Latest / Pediatrics Now: Cases Updates and Discussions for the Busy Pediatric Practitioner / Understanding Autism: Key Insights from DSM-5 to Intervention Strategies
Transcript
- 0:00Music.
- 0:09Let's listen in. Goals for today's presentation are to help understand the DSM-5
- 0:16diagnostic criteria for ASD or autism spectrum disorder,
- 0:20differentiate the autism spectrum disorder from some of the neurodevelopmental
- 0:25disorders and the social communication disorders,
- 0:28look at some of the common commodities, how there is like an overlap of symptoms,
- 0:32and then we'll also briefly review the evidence-based behavioral and pharmacological interventions.
- 0:40Right so autism spectrum disorder
- 0:43as probably most of your aware is a neurodevelopmental disorder
- 0:47that impacts people interact
- 0:50with other person social communication
- 0:53their learning and their behavior now it is a developmental disc it is described
- 0:58as a developmental disorder however it can be diagnosed at any age it is described
- 1:04as a developmental disorder because the symptoms generally appear in the first
- 1:08few years of life are noted or recognized in there.
- 1:13A little bit about the prevalence in epidemiology. As per the 2023 data from
- 1:19CDC, 1 in 31 children aged 8 have been diagnosed with autism spectrum disorder.
- 1:26Globally, the prevalence in 2021 was around 1%, although it is still increasing
- 1:34with better evidence and improving access to cares.
- 1:37It is more commonly diagnosed in males compared to females, and it's about like
- 1:42four is to one ratio, three to four is to one ratio, depending on which study you look at.
- 1:46The average age of diagnosis is about four years, although the symptoms and
- 1:52signs are recognized even earlier.
- 1:56Now, what causes autism? It appears to be a combination of several genetic and
- 2:01environmental factors.
- 2:03There definitely appears to be a very strong genetic predisposition.
- 2:07The current heritability estimate for autism spectrum disorder is about 0.83,
- 2:13which indicates it's a very strong genetic component.
- 2:17Some of the environmental factors that's associated with higher risk of autism
- 2:22include like prenatal exposures to toxins, drugs, infections,
- 2:27and even some prescription medications.
- 2:30Increased parental age is another risk factor. There is also some association
- 2:34between untreated and undertreated mental illness during pregnancy and autism in the offsprings.
- 2:40One thing that needs to be emphasized, because there is a very strong myth out
- 2:45there, is that there is no evidence to suggest any association between vaccines and autism.
- 2:52Several large studies done in multiple countries have confirmed the same.
- 2:57So this is a myth that needs to be broken.
- 3:01And talking about myths, there are several common myths about autism.
- 3:05We already spoke about the vaccines.
- 3:08Now, there's another myth that autism is only a childhood condition.
- 3:12Adults do not have autism. That's not true. Once diagnosed with autism,
- 3:15they have autism for life.
- 3:17It cannot be cured. So far with the current treatments and the interventions,
- 3:21we do not have a cure for autism. We can only manage the symptoms with behavioral
- 3:26and pharmacological interventions.
- 3:29Some people learn coping skills and mask their symptoms, but it cannot be completely cured.
- 3:35Not all autistic people have a special talent, or not all autistic people have
- 3:41learning disabilities.
- 3:43Autistic people are antisocial. This is another common myth.
- 3:47The difference between people who have autism and antisocial personality disorder is that in autism,
- 3:54they have in the individual has a deficit
- 3:58in understanding the social norms of
- 4:00the social rules whereas an and whereas an
- 4:03antisocial person they understand the rules but they just disregard they don't
- 4:08care for the rules only boys are artistic again it is seen across all genders
- 4:14it's just that boys or males are more diagnosed with autism and it is not caused by bad parenting,
- 4:22Now, the good parental support, kids or individuals can develop better coping
- 4:28skills, masking skills, but just autism is not the outcome of bad parenting.
- 4:34Now, before we jump into the diagnostic criteria, I would like to emphasize
- 4:39that autism is a spectrum disorder.
- 4:42If you've met one person with autism, you've only met one person with autism
- 4:46because they're like, each individual is like highly unique and they exhibit
- 4:50different challenges and abilities.
- 4:52This course is to highlight the importance of recognizing the diversity within
- 4:58the autism community and avoiding generalizations.
- 5:02Now, coming to the DSM-5 diagnostic criteria, which guides us in the diagnosis
- 5:07of ASD, the essential features of ASD are broadly organized into two sections.
- 5:12Part A, or criteria A, which discusses about the deficits in social communication and interaction.
- 5:20And then that criteria B, which discusses about the restricted repetitive patterns
- 5:24of behaviors, interests, or activities.
- 5:28Now, for someone to be diagnosed with autism,
- 5:32They need to demonstrate the deficits or issues in all the three areas that's
- 5:37shown here, which is the social-emotional reciprocity, nonverbal communicative
- 5:43behaviors, developing, maintaining, and understanding relationships.
- 5:46What does that mean? We will look at them individually.
- 5:49So social-emotional reciprocity, it can be described as the ability to engage
- 5:55with others and share thoughts and feelings.
- 5:59Now when someone has deficits in social emotional reciprocity and it it varies
- 6:05according to the age in young children it can manifest as like little or no
- 6:09showing no initiation of social interactions,
- 6:11no sharing of emotions they would probably like have a hard time approaching
- 6:15peers on the playground they are interested but they can they do not know how
- 6:19to approach they typically wait for others to approach and sometimes it can
- 6:23be as severe as even if someone else approaches,
- 6:25they just ignore them.
