Micro 22: Mycobacterium and Related Acid-Fast Bacteria
This episode explores the genus Mycobacterium, defined by its distinctive acid-fast cell wall rich in mycolic acids. Drawing from Murray’s chapter, it examines how this lipid-heavy structure confers resistance to desiccation, disinfectants, and many antibiotics - while also shaping immune interaction.
The central organism is Mycobacterium tuberculosis, with emphasis on airborne transmission, granuloma formation, latency, and reactivation. The episode traces the path from inhalation to alveolar macrophage infection, through cell-mediated immune containment and the formation of caseating…
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