274-AGE-Induced Viscoelasticity Drives HCC via TNS1

Paper Talk · Nov 28, 2025 · 14m

The aper presents research demonstrating that changes in the extracellular matrix (ECM) viscoelasticity, specifically caused by Advanced Glycation End-products (AGEs), promote the progression of liver cancer (hepatocellular carcinoma or HCC) in pre-cirrhotic conditions, independent of matrix stiffness. The accumulation of AGEs, a characteristic of Type 2 diabetes mellitus (T2DM) and non-alcoholic steatohepatitis (NASH), modifies collagen architecture, enhancing the liver's viscoelastic properties by promoting faster stress relaxation. Mechanistically, this high viscoelasticity activates a…