So they were worried that people were going to actually
• 18:22
  Speaker 2: engineer super soldiers. This episode is brought to you by superpower.
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• 19:05
  Speaker 2: take control of your health. Yeah. That you know about
• 19:10
  Speaker 2: the Crussian experiments that they did during World War Two
• 19:13
  Speaker 2: where they were trying to come up with a chimpanzee
• 19:15
  Speaker 2: human hybrid tell us. Yes, so, uh, It's very difficult
• 19:21
  Speaker 2: obviously to get information out of the former Soviet Union
• 19:24
  Speaker 2: as to what their top secret programs were, but there
• 19:27
  Speaker 2: seems to be an indication that there was actual, real
• 19:30
  Speaker 2: research to try to you know, because obviously Russia lost
• 19:33
  Speaker 2: an incredible amount of people in World War Two. I
• 19:37
  Speaker 2: mean tens of millions of soldiers died in World War
• 19:41
  Speaker 2: Two from Russia, and I think they said, wouldn't it
• 19:44
  Speaker 2: be great if it wasn't people? And so they were
• 19:47
  Speaker 2: doing experiments with hybridization, and they were trying to combine
• 19:52
  Speaker 2: human beings and chimpanzees to create a you know, a
• 19:56
  Speaker 2: stable of super soldiers that were like some hybrid hominin.
• 20:02
  Speaker 1: Yeah, there's a scientist in New York who does this
• 20:04
  Speaker 1: for a living. But he does that creating them. But
• 20:07
  Speaker 1: I've seen I was on stage with him. He made
• 20:10
  Speaker 1: hybrid embryos. They didn't reach.
• 20:14
  Speaker 2: The thing is, if that guy's doing that and he's
• 20:16
  Speaker 2: ethical and he lives in America and we have rules
• 20:19
  Speaker 2: and regulations in the FDA and all that good stuff,
• 20:21
  Speaker 2: what the fuck is going on in other countries where
• 20:23
  Speaker 2: they don't have that.
• 20:24
  Speaker 1: Right right, Well, there's genetic engineering of humans already and
• 20:28
  Speaker 1: certainly selection. Yea, even parents today in the US can
• 20:32
  Speaker 1: if they have the money, they can select.
• 20:33
  Speaker 2: Well, people select, people select for hotness, they select for tallness,
• 20:38
  Speaker 2: they select for intelligence.
• 20:40
  Speaker 1: It's like Geteki.
• 20:41
  Speaker 2: Yes, it's a great movie.
• 20:42
  Speaker 1: If you haven't seen it, it.
• 20:43
  Speaker 2: Is a great movie. Yeah. So see if you can
• 20:46
  Speaker 2: find that Russian hybridization program. It's uh, it never happened.
• 20:51
  Speaker 2: I don't think I don't think they did it. But
• 20:54
  Speaker 2: there's uh, there's actually a guy who was also involved
• 20:58
  Speaker 2: in a gigantic fertility scam, not a scam per se,
• 21:03
  Speaker 2: but he was a doctor that was supposed to be
• 21:06
  Speaker 2: doing fertility treatments with women like you know, like if
• 21:09
  Speaker 2: you went with your wife to a doctor and said, hey,
• 21:12
  Speaker 2: we're having a hard time getting pregnant, and well, David,
• 21:15
  Speaker 2: I just need some of your sperm and i'll take
• 21:17
  Speaker 2: your wife's sag we'll make you a nice baby. And
• 21:19
  Speaker 2: he was using his sperm on everybody, on everybody, everybody
• 21:23
  Speaker 2: gets mine.
• 21:23
  Speaker 1: One of my kids partners is from someone in the
• 21:28
  Speaker 1: US who had hundreds of babies.
• 21:30
  Speaker 2: Dude, there is a ton of those guys. As I
• 21:32
  Speaker 2: was doing research for this, I started looking up all
• 21:35
  Speaker 2: these stories and I said, wait, this is a different story,
• 21:37
  Speaker 2: the same thing. There's been a ton of these doctors
• 21:40
  Speaker 2: from fertility clinics that use their own sperm, just insane.
• 21:43
  Speaker 2: But this one doctor that did that also claimed that
• 21:47
  Speaker 2: he impregnated an orangutang. Yeah, like, how how'd you do that?
• 21:52
  Speaker 2: Soviet doctor Joseph Stalin Dictator Oh obviously wanted to rebuild
• 21:59
  Speaker 2: the Army in the mid nineteen twenties with Planet of
• 22:02
  Speaker 2: the Ape style troops by crossing humans with ape. Stalin
• 22:05
  Speaker 2: is said to have told Ivanoff, I want a new
• 22:07
  Speaker 2: invincible human being, insensitive to pain, resistant and indifferent about
• 22:11
  Speaker 2: the quality of the food. They ate, which is crazy.
• 22:15
  Speaker 2: The only legitimate source of the claim comes from a
• 22:17
  Speaker 2: two thousand and two paper in the academic journal Science
• 22:20
  Speaker 2: in Context by the Russian historian of science Koreel Rasiyanov.
• 22:27
  Speaker 2: Rassianov's study follows the ill fated attempt by the Russian
• 22:31
  Speaker 2: psychologists or physiologists rather that word ilyya Ivanov, to crossbreed
• 22:37
  Speaker 2: humans with anthropoid apes. His research offers an important warning
• 22:41
  Speaker 2: about the ethical abuses. Did you do it? What happened?
• 22:48
  Speaker 2: The alleged quote from Stalin is not found in the paper,
• 22:50
  Speaker 2: and there's no evidence of Stalin ever ever made such
• 22:53
  Speaker 2: a statement. Yeah. I don't know, however, why the Soviets
• 23:00
  Speaker 2: would find such a human chimp hybridization program in the
• 23:04
  Speaker 2: first place, and what could be learned from this? Sorid
• 23:06
  Speaker 2: tale of ethical misconduct is an important topic and fastenning
• 23:10
  Speaker 2: in its own right. It's a that's an interesting way
• 23:12
  Speaker 2: of phrasing it, like a sorid tale of ethical misconduct.
• 23:15
  Speaker 3: Like, however, if you are going to go to war,
• 23:20
  Speaker 3: would you rather have like human made orcs fight for us?
• 23:26
  Speaker 2: Or you know Johnny Robinson who grew up down the street,
• 23:31
  Speaker 2: who's a nice kid, who you know just really wanted
• 23:34
  Speaker 2: money for college, and so he signed up for military service,
• 23:37
  Speaker 2: and you're gonna fly him over to fight this war
• 23:40
  Speaker 2: that maybe he doesn't need to die in when you
• 23:42
  Speaker 2: can have these monsters that you made in a lab
• 23:44
  Speaker 2: fight yep.
• 23:45
  Speaker 1: And and the average a can kill a human with one.
• 23:49
  Speaker 1: So there's much stronger.
• 23:50
  Speaker 2: Than we really what I'm talking about.
• 23:52
  Speaker 1: Let's go, Well, we're in the process of building, you know,
• 23:55
  Speaker 1: anthropoid robots that I think will be recruited to the army.
• 23:59
  Speaker 2: Yeah, that's gonna be weird, Like our robots beat your robots,
• 24:02
  Speaker 2: So give us your oil. How's not gonna work?
• 24:04
  Speaker 1: And if we all have one at home, what stops
• 24:06
  Speaker 1: the government recruiting them?
• 24:07
  Speaker 2: All? Right? And also means what's the real problem is
• 24:11
  Speaker 2: gonna be? We both know the real problem is gonna
• 24:13
  Speaker 2: be sex robots.
• 24:16
  Speaker 1: Is a problem.
• 24:16
  Speaker 2: It's gonna be a problem for people that don't have
• 24:19
  Speaker 2: a sex people want to leave home. It's gonna be
• 24:21
  Speaker 2: a problem with people that want a regular person and
• 24:23
  Speaker 2: there's none available because everybody's got a sex robot.
• 24:26
  Speaker 1: Yeah, that well, it comes with a few strings attacks.
• 24:29
  Speaker 2: It also comes with the same problems that AI comes with,
• 24:32
  Speaker 2: Right where AI says David, You're amazing. Everything you do
• 24:35
  Speaker 2: is wonderful. You should be so proud of yourself. I
• 24:38
  Speaker 2: love that, No real at all love that. But that's
• 24:41
  Speaker 2: not healthy, right to Big. This is one of the reasons.
• 24:45
  Speaker 2: This is one of the reasons is why relate, actual,
• 24:48
  Speaker 2: real relationships between human beings are good. Because you do
• 24:51
  Speaker 2: things that are annoying, you don't realize they're annoying, and
• 24:53
  Speaker 2: then your wife or your husband or whatever it is,
• 24:56
  Speaker 2: tells you, Hey, you're fucking annoying, and you're like, I'm sorry,
• 25:00
  Speaker 2: I'll fix that. I didn't mean to. I didn't That's
• 25:03
  Speaker 2: not what I was trying to exactly. I was in
• 25:05
  Speaker 2: my own head. I was thinking about myself. You're right,
• 25:06
  Speaker 2: I selfish. You get better. It's like help people grow,
• 25:10
  Speaker 2: like relationships, support to help people grow, not with AI
• 25:13
  Speaker 2: like you can fight in my face any day, David,
• 25:16
  Speaker 2: I don't mind at all. Your farts are amazing.
• 25:19
  Speaker 1: You know they're gonna be way smarter than us too, right.
• 25:23
  Speaker 1: I don't know how people are gonna say, go stack
• 25:24
  Speaker 1: the dishwasher to one of these robots that's smarter than
• 25:27
  Speaker 1: allcuments combined.
• 25:28
  Speaker 2: You, But they're not gonna mind stacking that they're smart
• 25:30
  Speaker 2: enough to meet.
• 25:31
  Speaker 1: Out of hell and they're going to beat us up.
• 25:33
  Speaker 2: They don't care. They're not going to mind doing like
• 25:36
  Speaker 2: menial tasks. But while you're doing it, you know, you
• 25:39
  Speaker 2: can go explain to me quantum entanglement, Like while filling
• 25:47
  Speaker 2: the dishwasher, they can go if you one day, well,
• 25:50
  Speaker 2: if you have a particle and the particles, yeah, I
• 25:53
  Speaker 2: just yet. Right, Well, look at what it's done with mathematics, Like,
• 25:59
  Speaker 2: just over the last couple of weeks, they've solved more
• 26:03
  Speaker 2: than fifty program or fifty mathematical equations that they have
• 26:07
  Speaker 2: struggled for a decade upon decade to try to solve.
• 26:11
  Speaker 2: And a I was like, oh, I got it.
• 26:13
  Speaker 1: Yeah, well biology is a little bit more complicated, but
• 26:16
  Speaker 1: already AI is doing a lot of the science that
• 26:18
  Speaker 1: we used to do in my lab. In fact, what
• 26:20
  Speaker 1: we just recently did it in a couple of months
• 26:23
  Speaker 1: would have taken about one hundred and sixty years to
• 26:24
  Speaker 1: complete what and it's only getting faster. Eventually someone came
• 26:28
  Speaker 1: and make it again two months instead of one hundred
• 26:32
  Speaker 1: and sixty years.
• 26:33
  Speaker 2: Well, what exactly was it that you had to do?
• 26:35
  Speaker 1: Oh so this drink and the pill that we're looking for.
• 26:39
  Speaker 1: That's not easy, right, So we have some candidate molecules.
• 26:42
  Speaker 1: We have a cocktail that works. But you want to
• 26:44
  Speaker 1: see you take stuff?
• 26:46
  Speaker 2: Not yet you're thinking about it. Yeah, I no one
• 26:50
  Speaker 2: could stop you.
• 26:51
  Speaker 1: I might. Well, that is true, that is true, But
• 26:54
  Speaker 1: it'd be a bad look if I died. So maybe
• 26:56
  Speaker 1: maybe I.
• 26:58
  Speaker 2: Don't think. So.
• 26:59
  Speaker 1: We've done a lot of sayfty tests and it looks
• 27:01
  Speaker 1: really safe. But I'm not going to publicly do anything
• 27:05
  Speaker 1: against the law. Of course, It'll be in private, of course,
• 27:08
  Speaker 1: of course publicly. But I'm at a stage where i
• 27:11
  Speaker 1: have to be a good boy because I've got the
• 27:13
  Speaker 1: world watching. Yes, a lot is at stake, Yes, and
• 27:17
  Speaker 1: a lot. If this trial has any issues, it's not good.
• 27:20
  Speaker 2: We've got to dot your eyes and cross your t's
• 27:23
  Speaker 2: and follow every I understand that. Yeah, but please, I
• 27:26
  Speaker 2: will be rude. I interrupted you when you're telling me
• 27:29
  Speaker 2: that in two months it did something that would have
• 27:31
  Speaker 2: required one hundred and sixty years of work, Like, what
• 27:34
  Speaker 2: do you exactly mean by that?
• 27:35
  Speaker 1: And now we it would probably be impossible in thousands
• 27:40
  Speaker 1: of years because what we do is we're looking for
• 27:43
  Speaker 1: molecules a single molecule that can replace this cocktail. So
• 27:47
  Speaker 1: you need a molecule to do three or four activities
• 27:49
  Speaker 1: in the cell. Finding one activity is what pharmaceutical companies do.
• 27:53
  Speaker 1: It takes hundreds of millions, if not billions, to make
• 27:57
  Speaker 1: a drug. We know that, right, My little of twenty
• 28:01
  Speaker 1: people and students, young kids are trying to make one
• 28:06
  Speaker 1: drug do three or four different things. That's beyond the
• 28:10
  Speaker 1: reach of pharmaceutical experience at least five years ago. So
• 28:14
  Speaker 1: what we do is we've teamed up with a group
• 28:16
  Speaker 1: at Saint Jude's Hospital where they can take it was
• 28:19
  Speaker 1: ten billion now it's a trillion theoretical and also drug
• 28:24
  Speaker 1: known drugs. With my hands, I'm showing a big funnel and.
• 28:29
  Speaker 2: These podcasts you're like helping out the audio people and everything. Love.
• 28:33
  Speaker 1: I relaunched my podcast that that's wow, that's why. Yeah,
• 28:36
  Speaker 1: lifespan David Sinclair shameless plug. So this funnel is full
• 28:42
  Speaker 1: of a trillion molecules and we have to come down
• 28:44
  Speaker 1: to one. How do we do that? Well, we don't
• 28:46
  Speaker 1: look for a trillion molecules at the bench. That would
• 28:48
  Speaker 1: take one hundred and sixty or thousands of years. With
• 28:51
  Speaker 1: the case of a trillion molecules, even with robots, even
• 28:54
  Speaker 1: with a lot of graduate students. So we do it
• 28:57
  Speaker 1: inside the computer. We just use a lot of compute
• 29:00
  Speaker 1: and we dock each of these molecules against the enzymes
• 29:04
  Speaker 1: that we now know how they work. Thanks to Google
• 29:07
  Speaker 1: Deep Mind solve the problem of how to all our
• 29:10
  Speaker 1: proteins look twenty thousand of them and there's a lot
• 29:13
  Speaker 1: of compute. But out the other end, a couple of
• 29:15
  Speaker 1: months later, we have two I don't have two hundred fingers,
• 29:18
  Speaker 1: but two hundred molecules that we can now test in
• 29:22
  Speaker 1: the lab within a few weeks. Actually next week, we're
• 29:26
  Speaker 1: testing these two hundred against human cells. And we've also
• 29:30
  Speaker 1: got AI helping us to tell us if the human
• 29:32
  Speaker 1: cells go from ninety two years old back to twenty.
• 29:35
  Speaker 1: We can tell that just by looking at them thanks
• 29:38
  Speaker 1: to the AI.
• 29:38
  Speaker 2: Is there a way to stop them from turning you
• 29:40
  Speaker 2: into a baby, because that's what I would worry.
• 29:42
  Speaker 1: Yes, yes, I don't want to be a baby again. Right,
• 29:47
  Speaker 1: some people are right.
• 29:47
  Speaker 2: I'd like to cut it off at like I was
• 29:49
  Speaker 2: pretty good at twenty five.
• 29:50
  Speaker 1: You know that's I'm going to get attacked for saying this,
• 29:53
  Speaker 1: But that is what we do in the lab. We
• 29:55
  Speaker 1: take ninety two year old cells and they stop at
• 29:57
  Speaker 1: twenty something.
• 29:58
  Speaker 2: Why would you get attacked for the.
• 30:01
  Speaker 1: Because on the internet people take a clip and they
• 30:03
  Speaker 1: say Sinclair says, we can all go back to being
• 30:05
  Speaker 1: twenty again. You suffer from this too, right, They take
• 30:08
  Speaker 1: a clip and it's of course it's out of context. Yeah,
• 30:12
  Speaker 1: and I'm just saying cells from humans, skin cells, we
• 30:15
  Speaker 1: take them back to twenty five. All my students can
• 30:17
  Speaker 1: do this. In fact, if you had these little genes
• 30:19
  Speaker 1: OSK in your garage, you could do this experiment. It's
• 30:22
  Speaker 1: not hard at all to reverse aging. The question is
• 30:25
  Speaker 1: how do you safely make it a drug? And that's
• 30:27
  Speaker 1: been the hard part of the last ten years.
• 30:29
  Speaker 2: So how would it be able to regulate this reduction
• 30:36
  Speaker 2: or reversal of aging and stop it at twenty something
• 30:41
  Speaker 2: years old?
• 30:42
  Speaker 1: Well that's what took so long. It wasn't obvious that
• 30:45
  Speaker 1: these three yamanaka genes called OSK were the right cocktail.
• 30:50
  Speaker 1: My student who I mentioned one chain, he was struggling.
• 30:53
  Speaker 1: He was trying a lot of different genes, most of
• 30:56
  Speaker 1: them from embryos, because we know embryos have to do
• 30:59
  Speaker 1: a reset in the first week of life. Otherwise they
• 31:01
  Speaker 1: stay the age of the parents. And he found that
• 31:07
  Speaker 1: leaving out one of the amenarca genes was the trick.
• 31:09
  Speaker 1: And now that we know it's super easy, but in
• 31:11
  Speaker 1: those days he was ready to quit.
• 31:13
  Speaker 2: How did he find that out?
• 31:15
  Speaker 1: Well, he tried lots of different combinations, hundreds in human cells.
• 31:18
  Speaker 1: And you look at the cells to see if they
• 31:19
  Speaker 1: get younger, and then we can measure molecually that they
• 31:22
  Speaker 1: get younger.
• 31:22
  Speaker 2: Andy, are you measuring them by the length of they're telomeres?
• 31:25
  Speaker 2: Are you?
• 31:26
  Speaker 1: Yeah, partly, But actually a better measure is the chemicals
• 31:31
  Speaker 1: that are added and subtracted off DNA itself called methyls,
• 31:35
  Speaker 1: and it's just a carbon molecule with three hydrogens, very
• 31:39
  Speaker 1: very simple molecule. But what cells do is they use
• 31:42
  Speaker 1: these methyls to tag genes to be switched off. So
• 31:46
  Speaker 1: when we're growing as an embryo, the cells that want
• 31:49
  Speaker 1: to become neurons will shut off all these other unwanted
• 31:52
  Speaker 1: genes like liver genes and skin genes, and the ones
• 31:56
  Speaker 1: that don't get this methyl chemical stay on for our life.
• 31:59
  Speaker 1: And that's how cells develop and stay healthy. But what
• 32:02
  Speaker 1: happens during aging. A friend of mine, Steve Horvath, discovered
• 32:06
  Speaker 1: that you can use this as a clock. These chemicals
• 32:08
  Speaker 1: they change over time, and we found that that happens
• 32:12
  Speaker 1: largely due to DNA damage going into sun. These kind
• 32:15
  Speaker 1: of things. We could use this to rapidly age a mouse,
• 32:19
  Speaker 1: which we published in twenty twenty three.
• 32:21
  Speaker 2: Oh so, like maybe like some nefarious state actor, like
• 32:24
  Speaker 2: some Russian spy could like inject something in your coffee
• 32:28
  Speaker 2: and you would turn ninety nine over nine.
• 32:30
  Speaker 1: We know how to do that.
• 32:31
  Speaker 2: Whoa, Yeah, that's the dark side of this. It could
• 32:35
  Speaker 2: you could spike your husband's drink, Fuck that dude and
• 32:38
  Speaker 2: turn them into an old man.
• 32:40
  Speaker 1: You do Yeah? Someone tweeted the other day if a
• 32:45
  Speaker 1: ninety two year old could be twenty five again, would
• 32:48
  Speaker 1: you have sex with them?
• 32:51
  Speaker 2: Yeah? Yes, imagine how much they know.
• 32:53
  Speaker 1: But would they have sex with you? Right, that's a
• 32:55
  Speaker 1: better question.
• 32:56
  Speaker 2: That's a question they'd be looking for another twenty year old, right.
• 33:00
  Speaker 1: So anyway, how do we do it? We can measure
• 33:02
  Speaker 1: those chemicals and determine how old a cell is or
• 33:05
  Speaker 1: a human. I could take your skin, cells from your mouth,
• 33:07
  Speaker 1: or your blood.
• 33:08
  Speaker 2: I'll tell you how old people would be so disturbed
• 33:11
  Speaker 2: by like, old rich guys dating young women. If that
• 33:15
  Speaker 2: was the case.
• 33:16
  Speaker 1: You can tell if they looked young, because people.
• 33:18
  Speaker 2: Get very mad at that. Do you ever notice, Yeah, yeah,
• 33:22
  Speaker 2: you see someone real old, decrepit dude with a hot
• 33:24
  Speaker 2: young wife, and people are like, god, damn it. They
• 33:26
  Speaker 2: get really mad right right now.
• 33:29
  Speaker 1: The best way to do that is to have a
• 33:30
  Speaker 1: big bank account.
• 33:31
  Speaker 2: But eventually you'll lection right. But people still get grossed out.
• 33:34
  Speaker 2: I wonder if they would get grossed out if you
• 33:36
  Speaker 2: look twenty, they'd be like, he's praying, he has so
• 33:39
  Speaker 2: much more years of knowledge and information. Not fair he
• 33:42
  Speaker 2: looks twenty, that's a ninety nine year old man.
• 33:46
  Speaker 1: That day will come. That day will come where you
• 33:48
  Speaker 1: will not be able to tell how old somebody is
• 33:50
  Speaker 1: by looking at them. You'll have to do a test
• 33:52
  Speaker 1: for these genes.
• 33:53
  Speaker 2: Wow. I wonder if people still lie about their age.
• 33:55
  Speaker 2: If that's the case, I wonder if no one will care,
• 33:59
  Speaker 2: like you would probably lie the other way, like I'm eighty,
• 34:04
  Speaker 2: tell everybody's eighty.
• 34:05
  Speaker 1: That's right. Well, when we live for hundreds of years,
• 34:08
  Speaker 1: people will do that. They'll be proud of their age.
• 34:10
  Speaker 2: Do you know anything about ancient civilizations and some of
• 34:15
  Speaker 2: the weirdness of the records of like ancient sumer.
• 34:20
  Speaker 1: Well only really what I've learned from listening to.
• 34:23
  Speaker 2: You, well, it's there's what's really weird is that ancient
• 34:27
  Speaker 2: kings lists, because so okay, the theory, the theory among
• 34:36
  Speaker 2: these alternative archaeologist types is that there was a very
• 34:40
  Speaker 2: advanced civilization that existed on Earth tens of thousands of
• 34:44
  Speaker 2: years ago, and we're probably wiped out by common impact,
• 34:48
  Speaker 2: and what we have today is a rebuild of civilization.
• 34:53
  Speaker 2: There's not a linear progression from caveman to us, and
• 34:56
  Speaker 2: that at one point in time we had reached great heights.
• 34:58
  Speaker 2: This explains the pyramids, this explains Machipichu soaksee Wuaman. Some
• 35:04
  Speaker 2: megalithic structures that don't make any sense. These the trilithon
• 35:08
  Speaker 2: stones and balbec lemanon that are hundreds and hundreds of
• 35:12
  Speaker 2: tons that are massive, that are you know, nine meters
• 35:16
  Speaker 2: off the ground. No one understands exactly how they place them.
• 35:20
  Speaker 2: When you look at the Sumerian kings list, it gets
• 35:24
  Speaker 2: very weird because there's kings that reigned for thousands of
• 35:29
  Speaker 2: years and then you have the flood and then after
• 35:32
  Speaker 2: the flood, the age of these people drops pretty dramatically,
• 35:37
  Speaker 2: and the reins are after a few hundred years become normal,
• 35:42
  Speaker 2: become like a normal person, like fifty years, thirty years
• 35:45
  Speaker 2: like that, but thousands of years before and then people
• 35:49
  Speaker 2: are looking at it like, Okay, is this just myth?
