871-scFOCAL: Drug Sensitivity Across tumor Cell States

Paper Talk · Apr 29, 2026 · 15m

This paper introduces scFOCAL, a new computational framework designed to overcome intratumor heterogeneity in glioblastoma by predicting how specific cell populations respond to medication. By integrating single-cell RNA sequencing with large-scale drug response datasets, researchers can identify which tumor cells are sensitive or resistant to various therapies in silico. The study demonstrates the platform's accuracy by predicting that alisertib treatment leads to a shift from neural-progenitor-like states to resistant mesenchymal-like states, a finding confirmed through in vivo xenograft…