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This Moment in Medicine: First-Line ADCs in Metastatic TNBC with Dr. Senthil Damodaran

Are antibody-drug conjugates becoming the new first-line standard for metastatic triple-negative breast cancer?

At This Moment in Medicine, hosted by Community Health Media, Dr. Senthil Damodaran reviews the latest data moving ADCs earlier in the treatment landscape for metastatic TNBC.

The presentation focuses on TROPION-Breast02, ASCENT-03, and ASCENT-04, comparing datopotamab deruxtecan (Dato-DXd) and sacituzumab govitecan with chemotherapy, with or without pembrolizumab depending on PD-L1 status. Dr. Damodaran also examines efficacy, toxicity, sequencing, and the practical tradeoffs that…

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