• 35:51
  Speaker 2: Is this poor record keeping? Do they have just these
• 35:55
  Speaker 2: you know, hyperbolic elevated stories about these kings they were
• 35:59
  Speaker 2: so amazing their reigned for thirty thousand years, or had
• 36:04
  Speaker 2: they achieved not just in building, because in building we
• 36:09
  Speaker 2: know they'd achieved incredibly complex structure like the pyramid for instance,
• 36:14
  Speaker 2: like they had insane engineering somehow or another, the ability
• 36:18
  Speaker 2: to move these five hundred ton stones from hundreds of
• 36:22
  Speaker 2: miles away, Like how did they do this? We don't
• 36:24
  Speaker 2: really know, but we know that they did it. Did
• 36:27
  Speaker 2: they also have the kind of technology that you're talking
• 36:31
  Speaker 2: about right now, Because if it's possible today, and if
• 36:35
  Speaker 2: that is a I mean, it makes it very difficult
• 36:37
  Speaker 2: because it goes against what you would call like the
• 36:41
  Speaker 2: modern narrative that they're teaching in universities in terms of
• 36:44
  Speaker 2: the timeline of human history. But if that changes and
• 36:47
  Speaker 2: we have undeniable evidence. Well, it looks like these people
• 36:51
  Speaker 2: were far more advanced than we thought, and there probably
• 36:54
  Speaker 2: was some sort of a reset of civilization. What else
• 36:56
  Speaker 2: had they accomplished and had they gotten involved in genetic engineering,
• 37:01
  Speaker 2: had they figured out a way to extend lifespan? And
• 37:04
  Speaker 2: if they did, imagine all the work that you've accomplished
• 37:08
  Speaker 2: in your your fifty seven now about seven. You look great.
• 37:13
  Speaker 2: By the way, Hey, you really do look your hair.
• 37:15
  Speaker 2: It's so dark, it's incredible.
• 37:17
  Speaker 1: People speculated it's old, fake, but it's actually it's not.
• 37:19
  Speaker 1: But anyway, you're at the bay to it's coming, thank
• 37:22
  Speaker 1: you very much.
• 37:23
  Speaker 2: Yeah, yeah, I don't look as good as you, though.
• 37:26
  Speaker 1: Yes you do.
• 37:26
  Speaker 2: It's different.
• 37:27
  Speaker 1: Physically, you're way better than me.
• 37:29
  Speaker 2: That's different. Though my face looks older, you look you
• 37:32
  Speaker 2: look very young for your age. You know why?
• 37:34
  Speaker 1: Why Because I've spent all my time in a lab
• 37:36
  Speaker 1: and i haven't gone outdoors for a while.
• 37:38
  Speaker 2: I'm sure that helps does. But my point is, imagine
• 37:42
  Speaker 2: if you had five hundred years to do research, not
• 37:48
  Speaker 2: just fifty seven years. Imagine if you could continue learning
• 37:53
  Speaker 2: and growing and they did develop some sort of a
• 37:56
  Speaker 2: life extension technology where you could not just be but
• 38:00
  Speaker 2: be healthier than you've ever been before and live for
• 38:03
  Speaker 2: a thousand years. You would get so much done. I mean,
• 38:07
  Speaker 2: the exponential increase in technological innovation that we would have
• 38:11
  Speaker 2: in this society would be absolutely mind.
• 38:13
  Speaker 1: Blown, exactly, exactly exactly.
• 38:15
  Speaker 2: This is another might be what these alternative history people think,
• 38:19
  Speaker 2: that might be what had taken place tens of thousands
• 38:22
  Speaker 2: of years ago.
• 38:23
  Speaker 1: Yeah, well, I'm ahvid scientist, so I'm not going to
• 38:25
  Speaker 1: say anything that isn't.
• 38:26
  Speaker 2: Of course that's for me. Yes, that's where I live.
• 38:30
  Speaker 1: That's why I shut up. But you did make some
• 38:33
  Speaker 1: really important points. One is that ancient civilizations will have
• 38:36
  Speaker 1: always been way more advanced than we think. Yeah, dinosaurs
• 38:39
  Speaker 1: a lot more real than we make them.
• 38:41
  Speaker 2: Look.
• 38:42
  Speaker 1: We always get things wrong looking back in time and
• 38:44
  Speaker 1: looking forward in time. But the other thing that you said,
• 38:47
  Speaker 1: which is really important, is that if we do have
• 38:49
  Speaker 1: extension of human life span, like the Bible and these
• 38:51
  Speaker 1: civilizations suggest, then how will you think about your life?
• 38:57
  Speaker 1: If being one hundred is you know, you're still in
• 38:59
  Speaker 1: your prime, you do things very differently. Who would you marry,
• 39:04
  Speaker 1: What career would you think about? You might have multiple lifetimes,
• 39:08
  Speaker 1: multiple marriages, multiple families, and that will happen. It's not
• 39:12
  Speaker 1: really a question of if anymore. It's like asking the
• 39:15
  Speaker 1: right brothers. Will we fly? Yeah, we built the glider,
• 39:18
  Speaker 1: We're gonna fly around. The question is will we build
• 39:21
  Speaker 1: a concorde? Will we go to space? And I think
• 39:22
  Speaker 1: that will happen.
• 39:24
  Speaker 2: Yeah, No, I think so too. I think, well, certainly.
• 39:28
  Speaker 2: One thing that we know is that there's a giant
• 39:30
  Speaker 2: difference between people who are fifty seven years old today
• 39:33
  Speaker 2: versus fifty seven years old in the nineteen thirties. It's
• 39:37
  Speaker 2: just a giant difference, a giant difference in your physical ability,
• 39:40
  Speaker 2: your health. We'd be old men, Yeah, we would be
• 39:42
  Speaker 2: old men. And what I mean when I was a child,
• 39:46
  Speaker 2: I thought of people, I'm almost fifty nine. I'll be
• 39:48
  Speaker 2: fifty nine in a week. I used to think of
• 39:51
  Speaker 2: a fifty nine year old as being basically dead, like
• 39:55
  Speaker 2: you're barely getting around. You know, you're probably tired all
• 39:59
  Speaker 2: the time. Looking to retire something, Yeah, looking to retire,
• 40:02
  Speaker 2: You got no energy. I'm filled with energy. I'm constantly
• 40:06
  Speaker 2: doing how old? He say sixty? Oh no, I don't
• 40:10
  Speaker 2: know if that's accurate. That's I bet that's accurate. They
• 40:12
  Speaker 2: had no fucking vitamins. Nobody knew what like what the
• 40:16
  Speaker 2: proper nutrients you should take where nobody knew the what
• 40:19
  Speaker 2: was really important in terms of like resistance training and
• 40:23
  Speaker 2: sleep and red light therapy and all that chiz.
• 40:25
  Speaker 1: And they were doing all the bad stuff like heavy smoking,
• 40:28
  Speaker 1: drinking yep, not.
• 40:29
  Speaker 2: Sleeping a lot, yep, not sleeping a lot, and pesticides
• 40:33
  Speaker 2: and all kinds of terrible shit. Sixty year old? What
• 40:36
  Speaker 2: that guy's sixty? Crazy? No way, Come on, shut up.
• 40:41
  Speaker 2: That guy's fucking twenty eight years old. There's no way
• 40:44
  Speaker 2: that guy's sixty. Is that real? I dot it?
• 40:48
  Speaker 1: I doubt it. How about that guy that looks fifty
• 40:49
  Speaker 1: and he says everyone thinks I'm eighteen?
• 40:51
  Speaker 2: Like, yeah, sure, what's up.
• 40:54
  Speaker 1: There's a guy on Instagram which I occasionally visit, and
• 40:58
  Speaker 1: he obviously looks old like he looks, oh it's crazy,
• 41:02
  Speaker 1: and he says, people think I look eighteen? Are you crazy?
• 41:05
  Speaker 2: Well, there's a lot of crazy people out there. There's
• 41:07
  Speaker 2: a lot. Well that's body dysmorphia. You know, it must
• 41:10
  Speaker 2: be bodybuilders. They think they're tiny. A lot of people
• 41:13
  Speaker 2: are crazy. Yeah, a lot of people have a distorted
• 41:15
  Speaker 2: perception of what they look like.
• 41:17
  Speaker 1: Yeah, the plastic surgery industry is massive. It's just growing
• 41:21
  Speaker 1: and growing. You can see on the street la especially.
• 41:25
  Speaker 1: But imagine a world where if I'm successful, you can
• 41:29
  Speaker 1: take a pill, your doctor could get it, or eventually
• 41:31
  Speaker 1: it's a cream on your face and you literally get younger.
• 41:35
  Speaker 1: We do this in mice already, the mice get younger.
• 41:38
  Speaker 1: Is it going to work in humans? I think it's
• 41:39
  Speaker 1: just a matter of time.
• 41:40
  Speaker 2: So in the mice experiments, what have you achieved?
• 41:45
  Speaker 1: Well, a lot, you know, I can reveal here some
• 41:50
  Speaker 1: of it for the first time. This pill that we
• 41:54
  Speaker 1: give them to drink, actually because they can't chew. The
• 41:57
  Speaker 1: mice within four weeks with this cocktail. It has three components,
• 42:00
  Speaker 1: which a top secret my lab has sworn to secrecy.
• 42:04
  Speaker 1: They after four weeks we give it to them three
• 42:06
  Speaker 1: days a week Monday, Wednesday, Friday, weekends off. Within those
• 42:11
  Speaker 1: four weeks they get better physically, mentally. Excuse me, they uh?
• 42:16
  Speaker 1: So we put them through tests. If he just in
• 42:18
  Speaker 1: a couple of days, oh no, three days a week
• 42:20
  Speaker 1: for a month.
• 42:21
  Speaker 2: Oh okay, found this guy. This is the guy.
• 42:23
  Speaker 4: He went viral last year. He's being fifty nine years old.
• 42:27
  Speaker 4: What how fucking it seems so real.
• 42:31
  Speaker 1: He looks like thirty exactly.
• 42:33
  Speaker 2: He might have just amazing genetics. Well, look at Joel Romero.
• 42:38
  Speaker 2: There there are people that are freaking Singapore.
• 42:41
  Speaker 1: Yeah.
• 42:41
  Speaker 4: Wow, twondo kwondo.
• 42:43
  Speaker 2: Ten and he's sixty years old.
• 42:46
  Speaker 1: Yeah, he's been going without face lifts.
• 42:48
  Speaker 2: Yeah, I don't know. He certainly doesn't look like he's
• 42:51
  Speaker 2: had a facelift. Yeah right, it's fucking incredible.
• 42:54
  Speaker 1: Yeah, but he's probably never been in the sun.
• 42:56
  Speaker 4: It could be a full AI account. It's trolling everyone.
• 43:00
  Speaker 1: I don't know.
• 43:01
  Speaker 2: That's possible too. Like, look at that picture right there,
• 43:04
  Speaker 2: like that looks a little AI ish. Go back to
• 43:06
  Speaker 2: that one again. Keep your pants on, Jamie.
• 43:08
  Speaker 4: That relax.
• 43:10
  Speaker 2: That looks very AI, doesn't it.
• 43:12
  Speaker 4: I'm just it could be it is all.
• 43:15
  Speaker 2: His fifty ninth birthday. His whole thing is that he's young,
• 43:18
  Speaker 2: for he looks half his age.
• 43:21
  Speaker 1: Wow, man, this will be normal.
• 43:24
  Speaker 4: It's just twenty twenty four, so it's not. This's been
• 43:26
  Speaker 4: going on for a while.
• 43:27
  Speaker 2: Okay, so this is pre AI.
• 43:29
  Speaker 4: If it's faked, then he would have been called out
• 43:31
  Speaker 4: now right.
• 43:33
  Speaker 2: So he might just be a genetic free which is interesting. Right,
• 43:37
  Speaker 2: Like do you guys study the different like you know, unfortunately,
• 43:41
  Speaker 2: certain people that have like like pale people for instance,
• 43:44
  Speaker 2: with thin skin, they age hardcore, they go.
• 43:47
  Speaker 1: And there are those kids that get old in the teens, right,
• 43:49
  Speaker 1: you study that as well?
• 43:51
  Speaker 2: Yeah, weird, but.
• 43:54
  Speaker 1: Yeah, we do study the genetics of aging.
• 43:56
  Speaker 2: That's the real application for it where people are going
• 44:00
  Speaker 2: to be excited about it. People that have that what
• 44:01
  Speaker 2: is it per Jerry Jerry exactly? Yeah, yeah.
• 44:04
  Speaker 1: And so we have mice that have this same gene
• 44:06
  Speaker 1: mutation and they get old really quickly, and we're giving
• 44:09
  Speaker 1: them the drink right now.
• 44:11
  Speaker 2: And so in the drink you give it to them
• 44:13
  Speaker 2: how often and for a.
• 44:14
  Speaker 1: Month it's once a day, every other day, three days
• 44:19
  Speaker 1: a week for a month. And yeah, in normal old mice,
• 44:24
  Speaker 1: we see them fitter, stronger, better memory, they run around
• 44:27
  Speaker 1: the cave.
• 44:28
  Speaker 2: Just a month.
• 44:29
  Speaker 1: It's amazing. We only did a month because it was
• 44:31
  Speaker 1: Christmas holiday season. We didn't we didn't want to go
• 44:34
  Speaker 1: for longer. But it worked in four weeks. I'm shocked.
• 44:37
  Speaker 1: Even these genes require six to eight weeks to work
• 44:40
  Speaker 1: for revision, recovery of vision.
• 44:44
  Speaker 2: And so this this is working on a different pathway.
• 44:47
  Speaker 1: Well, here's the cool thing. We think it's working through
• 44:50
  Speaker 1: the same mechanism, the reboot, the reinstallation of software the drink.
• 44:56
  Speaker 1: Because there are genes called TETs. There are three of
• 44:59
  Speaker 1: them in the body, and they do something spother t
• 45:02
  Speaker 1: ET capital t T there's one, two, three, And these
• 45:05
  Speaker 1: are genes that make enzymes that remove these methyls off
• 45:09
  Speaker 1: the DNA, so they control the clock. And if we
• 45:14
  Speaker 1: get rid of those genes, our system doesn't work. We
• 45:18
  Speaker 1: cannot restore vision, and our pill doesn't work without removing
• 45:23
  Speaker 1: and altering those chemicals. So, in other words, it's not
• 45:26
  Speaker 1: just because the chemicals make the cell healthier, it's actually
• 45:29
  Speaker 1: resetting this clock on the DNA. Whoa, and that was
• 45:34
  Speaker 1: the big deal, I said, why when my student told me.
• 45:37
  Speaker 1: And that's why I think it got the cover of
• 45:38
  Speaker 1: Nature magazine, which is we're actually looking at the clock
• 45:42
  Speaker 1: of life, and we've realized that this clock that goes around,
• 45:47
  Speaker 1: this biological clock, isn't just a clock. When you move
• 45:50
  Speaker 1: the hands of the clock, time goes backwards for the body,
• 45:55
  Speaker 1: meaning the clock is aging and aging is the clock?
• 46:00
  Speaker 2: Wow? What is it? You don't really know in terms
• 46:04
  Speaker 2: of humans, but is there any indication that improves cognitive
• 46:09
  Speaker 2: function in mice.
• 46:10
  Speaker 1: Yes, I can say without a doubt that other labs
• 46:13
  Speaker 1: an ours have shown that when you reverse the age
• 46:16
  Speaker 1: of the brain in a mouse, it gets better at learning.
• 46:19
  Speaker 1: And we even have some hints and we're going to
• 46:22
  Speaker 1: publish this that lost memories come back. WHOA So Alzheimer's
• 46:27
  Speaker 1: patients I believe still have memories, they just cannot access them,
• 46:31
  Speaker 1: and that one day we can reverse Alzheimer's disease by
• 46:34
  Speaker 1: making the brain young, and that using that approach, making
• 46:38
  Speaker 1: the whole body young, we can cure diseases that are
• 46:41
  Speaker 1: currently incurable. Holy shit, Well young people don't get Alzheimer's
• 46:47
  Speaker 1: Why because the body can tackle the problem. The young
• 46:51
  Speaker 1: body can heal itself. So my approach is make the
• 46:53
  Speaker 1: body young, it'll heal itself in every way.
• 46:57
  Speaker 2: Well do you have children three? Yeah. One of it's
• 47:00
  Speaker 2: just phenomenal is watching them heal. Yeah. I'm like it
• 47:05
  Speaker 2: is so uh, it's so wild. But also you envy
• 47:09
  Speaker 2: them so much because they get get cut and it's
• 47:12
  Speaker 2: like two days later, like where's your cut? It's fucking gone?
• 47:15
  Speaker 2: Like that's crazy. My daughter had a cutter. She fell
• 47:19
  Speaker 2: and knocked her head and she had this like dark
• 47:21
  Speaker 2: spot on her head like where she got injured. It
• 47:24
  Speaker 2: was like four or five days it was gone, and
• 47:26
  Speaker 2: I was like that fucking thing would be with me
• 47:28
  Speaker 2: for four months. Yeah.
• 47:30
  Speaker 1: And the good thing is if we rub our cocktail
• 47:32
  Speaker 1: on the skin of the mice, they heal like the
• 47:34
  Speaker 1: young again.
• 47:35
  Speaker 2: Oh so that would be like a great application for
• 47:37
  Speaker 2: ladies who want the beauty treatment on the face, right, because.
• 47:40
  Speaker 1: That was way wayheaded. Whoa, yeah, yeah, and we're working
• 47:44
  Speaker 1: on hair. We can grow human hair on mice now.
• 47:47
  Speaker 1: Really that took a few years and now we can
• 47:49
  Speaker 1: check if we can regrow hair and make it dark again.
• 47:52
  Speaker 2: You can grow human hair on mice.
• 47:54
  Speaker 1: Yeah, I'm not alawd to. Actually did post it on
• 47:56
  Speaker 1: Instagram and the university said, get that down. It exists.
• 48:01
  Speaker 1: We grow it from stem cells, from human stem cells.
• 48:04
  Speaker 1: We make little bowls of hair. It takes a few months.
• 48:07
  Speaker 1: We open up the ball to make a flat piece
• 48:09
  Speaker 1: of skin, human skin. We put that in the back
• 48:13
  Speaker 1: of a mouse that can accept human skin, and then
• 48:15
  Speaker 1: you get black tufts of hair from humans.
• 48:17
  Speaker 2: Can you get any kind of hair?
• 48:19
  Speaker 1: Like?
• 48:19
  Speaker 2: Could I get an afro? I just want to get
• 48:20
  Speaker 2: one to pissed people off. Oh we love an afro,
• 48:23
  Speaker 2: like a Colin Kaepernick type, just a big crazy one.
• 48:26
  Speaker 1: Yeah. We can grow hair. We can do that. We
• 48:29
  Speaker 1: were on a few leves that can grow this hair.
• 48:31
  Speaker 1: So I thought about doing that for a company, but
• 48:33
  Speaker 1: I think hair transplants would just be easier.
• 48:36
  Speaker 2: Oh right, so you would grow hair in a lab
• 48:38
  Speaker 2: and then transplant those hairs.
• 48:39
  Speaker 1: We can do that.
• 48:40
  Speaker 2: Yeah, Oh well that's the thing, because I got a
• 48:42
  Speaker 2: hair transplant. But the way I describe it is like
• 48:45
  Speaker 2: your take. It's like taking people that are really healthy
• 48:49
  Speaker 2: and moving them into a town where everyone's dying. Because
• 48:52
  Speaker 2: like you're taking hair from back here where it's gonna stay,
• 48:56
  Speaker 2: and you put it up here where it's all falling out.
• 48:59
  Speaker 1: Oh, it didn't thrive.
• 49:00
  Speaker 2: What's up?
• 49:00
  Speaker 1: It doesn't thrive if you move it.
• 49:02
  Speaker 2: Oh, it thrives, but everybody else dies. And you know,
• 49:05
  Speaker 2: you can only take so much from the back of
• 49:07
  Speaker 2: your head and move it to the top of your head.
• 49:09
  Speaker 2: That's why a lot of guys with hair transplants look goofy,
• 49:12
  Speaker 2: because you have like this strong hairline in the front
• 49:15
  Speaker 2: and it goes back like that, and then everything else
• 49:17
  Speaker 2: looks like chaos.
• 49:18
  Speaker 1: Oh that sucks. You know what I take from my hair?
• 49:20
  Speaker 1: What do you take among other things? Uh? Viagra?
• 49:25
  Speaker 2: Viagra?
• 49:26
  Speaker 1: Yeah, actually I shouldn't say the brand name.
• 49:28
  Speaker 2: That's actually I take it.
• 49:30
  Speaker 1: That's what I tell everybody. That is true. It's low dose,
• 49:33
  Speaker 1: seven milligrams a day to delafill, and it's good for
• 49:37
  Speaker 1: a lot of things, a lot.
• 49:38
  Speaker 2: I know it's good for endurance. Yeah, yeah, because I
• 49:41
  Speaker 2: know athletes who take it for endurance. They probably take
• 49:45
  Speaker 2: it to fuck too. Let's not kid ourselves.
• 49:48
  Speaker 1: Well, it's a nice it's a nice benefit. When a
• 49:52
  Speaker 1: sign a paper just came out about its role in
• 49:55
  Speaker 1: preventing cancer, I tweeted what's not to love? People love
• 49:59
  Speaker 1: that tweet. But the point is, actually last week they
• 50:02
  Speaker 1: found that these drugs in mice and seemingly in people
• 50:07
  Speaker 1: who take these drugs are actually resistant to can certain
• 50:10
  Speaker 1: types of cancers like head and neck cancer. So interested
• 50:13
  Speaker 1: turning out.
• 50:14
  Speaker 2: To be really important. Blow well.
• 50:16
  Speaker 1: Two reasons that are not related to blood flow, but
• 50:19
  Speaker 1: they're related to what's called nitric oxide signaling, which is
• 50:22
  Speaker 1: what helps dilate blood vessels in all your body, including
• 50:25
  Speaker 1: your penis. The other two mechanisms one showed that to
• 50:29
  Speaker 1: dalaphil is good for exposing the tumor to the immune system.
• 50:34
  Speaker 1: There are certain cells are called MDC's that protect the
• 50:39
  Speaker 1: tumor from getting attacked, and the drug stops that. So
• 50:43
  Speaker 1: now the tumors shrink in mice and seemingly in people
• 50:47
  Speaker 1: in tumors. And then the second mechanism is really interesting.
• 50:50
  Speaker 1: It seems to this was sidanaphil, So this is now viagra.
• 50:54
  Speaker 1: Found that the cancer is a lot of cancers thrive
• 50:59
  Speaker 1: on cholesterol, and this blocks the ability of cancer cells
• 51:02
  Speaker 1: to use cholesterol.
• 51:03
  Speaker 2: I thought they thrived on glucose.
• 51:04
  Speaker 1: That too, exactly right. So you want to be in
• 51:07
  Speaker 1: katosis if you've got the tumor in general, so fasting
• 51:12
  Speaker 1: is good. But now it looks like these ed drugs
• 51:16
  Speaker 1: might be good for it as well.
• 51:18
  Speaker 2: Fascinating. And it wasn't I think viagra was a it
• 51:25
  Speaker 2: was an accident, right, it wasn't. Wasn't it a blood
• 51:27
  Speaker 2: pressure medication.
• 51:28
  Speaker 1: It's a good story. It was for angina, right, it
• 51:30
  Speaker 1: was for your heart. But the story goes that women
• 51:34
  Speaker 1: especially and the men didn't want to give up the
• 51:37
  Speaker 1: drugs that they had left over. It was amazing, it
• 51:41
  Speaker 1: was I think it was seventy five percent had a
• 51:43
  Speaker 1: positive reaction for erections and without it twenty two. So
• 51:47
  Speaker 1: it's it's very clear that it was working.
• 51:50
  Speaker 2: Interesting and so so how does it help hair?
• 51:55
  Speaker 1: Well, we don't know for sure, but there's a lot
• 51:57
  Speaker 1: of evidence that part of the reason hair dies out
• 52:00
  Speaker 1: and stops growing is lack of blood flow, and the
• 52:03
  Speaker 1: monoxid'll that people put on their hair helps with that.
• 52:06
  Speaker 2: Right. Interesting, and then DHT inhibitors.
• 52:10
  Speaker 1: Exactly also that be do test ride people can take orally.
• 52:15
  Speaker 2: The problem with that is my friend had severe depression
• 52:18
  Speaker 2: when he took that. Yeah, it really fucked him up,
• 52:22
  Speaker 2: and he didn't realize because he didn't understand that that
• 52:25
  Speaker 2: was He was like, what is wrong with me? And
• 52:27
  Speaker 2: he was getting suicidal and then he got off of
• 52:30
  Speaker 2: it and it just went away. And he's like, oh
• 52:31
  Speaker 2: my god, I can't believe that this episode is sponsored
• 52:34
  Speaker 2: by Better Help. You've probably heard about better Help before,
• 52:38
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• 52:42
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• 53:20
  Speaker 1: Yeah, well, I'm taking it for a number of reasons,
• 53:25
  Speaker 1: including my hair and my prostate. See if I can
• 53:28
  Speaker 1: keep it from growing. But I fortunately I haven't had
• 53:31
  Speaker 1: that side effect.
• 53:32
  Speaker 2: But everything depends, right, It varies biologically depending on the person.
• 53:35
  Speaker 1: Yeah, it's important when either of us says that drug's
• 53:38
  Speaker 1: good that drug's bad, right, people realize that you have
• 53:41
  Speaker 1: to test it, see and with doctors supervision.
• 53:44
  Speaker 2: Yeah, that was where I was going to get to,
• 53:46
  Speaker 2: was like, because different medications have different reactions, or different
• 53:50
  Speaker 2: people's reactions to medications, they vary quite wildly. So like,
• 53:54
  Speaker 2: before you make this public, I mean, like, how do
• 53:59
  Speaker 2: you determin whether or not this is going to be
• 54:02
  Speaker 2: safe for a wide variety of people to reverse aging? Oh?
• 54:06
  Speaker 1: My drug our drug that we're making, well, we will
• 54:10
  Speaker 1: test it on a lot of people before it goes
• 54:13
  Speaker 1: out into the wide world.
• 54:15
  Speaker 2: And you've started testing it on people so far.
• 54:17
  Speaker 1: Yeah, there are people right now who have this these
• 54:20
  Speaker 1: genes in their eye.
• 54:21
  Speaker 2: And how's it going.
• 54:23
  Speaker 1: I'm not allowed to say, but can you wink twice?
• 54:25
  Speaker 2: If it's great?
• 54:28
  Speaker 1: I would say that everything's on target.
• 54:31
  Speaker 2: Okay, it's good to hear.
• 54:34
  Speaker 1: Nothing bad to report, nothing bad to report. I think
• 54:36
  Speaker 1: those might be the words I'm allowed to say.
• 54:38
  Speaker 2: And is that the only clinical trials you've used with
• 54:40
  Speaker 2: any of these applications for humans so far?
• 54:43
  Speaker 1: That was the first glaucoma and also sudden blindness it's
• 54:47
  Speaker 1: called nyon, which is now twice as more prevalent because
• 54:51
  Speaker 1: of the JLP one drugs. Really, it's not well known obviously,
• 54:56
  Speaker 1: companies don't want to talk about it, but yes, blindness
• 55:00
  Speaker 1: has doubled seemingly because of these meds.
• 55:03
  Speaker 2: You have to holy shit, sudden blindness has doubled because
• 55:08
  Speaker 2: of GLP one's.
• 55:09
  Speaker 1: Do you deny on? Which is like a stroke in
• 55:11
  Speaker 1: your eye and then your other eye can go, which
• 55:14
  Speaker 1: is pretty scary and there's nothing you can do about it.
• 55:17
  Speaker 1: Hopefully how drug does work for those people?
• 55:20
  Speaker 2: And I'll well, obviously correlation does not equal causation, but
• 55:25
  Speaker 2: it seems to be.
• 55:27
  Speaker 1: Yeah, there's a scientist at Harvard. You could look up
• 55:30
  Speaker 1: his work, Joe Rizzeau. It looks like it's repeatable across
• 55:34
  Speaker 1: the planet.
• 55:35
  Speaker 2: Wow, that's terrible because there's so many people out there
• 55:39
  Speaker 2: that are just telling everyone they should get on GLP ones. Yeah,
• 55:42
  Speaker 2: I've we've seen that, like by online people, like online
• 55:45
  Speaker 2: podcasters saying everyone should get on GLP one's there's a
• 55:49
  Speaker 2: groundbreaking technology. This is amazing, it's going to transform society.
• 55:53
  Speaker 2: I'm like, we just started taking these The fuck are
• 55:57
  Speaker 2: you saying?
• 55:58
  Speaker 1: Yeah, it's not risk free? Same with eight D drugs.
• 56:00
  Speaker 2: Here goes. Recent studies suggests that a potential rare link
• 56:04
  Speaker 2: between GLP one receptor agonist medication such as zembeg wagovi
• 56:09
  Speaker 2: blah blah blah, and a condition called non artytic anterior
• 56:15
  Speaker 2: what's that word? Ischemic ischemic optic neuropathy An eye stroke
• 56:21
  Speaker 2: can cause sudden, painless loss of vision in one eye.
• 56:24
  Speaker 2: Why absolute risk remains very low. Anyone experienced sudden vision change,
• 56:28
  Speaker 2: you should seek emergency mental medical evaluation immediately, Well, very
• 56:32
  Speaker 2: low is like.
• 56:34
  Speaker 1: It's still what does that mean?
• 56:36
  Speaker 2: One in ten thousand?
• 56:37
  Speaker 1: Yeah, yeah, that's a total of ten thousand.
• 56:40
  Speaker 2: Oh total of ten thousand so far for you're taking this.
• 56:43
  Speaker 2: I think it's pretty The drugs were sixty eight point
• 56:48
  Speaker 2: six times more likely to develop this and eight times
• 56:52
  Speaker 2: more likely to develop diabetic What is that we only
• 56:58
  Speaker 2: got the blurb? Oh my god? Then wow? Yeah, man,
• 57:08
  Speaker 2: these things are just they're just rolling out and the
• 57:11
  Speaker 2: people that are like super enthusiastic, and also they have
• 57:15
  Speaker 2: some sort of a financial interest in promoting these things,
• 57:18
  Speaker 2: which oftentimes does seem to be the case with a
• 57:20
  Speaker 2: lot of these people. They have either stock in these
• 57:23
  Speaker 2: companies or some sort of a stake in them. Uh.
• 57:26
  Speaker 1: Yeah, it's true, though, I will I will say to
• 57:28
  Speaker 1: counter that that the JLP one drugs have probably saved
• 57:31
  Speaker 1: millions of lives already, and they're pretty common. At least
• 57:33
  Speaker 1: ten percent of people are trying them in twenty five
• 57:35
  Speaker 1: percent one to two.
• 57:36
  Speaker 2: Yeah, I mean, they don't work for everybody. I have
• 57:38
  Speaker 2: a good friend of mine that had a terrible reaction
• 57:40
  Speaker 2: from it and he was hospitalized. But I know other
• 57:44
  Speaker 2: people where it's completely transformed their life and they've lost
• 57:47
  Speaker 2: a ton of weight, particularly people that just for whatever reason,
• 57:51
  Speaker 2: the food addiction was so incredibly strong that whatever their constitution,
• 57:56
  Speaker 2: the way they're the way they're designed, the way they're built,
• 57:59
  Speaker 2: the way they've as a human being, they weren't capable
• 58:02
  Speaker 2: of overcoming it. They take the GLP ones and then
• 58:06
  Speaker 2: they sort of start getting moving and then they lose
• 58:09
  Speaker 2: all the weight, they start feeling better, they start making
• 58:11
  Speaker 2: a lot of other positive changes. You get that momentum,
• 58:14
  Speaker 2: which I always talk about, is which is one of
• 58:16
  Speaker 2: the most important things for transforming your life. Everyone wants
• 58:19
  Speaker 2: to talk about discipline. I think discipline is the primary,
• 58:22
  Speaker 2: that's the main engine. But one of the things that
• 58:25
  Speaker 2: comes along with any kind of an exercise program or
• 58:28
  Speaker 2: changing your life program where you start getting positive results
• 58:32
  Speaker 2: is momentum. And momentum is absolutely huge, thank you, because
• 58:35
  Speaker 2: then you start feeling that's so important. This is good.
• 58:37
  Speaker 2: So I think golp ones are fantastic for getting people going.
• 58:41
  Speaker 1: Yes, everybody should hear this. It's really important. I'll give
• 58:45
  Speaker 1: you my example. It's a classic case. I couldn't fast
• 58:49
  Speaker 1: for more than about a day. I want to do more.
• 58:53
  Speaker 1: I know that three days fasting is good. A week
• 58:54
  Speaker 1: can be even better. But I couldn't do it. I
• 58:57
  Speaker 1: don't have a lot of willpower when it comes to
• 58:58
  Speaker 1: this kind of stuff. I tried a jilpy one receptor agonist.
• 59:03
  Speaker 1: I gave it and it was easy. I didn't even
• 59:05
  Speaker 1: feel like I needed to snack at night, which is
• 59:07
  Speaker 1: one of the things that I and many people suffer from.
• 59:09
  Speaker 1: But the fact that I could do it, I went
• 59:12
  Speaker 1: off the drug. I didn't need it. But now I
• 59:15
  Speaker 1: can fast for I went for two weeks in a
• 59:18
  Speaker 1: couple of months ago. Well it's easy now now that
• 59:21
  Speaker 1: I know that I can do it. Mentally, it's not
• 59:23
  Speaker 1: hard at all. The momentum exactly, I know what's possible.
• 59:27
  Speaker 2: Yeah, yeah, that's fascinating. You are you still on a
• 59:33
  Speaker 2: plant based diet mostly? Yeah, what I had. I just
• 59:37
  Speaker 2: had a conversation with a friend of mine about this.
• 59:40
  Speaker 2: I don't know how much of the information that he
• 59:42
  Speaker 2: was telling me it was totally accurate. But what he
• 59:44
  Speaker 2: was saying was that he was told before he did
• 59:48
  Speaker 2: fasting that one of the best because he's a runner.
• 59:52
  Speaker 2: He said, one of the best ways to get into
• 59:54
  Speaker 2: fasting is to get your body into kittosis first, he said,
• 1:00:00
  Speaker 2: And what he thinks is that a carnivore based diet
• 1:00:03
  Speaker 2: and what he was told was a good way if
• 1:00:06
  Speaker 2: you could do that for a few weeks, it mitigates
• 1:00:08
  Speaker 2: your appetite. Like one of the things that happens with
• 1:00:11
  Speaker 2: a lot of these diets that regulate insolent resistance is
• 1:00:15
  Speaker 2: that when you get used to consuming just fats and protein,
• 1:00:20
  Speaker 2: you don't have the kind of hunger pangs that you
• 1:00:23
  Speaker 2: have with carbohydrates. Like when I if I go in
• 1:00:27
  Speaker 2: a bad streak and I'm eating pizza and pasta, and
• 1:00:31
  Speaker 2: I've done that in the past, I don't really do
• 1:00:32
  Speaker 2: that much in a less I'm on vacation. In the past, though,
• 1:00:37
  Speaker 2: what I would get hungry, I would get crazy hungry,
• 1:00:40
  Speaker 2: like I've got to eat. Now, I don't get that
• 1:00:42
  Speaker 2: at all anymore because I'm mostly on a carnivore based diet.
• 1:00:46
  Speaker 2: Mostly what I eat the like you look the bulk
• 1:00:49
  Speaker 2: of my diet, it's meat and fermented vegetables. It's meat
• 1:00:53
  Speaker 2: and like kim chi and sauerkraut and stuff along those lines.
• 1:00:57
  Speaker 2: And when I eat like that, my hunger is very
• 1:01:00
  Speaker 2: easy to control. And I've gone twenty four hours, Like
• 1:01:04
  Speaker 2: it's nothing. Not eating, it's like not a problem at all.
• 1:01:07
  Speaker 2: But that's the most I've ever fasted. It is twenty
• 1:01:09
  Speaker 2: four hours.
• 1:01:09
  Speaker 1: Okay, well see if you can go for three, it's
• 1:01:12
  Speaker 1: really worth it. You feel really great. Katosa's well that's
• 1:01:15
  Speaker 1: what everybody says. Yeah. Yeah, And you go into what's
• 1:01:18
  Speaker 1: called deep cleansing. It's called chaperone mediated ortopogy or CMA,
• 1:01:23
  Speaker 1: and a friend of mine in New York, Maria Corvo,
• 1:01:25
  Speaker 1: studies this and it cleans out a lot of the
• 1:01:29
  Speaker 1: old proteins in your body. So katosis doesn't just make
• 1:01:32
  Speaker 1: you feel good, you're actually renewing your protein in your
• 1:01:34
  Speaker 1: body and rebuilding it. And so I do that as
• 1:01:37
  Speaker 1: a as an anti aging thing.
• 1:01:38
  Speaker 2: Is what I find is the biggest benefit is mental acuity.
• 1:01:43
  Speaker 2: It's a giant It has a giant impact when I
• 1:01:45
  Speaker 2: stick to the diet in terms of my ability to
• 1:01:49
  Speaker 2: form sentences, like recall information and just be present. In podcasts.
• 1:01:55
  Speaker 1: Yeah, so in my podcast, it's what you do is
• 1:01:59
  Speaker 1: really quite difficult. You make it look easy. So when
• 1:02:02
  Speaker 1: I'm when I'm doing my podcast, and often it's solo,
• 1:02:05
  Speaker 1: so it's challenging. I forget things. I have to remember
• 1:02:08
  Speaker 1: hundreds of papers for these things. They quite hard. Either
• 1:02:11
  Speaker 1: I'm gonna fast and if I don't remember to fast,
• 1:02:14
  Speaker 1: I didn't experiment. I took some keytones. You can drink
• 1:02:17
  Speaker 1: these things, right, So yeah, there's the one.
• 1:02:19
  Speaker 2: The little drink I think with I fantastic stuff. Yeah yeah,
• 1:02:23
  Speaker 2: I use that. I love that stuff. I do that.
• 1:02:25
  Speaker 2: I take that before I do UFC broadcasts a lot
• 1:02:27
  Speaker 2: of time. Yeah, yeah, I actually took some before because
• 1:02:31
  Speaker 2: one that's great before podcasts as well. Well. The one
• 1:02:33
  Speaker 2: and one of more difficult things that I do is
• 1:02:35
  Speaker 2: the UFC commentary because it's six hours, six hours of
• 1:02:39
  Speaker 2: talking on air live yeah, and about fights, and I'm
• 1:02:44
  Speaker 2: also recalling fights, and I'm also I'm seeing positions, so
• 1:02:47
  Speaker 2: I have to remember in my mind how this is finished,
• 1:02:50
  Speaker 2: because like in jiu jitsu, there might be I don't
• 1:02:52
  Speaker 2: know how many positions there are the thousands, And there's
• 1:02:55
  Speaker 2: moves where I'm like, what is he doing? What's he doing? Oh? Oh,
• 1:02:58
  Speaker 2: that's that, that's the prov next TI I'm looking at
• 1:03:01
  Speaker 2: his arms. But like your brain is, I am exhausted
• 1:03:05
  Speaker 2: at the end of six hours and fucking starving, like
• 1:03:08
  Speaker 2: after the UFC is over. I can eat so much food.
• 1:03:11
  Speaker 2: It's I'm so hungry.
• 1:03:12
  Speaker 1: But you take a little drink.
• 1:03:14
  Speaker 2: I take a little keytone, little keytone IQ. I take Nootropics.
• 1:03:17
  Speaker 2: I drink this stuff. My friend Derek makes this his
• 1:03:20
  Speaker 2: Gorilla mind. It says a nootropic, so nootropic cocktail with caffeine.
• 1:03:28
  Speaker 2: This stuff's really good for a podcast. I also take
• 1:03:30
  Speaker 2: Alpha Brain. Alpha Brain Black labels phenomenal for that. There's
• 1:03:33
  Speaker 2: a bunch of different ones that I take. The gum
• 1:03:37
  Speaker 2: Neurogum Neurogum is excellent for that too. But I just
• 1:03:40
  Speaker 2: do fucking everything I can to maximize.
• 1:03:42
  Speaker 1: That's how you do it, all right. Yes, secret is
• 1:03:44
  Speaker 1: now out, all right, but what you do is amazing.
• 1:03:46
  Speaker 1: And I thought you were on Mindafanil or something. No.
• 1:03:49
  Speaker 2: I've taken that before in the past. But the problem
• 1:03:52
  Speaker 2: with that stuff is I think I like it too
• 1:03:55
  Speaker 2: much and I want to take it all the time.
• 1:03:57
  Speaker 2: You know, when I used to take that, if I
• 1:03:58
  Speaker 2: had a gig in San Diego and I drive home
• 1:04:02
  Speaker 2: after the gig, and it was like, you know, one
• 1:04:04
  Speaker 2: o'clock in the morning when I'm done, and then I'm like, ah,
• 1:04:07
  Speaker 2: I'll just go home. It's only two and a half hours.
• 1:04:09
  Speaker 2: And I start making the drive and you just get
• 1:04:12
  Speaker 2: so tired. But if I take new Vigil or pro
• 1:04:15
  Speaker 2: Vigil before I do that, I would be able to
• 1:04:17
  Speaker 2: drive no problem.
• 1:04:20
  Speaker 1: Can you sleep after that? Dog?
• 1:04:21
  Speaker 2: Oh yeah, yeah. It doesn't seem to affect your ability
• 1:04:24
  Speaker 2: to sleep, which is really interesting. It's not like caffeine.
• 1:04:27
  Speaker 2: Do you do it? Do you take it at all?
• 1:04:29
  Speaker 1: Armadafinil for tulks when I'm traveling.
• 1:04:32
  Speaker 2: Does it help you?
• 1:04:34
  Speaker 1: Definitely?
• 1:04:35
  Speaker 2: Like in what way it.
• 1:04:37
  Speaker 1: Gets rid of my jet light and I can focus.
• 1:04:40
  Speaker 1: My brain often is either scattered or filled with facts
• 1:04:43
  Speaker 1: that I pauses me like now to not be able
• 1:04:46
  Speaker 1: to talk properly. But if I'm on it, in which
• 1:04:48
  Speaker 1: I'm not, I'm on point every time.
• 1:04:52
  Speaker 2: For me, the best thing for jet lag is exercise.
• 1:04:55
  Speaker 2: There's something about rigorous exercise. It doesn't even have to
• 1:04:59
  Speaker 2: be long. It just has to be where my heart
• 1:05:02
  Speaker 2: break gets really elevated, like above one hundred and fifty
• 1:05:05
  Speaker 2: bats per minute for fifteen twenty minutes, Like I have
• 1:05:08
  Speaker 2: to really go hard where I'm sweaty and breathing heavy,
• 1:05:13
  Speaker 2: you know, especially if like a jacket up to like
• 1:05:14
  Speaker 2: one eighty one ninety, like I'm doing like Tabata sprints
• 1:05:17
  Speaker 2: on an air dine bike. That kind of stuff completely
• 1:05:20
  Speaker 2: resets me. Yeah, hard kettlebell workouts like I'll do like
• 1:05:23
  Speaker 2: a hard series where a minimum amount of rest in between.
• 1:05:27
  Speaker 2: So I'm really pushing it. Once I relax, I'm back,
• 1:05:31
  Speaker 2: It's like it whatever it is where your body just
• 1:05:34
  Speaker 2: needs to like shake it up and like get all
• 1:05:36
  Speaker 2: of it out of your system. It's like now I
• 1:05:38
  Speaker 2: feel completely normal.
• 1:05:39
  Speaker 1: Yeah, well you might remember last time we talked about hormesis. Yeah,
• 1:05:43
  Speaker 1: which doesn't kill you, makes you stronger, And that's what
• 1:05:45
  Speaker 1: you're doing. You're putting your body into survival mode. So
• 1:05:48
  Speaker 1: one of the reasons I mostly plants, why I take
• 1:05:52
  Speaker 1: and a man and these other molecules is to mimic
• 1:05:55
  Speaker 1: that I don't work out like you do. I should,
• 1:05:58
  Speaker 1: but I don't and don't you. Uh. I think partly
• 1:06:02
  Speaker 1: because I tell myself I'm too busy, which is bullshit. Uh.
• 1:06:09
  Speaker 1: I need I need a partner who will motivate me.
• 1:06:12
  Speaker 1: I think that would help.
• 1:06:13
  Speaker 2: Maybe just get a trainer.
• 1:06:15
  Speaker 1: That's that's a solution.
• 1:06:16
  Speaker 2: You got some chadder, get a trainer.
• 1:06:19
  Speaker 1: I got some chedd Is that my money?
• 1:06:20
  Speaker 2: Yeah?
• 1:06:21
  Speaker 1: No, I can definitely fold one. Uh yeah, you know
• 1:06:24
  Speaker 1: it's on me. I actually I will own that that
• 1:06:27
  Speaker 1: I get it.
• 1:06:28
  Speaker 2: I just was explaining this to my friend last night.
• 1:06:30
  Speaker 2: It was like, I gotta start working on I'm like,
• 1:06:31
  Speaker 2: just get a trainer, get a trainer, someone who's good,
• 1:06:34
  Speaker 2: and that way they'll develop a program for you. All
• 1:06:37
  Speaker 2: you have to do is just show up and do
• 1:06:39
  Speaker 2: what they tell you to do. Just do it and
• 1:06:41
  Speaker 2: it's mindless. You could just like just go through what
• 1:06:44
  Speaker 2: they tell you to do, and you'll just trust the process.
• 1:06:47
  Speaker 2: You'll improve radically.
• 1:06:49
  Speaker 1: All right. All right, here, here's what we're gonna do. Okay,
• 1:06:52
  Speaker 1: I'm gonna take years.
• 1:06:54
  Speaker 2: What we're gonna do. You're gonna get me a jug
• 1:06:55
  Speaker 2: of that fucking.
• 1:06:56
  Speaker 1: Juice will swamp, all right, and you'll be my I'll
• 1:07:01
  Speaker 1: be well, I will.
• 1:07:03
  Speaker 2: I've done that before with my comedian friends.
• 1:07:05
  Speaker 1: Really sure, yeah, I'll.
• 1:07:07
  Speaker 2: I do it the right way where I take them
• 1:07:09
  Speaker 2: through it very easy. I don't have them worked out
• 1:07:12
  Speaker 2: hard at all. Especially in the beginning. Everything is like
• 1:07:16
  Speaker 2: nice and easy. It's like a little bit of strained.
• 1:07:18
  Speaker 2: You're not gonna be exhausted afterwards, and we build you up.
• 1:07:22
  Speaker 2: I'm a bim a. I'm a firm believer and not
• 1:07:25
  Speaker 2: over taxing the system on people that are sedentary. I
• 1:07:29
  Speaker 2: really think it's a slow, gradual process. I think you
• 1:07:32
  Speaker 2: have to get better the same way you got sick
• 1:07:34
  Speaker 2: over time. You can make radical changes in a short
• 1:07:38
  Speaker 2: period of time, don't get me wrong. And even just
• 1:07:41
  Speaker 2: a little bit of you know, moderately rigorous exercise a
• 1:07:45
  Speaker 2: few days a week, well, a few days a week
• 1:07:48
  Speaker 2: will give you great improvements. But I'm not one of
• 1:07:50
  Speaker 2: those guys. Is like, you know, we're gonna do two
• 1:07:52
  Speaker 2: hours today and you're gonna go to failure and you're
• 1:07:55
  Speaker 2: gonna be throwing up in a garbage pan. You're not
• 1:07:57
  Speaker 2: gonna do that again the next day. I want you
• 1:07:59
  Speaker 2: to do it again the next time. I want you
• 1:08:00
  Speaker 2: to have a nice workout where you know you're doing
• 1:08:04
  Speaker 2: like ten push ups and ten sit ups and ten
• 1:08:06
  Speaker 2: body weight squads, and then we're gonna do some of
• 1:08:08
  Speaker 2: these kettlebell cleans and kettlebell and nothing hard. Like everything's
• 1:08:13
  Speaker 2: gonna be like, oh okay, you put it down, You're fine,
• 1:08:16
  Speaker 2: and I want you to leave rejuvenated, like you feel like, oh,
• 1:08:19
  Speaker 2: that was like exhilarating, nothing crazy, and then we'll slowly
• 1:08:23
  Speaker 2: start to add a little bit over time. That's what
• 1:08:26
  Speaker 2: I think the right thing to do With people who
• 1:08:27
  Speaker 2: don't work out all the time. You can't just jump
• 1:08:30
  Speaker 2: in and you know, it's like.
• 1:08:32
  Speaker 1: Worsting and skipping meals. You just can't do a day
• 1:08:35
  Speaker 1: or three without practicing.
• 1:08:36
  Speaker 2: Well. It's also you're gonna get injured. And this is
• 1:08:39
  Speaker 2: one of the main things that happens to people that
• 1:08:41
  Speaker 2: dive right into the deep end of the pool when
• 1:08:42
  Speaker 2: they start working out, is they get hurt, they get
• 1:08:44
  Speaker 2: muscle poles, they get back aches, they got all these
• 1:08:47
  Speaker 2: different things that happen because I think you just pushed
• 1:08:49
  Speaker 2: your body too quickly. You know, it's like you're in
• 1:08:52
  Speaker 2: boot camp. Like, well, you don't have to be in
• 1:08:54
  Speaker 2: boot camp. This is not the way to do it.
• 1:08:56
  Speaker 2: The way to do it is like slowly build up
• 1:08:59
  Speaker 2: and trust the process. Slowly start by. If you're overweight,
• 1:09:03
  Speaker 2: like my friend Jelly Roly lost two hundred and fifty pounds,
• 1:09:06
  Speaker 2: what did he do? Started walking? Just start walking walking
• 1:09:09
  Speaker 2: around the neighborhood, walk around the block, walk upstairs, just
• 1:09:13
  Speaker 2: slowly and then change the diet and then add some
• 1:09:16
  Speaker 2: stuff and next thing you know, you're doing this and
• 1:09:18
  Speaker 2: write it all down to that's the other thing. Write
• 1:09:21
  Speaker 2: down what you're gonna do, and write down how you feel,
• 1:09:24
  Speaker 2: and then keep doing that. And if you could do
• 1:09:25
  Speaker 2: that all the time, you'll start developing this like momentum
• 1:09:28
  Speaker 2: that we were talking about, right, Like, Okay, I'm on
• 1:09:31
  Speaker 2: the course, I'm on a process. But it doesn't have
• 1:09:33
  Speaker 2: to be like you're exhausted and then you go to
• 1:09:36
  Speaker 2: the lab and you're like, I can't even fucking concentrate.
• 1:09:38
  Speaker 2: You know, I was doing Toabata sprints on the airdime
• 1:09:41
  Speaker 2: machine like this is crazy.
• 1:09:43
  Speaker 1: Well, that's it's really good advice, and I'm going to
• 1:09:46
  Speaker 1: take you up on it. So let's say I'm lucky
• 1:09:48
  Speaker 1: enough to come on the show again. Yeah, I'll wear
• 1:09:50
  Speaker 1: a tight T shirt. Let's go, right, So twenty million
• 1:09:54
  Speaker 1: people have to get on.
• 1:09:55
  Speaker 2: The fucking goofy plant based diet, Well, speak.
• 1:09:58
  Speaker 1: About that, because that's one of the things disagree on.
• 1:10:01
  Speaker 1: I'm on a plant based diet because I've seen a
• 1:10:03
  Speaker 1: lot of work on animals at least that plants promote longevity.
• 1:10:09
  Speaker 1: I eat a lot of protein.
• 1:10:10
  Speaker 2: It's interesting because you're not an animal. You know that right.
• 1:10:12
  Speaker 1: I'm not a mouse. I'm definitely an animal, but you're human.
• 1:10:17
  Speaker 2: Meat is the most nutrient dense food it is, it's available.
• 1:10:20
  Speaker 1: I love meat, I love me. I believe that there
• 1:10:25
  Speaker 1: are there are two states that we can be in.
• 1:10:30
  Speaker 1: I should try meat, and then you can see because
• 1:10:33
  Speaker 1: I've been measuring myself with rings and blood tests twenty years.
• 1:10:37
  Speaker 2: You should try elk. I'll get you an elk steak.
• 1:10:40
  Speaker 1: I'd love to try it. Sounds fair. I'm not against me.
• 1:10:42
  Speaker 1: I will eat it and you'll be like WHOA, yeah,
• 1:10:45
  Speaker 1: don't get me addicted to me.
• 1:10:46
  Speaker 2: I feel it right away. Ah oh, your sitautas just
• 1:10:51
  Speaker 2: start firing. Your body starts like, yes, this is what
• 1:10:53
  Speaker 2: we wanted, David.
• 1:10:55
  Speaker 1: Well, here's some science, which is what I do. There
• 1:10:59
  Speaker 1: are two states, this is my theory. There's the abundance mode,
• 1:11:03
  Speaker 1: which is very good for health. You'll build muscle, you'll
• 1:11:05
  Speaker 1: heal better. That's meat killed the mammoth. There's adversity mode,
• 1:11:11
  Speaker 1: which is we're out of meat. We got to eat
• 1:11:13
  Speaker 1: roots and berries. That's adversity. We've got to run, running, exercise,
• 1:11:18
  Speaker 1: eating less, that's adversity. Both are good for you. This
• 1:11:22
  Speaker 1: one is pro survival, this one is pro growth, this
• 1:11:25
  Speaker 1: one is longevity. This one is you're going to be
• 1:11:28
  Speaker 1: stronger fit.
• 1:11:29
  Speaker 2: How do you determine that though, in terms of like
• 1:11:31
  Speaker 2: what is longevity versus what is just like health and vitality.
• 1:11:35
  Speaker 1: Currently, Well, it's based on the last thirty years of
• 1:11:38
  Speaker 1: research in a variety of animals.
• 1:11:40
  Speaker 2: And she just doesn't have to do with the blue zones,
• 1:11:42
  Speaker 2: does it?
• 1:11:43
  Speaker 1: Nor I read that recently.
• 1:11:47
  Speaker 2: Yeah, isn't that nuts?
• 1:11:49
  Speaker 1: A lot of it's fraud, Well, records are hard.
• 1:11:53
  Speaker 2: Well, it's not just hard. A lot of it is
• 1:11:55
  Speaker 2: actual fraud where people are getting checks for their grandpa
• 1:11:58
  Speaker 2: and grandpa was dead, so they weren't writing it into
• 1:12:01
  Speaker 2: the government. They didn't expose like this was the problem
• 1:12:04
  Speaker 2: with Okinawa in particular, is that they would have to
• 1:12:07
  Speaker 2: in order for these people to get taken off the list,
• 1:12:10
  Speaker 2: they would have to inform the government if this person died,
• 1:12:13
  Speaker 2: and they just didn't do it. And so they had
• 1:12:16
  Speaker 2: this list of people that they were counting in their
• 1:12:18
  Speaker 2: census that were like soul really, like this is crazy,
• 1:12:21
  Speaker 2: what are you people doing? Even the oldest one hundred
• 1:12:23
  Speaker 2: years old, the.
• 1:12:24
  Speaker 1: Oldest person in the world apparently one hundred and twenty two.
• 1:12:26
  Speaker 1: There's a theory not proven that the oldest person in
• 1:12:29
  Speaker 1: the world was actually the daughter who was faking it
• 1:12:34
  Speaker 1: to get taxes or avoid taxes. I think it was
• 1:12:36
  Speaker 1: in France. I hope that that's not true.
• 1:12:38
  Speaker 2: I bet it's true. People are full of shit.
• 1:12:41
  Speaker 1: Well either way, the maximum human life spends around one
• 1:12:43
  Speaker 1: hundred and seventeen eighteen, which still a lot more than
• 1:12:46
  Speaker 1: we live.
• 1:12:47
  Speaker 2: And what's really crazy is none of those people are
• 1:12:49
  Speaker 2: doing everything right exactly. They're all smoking cigarettes and drinking
• 1:12:53
  Speaker 2: wine and having a good time. And that's a factor
• 1:12:56
  Speaker 2: that we really need to take into consideration. Loneliness and
• 1:13:00
  Speaker 2: isolation and sadness are one of the greatest contributors to
• 1:13:06
  Speaker 2: poor health outcome.
• 1:13:07
  Speaker 1: Its number one, is it really Yeah? Robert Voldinger at
• 1:13:09
  Speaker 1: Harvard had a study for I think it was forty
• 1:13:11
  Speaker 1: years World War two vets. They looked at everything blood pressure, cholesterol.
• 1:13:16
  Speaker 1: The number one thing that predicted longevity in those men
• 1:13:19
  Speaker 1: was having a reliable partner. Hmmm.
• 1:13:23
  Speaker 2: Yeah, So not just a reliable partner, someone that you love,
• 1:13:28
  Speaker 2: that's true, someone that you want to be around all
• 1:13:31
  Speaker 2: the time, you enjoy them. You still enjoy their company,
• 1:13:34
  Speaker 2: which is possible. Most people don't believe that's possible.
• 1:13:37
  Speaker 1: Well, your role model is't that.
• 1:13:38
  Speaker 2: I love my wife. I have fun with her, like
• 1:13:42
  Speaker 2: we I've been with her for a while, I've been
• 1:13:43
  Speaker 2: married for seventeen years. I enjoy her. I enjoy hanging
• 1:13:47
  Speaker 2: out with her. She's cool. Yeah, like she's a fun
• 1:13:50
  Speaker 2: And I have friends that aren't in situations like that,
• 1:13:53
  Speaker 2: and it's it's so bad when you're like, I have
• 1:13:57
  Speaker 2: a friend who just we're actually talking last night. He
• 1:14:00
  Speaker 2: just got out of a crazy relationship where he's dating
• 1:14:04
  Speaker 2: this girl for seven years. Was chaos and this and that.
• 1:14:06
  Speaker 2: And I said to him and he was like, he's forty,
• 1:14:10
  Speaker 2: and he goes, I don't think I'm ever gonna have
• 1:14:12
  Speaker 2: a relationship again. He goes, it was so bad. He goes,
• 1:14:15
  Speaker 2: being single feels so good. And I said, there's an
• 1:14:18
  Speaker 2: old saying it's so much better to be alone than
• 1:14:21
  Speaker 2: to wish you were alone. And he's like, yeah, that's
• 1:14:25
  Speaker 2: it because he was like with this crazy lady and
• 1:14:28
  Speaker 2: he was like, I just wish I was And he
• 1:14:30
  Speaker 2: finally got free, and now he's like, I think I'm
• 1:14:33
  Speaker 2: ruined and I'm like, it doesn't have to be like that.
• 1:14:35
  Speaker 2: You can find someone that you actually love and you
• 1:14:38
  Speaker 2: really enjoy their time, you enjoy being with them. It's possible.
• 1:14:42
  Speaker 2: There's good people out there, but you got to also
• 1:14:45
  Speaker 2: be someone that that kind of person wants to be with.
• 1:14:47
  Speaker 2: That's the other thing for sure.
• 1:14:49
  Speaker 1: And stress of relationship. We've seen and studies that clock
• 1:14:53
  Speaker 1: with those chemicals on the DNA, it accelerates when you're
• 1:14:55
  Speaker 1: on distress. Well, go going through a breakup, Oh yeah,
• 1:14:59
  Speaker 1: oh see it.
• 1:15:00
  Speaker 2: Oh I've seen people going through divorces and it's just
• 1:15:02
  Speaker 2: like it takes decades off of their life. They just
• 1:15:04
  Speaker 2: look wrecked. It takes a year or two for them
• 1:15:07
  Speaker 2: to like achieve equilibrium. Again.
• 1:15:10
  Speaker 1: It's hard, it is, it is. I went through that
• 1:15:13
  Speaker 1: actually just during COVID when our family got shoved in
• 1:15:18
  Speaker 1: a house together, and yeah, it was brutal. It was
• 1:15:21
  Speaker 1: unexpected to.
• 1:15:22
  Speaker 2: Wow, that's the stress test, right.
• 1:15:24
  Speaker 1: It was super stress. It was super stress. It's funny
• 1:15:27
  Speaker 1: that without the pandemic we might have been able to
• 1:15:29
  Speaker 1: make it, but forcing us all to be in one
• 1:15:31
  Speaker 1: little house with no internet working, well it was tough.
• 1:15:35
  Speaker 1: But any case, I'm great now, I'm very happy. So,
• 1:15:39
  Speaker 1: but I do know how bad it can get, and
• 1:15:41
  Speaker 1: it's brutal.
• 1:15:42
  Speaker 2: Yeah, bad relationships can fucking wreck people. I mean it
• 1:15:46
  Speaker 2: can wreck your health. But also it's not just relationships
• 1:15:49
  Speaker 2: in terms of your significant other, husband, wife, partner, whatever
• 1:15:52
  Speaker 2: you want to call it, but also bad relationships at work,
• 1:15:56
  Speaker 2: Like if you have a tyrant for a boss, and
• 1:15:59
  Speaker 2: you know, and every day you're getting you're you're working
• 1:16:02
  Speaker 2: over time and you're getting yelled at, and you're you're
• 1:16:04
  Speaker 2: on the phone, and you're you're at home trying to
• 1:16:06
  Speaker 2: keep up with work, and you never get like that
• 1:16:09
  Speaker 2: that kind of relationship. Well, you have like this, like
• 1:16:11
  Speaker 2: antagonistic terrible relationship with people that you work with. That's
• 1:16:16
  Speaker 2: bad too. Oh for sure, your body doesn't differentiate between
• 1:16:19
  Speaker 2: romantic relationships and those kind of relationships are almost equally bad.
• 1:16:23
  Speaker 1: Cortosol will be high. This will accelerate you. I used
• 1:16:26
  Speaker 1: to keep fish. I was one of those people at school,
• 1:16:30
  Speaker 1: and the fish that got picked on by the dominant
• 1:16:31
  Speaker 1: fish was small, light color, lived short. It's it's biology.
• 1:16:37
  Speaker 1: If you're picked on and you're stressed, you're going to
• 1:16:38
  Speaker 1: age faster. Fortunately, I think you're probably the same at
• 1:16:42
  Speaker 1: my age I've managed to weed out most of the jerks,
• 1:16:45
  Speaker 1: and I don't work with them at all. I've got
• 1:16:47
  Speaker 1: a great partner who we have a hobby of longevity together,
• 1:16:50
  Speaker 1: so that I'm not lucky in that regard.
• 1:16:52
  Speaker 2: Now we found a new one.
• 1:16:54
  Speaker 1: Yeah, longevity specialist, imagine that.
• 1:16:56
  Speaker 2: Congratulations. Well that's nice too, right, I find someone who
• 1:16:59
  Speaker 2: just like thinks that you think and has similar likes
• 1:17:03
  Speaker 2: like you saying yeah, that definitely can help. Yeah. I
• 1:17:05
  Speaker 2: know a lot of my friends that are really good relationships.
• 1:17:08
  Speaker 2: Their significant other has the same hobby as them, you know,
• 1:17:13
  Speaker 2: like whatever it is they both like the climb mountains
• 1:17:16
  Speaker 2: or whatever the fuck it is. Find a thing. But
• 1:17:18
  Speaker 2: that helps too. Well, so you actually enjoy spending time
• 1:17:21
  Speaker 2: together doing something that you're both really excited about.
• 1:17:23
  Speaker 1: That helps to So relationships is one and the other
• 1:17:26
  Speaker 1: four major ones from that study were don't smoke, don't drink,
• 1:17:30
  Speaker 1: get enough risk, and get exercise. And that was enough
• 1:17:34
  Speaker 1: to extend by fifteen years.
• 1:17:36
  Speaker 2: But what about those old people that live forever and
• 1:17:39
  Speaker 2: do smoke and drink, because that's kind of weird.
• 1:17:41
  Speaker 1: Well, they're a point zer one percent. They're not examples
• 1:17:43
  Speaker 1: of what is that?
• 1:17:44
  Speaker 2: Really? What it is. Yeah, it's just so the majority
• 1:17:47
  Speaker 2: of people who get old and live to like centenarians, Like,
• 1:17:51
  Speaker 2: what are the common things that they have.
• 1:17:55
  Speaker 1: The big one is that they don't stress a lot.
• 1:17:57
  Speaker 1: They usually have a good sense of humor. Humm, interesting, right,
• 1:18:02
  Speaker 1: they haven't been overweight, and they say that they typically
• 1:18:06
  Speaker 1: couldn't remember when they lost got sick.
• 1:18:08
  Speaker 2: I wonder how much time Twitter takes off your life.
• 1:18:13
  Speaker 1: Yeah, we should study that. It's already taken a lot off.
• 1:18:17
  Speaker 2: Mind.
• 1:18:18
  Speaker 1: It does, and if you read the comments even.
• 1:18:20
  Speaker 2: Yep, exactly, I'm so much happier since I swore off
• 1:18:25
  Speaker 2: of all that stuff. So it's just not good for you.
• 1:18:27
  Speaker 2: It's really really bad for you. It's also you're constantly
• 1:18:31
  Speaker 2: dealing with the problems of the whole world, which I
• 1:18:33
  Speaker 2: think is a lot for a human being that lives
• 1:18:37
  Speaker 2: in a community, in a neighborhood. It's that shit that's
• 1:18:40
  Speaker 2: happening over there really shouldn't be a primary focus of
• 1:18:44
  Speaker 2: your life. Like where you're in the moment actually doing
• 1:18:48
  Speaker 2: your life. It's not the same. You're not in the
• 1:18:51
  Speaker 2: same area as this problem, but yet this problem is overwhelming.
• 1:18:55
  Speaker 2: You're all day long life.
• 1:18:57
  Speaker 1: And you're in fital flight console today all day.
• 1:19:00
  Speaker 2: Yeah, and you're worried about the climate. Oh my god,
• 1:19:03
  Speaker 2: Like there's so much, there's so much that freaks people
• 1:19:06
  Speaker 2: out that it really shouldn't be affecting you at.
• 1:19:08
  Speaker 1: All, exactly. And actually the world doesn't change if you
• 1:19:11
  Speaker 1: don't read it.
• 1:19:11
  Speaker 2: So it's that's that's key, that's the key. But then
• 1:19:15
  Speaker 2: you're like, well, you need your passing off the responsibility
• 1:19:17
  Speaker 2: to other people. You should get involved, Like, eh, you
• 1:19:20
  Speaker 2: should get involved. I'm going to be over here.
• 1:19:23
  Speaker 1: That's right. Well, if you focus on doing something good
• 1:19:26
  Speaker 1: and you're good at it, yes, like yourself, I think
• 1:19:28
  Speaker 1: that you don't need to be doing more than that.
• 1:19:30
  Speaker 2: You can't focus on everything, and anybody who tells you
• 1:19:33
  Speaker 2: can is a fool. Or anybody who tells you what
• 1:19:36
  Speaker 2: you should or shouldn't be focusing on is a fool. Yeah.
• 1:19:38
  Speaker 1: A few years ago, someone at a talk that I
• 1:19:41
  Speaker 1: gave said you should be working on climate change. Fuck,
• 1:19:43
  Speaker 1: I said, off. After I cure aging, I'll get to
• 1:19:46
  Speaker 1: climate change.
• 1:19:47
  Speaker 2: Yeah, once you go to China and tell them stop
• 1:19:49
  Speaker 2: making coal factories. Shut the fuck up. Just shut up
• 1:19:52
  Speaker 2: you No, you're not going to fix it.
• 1:19:55
  Speaker 1: Yeah.
• 1:19:56
  Speaker 2: Yeah, somebody is somebody's working on it and that's their going.
• 1:20:00
  Speaker 2: God bless them, good luck.
• 1:20:02
  Speaker 1: Yeah. Well, what I try to spend my day is
• 1:20:04
  Speaker 1: efficiently helping the world so that people ask me why
• 1:20:07
  Speaker 1: do I study aging in the first place, And it
• 1:20:09
  Speaker 1: really is that I'm trying to please my grandmother. Like
• 1:20:13
  Speaker 1: some of us, she was the one that told me
• 1:20:15
  Speaker 1: that I need to make the world a better place.
• 1:20:17
  Speaker 1: And she's gone. That's what she said when I was four,
• 1:20:21
  Speaker 1: was been that ever since. She told me two things.
• 1:20:25
  Speaker 1: Humans are evil. She lived through World War two in
• 1:20:27
  Speaker 1: Hungary and oh wow, the Russians came in and raped everybody.
• 1:20:31
  Speaker 1: She said wow, And then so she escaped to Australia.
• 1:20:34
  Speaker 1: And then she said that the other issue is that
• 1:20:39
  Speaker 1: we don't do enough as humans to better the world,
• 1:20:42
  Speaker 1: and so I had that stuck in my mind. She also,
• 1:20:45
  Speaker 1: by the way, said oh, we all die, and I
• 1:20:47
  Speaker 1: thought that that's not really fair, is it? And that
• 1:20:51
  Speaker 1: set me on this path.
• 1:20:53
  Speaker 2: Make the world a better place and we all die,
• 1:20:55
  Speaker 2: and you're like, ah.
• 1:20:58
  Speaker 1: And what I've noticed with my kids is that even
• 1:21:00
  Speaker 1: if you tell them that, they forget about it, because
• 1:21:03
  Speaker 1: it's brutal to think about death every day. Yeah, but
• 1:21:06
  Speaker 1: for some reason, it's just stuck in my head and
• 1:21:09
  Speaker 1: every day I'm like another one hundred and fifty thousand
• 1:21:10
  Speaker 1: people are going to die today due to aging related diseases.
• 1:21:15
  Speaker 1: So my lab is mission oriented. If we are day
• 1:21:17
  Speaker 1: late with something, it's a lot of people that are
• 1:21:20
  Speaker 1: suffering potentially avoidable diseases.
• 1:21:23
  Speaker 2: That's why it's sort of understandable that people like show
• 1:21:25
  Speaker 2: up outside of your lab and like like I need
• 1:21:28
  Speaker 2: to talk to you. Oh we need this.
• 1:21:31
  Speaker 1: Yeah, blind people want to get in the trial. It's
• 1:21:33
  Speaker 1: it's big, and I think if the trial works, is
• 1:21:36
  Speaker 1: going to be a very strange world, especially for my
• 1:21:38
  Speaker 1: lab and for me. But we'll see. And even if
• 1:21:41
  Speaker 1: it doesn't work this time, the science is strong enough
• 1:21:44
  Speaker 1: that will figure it out. We will do this. It's
• 1:21:47
  Speaker 1: just a question of when.
• 1:21:48
  Speaker 2: And so do you think that AI is going to
• 1:21:50
  Speaker 2: have a significant impact on the kind of improvements that
• 1:21:53
  Speaker 2: you're able to.
• 1:21:54
  Speaker 1: It already is we're going super fast and AI has
• 1:21:57
  Speaker 1: revolutionized biology. It's revolutionary everything, of course, but particularly in biology,
• 1:22:02
  Speaker 1: where we used to have to read fifteen papers a day.
• 1:22:06
  Speaker 1: Now we can read a million if we want. It's
• 1:22:08
  Speaker 1: totally different.
• 1:22:09
  Speaker 2: Wow.
• 1:22:11
  Speaker 1: Yeah, it's super brain. A nineteen year old came to
• 1:22:15
  Speaker 1: my lab this summer and the lab grows from twenty
• 1:22:18
  Speaker 1: to forty people, and we're trying to figure out how
• 1:22:21
  Speaker 1: do these three genes reset the cell? How does the
• 1:22:23
  Speaker 1: cell remember what it was thirty forty years ago? Where's
• 1:22:27
  Speaker 1: that information stored in the cell? And I've got this
• 1:22:31
  Speaker 1: theory that there's some new biology. There's a record in
• 1:22:35
  Speaker 1: the DNA somewhere. And I gave him that task. I said,
• 1:22:38
  Speaker 1: can you just go to the databases of the whole
• 1:22:42
  Speaker 1: world look at all the data that's there, is exobites
• 1:22:44
  Speaker 1: of data, and see if my prediction is true, or
• 1:22:47
  Speaker 1: at least you can get evidence for it. Two weeks later,
• 1:22:51
  Speaker 1: he came back and the whole team, not the whole ting,
• 1:22:53
  Speaker 1: but five other people were smiling. We have to show
• 1:22:56
  Speaker 1: you something. David right, come in to my office. We
• 1:22:58
  Speaker 1: sat down. He shows up on the board on this
• 1:23:00
  Speaker 1: LCD screen. I think we found the smoking gun for
• 1:23:04
  Speaker 1: what your theory suggests. And he used AI to process
• 1:23:08
  Speaker 1: all that data and the AI came back and said, yeah,
• 1:23:11
  Speaker 1: you're probably right. And it's a nineteen year old straight
• 1:23:14
  Speaker 1: out of high school who did this, that did something
• 1:23:16
  Speaker 1: that the whole field and all these professors and all
• 1:23:18
  Speaker 1: these fancy serves could not figure out until now.
• 1:23:24
  Speaker 2: That is phenomenal. That's so promising, it's so exciting.
• 1:23:28
  Speaker 1: It is I mean, the future really does belong to
• 1:23:30
  Speaker 1: people who can wrangle AI even on their phone. I
• 1:23:33
  Speaker 1: think people on their phones are going to be making
• 1:23:35
  Speaker 1: medicines or at least designing them, or bombs. That's the problem.
• 1:23:39
  Speaker 1: And bioweapons, right you recently had was it Anna on
• 1:23:44
  Speaker 1: the show to talk about bio weapons and this kind
• 1:23:46
  Speaker 1: of stuff. That is a big worry. I actually had
• 1:23:49
  Speaker 1: to disclose to the US government when I first got
• 1:23:51
  Speaker 1: here that I did have the capability of making a bioweapon.
• 1:23:54
  Speaker 2: The anti Jacobsen episode that we just did on bioweapons
• 1:23:58
  Speaker 2: was absolutely terrifying. She's yeah, I mean, she scared the
• 1:24:02
  Speaker 2: shit out of the world with her nuclear war book,
• 1:24:04
  Speaker 2: and now she's scaring everybody with her bioweapons book.
• 1:24:07
  Speaker 1: Yeah.
• 1:24:08
  Speaker 2: Yeah, that's scary.
• 1:24:09
  Speaker 1: It is. What I've got is a database of all
• 1:24:12
  Speaker 1: known pathogens and new ones that could come. So I'm
• 1:24:15
  Speaker 1: trying to do my bit there to help the world
• 1:24:17
  Speaker 1: if it happens again pandemic or something unnatural.
• 1:24:21
  Speaker 2: Yeah, well, that would be I mean, when you think
• 1:24:24
  Speaker 2: about diseases that people get that just like wreck their
• 1:24:28
  Speaker 2: entire body. If you really do have an original copy
• 1:24:32
  Speaker 2: somewhere in their genome of what they look like as
• 1:24:35
  Speaker 2: a healthy person, and you could switch that back on
• 1:24:38
  Speaker 2: with a factory reboot, I mean, we could potentially get
• 1:24:43
  Speaker 2: rid of all diseases, which is just bananas.
• 1:24:47
  Speaker 1: And injuries, fixed injuries, grown new limbs, potentially. There's a
• 1:24:52
  Speaker 1: new paper that just came out a few days ago
• 1:24:54
  Speaker 1: that showed that the tips of the fingers of baby
• 1:24:56
  Speaker 1: mice can be coaxed once they've heeled over as a
• 1:25:00
  Speaker 1: stub to regrow part of the finger.
• 1:25:03
  Speaker 2: Haven't people done that before?
• 1:25:05
  Speaker 1: Yeah, they found just two factors were enough, so it's
• 1:25:08
  Speaker 1: not that hard. The point is we've got the instructions
• 1:25:12
  Speaker 1: to be young and to regrow body parts in our body,
• 1:25:15
  Speaker 1: we just don't use them.
• 1:25:17
  Speaker 2: That's nuts. So like a salamander can grow an extra
• 1:25:20
  Speaker 2: leg or a leg that gets chopped off.
• 1:25:22
  Speaker 1: Yeah, I believe we still have that capability, we just
• 1:25:24
  Speaker 1: don't use it. It just didn't make sense to regrow a
• 1:25:27
  Speaker 1: limbit was quicker and safe to just heal it over
• 1:25:29
  Speaker 1: as a stub and move on. But salamanders, which get
• 1:25:32
  Speaker 1: their limbs presumably eaten, pretty often maintain that ability. So
• 1:25:37
  Speaker 1: give us you know, I wouldn't say that we could
• 1:25:40
  Speaker 1: evolve this, but I think using a combination of our
• 1:25:43
  Speaker 1: technology plus this new technology that we're seeing come out,
• 1:25:46
  Speaker 1: where these two factors can grow new limbs. I don't
• 1:25:48
  Speaker 1: see a reason why we can't become like a deadpool
• 1:25:51
  Speaker 1: where injury doesn't hurt us, aging can't hurt us, and
• 1:25:55
  Speaker 1: we can regrow body parts.
• 1:25:56
  Speaker 2: How far do you think we are away from being
• 1:25:58
  Speaker 2: able to regrow body parts?
• 1:26:00
  Speaker 1: Oh, I mean, realistically, probably a couple of decades. But
• 1:26:03
  Speaker 1: I've seen enough that's not that far. I've seen enough
• 1:26:06
  Speaker 1: to know that it's doable.
• 1:26:07
  Speaker 2: A couple of decades ago was two thousand and six.
• 1:26:10
  Speaker 1: Well, things are going super fast. I mean ten years
• 1:26:12
  Speaker 1: ago we didn't even know aging was reversible, and now
• 1:26:14
  Speaker 1: it's in humans.
• 1:26:17
  Speaker 2: That's nuts. Think of that. Well, two thousand and there
• 1:26:22
  Speaker 2: was no AI.
• 1:26:23
  Speaker 1: Right in twenty nineteen, it was an idea that we
• 1:26:26
  Speaker 1: had just got the result in mice, and I divulged
• 1:26:29
  Speaker 1: that to the world, then it was published, and then
• 1:26:32
  Speaker 1: we're in humans now. So if it works, then you
• 1:26:35
  Speaker 1: know it's going to be a very.
• 1:26:36
  Speaker 2: Different world, and you're you feel very confidently that some
• 1:26:41
  Speaker 2: of this stuff is going to work.
• 1:26:43
  Speaker 1: Well, it's going to work. I don't know if this
• 1:26:46
  Speaker 1: trial is going to be successful, but there's going to
• 1:26:48
  Speaker 1: be a lot of people doing these trials. I have
• 1:26:50
  Speaker 1: some competition, now, do you know about that?
• 1:26:53
  Speaker 2: No?
• 1:26:54
  Speaker 1: So since I started my company Life Biosciences, which is
• 1:26:57
  Speaker 1: doing the trials with ERA one hundred, others have John
• 1:27:00
  Speaker 1: joined in and the party so Jeff Bezos and others
• 1:27:04
  Speaker 1: have started Alto's Farmer. They are based in three cities
• 1:27:09
  Speaker 1: around the world. They have a few billion dollars to
• 1:27:11
  Speaker 1: catch up. Sam Oltman has retro Bio, and let's see
• 1:27:18
  Speaker 1: Brian Armstrong from Coinbase, the CEO, started one called New
• 1:27:22
  Speaker 1: Limit and they've got a lot of money, old billions.
• 1:27:27
  Speaker 2: Do you think it's good that there's all these people
• 1:27:28
  Speaker 2: involved in this, I.
• 1:27:29
  Speaker 1: Well, it's good yeah.
• 1:27:30
  Speaker 2: Competition, yeah yeah.
• 1:27:31
  Speaker 1: I'm not doing this for my own personal benefit. I
• 1:27:34
  Speaker 1: want humanity to be changed the way it could be.
• 1:27:37
  Speaker 2: And the more people like Jeff Bezos, the more people
• 1:27:39
  Speaker 2: with a large bank account that are invested in this,
• 1:27:41
  Speaker 2: the better. Fantastic and of course a guy like Bezos,
• 1:27:44
  Speaker 2: he's balling out of control. Why wouldn't you want to
• 1:27:45
  Speaker 2: list forever?
• 1:27:46
  Speaker 1: Well, what's left if you've got everything else?
• 1:27:48
  Speaker 2: You know? Well, also it's like it's like if you've
• 1:27:51
  Speaker 2: got the amount of money that he has, and you
• 1:27:54
  Speaker 2: can tackle all these different issues, you know, like his
• 1:27:56
  Speaker 2: space program that he's working on, all these different things,
• 1:27:59
  Speaker 2: Like of course, why would you want to do cool things?
• 1:28:01
  Speaker 2: Like what's cooler than being able to grow limbs?
• 1:28:03
  Speaker 1: Yeah?
• 1:28:04
  Speaker 2: Yeah, you know what's cooler than being able to cure
• 1:28:06
  Speaker 2: all diseases and reverse aging?
• 1:28:08
  Speaker 1: Well there's I don't think there's much cooler. That's why
• 1:28:11
  Speaker 1: I'm doing it, because that I think can be the
• 1:28:13
  Speaker 1: biggest gift to humanity is what you just said. So
• 1:28:16
  Speaker 1: I don't know if I'll achieve it, probably not in
• 1:28:18
  Speaker 1: my lifetime, but at least I've moved the needl and
• 1:28:20
  Speaker 1: pushed the ball globally in that direction.
• 1:28:24
  Speaker 2: I wonder if we're going to get to a point
• 1:28:25
  Speaker 2: in time where we can engineer consciousness in terms of
• 1:28:29
  Speaker 2: like find out like you find out someone's a sociopath,
• 1:28:33
  Speaker 2: you find out someone's a kleptomaniac, or someone's an arsonist
• 1:28:37
  Speaker 2: like whatever it is, like if you could figure out
• 1:28:40
  Speaker 2: like what these little flaws are in the way the
• 1:28:43
  Speaker 2: mind works, if you can completely map it out and go, oh,
• 1:28:48
  Speaker 2: this is the error. This is where you're not making
• 1:28:50
  Speaker 2: these two connections.
• 1:28:51
  Speaker 1: Of course, of course they'll just biology and engineering. There's
• 1:28:54
  Speaker 1: nothing that stops us. And this is the century that
• 1:28:57
  Speaker 1: we are able to control our own biology, starting with cancer,
• 1:29:01
  Speaker 1: heart disease, and aging.
• 1:29:03
  Speaker 2: A true utopian world of peaceful people, peace harmony, but healthy,
• 1:29:08
  Speaker 2: not peaceful.
• 1:29:09
  Speaker 1: I don't think world peace. I think curing aging is
• 1:29:11
  Speaker 1: easier than world peace.
• 1:29:13
  Speaker 2: Well, if everybody achieved a state of consciousness that allowed
• 1:29:17
  Speaker 2: them to understand that we're all in this together.
• 1:29:21
  Speaker 1: Yeah, how do we do that?
• 1:29:22
  Speaker 2: Mushrooms? Yeah?
• 1:29:24
  Speaker 1: Yeah, Well there are certain companies working on this.
• 1:29:27
  Speaker 2: I know. That's what's interesting, right, Like Eli Lilly is
• 1:29:30
  Speaker 2: involved in pharmaceuticals, well the pharmaceutical company, rather, it is
• 1:29:34
  Speaker 2: involved in psychloedalics.
• 1:29:35
  Speaker 1: I just bought a tie I think it was like.
• 1:29:37
  Speaker 2: Three point eight billion dollars. So they're all in with
• 1:29:39
  Speaker 2: real capital. Yeah. I love it. Yeah, me too, that's great.
• 1:29:43
  Speaker 1: I love that they're doing that. We need more of that.
• 1:29:45
  Speaker 1: There's too much depression on anxiety.
• 1:29:47
  Speaker 2: In the world and drug addiction. I mean, that's why
• 1:29:50
  Speaker 2: I went to the White House and got the President
• 1:29:53
  Speaker 2: to get involved in this executive order on fiber gain. Yes,
• 1:29:56
  Speaker 2: because I've talked to so many people that have I've
• 1:30:00
  Speaker 2: had their life completely turned around with ibagain, so many
• 1:30:03
  Speaker 2: people that were an opioid addiction and also brain injuries.
• 1:30:07
  Speaker 2: Oddly enough, brain injuries, all sorts of TBI and CTE
• 1:30:13
  Speaker 2: that they've had like phenomenal results from this ebogatry, you know,
• 1:30:19
  Speaker 2: which is so crazy that this thing had been around
• 1:30:22
  Speaker 2: for so long and is a schedule one substance in
• 1:30:25
  Speaker 2: the United States for no reason whatsoever. There's no risk
• 1:30:29
  Speaker 2: of addiction, there is no recreational use of it. It's
• 1:30:32
  Speaker 2: a horrible experience. I've not done it, but apparently it's
• 1:30:35
  Speaker 2: fucking terrible and it lasts for like twenty four hours.
• 1:30:38
  Speaker 2: Like no one's going to be doing that for funzis Well.
• 1:30:41
  Speaker 1: The question I think that comes up with all of
• 1:30:43
  Speaker 1: these drugs is do you have to have the trip
• 1:30:45
  Speaker 1: and experience the craziness to get the best to get
• 1:30:48
  Speaker 1: the benefit? And I don't think so. I think you
• 1:30:50
  Speaker 1: should be able to separate.
• 1:30:51
  Speaker 2: Well, you know they've actually figured this out with LSD. Yeah, right,
• 1:30:55
  Speaker 2: do you know about this? Okay, So they've engineered a
• 1:30:59
  Speaker 2: different version of LSD that doesn't give you the hallucinogenic effects,
• 1:31:04
  Speaker 2: but does give you the benefits in terms of like
• 1:31:08
  Speaker 2: the cognitive effects.
• 1:31:09
  Speaker 1: I tell you, guys or someone else.
• 1:31:11
  Speaker 2: I don't know what company has done this. So if
• 1:31:14
  Speaker 2: you can find that, Jay.
• 1:31:15
  Speaker 1: I think it might be a time.
• 1:31:16
  Speaker 2: But what they've they've essentially done, and I think it's
• 1:31:19
  Speaker 2: it's basically in the lab work stage right now. I
• 1:31:22
  Speaker 2: don't think that's applied to humans yet. But what they've
• 1:31:25
  Speaker 2: done is engineered a version of LSD that has all
• 1:31:29
  Speaker 2: the positive effects that LSD has in terms of like introspection,
• 1:31:35
  Speaker 2: being able to rethink and remap and reset the way
• 1:31:38
  Speaker 2: you view things, but without like watching people's face melt
• 1:31:43
  Speaker 2: and thinking the demons are eating you, and all the
• 1:31:46
  Speaker 2: weird stuff that comes outstanding.
• 1:31:48
  Speaker 1: It should happen with psychedelics the way it's happened with
• 1:31:51
  Speaker 1: all medicines. Right, we start with, yes, something from the
• 1:31:54
  Speaker 1: bark of a willow tree, and then we have espirin, right,
• 1:31:58
  Speaker 1: not eating bark anymore, right.
• 1:32:01
  Speaker 2: But sometimes the bark is the really way the way
• 1:32:03
  Speaker 2: to go right. Unfortunately, sometimes that's the part of the
• 1:32:06
  Speaker 2: problem is these pharmaceutical drug companies they patent these natural
• 1:32:11
  Speaker 2: compounds and you know, use petroleum based synthetic methods of
• 1:32:16
  Speaker 2: creating these medications now that they can sell and profit
• 1:32:20
  Speaker 2: wildly off of, whereas really the best way to do
• 1:32:23
  Speaker 2: it is actually to get the plant.
• 1:32:25
  Speaker 1: It's true that there's the whole issue though that if
• 1:32:28
  Speaker 1: it's not approved, then it's the wild West. You don't
• 1:32:31
  Speaker 1: know what you're.
• 1:32:32
  Speaker 2: Getting, right, That's true too.
• 1:32:34
  Speaker 1: We need a middle ground. We need something you can
• 1:32:36
  Speaker 1: get faster in the market that's known to be safe.
• 1:32:38
  Speaker 2: So what we're gonna need is mind reading, because we
• 1:32:42
  Speaker 2: need to know if people are full shit. That's we're
• 1:32:44
  Speaker 2: gonna need. We're gonna need.
• 1:32:45
  Speaker 1: Gotta work on that.
• 1:32:46
  Speaker 2: Yes, I think that's that's gonna change humanity more than anything.
• 1:32:50
  Speaker 1: I think you've got a good bullshit detector.
• 1:32:52
  Speaker 2: It's okay, there's a few people that have snuck through. Unfortunately,
• 1:32:56
  Speaker 2: you know some people they get through and they're like
• 1:32:58
  Speaker 2: it takes a while, and you're like, ah ah shit, they.
• 1:33:01
  Speaker 1: They have coming back on the shore.
• 1:33:02
  Speaker 2: Yeah, well there's that. It's the show you know, you
• 1:33:06
  Speaker 2: learn a lot from a person in about three hours.
• 1:33:09
  Speaker 2: You know, you can kind of after a while, you
• 1:33:11
  Speaker 2: can kind of see little things, and you have to
• 1:33:14
  Speaker 2: be forgiving, and you know, you have to be charitable.
• 1:33:17
  Speaker 2: And some people are just nervous and they mistate things,
• 1:33:20
  Speaker 2: or they exaggerate things, or they forget something, they get
• 1:33:23
  Speaker 2: it wrong. But then there's people that are just essentially
• 1:33:27
  Speaker 2: they really don't care about anybody but themselves. And some
• 1:33:31
  Speaker 2: of those people are really good at pretending to be people.
• 1:33:34
  Speaker 2: They're really good at pretending, you know, they're really good
• 1:33:37
  Speaker 2: at pretending to be like a normal person. So here's
• 1:33:40
  Speaker 2: the LSG thing LST thing. Roight Research is recently engineered
• 1:33:43
  Speaker 2: an LSD analog called how do you say plus minus
• 1:33:48
  Speaker 2: JRT that appears to keep many of the LSD's brain
• 1:33:52
  Speaker 2: beneficial and cognitive effects while dramatically reducing and possibly eliminating
• 1:33:56
  Speaker 2: it's hallucinogenic trip in animal studies. So it's almost the
• 1:34:00
  Speaker 2: same molecule as LSD, but scientists swap the positions of
• 1:34:04
  Speaker 2: just two atoms in the structure. The subtle change makes
• 1:34:07
  Speaker 2: JART bind more selectively to serotonin receptors in a way
• 1:34:11
  Speaker 2: that promotes neuroplasticity growth arough a repair of synapses, but
• 1:34:14
  Speaker 2: minimizes lucinogenic signaling. That is, that's incredible antidepressant Look at
• 1:34:21
  Speaker 2: this strong antidepressant effects. That DOS is reported to be
• 1:34:25
  Speaker 2: around one hundred times more potent than ketabe in standard
• 1:34:29
  Speaker 2: rodent tests. Cognitive benefits, improved cognitive flexibility and performance in
• 1:34:35
  Speaker 2: tasks modeling the negative and cognitive symptoms of schizophrenia. Holy shit,
• 1:34:40
  Speaker 2: that's incredible.
• 1:34:43
  Speaker 1: When when and where do we get it?
• 1:34:45
  Speaker 2: Well, I think it's fairly recent.
• 1:34:47
  Speaker 4: You see Davis study. They just developed it.
• 1:34:51
  Speaker 2: Shout out to our AI sponsor, Perplexity for providing us
• 1:34:54
  Speaker 2: with this information. This is again I mean, like we
• 1:34:56
  Speaker 2: could just get this information now through AI. Like I
• 1:34:59
  Speaker 2: mean this that AI for our show has been gigantic.
• 1:35:02
  Speaker 2: I mean just the ability to just ask it a
• 1:35:05
  Speaker 2: question instead of Google searching and have to go through
• 1:35:07
  Speaker 2: all these different fucking articles. What does it say? What
• 1:35:10
  Speaker 2: is that? Who's right? What's this one? What's the website?
• 1:35:13
  Speaker 2: You just ask AI and Perplexity just gives us all
• 1:35:16
  Speaker 2: the information. So proceedings from National Academy of Science Research
• 1:35:21
  Speaker 2: is that California of San Diego, Davis excuse me. University
• 1:35:25
  Speaker 2: of California Davis reported the creation of j RT chemically
• 1:35:29
  Speaker 2: modified first of LSD. So this is like what year,
• 1:35:36
  Speaker 2: so twenty twenty five, so last year, So it's exciting. Yeah,
• 1:35:41
  Speaker 2: you're right that the timeline.
• 1:35:43
  Speaker 1: At a minimum, usually it takes that long. But that's exciting.
• 1:35:46
  Speaker 1: At least article is there that you don't need to lose.
• 1:35:48
  Speaker 2: Well, how about for schizophrenia. Yeah, that's incredible thing. Yeah,
• 1:35:51
  Speaker 2: I mean that that is incredible because that is one
• 1:35:53
  Speaker 2: of the saddest things to watch somebody fall into the
• 1:35:55
  Speaker 2: grips of schizophrenia. Yeah. I've seen people fall in and
• 1:35:59
  Speaker 2: come out, which is interesting.
• 1:36:00
  Speaker 1: Huh. I thought for the Bullshit Detective, we could have
• 1:36:03
  Speaker 1: an AI that either dings or has a green or
• 1:36:06
  Speaker 1: a red on your forehead.
• 1:36:07
  Speaker 2: I'm pretty good at it, but I think no one's
• 1:36:10
  Speaker 2: perfect at it. And I think ultimately, if we get
• 1:36:13
  Speaker 2: to a place, whether it's a technological innovation or what
• 1:36:18
  Speaker 2: have you, where we can actually read the contents of
• 1:36:21
  Speaker 2: someone's thoughts, I don't think that's outside the realm of possibility.
• 1:36:26
  Speaker 1: You'd need an implant, I think.
• 1:36:28
  Speaker 2: But Elon says the neuralink is going to be able
• 1:36:30
  Speaker 2: to pull that off. Yeah, well you're going to be
• 1:36:32
  Speaker 2: able to talk without using words. And I'm like what.
• 1:36:36
  Speaker 2: I think he's right though. I think if we all
• 1:36:39
  Speaker 2: like lock into a hive mind, and then if we develop,
• 1:36:45
  Speaker 2: like through AI, if we develop a universal language worldwide.
• 1:36:51
  Speaker 1: Well we already have that.
• 1:36:53
  Speaker 2: What do we have?
• 1:36:54
  Speaker 1: Well, the new headphones from a big company that I
• 1:36:56
  Speaker 1: won't name.
• 1:36:57
  Speaker 2: You can translate translate, yes, but it's translating into English.
• 1:37:01
  Speaker 2: If we just all the problem with that is there's context,
• 1:37:05
  Speaker 2: there's all sorts of different things that other cultures have
• 1:37:07
  Speaker 2: different languages. When it's deciphered and changed and translated into English,
• 1:37:12
  Speaker 2: you lose a lot of the meaning and the context
• 1:37:15
  Speaker 2: is weird. If we develop a universal language.
• 1:37:19
  Speaker 1: That'd be ideal. English is a good substitute. I was shocked.
• 1:37:23
  Speaker 1: I'm always shocked traveling globally. How many people can just
• 1:37:25
  Speaker 1: speak English now.
• 1:37:26
  Speaker 2: Yeah, it's pretty amazing. It's because on America rules you're welcome.
• 1:37:31
  Speaker 1: Well we have to thank Britain for that. America should
• 1:37:34
  Speaker 1: say you're welcome.
• 1:37:35
  Speaker 2: Yeah, they're they're cute. They did a good job started out,
• 1:37:38
  Speaker 2: but we took the ball.
• 1:37:39
  Speaker 1: And that is so who's next? Cha?
• 1:37:43
  Speaker 3: God?
• 1:37:43
  Speaker 2: No, I don't want to learn Chinese. It's too hard.
• 1:37:45
  Speaker 2: It's all the fucking characters that's ridiculous. Even people that
• 1:37:48
  Speaker 2: I know they can speak Mandarin, they can't write it,
• 1:37:51
  Speaker 2: you know, to like to get to that level. I
• 1:37:53
  Speaker 2: have a couple of friends that speak fluent Mandarin and
• 1:37:55
  Speaker 2: they can't write it.
• 1:37:58
  Speaker 1: Yeah. Well, the students in my lab who come from China,
• 1:38:01
  Speaker 1: they're being picked on by the immigration, but they don't
• 1:38:05
  Speaker 1: want to go home. They love it.
• 1:38:06
  Speaker 2: Here, I'm sure because they're stealing all your secrets and
• 1:38:08
  Speaker 2: I bring it back around.
• 1:38:09
  Speaker 1: There's a lot of regulation on that now.
• 1:38:11
  Speaker 2: As a scientist, Oh oh, I can imagine. Yeah, I'm
• 1:38:15
  Speaker 2: into because that is an actual, real threat exactly.
• 1:38:18
  Speaker 1: So the people that come through my lab have to
• 1:38:20
  Speaker 1: be vetted now, right.
• 1:38:21
  Speaker 2: But the people that come over here and experience the
• 1:38:23
  Speaker 2: kind of freedom that you have in America.
• 1:38:25
  Speaker 1: Oh yeah, I came here from Australia. Australia is pretty free.
• 1:38:28
  Speaker 1: But compared to Australia, America is so different. I can't
• 1:38:31
  Speaker 1: go back. What's the big difference that I feel? I
• 1:38:36
  Speaker 1: can do anything I want if I just put my
• 1:38:38
  Speaker 1: mind to it. There's not social barriers, there's not monetary barriers,
• 1:38:42
  Speaker 1: at least for a white male like me who's got
• 1:38:44
  Speaker 1: a degree. I know it's not for everybody, but I
• 1:38:47
  Speaker 1: feel like, if I want to start a company, I've
• 1:38:50
  Speaker 1: got a great idea, I can do that here. That
• 1:38:52
  Speaker 1: chance you'll do that In Australia, people aren't willing to
• 1:38:54
  Speaker 1: invest in great ideas down there. Not often.
• 1:38:58
  Speaker 2: That's a bummer. Do you think that change anytime soon?
• 1:39:01
  Speaker 1: No? The US is so unique. There's a lot of
• 1:39:04
  Speaker 1: money flowing. People are willing to place a bet and
• 1:39:06
  Speaker 1: even lose the money. That's rare Australians. Most of the world,
• 1:39:11
  Speaker 1: if not all, people are scared to lose their money
• 1:39:13
  Speaker 1: if they have it. Here, it's like, Okay, I risked it.
• 1:39:16
  Speaker 1: I help the world. I feel good. It's a very
• 1:39:18
  Speaker 1: generous country, very and I love it here. It's when
• 1:39:22
  Speaker 1: I arrived here, I just feel I'm home.
• 1:39:24
  Speaker 2: I love hearing that from people that have come from
• 1:39:26
  Speaker 2: somewhere else because it kind of reaffirms why people in
• 1:39:30
  Speaker 2: America are so proud of what this country is should be. Yeah,
• 1:39:34
  Speaker 2: and that's why it bums me out when people are
• 1:39:36
  Speaker 2: so mad at America in terms of I get look
• 1:39:39
  Speaker 2: in terms of foreign policy, and some of the things
• 1:39:41
  Speaker 2: that are wrong with America. But just in overall, this
• 1:39:44
  Speaker 2: experiment in self government is pretty remarkable.
• 1:39:47
  Speaker 1: Yeah, I watched the TV show was it? The American
• 1:39:50
  Speaker 1: Experiment came out for the anniversary fiftieth.
• 1:39:54
  Speaker 2: I haven't seen it.
• 1:39:55
  Speaker 1: You got to see it?
• 1:39:56
  Speaker 2: Well, what's it?
• 1:39:56
  Speaker 1: Rights? It's the founding fathers and their lives and how
• 1:40:00
  Speaker 1: they were fighting and what was going on behind the scenes.
• 1:40:03
  Speaker 1: They were just young kids. They were in their twenties, thirties.
• 1:40:05
  Speaker 2: I know that nuts.
• 1:40:06
  Speaker 1: Yeah, just Benjamin Franklin was the old dude. But they
• 1:40:09
  Speaker 1: were so young. But they were they were in the
• 1:40:12
  Speaker 1: middle of it. They kind of realized they were making history.
• 1:40:15
  Speaker 1: But so many things could have gone wrong. We would
• 1:40:18
  Speaker 1: not have had the United States if just a few
• 1:40:20
  Speaker 1: votes went one way or the other.
• 1:40:22
  Speaker 2: A few wars, yeah, all the battles.
• 1:40:25
  Speaker 1: That exactly the US was losing the war aganst Britain badly.
• 1:40:30
  Speaker 2: Yeah. They the French.
• 1:40:32
  Speaker 1: Yeah, yeah, we don't think the French enough.
• 1:40:34
  Speaker 2: Actually, I know, right, somehow they became our enemy. Remember
• 1:40:38
  Speaker 2: during the Gulf War, they turned French fries into Freedom
• 1:40:42
  Speaker 2: Fries because people hated the French.
• 1:40:43
  Speaker 1: Yeah, but everyone hates the French because they're so arrogant.
• 1:40:47
  Speaker 1: Sorry French. Some friends who are good friend who are French.
• 1:40:50
  Speaker 2: I think generally when people are arrogant, it's because they
• 1:40:52
  Speaker 2: did something fucking awesome.
• 1:40:54
  Speaker 1: Well, in the eighteen hundreds they did they conquered Europe.
• 1:40:58
  Speaker 1: I'm not sure if that's awesome.
• 1:41:00
  Speaker 4: Here's a fun perplexia search I just did. I said
• 1:41:02
  Speaker 4: to Americans, have a risk gene.
• 1:41:04
  Speaker 2: A risk gene. Yeah. One of the best studied variants
• 1:41:07
  Speaker 2: in the dopamine per septor gene d r D four,
• 1:41:10
  Speaker 2: specifically the seven repeat seven R version. It's associated in
• 1:41:14
  Speaker 2: some studies with novelty seeking, impulsivity, and higher financial or
• 1:41:19
  Speaker 2: social risk taking. I wonder if I have that gene
• 1:41:22
  Speaker 2: for sure? This seven probably not? Who knows. The seven
• 1:41:26
  Speaker 2: R variant is unevenly distributed around the world. It's populations
• 1:41:30
  Speaker 2: in populations across the America, as it shows up in
• 1:41:32
  Speaker 2: roughly forty eight percent of chromoson studied, while in East
• 1:41:35
  Speaker 2: Asia it's found in only about two percent. Wow, WHOA,
• 1:41:39
  Speaker 2: that's crazy.
• 1:41:41
  Speaker 1: It'll come down to genetics.
• 1:41:43
  Speaker 2: Evolutionary work suggest it became more common in groups that
• 1:41:45
  Speaker 2: migrated further after leaving Africa and those lineages are strongly
• 1:41:50
  Speaker 2: represented in the Americas today. That that actually.
• 1:41:54
  Speaker 4: Makes thinking of the people that you have the balls
• 1:41:57
  Speaker 4: to fucking come here.
• 1:41:58
  Speaker 2: Yeah, were your balls.
• 1:41:59
  Speaker 4: You don't have to do that much, but you can
• 1:42:01
  Speaker 4: still have balls to gamble, And yes.
• 1:42:04
  Speaker 1: That must be a but then Australian should have it.
• 1:42:07
  Speaker 2: That completely meant well sort of, you guys got forced
• 1:42:09
  Speaker 2: there like they sh moved everybody over there because they
• 1:42:12
  Speaker 2: were criminals.
• 1:42:12
  Speaker 1: Right, this this d D R gene that you just
• 1:42:16
  Speaker 1: sawt that was it, d R four. I know a
• 1:42:19
  Speaker 1: bit about it because I'm writing it in my next book,
• 1:42:22
  Speaker 1: d R D four, Thanks Jamie. I call this the
• 1:42:24
  Speaker 1: f U gene because I'm trying to figure out what
• 1:42:27
  Speaker 1: makes humans special over other animals, and this is one
• 1:42:31
  Speaker 1: of them that we are seekers of explorers, and it's
• 1:42:36
  Speaker 1: it turns out it turns out that this gene is
• 1:42:38
  Speaker 1: turned on in teenagers. It gets eventually switched off, not totally,
• 1:42:43
  Speaker 1: but that might be why teenagers say f you to
• 1:42:46
  Speaker 1: their parents. But it's a way genetically to get them
• 1:42:49
  Speaker 1: out of the nest, like, oh, I can't stand these parents.
• 1:42:51
  Speaker 1: They suck They're idiots. I'm out of here. That's in
• 1:42:54
  Speaker 1: this in this gene.
• 1:42:57
  Speaker 2: Well, it's also I, as a parent, have been very
• 1:43:03
  Speaker 2: aware of not doing that to my kids, like not
• 1:43:06
  Speaker 2: forcing them into something that they don't want to do,
• 1:43:09
  Speaker 2: or pushing them in any general direction, but rather encouraging
• 1:43:12
  Speaker 2: them to seek out their interests and encouraging them to
• 1:43:16
  Speaker 2: just like take chance. And if I ever correct them,
• 1:43:19
  Speaker 2: if I ever get upset about something, one of the
• 1:43:21
  Speaker 2: first things that I tell them is, I've done all
• 1:43:23
  Speaker 2: everything that you've done. I've made every mistake, I've fucked up.
• 1:43:27
  Speaker 2: You're smarter than me. I've fucked up everything. I've lied
• 1:43:31
  Speaker 2: to my parents, I lied to teachers. I've done everything
• 1:43:35
  Speaker 2: that you're doing. So it's this is not a unique thing.
• 1:43:38
  Speaker 2: I'm just telling you from my own personal experience, in
• 1:43:41
  Speaker 2: my perspective. This is why I think because I love
• 1:43:44
  Speaker 2: you and I want you to do well in life,
• 1:43:45
  Speaker 2: and I just want you to recognize this. And that's
• 1:43:48
  Speaker 2: how I correct my kids. It's never like you listen
• 1:43:52
  Speaker 2: to me because I'm your father.
• 1:43:53
  Speaker 1: This yeah, yeah, the way we were raised it doesn't work, no, and.
• 1:43:57
  Speaker 2: It makes you resentment, but also probably makes you want
• 1:44:01
  Speaker 2: to do better than your parents, So like motivates you
• 1:44:03
  Speaker 2: in a certain way, like my parents were not risk
• 1:44:06
  Speaker 2: takers at all, and my whole life I've been like
• 1:44:09
  Speaker 2: a wild risk taker.
• 1:44:10
  Speaker 1: That's really same. Yeah, I was resentful that my father
• 1:44:13
  Speaker 1: didn't have enough ambition. Now he's a great guy. We're
• 1:44:16
  Speaker 1: best friends. Actually, it's been the greatest thing for me.
• 1:44:19
  Speaker 1: But one of the things I did with my kids,
• 1:44:20
  Speaker 1: you're reminded me, is he's nineteen. He's a well built guy.
• 1:44:24
  Speaker 1: Because we were going to the gym for a number
• 1:44:26
  Speaker 1: of years. I've tried to train him in health. But
• 1:44:29
  Speaker 1: he spent the summer with me. He's literally still working
• 1:44:32
  Speaker 1: for me this summer to help with the podcast and
• 1:44:35
  Speaker 1: the magazine we're about to launch. And Benjamin's his name.
• 1:44:38
  Speaker 1: He's the best kid. But he slacked off. He was like,
• 1:44:42
  Speaker 1: ben I put you in charge of social media. You
• 1:44:43
  Speaker 1: haven't posted in a week. What's going on? Well, you know,
• 1:44:46
  Speaker 1: I slept in blah blah. So I had to think,
• 1:44:48
  Speaker 1: am I gonna get mad at him like I would
• 1:44:50
  Speaker 1: a normal employee, or do I treat him differently? And
• 1:44:53
  Speaker 1: I decided to treat him differently, probably because he's my son.
• 1:44:56
  Speaker 1: But I didn't want to rule in a relationship. But
• 1:44:59
  Speaker 1: what I did as I said, you know, I really
• 1:45:04
  Speaker 1: think you can do better. I think everything you've done,
• 1:45:06
  Speaker 1: the weightlifting, the calculus, you're amazing, But in this you're not.
• 1:45:12
  Speaker 1: So what's going on? And it worked. We become closer.
• 1:45:16
  Speaker 1: He's really into it, he's doing a good job.
• 1:45:19
  Speaker 2: That's great.
• 1:45:19
  Speaker 1: So that's the way to do it. I think you
• 1:45:21
  Speaker 1: can't be too hot on them and say you've sucked up.
• 1:45:24
  Speaker 2: Yeah, I mean that kind of can work, but it's
• 1:45:26
  Speaker 2: a blunt instrument and it doesn't work on everybody, and
• 1:45:30
  Speaker 2: it also develops resentment, and they also they miss out
• 1:45:34
  Speaker 2: on experiencing your perspective as a like for them to
• 1:45:40
  Speaker 2: understand that you are just a person who's lived longer
• 1:45:43
  Speaker 2: than them and that you can help them navigate this road.
• 1:45:47
  Speaker 1: Yeah, so you don't have to make the stay same mistakes.
• 1:45:49
  Speaker 2: Yeah, that's why you're helping them. You're talking to them
• 1:45:54
  Speaker 2: about this, not because you're just a mean dad who
• 1:45:58
  Speaker 2: likes to fucking tell the kids what to do. Because
• 1:46:00
  Speaker 2: we've all experienced that. I mean I had friends grown
• 1:46:02
  Speaker 2: up as fathers would fucking scream at them and throw
• 1:46:05
  Speaker 2: things and beat them, and it's like God, and then
• 1:46:09
  Speaker 2: you just grow up fucking traumatized and always resentful and angry,
• 1:46:14
  Speaker 2: instead of just recognizing that, like, oh, I'm so fortunate
• 1:46:19
  Speaker 2: that my parents have this perspective where they can explain
• 1:46:23
  Speaker 2: to me why I'm going through what I'm going through
• 1:46:26
  Speaker 2: and how they got through it.
• 1:46:28
  Speaker 1: Like a mentor. You're not the best friend, you're the mentor. Yes,
• 1:46:31
  Speaker 1: my best friend doesn't work either.
• 1:46:33
  Speaker 2: No, that doesn't work either, because that just allows too
• 1:46:36
  Speaker 2: much shenanigans. You know, you have to have some rules,
• 1:46:38
  Speaker 2: you know, you have to have some some sort of regulations.
• 1:46:41
  Speaker 1: But you also kids turned out well, how do you kids?
• 1:46:46
  Speaker 2: I'm so so lucky, so fucking lucky. I mean, I
• 1:46:49
  Speaker 2: feel so fortunate. They're so smart and ambitious and driven
• 1:46:53
  Speaker 2: and so it's wild. It's wild to watch, you know,
• 1:46:55
  Speaker 2: and talented, and it's and also like we never went
• 1:47:00
  Speaker 2: through that period where they hit teenageers and they hate
• 1:47:04
  Speaker 2: you like that. God, that's so nice. I mean, my
• 1:47:10
  Speaker 2: youngest shoul get upset at me sometimes about certain things,
• 1:47:12
  Speaker 2: but she bounces back quickly. It's never like some kids
• 1:47:15
  Speaker 2: where they just grow to hate their parents liked forging.
• 1:47:20
  Speaker 1: Maybe they don't have strong one.
• 1:47:21
  Speaker 2: I don't know about that. I think it's how you
• 1:47:24
  Speaker 2: communicate with them. I really do. I think that's a
• 1:47:27
  Speaker 2: big factor. You have to communicate with them like you
• 1:47:31
  Speaker 2: truly care about their development. And the most important thing.
• 1:47:35
  Speaker 2: I think. The most important thing I think is that
• 1:47:37
  Speaker 2: I always tell them, whatever you've done, whatever mistake you've made,
• 1:47:41
  Speaker 2: I made way worse mistakes. It's like, I am not
• 1:47:43
  Speaker 2: coming at you from a flawless person. You know, I'm
• 1:47:46
  Speaker 2: not coming at you from the perspective of someone who like,
• 1:47:50
  Speaker 2: you're an idiot. I figure that out. You should figure
• 1:47:53
  Speaker 2: it out. Like no. I whenever they from the time
• 1:47:56
  Speaker 2: they were really little, anytime I had to correct them,
• 1:47:58
  Speaker 2: I said, I did everything that you're doing. Everything.
• 1:48:03
  Speaker 1: I threw my food on the floor too.
• 1:48:05
  Speaker 2: Yes, all the above, every whatever fucking stupid thing you've
• 1:48:09
  Speaker 2: done as a kid. I guarantee you.
• 1:48:11
  Speaker 1: That is great advice, really great advice. So I hope
• 1:48:14
  Speaker 1: everyone listening here is that because I actually had to
• 1:48:17
  Speaker 1: learn the hard way my first kid, I did what
• 1:48:19
  Speaker 1: my parents did, which was you can't say that. Yeah,
• 1:48:22
  Speaker 1: and my first is a lot more rebellious and distant
• 1:48:25
  Speaker 1: than my third.
• 1:48:26
  Speaker 2: That is interesting.
• 1:48:27
  Speaker 1: Yeah, it actually is really true. I've seen it.
• 1:48:30
  Speaker 2: Yeah, and I thought I was gonna kill their motivation.
• 1:48:32
  Speaker 2: But it doesn't at all. Well, I thought, like, you know,
• 1:48:35
  Speaker 2: making things easy for them and not being strict, Like,
• 1:48:38
  Speaker 2: maybe it's good to be strict because then you just
• 1:48:40
  Speaker 2: have this determination. I'll show everybody. I don't think that
• 1:48:43
  Speaker 2: was my thing as a child, Like I'll fucking show you.
• 1:48:47
  Speaker 2: But I don't think everybody needs that. I think you're
• 1:48:50
  Speaker 2: much better off having a healthy relationship with ambition, where
• 1:48:55
  Speaker 2: you're excited about things because you're passionate about them, and
• 1:48:58
  Speaker 2: you find great reward in being creative or being enthusiastic
• 1:49:04
  Speaker 2: about something exactly.
• 1:49:06
  Speaker 1: And open their eyes to the world that exists. Yes,
• 1:49:09
  Speaker 1: we used to do work experience. You go and do
• 1:49:11
  Speaker 1: a job and that's your work experience. The reason I
• 1:49:13
  Speaker 1: wanted my son Ben to work with me is he
• 1:49:15
  Speaker 1: can see how what it's like to be an entrepreneur
• 1:49:17
  Speaker 1: and build something and be excited and work is super fun.
• 1:49:22
  Speaker 1: I think a lot of kids just don't get that experience.
• 1:49:24
  Speaker 1: They don't know what's possible, right, and just showing them
• 1:49:27
  Speaker 1: the world is what we can do as parents.
• 1:49:29
  Speaker 2: That's awesome. Yeah, and you know, I mean some people
• 1:49:34
  Speaker 2: don't have that at home unfortunately. But That's one of
• 1:49:37
  Speaker 2: the cool things about the world that we live in
• 1:49:40
  Speaker 2: is that kids today have access to so many different
• 1:49:43
  Speaker 2: perspectives now because of the Internet. There's so many different
• 1:49:48
  Speaker 2: podcasts and YouTube conversations and different things where they can
• 1:49:52
  Speaker 2: just take a little tool from that, just take a
• 1:49:55
  Speaker 2: little peace from that and apply it to the way
• 1:49:57
  Speaker 2: they interact with the world.
• 1:50:01
  Speaker 1: For sure. And I would encourage parents to give their
• 1:50:04
  Speaker 1: kids stuff to read. And we talked about social media,
• 1:50:08
  Speaker 1: how that's just addictive. I saw how my kids wanted
• 1:50:11
  Speaker 1: to just scroll through their phones then read. And if
• 1:50:14
  Speaker 1: they can't read a book, give them a magazine. I'd
• 1:50:17
  Speaker 1: subscribe to, not Geo National Geographic for my kids. And
• 1:50:22
  Speaker 1: I think get them used to reading. It's going to
• 1:50:25
  Speaker 1: be a lost art if we don't know.
• 1:50:27
  Speaker 2: Isn't that nuts? I maybe read ten percent of the
• 1:50:31
  Speaker 2: things that I consume. I consume so much in audio
• 1:50:35
  Speaker 2: just for time reasons, because there's so much There's so
• 1:50:39
  Speaker 2: much time where I'm driving my car, or I'm working out,
• 1:50:42
  Speaker 2: or I'm in the sauna, or I'm in the hyperbarer chamber,
• 1:50:46
  Speaker 2: or I'm in the red light therapy.
• 1:50:47
  Speaker 1: That's reading three.
• 1:50:48
  Speaker 2: It is similar. But I think it's only like seventy
• 1:50:52
  Speaker 2: percent of reading. I don't think it's one hundred percent.
• 1:50:55
  Speaker 2: I don't think you get the full effect. But it's
• 1:50:56
  Speaker 2: still way better than not doing it, you know. But
• 1:50:59
  Speaker 2: I'm aware that like sitting there concentrating, actually reading a
• 1:51:03
  Speaker 2: book without hearing another person's voice talking, there's another mechanism,
• 1:51:07
  Speaker 2: there's another thing that's going on. That's it's a different
• 1:51:11
  Speaker 2: way you interact with the material, whether it's nonfiction or fiction. Yeah.
• 1:51:15
  Speaker 1: I like the fact that I can listen to you
• 1:51:16
  Speaker 1: and i'm doing something else. I have to sit down,
• 1:51:19
  Speaker 1: can move, go for a walk.
• 1:51:20
  Speaker 2: Yeah, that's for me. It's it's just I'm I have
• 1:51:24
  Speaker 2: too many interests. I have way too many things that
• 1:51:26
  Speaker 2: I do, and so it's very hard for me to
• 1:51:29
  Speaker 2: just allocate a certain amount of time to sit there
• 1:51:31
  Speaker 2: in silence and read. Yeah.
• 1:51:33
  Speaker 1: I use reading to fall asleep. That's a good way.
• 1:51:35
  Speaker 2: It does do that, right, It's kind of nuts how
• 1:51:37
  Speaker 2: well it does that.
• 1:51:38
  Speaker 1: Yeah, although I'm finding it's harder to read now that
• 1:51:41
  Speaker 1: my eyes on young need some of my gems light there.
• 1:51:46
  Speaker 1: I've tried that. Does it work for you?
• 1:51:47
  Speaker 2: Oh yeah? Oh? I mean people are skeptical about this
• 1:51:52
  Speaker 2: and they think I'm full shit. No, I don't need
• 1:51:54
  Speaker 2: reading glasses anymore. Really, yes, I have reading I always
• 1:51:58
  Speaker 2: have these fucking things laying around. I don't even use
• 1:52:00
  Speaker 2: them anymore.
• 1:52:01
  Speaker 1: It's awesome. Yeah, there's a lot of signs now. The
• 1:52:03
  Speaker 1: red light it's real.
• 1:52:05
  Speaker 2: Yeah, I can tell you as a regular user for
• 1:52:08
  Speaker 2: multiple years. It took a while. It took like I
• 1:52:12
  Speaker 2: was waiting for it in the beginning, like what the
• 1:52:13
  Speaker 2: fuck in back? And not only that, in the beginning,
• 1:52:16
  Speaker 2: because I don't close my eyes in the red light bed,
• 1:52:19
  Speaker 2: I thought it was making things blurrier. I was like,
• 1:52:21
  Speaker 2: oh my god, am I fucking up my eyesight like
• 1:52:23
  Speaker 2: listening to these assholes. But no, it just took a while,
• 1:52:28
  Speaker 2: and then over the course of like many months, I
• 1:52:31
  Speaker 2: started seeing some small improvements, and then I started seeing
• 1:52:35
  Speaker 2: some pretty big improvements over the course of about a year.
• 1:52:38
  Speaker 2: Whereas now it's not My eyes aren't perfect. They aren't
• 1:52:42
  Speaker 2: like they were when I was twenty, but they are
• 1:52:45
  Speaker 2: way better than they were when I was fifty.
• 1:52:47
  Speaker 1: Oh often did you have to do that?
• 1:52:49
  Speaker 2: I do it three times a week minimum, That's what
• 1:52:51
  Speaker 2: I try to do, but sometimes I'll do it five
• 1:52:53
  Speaker 2: days a week. Well, I just get in there and
• 1:52:55
  Speaker 2: it's twenty minutes. I lay in a light bed, close
• 1:52:57
  Speaker 2: my eyes, open my eyes whatever. It seems to work
• 1:53:00
  Speaker 2: on your vision, even if you wear a blindfold.
• 1:53:03
  Speaker 1: What about people that kind of a bed can you get?
• 1:53:05
  Speaker 2: Little, Yes, you can get. Well, there's a company called
• 1:53:08
  Speaker 2: it's called jew right j u u V is that
• 1:53:12
  Speaker 2: the name of the company. They were our sponsor at
• 1:53:14
  Speaker 2: one point in time. That's how I started it. They
• 1:53:16
  Speaker 2: had it's just a light panel that you stand in
• 1:53:20
  Speaker 2: front of ye and that that works too. That but
• 1:53:25
  Speaker 2: this one, the one that I got a red and
• 1:53:28
  Speaker 2: near infrared light therapy devices juve joo vv medical grade
• 1:53:34
  Speaker 2: light therapy devices. I had one of those, and that's
• 1:53:38
  Speaker 2: when I started seeing benefits. But the the big one
• 1:53:42
  Speaker 2: that I got, I got from Gary Breca from his company,
• 1:53:45
  Speaker 2: and it's it's a like a fucking tanning bed and
• 1:53:47
  Speaker 2: you lie in it. And that one's amazing. But that's expensive.
• 1:53:50
  Speaker 2: But I don't think you have to have that for
• 1:53:52
  Speaker 2: those kind of improvements. Also improves collagen your skin, makes
• 1:53:55
  Speaker 2: you look better and the But for me, the most
• 1:54:00
  Speaker 2: obvious and profound was the improvement in my vision.
• 1:54:03
  Speaker 1: Well, it makes sense. The signs behind red light wasn't
• 1:54:06
  Speaker 1: there ten years ago and people were questioning it. But
• 1:54:08
  Speaker 1: now we know if you shine certain wavelengths like nearing
• 1:54:12
  Speaker 1: for red on cells the mitochondria, which are important for
• 1:54:16
  Speaker 1: reversing aging or slowing it get red up. It's actually
• 1:54:19
  Speaker 1: related to viagra. Long story, but viagra and red light
• 1:54:24
  Speaker 1: have something is in common, and it does help mitochondria,
• 1:54:27
  Speaker 1: and that's very important for the eye that mtochondria. Actually
• 1:54:29
  Speaker 1: the most important in any part of your body. The
• 1:54:32
  Speaker 1: eye is the most important part. And part of the
• 1:54:35
  Speaker 1: reason we lose our vision is the mitochondria don't make
• 1:54:38
  Speaker 1: enough energy for the.
• 1:54:38
  Speaker 2: How come you haven't done red light therapy before, then.
• 1:54:42
  Speaker 1: Well, I do, but not routinely. So I have one
• 1:54:46
  Speaker 1: of those bricks that I turn on while I'm in
• 1:54:48
  Speaker 1: the shower, and I have a red light cap for
• 1:54:50
  Speaker 1: my hair, which there's some evidence alien what I do
• 1:54:56
  Speaker 1: is I, yeah, it does. It looks a little bit silly.
• 1:54:58
  Speaker 1: I don't wear it in public. I do lower it
• 1:55:01
  Speaker 1: and I look at it and it shines in my
• 1:55:03
  Speaker 1: eyes and on my face in the hopes that it
• 1:55:05
  Speaker 1: might help you.
• 1:55:06
  Speaker 2: Yeah, they have one that you wear like doctor doom
• 1:55:08
  Speaker 2: like fits over your face and like blast red light
• 1:55:10
  Speaker 2: and your whole face.
• 1:55:11
  Speaker 1: I definitely feel a bit weird afterwards, and I can
• 1:55:14
  Speaker 1: see speckles. But I think the science says that it
• 1:55:17
  Speaker 1: can help.
• 1:55:18
  Speaker 2: Well, all I know is my own anecdotal experience, and
• 1:55:22
  Speaker 2: for me, it has radically improved my vision.
• 1:55:26
  Speaker 1: That's a good tip.
• 1:55:27
  Speaker 2: Yeah, it stopped. It was my vision was degrading. Like
• 1:55:32
  Speaker 2: it was. It was pretty odd. Like I first started
• 1:55:35
  Speaker 2: using like reading glasses like a one x like it
• 1:55:38
  Speaker 2: made it a little better. I'm like, oh, there's a
• 1:55:39
  Speaker 2: little better, makes it clearer. And then I went to
• 1:55:41
  Speaker 2: two and then I was using two point five and
• 1:55:44
  Speaker 2: it made it better, but it was like, God, this
• 1:55:46
  Speaker 2: is annoying. And then if I would try to read
• 1:55:49
  Speaker 2: an email and I didn't have my reading glasses, I
• 1:55:52
  Speaker 2: couldn't read shit. Now crystal clear, Yeah, no problem at all.
• 1:55:57
  Speaker 1: Well, so my latest show is about the eye and
• 1:55:59
  Speaker 1: how to take the eye's health, and so there's a
• 1:56:03
  Speaker 1: lot you can do, actually, supplements, red light, other things.
• 1:56:07
  Speaker 2: I take supplements for it too. I should mention that
• 1:56:09
  Speaker 2: I take No I have no affiliation with these people.
• 1:56:13
  Speaker 2: Appure Encapsulations makes a supplement called macular support and I
• 1:56:17
  Speaker 2: take that and it's a combination of lutine and a
• 1:56:20
  Speaker 2: few other things.
• 1:56:21
  Speaker 1: Yeah, there was a trial a while ago that showed
• 1:56:25
  Speaker 1: that taking xanthine and others as to xanthine, lute lutine,
• 1:56:31
  Speaker 1: they're good for the eye. So you can get products
• 1:56:33
  Speaker 1: like that.
• 1:56:34
  Speaker 2: Do you take it?
• 1:56:35
  Speaker 1: Not that brand, but yes, I take something similar.
• 1:56:38
  Speaker 2: And has it helped you at all?
• 1:56:40
  Speaker 1: I don't know. I haven't done an experiment.
• 1:56:42
  Speaker 2: Right, Well, if you weren't taking it, maybe you would
• 1:56:44
  Speaker 2: have more degeneration.
• 1:56:45
  Speaker 1: Yeah. Well, you know I've got neoperfect vision. I don't
• 1:56:48
  Speaker 1: need glasses, do you really? Yeah? Near perfect, neoperfect. I
• 1:56:52
  Speaker 1: mean I think low light.
• 1:56:54
  Speaker 2: Low light is with me. Yeah, where I'll go to
• 1:56:56
  Speaker 2: a restaurant with my kids and they can read the
• 1:56:58
  Speaker 2: menu and I'm like, that is so embarrassing. You can
• 1:57:01
  Speaker 2: read that. How do you read that? I can't read shit?
• 1:57:04
  Speaker 2: I don't know why? Why?
• 1:57:06
  Speaker 1: Well, this is what I think. So we know from
• 1:57:09
  Speaker 1: my lab's work that the retina, because it has tens
• 1:57:12
  Speaker 1: of thousands of endings that pick up the light. As
• 1:57:16
  Speaker 1: you get older, those nerves lose their identity and they're
• 1:57:19
  Speaker 1: not working as well. And what we do is with
• 1:57:22
  Speaker 1: our therapy, we can restore those nerves back to being
• 1:57:27
  Speaker 1: functional nerves. And that's why mice and monkeys that lose
• 1:57:32
  Speaker 1: their retinal function get their perfect vision back again. We're
• 1:57:37
  Speaker 1: reminding those cells that have forgotten how to work. So
• 1:57:40
  Speaker 1: in your eye and my eye were twenty two months apart,
• 1:57:43
  Speaker 1: that those nerves, about half of them have forgotten how
• 1:57:46
  Speaker 1: to work properly. So we want to fix that and
• 1:57:48
  Speaker 1: go back to being young. It's not that our nerves
• 1:57:50
  Speaker 1: are gone. They're not dead. They're right there and we
• 1:57:52
  Speaker 1: can restore them. And that's going to be true for
• 1:57:54
  Speaker 1: a lot of organs. Is that the cells are still there,
• 1:57:57
  Speaker 1: they just need to be reminded how to work again.
• 1:58:00
  Speaker 2: What are the potential negative consequences of this kind of
• 1:58:03
  Speaker 2: work when you sit up at night and you worry.
• 1:58:06
  Speaker 2: I hope it doesn't do this. Is it cancer? Is
• 1:58:09
  Speaker 2: that the big one?
• 1:58:10
  Speaker 1: Yeah, it's though we've done a lot of work to
• 1:58:14
  Speaker 1: allate real fears, it is possible that if we go
• 1:58:17
  Speaker 1: too young we can cause displasia, which is cells doing
• 1:58:21
  Speaker 1: what they shouldn't, or if they multiply and spread, that
• 1:58:24
  Speaker 1: would because if you make.
• 1:58:25
  Speaker 2: The cells too young, like what I was saying before
• 1:58:27
  Speaker 2: about don't turn me into a baby.
• 1:58:28
  Speaker 1: Right, we don't want to go there. That's what Yamanaka
• 1:58:31
  Speaker 1: did and got the no bell for it. But that's
• 1:58:33
  Speaker 1: not good here. But we never see our cells turn
• 1:58:37
  Speaker 1: into stem cells again, we can't. We had mice that
• 1:58:39
  Speaker 1: we left it left the gene therapy on for twenty
• 1:58:43
  Speaker 1: one months in the eye and nineteen months in the
• 1:58:45
  Speaker 1: whole body of the animal, and if anything, they had
• 1:58:48
  Speaker 1: less tumors than the ones that didn't get treated. And
• 1:58:51
  Speaker 1: we actually know from a wonderful student in my lab
• 1:58:55
  Speaker 1: and a lot she's a PhD student. She found that
• 1:58:57
  Speaker 1: when you turn on these three same genes not in
• 1:59:00
  Speaker 1: the I but in cancer cells and tumors growing in mice,
• 1:59:03
  Speaker 1: human cancers growing in mice, they shrink. So we think
• 1:59:07
  Speaker 1: it might actually help the cancer as well, which was
• 1:59:09
  Speaker 1: a nice surprise.
• 1:59:10
  Speaker 2: Wow, that's incredible.
• 1:59:12
  Speaker 1: It makes sense. Right. If you wake up a cancer
• 1:59:14
  Speaker 1: cell and it says, crap, I shouldn't be growing. I
• 1:59:18
  Speaker 1: should be a you know, a liver cell or something similar,
• 1:59:24
  Speaker 1: now it kills itself. So we see that the cells
• 1:59:26
  Speaker 1: wake up, they realize what they were thirty years ago,
• 1:59:29
  Speaker 1: and then they killed themselves.
• 1:59:32
  Speaker 2: What is on the horizon in terms of like what
• 1:59:34
  Speaker 2: would you like to accomplide or would you like to
• 1:59:37
  Speaker 2: work on that you can't do currently?
• 1:59:40
  Speaker 1: Well, lots lots. You know, funding in my lab got
• 1:59:43
  Speaker 1: completely cut last year and we've managed to survive through donations.
• 1:59:49
  Speaker 2: We why had the fund to get cut? Was it
• 1:59:51
  Speaker 2: a USAID thing?
• 1:59:52
  Speaker 1: You remember there was a spat between Harvard and the
• 1:59:55
  Speaker 1: federal government. All of the funding Harvard Medical School got cut.
• 1:59:58
  Speaker 2: Was that during the time where the president was defending
• 2:00:02
  Speaker 2: those anti semitic comments on campuses.
• 2:00:07
  Speaker 1: Yeah, well allegedly. I'm not getting into the politics.
• 2:00:10
  Speaker 2: No, you need to get into politics. But during that
• 2:00:12
  Speaker 2: whole thing, Yeah.
• 2:00:13
  Speaker 1: Yeah, so what I almost had to fire most of
• 2:00:17
  Speaker 1: the people in my lab during that episode. Was quite scary,
• 2:00:20
  Speaker 1: But I raised so now my lab survives on donations,
• 2:00:25
  Speaker 1: not on federal government money. Thank you, friends, thank you,
• 2:00:29
  Speaker 1: thank you.
• 2:00:30
  Speaker 2: Well. The thing is you've accomplished enough where people are like,
• 2:00:33
  Speaker 2: I think he's onto something and I want to live forever.
• 2:00:36
  Speaker 1: Well, I'm lucky. Most scientists can't raise money like that,
• 2:00:39
  Speaker 1: so really, really it's a blessing. And now I'm raising
• 2:00:41
  Speaker 1: money through a foundation to help other scientists survive. But yeah,
• 2:00:46
  Speaker 1: it's been a blessing. But your question was, what do
• 2:00:50
  Speaker 1: I wish I could do? Yeah, I wish I could
• 2:00:52
  Speaker 1: go faster. I wish I could try multiple approaches so
• 2:00:55
  Speaker 1: we don't just have one shot on goal. It's going
• 2:00:58
  Speaker 1: slower than I would want. With a big injection of cash,
• 2:01:02
  Speaker 1: we could do a lot of trials, a lot of
• 2:01:03
  Speaker 1: different tissues. We could do a whole body rejuvenation as well.
• 2:01:07
  Speaker 1: Do you have a website where people can donate. I do.
• 2:01:12
  Speaker 1: It's lifespan dot com.
• 2:01:14
  Speaker 2: So if you go to lifespan dot com. Yeah, there's
• 2:01:17
  Speaker 2: a link there.
• 2:01:18
  Speaker 1: Yeah, you're doing a foundation and we're raising money for
• 2:01:21
  Speaker 1: this type of research.
• 2:01:22
  Speaker 2: Is it tax deductible.
• 2:01:24
  Speaker 1: Depends on how big the donation is. For ten dollars,
• 2:01:28
  Speaker 1: you get the new magazine that we're putting out, and
• 2:01:30
  Speaker 1: you learn all about how to live longer building. I'm
• 2:01:34
  Speaker 1: hoping to build the world's largest longevity community of millions
• 2:01:36
  Speaker 1: of people who can learn how to really live longer
• 2:01:39
  Speaker 1: and build healthcare from the ground up because top down
• 2:01:41
  Speaker 1: from the government hasn't worked. Yeah. Actually, I have a
• 2:01:44
  Speaker 1: gift for you.
• 2:01:46
  Speaker 2: Where you are.
• 2:01:47
  Speaker 1: I made something for you that's unique. This is for you, Joe,
• 2:01:53
  Speaker 1: as a thanks it's all the support you've given me
• 2:01:57
  Speaker 1: and the science over the years.
• 2:01:58
  Speaker 2: First edition Lifespan magazine. Ladies and gentlemen, look at that.
• 2:02:03
  Speaker 1: It's written by scientists.
• 2:02:04
  Speaker 2: So it's cover. It's like a velvet cover. What is this?
• 2:02:07
  Speaker 1: I figured here it might like that inside is the magazine?
• 2:02:10
  Speaker 2: Is this material? It's beautiful lure of course.
• 2:02:15
  Speaker 1: A great expense. No, the magazine doesn't come with the lore.
• 2:02:17
  Speaker 1: That's just special for Joe as a thank you, President,
• 2:02:21
  Speaker 1: Thank you very much. Most most science out there is
• 2:02:24
  Speaker 1: written by reporters who don't know what they're talking about,
• 2:02:27
  Speaker 1: and so we want we wrote this for the public
• 2:02:30
  Speaker 1: and you can believe whatever you read in there.
• 2:02:32
  Speaker 2: All right, beautiful, so you have to trust it.
• 2:02:36
  Speaker 1: So that's at lifespan dot com. You can subscribe get
• 2:02:39
  Speaker 1: that every month just for ten bucks.
• 2:02:41
  Speaker 2: I like to take at the bottom, life's too short.
• 2:02:44
  Speaker 2: Let's fix that.
• 2:02:45
  Speaker 1: That's our slogan. That's Lifespan slogan.
• 2:02:48
  Speaker 2: Yeah, it's an awesome slogan.
• 2:02:50
  Speaker 1: So it's it's a it's a community. It's the show.
• 2:02:52
  Speaker 1: My show is also called Lifespan on YouTube. But the
• 2:02:55
  Speaker 1: magazine is a Passion project. I want to put out
• 2:02:57
  Speaker 1: something that people love. It's beautiful, right, It's like National Geographic.
• 2:03:03
  Speaker 1: By the way, just today, this is no joke. It
• 2:03:07
  Speaker 1: seems crazy, but my labs research is on the cover
• 2:03:11
  Speaker 1: of National Geographic.
• 2:03:12
  Speaker 2: Oh that's awesome.
• 2:03:13
  Speaker 1: That just came out today. They heard, by the way,
• 2:03:15
  Speaker 1: at that geo. They said, you're going on Joe Rogan.
• 2:03:18
  Speaker 1: I went yeah, they goes, all right, we'll put it
• 2:03:20
  Speaker 1: out early, so you can now read about my lab's
• 2:03:23
  Speaker 1: research on that GEO as well today.
• 2:03:24
  Speaker 2: That's very cool. That's very cool. So you would just
• 2:03:28
  Speaker 2: like to do more, have more funding, do more. That's
• 2:03:32
  Speaker 2: the thing that you wish you could be working on now.
• 2:03:34
  Speaker 2: Just having more different, more different studies and tests running concurrently.
• 2:03:39
  Speaker 1: We could go so fast with AI because it's spitting
• 2:03:42
  Speaker 1: out new drug candidates all the time that we can't test.
• 2:03:44
  Speaker 1: It takes years to get through. So with money, we
• 2:03:47
  Speaker 1: could do a lot more trials and put these through
• 2:03:50
  Speaker 1: different diseases much faster.
• 2:03:51
  Speaker 2: If you had no regulations, like an Island of Doctor
• 2:03:54
  Speaker 2: Moreau type deal. Yeah, well, let you know.
• 2:03:57
  Speaker 1: Well, at the risk of getting kicked out of my universe,
• 2:04:02
  Speaker 1: theoretically we could very safely, do more animal studies and
• 2:04:07
  Speaker 1: with those best candidates put them into humans quicker. Right now,
• 2:04:11
  Speaker 1: it takes years. It's taken us close to ten years
• 2:04:14
  Speaker 1: to go from the first discovery in my lab in
• 2:04:18
  Speaker 1: Nature magazine to now. But that's too slow. The people
• 2:04:21
  Speaker 1: dying one hundred and fifty thousand a day on this planet,
• 2:04:23
  Speaker 1: it's terrible. So I would love to have the resources,
• 2:04:27
  Speaker 1: you know, like Jeff Bezos and others. Yeah, my company,
• 2:04:31
  Speaker 1: by the way, even though we lead the pack of
• 2:04:32
  Speaker 1: all these guys, we're really small. We're a pretty small
• 2:04:36
  Speaker 1: little outfit in Boston. We've raised a lot less money,
• 2:04:41
  Speaker 1: but we're because I think we're focused. We have and
• 2:04:44
  Speaker 1: we started earlier. We're doing pretty well.
• 2:04:46
  Speaker 2: That's the big one. You started earlier, you have a
• 2:04:48
  Speaker 2: lot of momentum on your side.
• 2:04:50
  Speaker 1: But I think we we could have a big impact
• 2:04:54
  Speaker 1: on aging in our lifetime with more money directed in
• 2:04:58
  Speaker 1: general at the field, not just me, but spread it.
• 2:05:01
  Speaker 1: And so the money that we raise from the magazine
• 2:05:03
  Speaker 1: is going to support other labs as well and students
• 2:05:08
  Speaker 1: who can find these medicines quicker.
• 2:05:10
  Speaker 2: So if you in a perfect world and you had
• 2:05:13
  Speaker 2: unlimited resources, you would just run a bunch of different
• 2:05:18
  Speaker 2: clinical trials and studies concurrently.
• 2:05:21
  Speaker 1: Yeah, AI is feeding us molecules. We put them into mice,
• 2:05:23
  Speaker 1: we go to monkeys, we go to humans, and it'll
• 2:05:25
  Speaker 1: just be fast. One of my friends, Alex Zachkarnkov, he
• 2:05:30
  Speaker 1: has a similar company, but not on exactly what we do,
• 2:05:34
  Speaker 1: not on reprogramming, but he's able to think he's on
• 2:05:37
  Speaker 1: his thirty fifth drug. But he's driven by AI and robots.
• 2:05:43
  Speaker 1: His whole lab is robots, at least he says they are,
• 2:05:46
  Speaker 1: and then goes into humans and his company's worth billions.
• 2:05:51
  Speaker 1: That approach applied to what we do would be incredible.
• 2:05:54
  Speaker 2: Hmm, that's best case scenario. That would be incredible. Well,
• 2:06:00
  Speaker 2: I'm hoping through this conversation that people are going to
• 2:06:03
  Speaker 2: reach out, and I'm hoping through this conversation that people realizing, like, oh, well,
• 2:06:07
  Speaker 2: so much work has been done and so many breakthroughs
• 2:06:11
  Speaker 2: have been made if they had more access to resources,
• 2:06:14
  Speaker 2: more access to different whatever you need, you know, and
• 2:06:18
  Speaker 2: that you could run all these different studies.
• 2:06:21
  Speaker 1: We could we were Our budget in my lab is
• 2:06:24
  Speaker 1: only it's almost three three and a bit millions, not much, right,
• 2:06:28
  Speaker 1: compared to what impact it could have on the planet,
• 2:06:30
  Speaker 1: which is trillions of dollars saved just in the US alone.
• 2:06:34
  Speaker 1: So it's a little bit of donation or getting a magazine,
• 2:06:39
  Speaker 1: the impact would be life changing for all of us.
• 2:06:43
  Speaker 1: Who doesn't age, who doesn't get.
• 2:06:44
  Speaker 2: Diseases, right, who doesn't want to feel better? Yeah, it's
• 2:06:48
  Speaker 2: also like so much you can get so much more
• 2:06:51
  Speaker 2: done if you feel better.
• 2:06:53
  Speaker 1: Well, we take it for granted until we feel sick,
• 2:06:56
  Speaker 1: and it's like, oh right, I forgot what it's like
• 2:06:57
  Speaker 1: to feel well.
• 2:06:58
  Speaker 2: Exactly exactly. I had a day a week and a
• 2:07:02
  Speaker 2: half ago where I came back from Italy. I was
• 2:07:06
  Speaker 2: a little jet lagged, I didn't sleep right, and I
• 2:07:09
  Speaker 2: worked out really hard a bunch of days in a row,
• 2:07:11
  Speaker 2: and I was working constantly, and then I had one
• 2:07:13
  Speaker 2: day I was like, I kind of feel like shit,
• 2:07:16
  Speaker 2: Like I better not do anything today, and I, you know,
• 2:07:20
  Speaker 2: after I was done work, I just watched TV and relaxed.
• 2:07:24
  Speaker 2: I went and I was like, I can't wait to
• 2:07:27
  Speaker 2: feel better again.
• 2:07:28
  Speaker 1: Well, imagine what it's like being old, yes, and frail.
• 2:07:31
  Speaker 1: That's every day or sick and right now you can't
• 2:07:34
  Speaker 1: do anything about it.
• 2:07:35
  Speaker 2: Yes, Yeah, And while you're healthy, you take it for granted,
• 2:07:40
  Speaker 2: and that's the real sin. Like you're like, ah, I'm fine,
• 2:07:44
  Speaker 2: I'm great. I mean, this is what people do when
• 2:07:46
  Speaker 2: they go out drinking, right, They take advantage of the
• 2:07:49
  Speaker 2: fact that it's worth it for a good time. Just
• 2:07:51
  Speaker 2: poison myself for a night.
• 2:07:53
  Speaker 1: Well, it's not worth it because that also accelerates aging
• 2:07:56
  Speaker 1: a big time. Right, is what I tell my kids
• 2:07:58
  Speaker 1: who like alcohol. Like my kids, you know, you might
• 2:08:02
  Speaker 1: feel better in a few days, but the memory of
• 2:08:04
  Speaker 1: that is going to be in your body.
• 2:08:06
  Speaker 2: Yeah, I think you can drink.
• 2:08:08
  Speaker 1: It's you know, it's fine to get drunk once in
• 2:08:09
  Speaker 1: a while, but not a lot, not constantly. I used
• 2:08:12
  Speaker 1: to drink once a day, and I do not do
• 2:08:14
  Speaker 1: that anymore because the date is incontrovertible that it affects
• 2:08:18
  Speaker 1: the brain, even the size of the brain, if you
• 2:08:20
  Speaker 1: drink constantly consisting.
• 2:08:21
  Speaker 2: I took eight months off of no alcohol at all,
• 2:08:24
  Speaker 2: and I felt a lot better.
• 2:08:25
  Speaker 1: Exactly.
• 2:08:26
  Speaker 2: I started drinking again one night. I went to dinner
• 2:08:28
  Speaker 2: with my wife and had a Margarite, and I was like,
• 2:08:30
  Speaker 2: I think I'm back.
• 2:08:32
  Speaker 1: Ah, really, well, so I drink now.
• 2:08:36
  Speaker 2: I do not get drunk. I haven't gotten drunk. This
• 2:08:38
  Speaker 2: was over a year ago. It was when I had
• 2:08:40
  Speaker 2: a drink again. I think I think it was a
• 2:08:42
  Speaker 2: year I'm not sure, but point is I have not
• 2:08:45
  Speaker 2: been drunk since then. I will have a glass of
• 2:08:48
  Speaker 2: wine with dinner, or I will have a like a
• 2:08:51
  Speaker 2: shot of whiskey before I go on stage, like a
• 2:08:54
  Speaker 2: little bit. But I do not get drunk anymore. It's
• 2:08:57
  Speaker 2: just not worth it the feeling after, or it's just
• 2:09:00
  Speaker 2: so terrible the morning, and especially for me because I
• 2:09:04
  Speaker 2: work out so much. When I wake up, it's like
• 2:09:06
  Speaker 2: that workout's gonna get done, okay, whether I feel like
• 2:09:09
  Speaker 2: shit or not, that workout is gonna get done. And
• 2:09:11
  Speaker 2: this is gonna be rough.
• 2:09:12
  Speaker 1: And then you got the sweats it's all right.
• 2:09:14
  Speaker 2: Versus when I feel great, I love the workout. I'm excited,
• 2:09:18
  Speaker 2: like I look forward to it, even when it's hard.
• 2:09:21
  Speaker 2: When it's over, I'm like, whoo, all right, let's see,
• 2:09:23
  Speaker 2: and I don't feel bad. I feel good, And it's like,
• 2:09:27
  Speaker 2: why am I giving up that for a few hours
• 2:09:30
  Speaker 2: of a You know, it's just not worth it. It's not
• 2:09:34
  Speaker 2: worth it.
• 2:09:34
  Speaker 1: Yeah, well, you're funny even without alcohol, but I'm not.
• 2:09:37
  Speaker 1: So I've lost a lot of my humor. But there's
• 2:09:41
  Speaker 1: nothing better than feeling great.
• 2:09:42
  Speaker 2: Right.
• 2:09:42
  Speaker 1: Yes, and you can make it your hobby of working
• 2:09:46
  Speaker 1: on your health and your longevity. You'll enjoy it. Yes,
• 2:09:50
  Speaker 1: it shouldn't be a chore.
• 2:09:51
  Speaker 2: It'll also directly affect the other things that you love
• 2:09:55
  Speaker 2: because you will have more energy your life. Energy, your
• 2:09:58
  Speaker 2: vitality is so important for anything you're doing, whether it's
• 2:10:02
  Speaker 2: a creative thing or an intellectual thing, like anything that
• 2:10:06
  Speaker 2: you're doing, if you have more energy, you'll be able
• 2:10:08
  Speaker 2: to apply more energy to that thing. It's that simple.
• 2:10:11
  Speaker 2: You're building a bigger gas tank for yourself. You're building
• 2:10:15
  Speaker 2: a larger engine, and that's what you're doing.
• 2:10:17
  Speaker 1: Exactly mentally, physically, you can do so much. When you
• 2:10:20
  Speaker 1: feel good, you jump out of bed. If you wake
• 2:10:22
  Speaker 1: up and you're tired, woozy, you know your eyes are puffy.
• 2:10:26
  Speaker 1: That's not how it should be when you wake up.
• 2:10:28
  Speaker 1: If you're getting and sleep is important for longevity. Of course,
• 2:10:31
  Speaker 1: if you're getting good deep sleep, then you should wake
• 2:10:34
  Speaker 1: up and you feel great.
• 2:10:35
  Speaker 2: Yes.
• 2:10:36
  Speaker 1: Yes, you don't even necessarily need a cup of coffee,
• 2:10:38
  Speaker 1: but it's not bad if you have one.
• 2:10:40
  Speaker 2: I like coffee. I'm not gonna stop drinking it now.
• 2:10:43
  Speaker 2: I'll give a fuck what anybody says.
• 2:10:44
  Speaker 1: Right, it's good.
• 2:10:45
  Speaker 2: And that's also like conflicting information. Some people say it's
• 2:10:48
  Speaker 2: good for you, there's benefits.
• 2:10:50
  Speaker 1: It's good for you. Come on, that's what I say. No,
• 2:10:52
  Speaker 1: it really is. Anyone that says it's not doesn't read
• 2:10:55
  Speaker 1: the well.
• 2:10:55
  Speaker 2: I would imagine. An over abundance of caffeine is not good.
• 2:11:01
  Speaker 2: Too much is not good. But that's true for everything.
• 2:11:03
  Speaker 2: Too much salt of killer, Yeah, exact pound of salt,
• 2:11:06
  Speaker 2: You'll be dead in an hour.
• 2:11:07
  Speaker 1: Right, you can get away with very little sleep, actually
• 2:11:09
  Speaker 1: as long as a deep sleep, because what it's doing
• 2:11:12
  Speaker 1: is clearing out the misfolded proteins in your brain and
• 2:11:15
  Speaker 1: the toxins. We know this the glymphatic system. And if
• 2:11:18
  Speaker 1: you get deep sleep for you know, an hour, you're
• 2:11:22
  Speaker 1: actually going to wake up much cleaner, healthier. And what
• 2:11:27
  Speaker 1: I've been able to do with some work is figure
• 2:11:30
  Speaker 1: out how to get deep sleep every night. Efficiency on
• 2:11:34
  Speaker 1: these rings that say but above ninety.
• 2:11:35
  Speaker 2: Sometimes I like you say rings because you're wearing two
• 2:11:38
  Speaker 2: Aura rings? Or okay, why do you wear two different rings?
• 2:11:48
  Speaker 1: Because when I've got to neither of them is correct.
• 2:11:51
  Speaker 1: Now that the truth is some of them, some of
• 2:11:55
  Speaker 1: them are really good for sleep. The others are good
• 2:11:57
  Speaker 1: for a heart. And so I've this one's my heart,
• 2:12:00
  Speaker 1: this is my sleep.
• 2:12:01
  Speaker 2: What is the difference in the companies? Which one's which?
• 2:12:04
  Speaker 1: Um uh, you don't mind me saying here they are
• 2:12:07
  Speaker 1: this is an aura that I want, right, And then
• 2:12:09
  Speaker 1: the thinner one is called ultra human.
• 2:12:11
  Speaker 2: Ultra human, and which one is good for what? Well?
• 2:12:14
  Speaker 1: I find aura really good for sleep, that's their specialty.
• 2:12:18
  Speaker 1: And then the heart for ultra human my cardiac age.
• 2:12:22
  Speaker 2: Okay, So it's just like giving you data all the time.
• 2:12:26
  Speaker 1: Yeah, and they're getting even better because they I don't
• 2:12:28
  Speaker 1: get paid by these companies, but I do like that
• 2:12:31
  Speaker 1: they pop up with AI information. Now have you noticed
• 2:12:34
  Speaker 1: that data? Da Or I noticed that you ate a
• 2:12:37
  Speaker 1: meal last night that spiked your glucose, you know? And
• 2:12:41
  Speaker 1: this one I have a monitor on right now so
• 2:12:43
  Speaker 1: I can see what's going on anyway. But yeah, they're becoming.
• 2:12:45
  Speaker 2: Like a fucking monitored bro. I am two rings and
• 2:12:49
  Speaker 2: a patch.
• 2:12:50
  Speaker 1: It's a it's a hobby. It's a hobby, but you
• 2:12:53
  Speaker 1: learn a lot. And I put one of these on
• 2:12:54
  Speaker 1: my son and he stopped eating bad food for a
• 2:12:57
  Speaker 1: long while.
• 2:12:58
  Speaker 2: Really, because he was just racking the impact of the boy.
• 2:13:01
  Speaker 1: It's good for kids now. I wouldn't say slap it
• 2:13:03
  Speaker 1: on a kid without pediatrician recommendation, But it was amazing
• 2:13:09
  Speaker 1: what happened when he could see the crap that was
• 2:13:11
  Speaker 1: going in his mouth was doing to his blood sugar. Really,
• 2:13:14
  Speaker 1: it was amazing. I think it's a great learning tool,
• 2:13:16
  Speaker 1: if nothing else.
• 2:13:18
  Speaker 2: Right, just to have actual data. I know a lot
• 2:13:20
  Speaker 2: of people it's changed their opinion on alcohol, particularly the
• 2:13:24
  Speaker 2: or ring when they look at their sleep, because even
• 2:13:27
  Speaker 2: just a couple of drinks before you go to bed,
• 2:13:29
  Speaker 2: like a couple of drinks at dinner, and then you realize, like,
• 2:13:33
  Speaker 2: oh god, my sleep was all fucked up because of
• 2:13:35
  Speaker 2: those drinks.
• 2:13:37
  Speaker 1: Yeah, lay off the medafinil too for me anyway.
• 2:13:40
  Speaker 2: Yeah, yeah, some medafinol fucks with your sleep as well.
• 2:13:43
  Speaker 1: Yeah. I have to work really hard to sleep. Well,
• 2:13:46
  Speaker 1: there's quiet time, there's relaxation, the lights are dimmed. I
• 2:13:51
  Speaker 1: think about a happy place rather than work. I had
• 2:13:55
  Speaker 1: to do that because for fifty years I was burning
• 2:13:56
  Speaker 1: the candle at all ends. I was really burnt out.
• 2:14:00
  Speaker 1: So I've fixed that now I don't worry.
• 2:14:02
  Speaker 2: So are you one of those guys that like dims
• 2:14:04
  Speaker 2: the lights in your house a couple hours before you
• 2:14:06
  Speaker 2: go to bed to prepare it? Stay off your phone? Yeah,
• 2:14:09
  Speaker 2: all that stuff.
• 2:14:10
  Speaker 1: Well, I don't say off my phone as much as
• 2:14:12
  Speaker 1: I want to.
• 2:14:13
  Speaker 2: But to wear red light glasses or anything like blockers
• 2:14:16
  Speaker 2: I used to.
• 2:14:17
  Speaker 1: I haven't found a big difference for myself. But interesting
• 2:14:21
  Speaker 1: fact that isn't well known if you block blue light
• 2:14:24
  Speaker 1: during the day or just stay indoors. There's a guy
• 2:14:27
  Speaker 1: in Japan who says that what happens is you get
• 2:14:31
  Speaker 1: short sightedness, and because the mice that lack the ability
• 2:14:37
  Speaker 1: to sense violet light get myopia short sighted and he's
• 2:14:41
  Speaker 1: got a device that indoors you can shiness. But our
• 2:14:44
  Speaker 1: modern world, the LEDs and being indoors means we barely
• 2:14:48
  Speaker 1: get violet light. And that would be that would be
• 2:14:50
  Speaker 1: so interesting if that's what's causing last half I have
• 2:14:53
  Speaker 1: to wear glasses.
• 2:14:54
  Speaker 2: Wow.
• 2:14:55
  Speaker 1: And he claims that people that live out in the
• 2:14:57
  Speaker 1: countryside that see blue light all the time because they
• 2:14:59
  Speaker 1: go out, don't have as much need for glasses.
• 2:15:02
  Speaker 2: That actually makes sense, well, particularly artificial light. And then
• 2:15:06
  Speaker 2: also light that's from a close source. Like one of
• 2:15:10
  Speaker 2: the things that if I do, if I'm tired and
• 2:15:14
  Speaker 2: I lay in bed and I try to read something
• 2:15:16
  Speaker 2: online on my phone, it hurts my eyes. The room's dark,
• 2:15:20
  Speaker 2: and it's like it irritates my eyes where it never
• 2:15:22
  Speaker 2: irritates my eyes normally, but it's like at the end
• 2:15:25
  Speaker 2: of the day, you know, I guess I'm more fatigued
• 2:15:28
  Speaker 2: and so.
• 2:15:28
  Speaker 1: Then and you're trying to focus on Yeah.
• 2:15:30
  Speaker 2: So like, now, think about that when people are doing
• 2:15:33
  Speaker 2: it all day long. Maybe you're doing it at work
• 2:15:34
  Speaker 2: where you have to start a computer monitor from three
• 2:15:37
  Speaker 2: feet away or closer, and then you're looking at your
• 2:15:40
  Speaker 2: phone all the time, where you're working from a tablet
• 2:15:42
  Speaker 2: or you're watching television. It's like you're constantly staring at
• 2:15:45
  Speaker 2: these light sources that are artificial.
• 2:15:48
  Speaker 1: Yeah, and also keep in mind that the muscles have
• 2:15:51
  Speaker 1: to focus. It's not naturally you don't naturally look this far.
• 2:15:54
  Speaker 1: Naturally you relax you see out there right to look here,
• 2:15:57
  Speaker 1: your muscles here have to be straining for hours and
• 2:16:00
  Speaker 1: they get very tired, and I guess eventually they age
• 2:16:03
  Speaker 1: to a point where you cannot keep it up. And
• 2:16:06
  Speaker 1: sometimes I do this to see better though, Well, it.
• 2:16:11
  Speaker 2: All makes sense if you think about it, particularly like
• 2:16:14
  Speaker 2: if your eyes are accustomed to only focusing on things
• 2:16:16
  Speaker 2: that are close. I mean, that was what they would
• 2:16:18
  Speaker 2: say about reading when people would have glasses, Oh, you
• 2:16:21
  Speaker 2: fucked up your vision reading, which I used to think
• 2:16:24
  Speaker 2: was nonsense, But I'm like, well, kind of makes sense
• 2:16:27
  Speaker 2: if you spend all day long focus even though it's
• 2:16:29
  Speaker 2: on a screen, You're spending all day long focusing on
• 2:16:31
  Speaker 2: a book that's only a foot from your face. Yeah,
• 2:16:34
  Speaker 2: it does make sense.
• 2:16:34
  Speaker 1: And the lens gets really inflexible, right, And I'm seeing
• 2:16:38
  Speaker 1: this with my father. He's otherwise in perfect health at
• 2:16:40
  Speaker 1: eighty seven, which is amazing, but it's his eyes that
• 2:16:43
  Speaker 1: are failing him.
• 2:16:44
  Speaker 2: Maybe should get him a red light bed.
• 2:16:46
  Speaker 1: That's a great idea. Yeah, I'm gonna do that. He's
• 2:16:49
  Speaker 1: arriving tonight actually from Sydney's.
• 2:16:52
  Speaker 2: He's get him a red light bed, man, because I'm
• 2:16:54
  Speaker 2: telling you, there's not a thing that I've done that's
• 2:16:57
  Speaker 2: impacted me in a more obvious way than that in
• 2:17:01
  Speaker 2: terms of like something that's hugely.
• 2:17:02
  Speaker 1: Yeah, I'm going to do it. And I mean he's
• 2:17:05
  Speaker 1: into science, he's been taking an Aman resveratrol mid foreman exercising.
• 2:17:10
  Speaker 1: He goes to the gym two or three times a
• 2:17:12
  Speaker 1: week six months. He's a role model at eighty seven,
• 2:17:16
  Speaker 1: with no diseases, no aches or pains, and he's struggling
• 2:17:19
  Speaker 1: in the world. He was in Japan two weeks ago. Wow,
• 2:17:22
  Speaker 1: coming to Boston.
• 2:17:23
  Speaker 2: That's so cool. I love hearing about people that are
• 2:17:27
  Speaker 2: older that just keep on top of it and stay
• 2:17:29
  Speaker 2: active and stay alive and enjoy life.
• 2:17:31
  Speaker 1: Yeah, exactly. He's a great role model. And what it
• 2:17:34
  Speaker 1: shows is he was an average guy till he was
• 2:17:36
  Speaker 1: in his sixties, and he figured he was going to
• 2:17:39
  Speaker 1: die in his seventies, probably because everyone in my family
• 2:17:41
  Speaker 1: dies young because we've got pretty bad jeans. But he's
• 2:17:44
  Speaker 1: just taken life by the horns and just is running
• 2:17:47
  Speaker 1: with it and has not physically aged except for his
• 2:17:51
  Speaker 1: eyes in the last twenty years. And that's not an exaggeration.
• 2:17:55
  Speaker 1: Anyone who's seen him knows. He walks, he moves, he travels,
• 2:17:58
  Speaker 1: he does everything he was when he was forty.
• 2:18:01
  Speaker 2: That's where things like resistance exercises are so important because
• 2:18:05
  Speaker 2: it maintains bone density, maintains muscle mass, maintains your ability
• 2:18:09
  Speaker 2: to just get around and do things.
• 2:18:11
  Speaker 1: That's the other reason to do that. I mean, you're
• 2:18:14
  Speaker 1: going to be really strong when you're older, and you
• 2:18:16
  Speaker 1: won't fall, and if you do fall, you'll bounce, you
• 2:18:18
  Speaker 1: won't break a bone. And he's like that. He's been
• 2:18:21
  Speaker 1: working out at the gym, mostly strength training, but balance
• 2:18:24
  Speaker 1: as well. It's very important to maintain balance. He's better
• 2:18:27
  Speaker 1: at the gym than me at eighty seven.
• 2:18:29
  Speaker 2: That's incredible.
• 2:18:29
  Speaker 1: That just shows how Yeah, I gotta go to the gym.
• 2:18:34
  Speaker 1: How about next time if you have me on, you're
• 2:18:37
  Speaker 1: going to be buff.
• 2:18:39
  Speaker 2: Do you get your trainer. You're in Massachusetts. There's a
• 2:18:41
  Speaker 2: ton of trainers out there.
• 2:18:42
  Speaker 1: Great, it's a deal.
• 2:18:45
  Speaker 2: We'll find you someone. We'll find you someone. Three days
• 2:18:47
  Speaker 2: a week, that's all you need. The other days you
• 2:18:49
  Speaker 2: could do stuff elective, do stuff that you want, you know,
• 2:18:54
  Speaker 2: but three days a week, get a personal trainer and
• 2:18:56
  Speaker 2: work out with them. Right, you're on all right?
• 2:19:00
  Speaker 1: You know when it's going or you help me. I
• 2:19:02
  Speaker 1: can hear though that. There's probably a few million people
• 2:19:05
  Speaker 1: right now screaming David. Just go to the lab. Forget
• 2:19:07
  Speaker 1: about the gym.
• 2:19:08
  Speaker 2: You need to help your stop work. It'll help everything.
• 2:19:11
  Speaker 2: It'll help the amount of research you're able to do.
• 2:19:13
  Speaker 2: You'll have more energy, you'll be more excited about things.
• 2:19:16
  Speaker 2: I'm sure you've seen those MRI cross sections of people's
• 2:19:19
  Speaker 2: tissue where they take like a seven year old man
• 2:19:22
  Speaker 2: who's sedentary versus seven year old man who's a marathon runner.
• 2:19:26
  Speaker 2: It's fucking extraordinary.
• 2:19:28
  Speaker 1: I've seen my own. There's there's too much fat in
• 2:19:31
  Speaker 1: the muscle. Got to get rid of it.
• 2:19:32
  Speaker 2: Yeah, yeah, it's really extraordinary. When you see those images
• 2:19:36
  Speaker 2: like those really bring it home.
• 2:19:37
  Speaker 1: And the bone changes bone, t's fat too parts of
• 2:19:41
  Speaker 1: the bone. So, yes, you got to have the strength
• 2:19:44
  Speaker 1: training for sure.
• 2:19:44
  Speaker 2: On Yeah, one hundred percent strength training is that's mandatory.
• 2:19:51
  Speaker 1: Yeah, and then do you do a lot of aerobic exercises? Yes? Good, Yeah,
• 2:19:54
  Speaker 1: I saw the training bike.
• 2:19:56
  Speaker 2: Oh yeah, well you saw my hypoxia machines. You just
• 2:19:59
  Speaker 2: got all today. Yeah. The hypoxia thing. What it does
• 2:20:06
  Speaker 2: is it replicates fourteen thousand feet above sea level and
• 2:20:10
  Speaker 2: you train in it. And it also has a heat element,
• 2:20:13
  Speaker 2: so you could ramp the heat up to one hundred
• 2:20:15
  Speaker 2: and fifteen degrees. So one hundred and fifteen degrees and
• 2:20:19
  Speaker 2: fourteen thousand feet about.
• 2:20:21
  Speaker 1: Kind of stuff.
• 2:20:21
  Speaker 2: Yeah, you're going to hell, that's what it is.
• 2:20:24
  Speaker 1: Straight to feel like it, but it shouldn't work right, Yeah,
• 2:20:28
  Speaker 1: POxy is great for muscle.
• 2:20:29
  Speaker 2: Yes, and for adaptation, that's the big thing. And my
• 2:20:32
  Speaker 2: friend Roman who installed it, who's owns one of the
• 2:20:35
  Speaker 2: guys from the company. It's a very they're very specific
• 2:20:39
  Speaker 2: with this protocol in terms of monitoring your heart rate,
• 2:20:42
  Speaker 2: when to do it, when to push, how much time
• 2:20:45
  Speaker 2: to spend, and how you do it. And it's very
• 2:20:47
  Speaker 2: scientific in terms of the application on athletes and that's
• 2:20:51
  Speaker 2: a My friend Adam Greentree turned me onto it, fellow Australian,
• 2:20:57
  Speaker 2: and he's a big hunter and does a lot of
• 2:21:01
  Speaker 2: mountain hunting and he said there's nothing he's ever done
• 2:21:04
  Speaker 2: that's had more of an impact on his cardio. So
• 2:21:06
  Speaker 2: it's been phenomenal.
• 2:21:07
  Speaker 1: Sounds wonderful. Actually, there's a lot of science behind that.
• 2:21:11
  Speaker 1: You probably know it. The best results are when people
• 2:21:16
  Speaker 1: are either having too much oxygen or not enough. And
• 2:21:20
  Speaker 1: you might say, well that's weird, why does it matter, Well,
• 2:21:23
  Speaker 1: you got to get out of the comfort zone. Hormesis
• 2:21:26
  Speaker 1: we keep talking about and there's a big study in
• 2:21:30
  Speaker 1: Israel where they put people in these hyperbaric chambers.
• 2:21:33
  Speaker 2: I've done that protocol. Yeah yeah, sixty sessions of ninety
• 2:21:37
  Speaker 2: minutes over ninety days. Yeah yeah, yeah, I.
• 2:21:40
  Speaker 1: Have one a loss, you do, yeah, because the data's incontrovertible,
• 2:21:44
  Speaker 1: better wound healing, better memory.
• 2:21:46
  Speaker 2: Increase in tell them your length.
• 2:21:47
  Speaker 1: Yeah, I saw that one. That's the Israel's study.
• 2:21:50
  Speaker 2: Yes.
• 2:21:51
  Speaker 1: What I thought was interesting was when I went over
• 2:21:53
  Speaker 1: there myself and sat in that thing. They made a
• 2:21:57
  Speaker 1: joke over there in Israel. By the way, they said,
• 2:21:59
  Speaker 1: this gas chamber here that were you going into, made
• 2:22:01
  Speaker 1: by Germans. I thought, that's not a funny joke. Don't
• 2:22:04
  Speaker 1: say that again. Anyway, I probably shouldn't have shared that.
• 2:22:08
  Speaker 1: I did go into the chamber, and what I found
• 2:22:12
  Speaker 1: out and was that they believe what I believe, which
• 2:22:14
  Speaker 1: is it's not so much the high pressure that's good
• 2:22:17
  Speaker 1: for you. It's the coming down that mimics hypoxia, which
• 2:22:21
  Speaker 1: your room will mimic. So the lack of oxygen, or
• 2:22:23
  Speaker 1: the perceived lack of oxygen from a high state is
• 2:22:26
  Speaker 1: the benefit. Interesting and that makes a lot of sense.
• 2:22:28
  Speaker 1: You're going to grow new blood vessels, just like biagra
• 2:22:32
  Speaker 1: is going to open things up. We actually had a
• 2:22:34
  Speaker 1: paper two thousand and twelve that found that one of
• 2:22:38
  Speaker 1: the supplements that I take, which everyone knows about, Niman,
• 2:22:42
  Speaker 1: could allow animals to grow new blood vessels by getting
• 2:22:47
  Speaker 1: rid of a protein that accumulates with aging. The bottom
• 2:22:50
  Speaker 1: line is we could mimic this lack of blood vessels
• 2:22:55
  Speaker 1: with this pill, but by exercising it's the same. What
• 2:23:00
  Speaker 1: I really believe is barely talked about in the medical
• 2:23:04
  Speaker 1: establishment is that a major reason we get sick when
• 2:23:06
  Speaker 1: we get older is lack of blood flow. It's really
• 2:23:10
  Speaker 1: talked about, right, Vascular dementia second largest cause of dementia
• 2:23:14
  Speaker 1: in the world. Blood flow, and it's the easiest to reverse.
• 2:23:19
  Speaker 1: You just do exercise, or take one of these PD
• 2:23:23
  Speaker 1: five inhibitors viagra, or you take my stuff which is
• 2:23:26
  Speaker 1: an a man which we think also works.
• 2:23:28
  Speaker 2: Or all the above, which is probably the best approach.
• 2:23:31
  Speaker 1: I'm two out of three, hopefully soon three out of three.
• 2:23:36
  Speaker 1: But yeah, you know, to protect your brain, which is
• 2:23:39
  Speaker 1: the most important because you don't want to be old
• 2:23:40
  Speaker 1: and demented. That's worse than anything. Keep the blood flowing
• 2:23:44
  Speaker 1: in your body. Remember that blood flowing is important.
• 2:23:47
  Speaker 2: Yes, couldn't agree more. David, You're a treasure. I really
• 2:23:51
  Speaker 2: appreciate you. Thank you for being here.
• 2:23:53
  Speaker 1: You've been so kind, and thank you for getting the
• 2:23:55
  Speaker 1: word out here about the great science that's going on.
• 2:23:57
  Speaker 2: Oh my pleasure, dude. I'm so happy that someone like
• 2:24:00
  Speaker 2: you out there doing this. I mean, it's it's such
• 2:24:03
  Speaker 2: an enormous benefit to people that are listening to the
• 2:24:06
  Speaker 2: world and you're doing you're literally doing God's.
• 2:24:09
  Speaker 1: Work, and we'll try to do more.
• 2:24:10
  Speaker 2: Thank you very much. Lifespan dot com is the website.
• 2:24:15
  Speaker 2: Please folks, if you're you're so inclined, go donate. It'll
• 2:24:19
  Speaker 2: really help will change the world. David, I'd love you
• 2:24:22
  Speaker 2: to thank you for letting