- 6:29Now, in older kids and adults without intellectual disability or language deficits,
- 6:34it can manifest as difficulties processing and responding to complex social
- 6:39cues, like how to join a conversation, when to join, what to say, what not to say.
- 6:45Also, some individuals have deficits in understanding jokes or sargasm.
- 6:51They have a hard time understanding, and they take the very concrete content
- 6:54of what is said instead of applying to the situation.
- 6:59They have difficulty with conversing with peers on a general basis.
- 7:04And this is not exclusively with peers. It can also be with family members.
- 7:09Some individuals who have developed compensation strategies for some of the
- 7:13social challenges, they still struggle when they're in a novel or a new or unsupported situation.
- 7:21And they can struggle with anxiety when that happens.
- 7:26The second part, the nonverbal communicative behaviors, deficits in this can
- 7:31manifest as a typical use of eye contact, gestures, body language, speech and intonation.
- 7:39An early feature which depicts this of autism, how this manifests is like impaired joint attention.
- 7:48They typically do not point to things that they are interested in or they do
- 7:52not share their interest.
- 7:53They have a hard time following
- 7:56someone's pointing or eye gaze they often
- 7:59fail to use expressive gestures spontaneously in communication among
- 8:03young people and adults with fluid language where there is no deficits the difficulty
- 8:08in coordinating non-verbal communication can be seen as like odd or like wooded
- 8:14or exaggerated body language not only do they have issues with showing appropriate
- 8:21body language, they also can represent,
- 8:23misrepresent, or misinterpret other's facial expressions or their body language.
- 8:30And the third component of the social communication, developing,
- 8:36maintaining, and understanding relationships.
- 8:38This can manifest as absent, reduced, or atypical social interest.
- 8:42It can manifest as light rejection by others A passivity or inappropriate approaches
- 8:47that seem aggressive or disruptive,
- 8:50In young children, there is often lack of social play, an imagination Older
- 8:56individuals, they must struggle to understand what behavior is considered appropriate
- 8:59in one situation but not to the other,
- 9:02Frequently, there is a desire to establish friendships Without a complete or
- 9:07realistic idea of what friendship entails,
- 9:10Again, when considering all these social communication areas,
- 9:14we need to consider what is the norm for the age, gender, and the culture.
- 9:21Moving on to criteria B, so the criteria A is the social deficits,
- 9:26and then the criteria B is the restricted repetitive patterns of behaviors,
- 9:30interests, or activities.
- 9:32Here, out of the four, you only need to meet the criteria at least for two of them.
- 9:37Some of the features are stereotype repetitive movements or speech,
- 9:43insistence on sameness, inflexible adherence to routines or rigidity,
- 9:47highly restricted fixated interests and then the sensory issues which could
- 9:52be like hyper or hyper reactivity to sensory input,
- 9:55now what does stereotype repetitive movements or speech look like it can be
- 9:59like a simple more water stereotypy like hand flapping finger flicking or like rocking movements,
- 10:08and what we usually call stemming repetitive use of objects like spinning coins
- 10:14lining up toys by color that can be another one Repetitive speech can present as echolalia,
- 10:21parroting of words, stereotype use of certain words or phrases that they see on TV.
- 10:30Individuals with limited language
- 10:33skills, it can present as high-pitched screeches or animal noises.
- 10:38Then the rigidity or the inflexible entrance to routines and insistence on sameness,
- 10:43this can manifest as resistance
- 10:46to change there is like distress at
- 10:50like very small changes also like for
- 10:53example eating a different breakfast or like going to
- 10:56taking an alternative route to school or work they need
- 11:00to adhere to those strict strictly there is
- 11:03also rigidity in thinking they might need
- 11:06to wear the same clothes every
- 11:09day or they might need the same breakfast or same color
- 11:12things every day there is ritualized
- 11:15patterns of verbal and non-verbal behavior like repetitive questioning or like
- 11:20pacing a perimeter that also is kind of like um inflexible at translate routine
- 11:25highly restricted and fixated interests here the emphasis is on the abnormal intensity.
- 11:35The focus of the interests. And it also can be a typical one,
- 11:40what is not normal for their age.
- 11:43Now, as we know, in toddler age or sometimes even in school age,
- 11:47kids have fixation on certain objects, what we describe as transitional objects.
- 11:50The way to kind of differentiate them is that transitional objects offer comfort
- 11:56and security while hyperfixations are intense and take a lot of the individual's
- 12:01time and get in the way of their social interactions.
- 12:05Okay and then the other common presentation is
- 12:09sensory issues they can either be hypersensitive to sensory input like very
- 12:15sensitive to loud noises certain textures foods or it could be hyper reactivity
- 12:22meaning like they have high very high point tolerance so you might see someone who
- 12:27comes to the emergency room or to your office with like a big injury to the
- 12:31head they don't care about it.
- 12:33You might be anxious or scared about it, but they don't really care about it.
- 12:36Their pain tolerance can be high.
- 12:38Now, not everyone is the same, but they can either be hyper or hyper.
- 12:43Again, because of the sensory issues, we have a lot of challenges they can have
- 12:47because of, let's say, they're having sensitivity to food textures,
- 12:51then it can also lead to feeding disorders.
- 12:55So among the criteria B, again, you only need two out of the four to meet the
- 12:59criteria for autism spectrum.
- 13:02Of the additional requirements the symptoms need to be present in early developmental
- 13:06period but they may not become fully manifested until the social demands exceed limited capabilities,
- 13:13or may be biased by learned strategies the symptoms should cause clinically
- 13:18significant impairment in functioning either in social occupational or other
- 13:22areas the disturbances are not better explained by just idd or global developmental
- 13:28delay now idd and autism they can frequently co-occur,
- 13:33but to make a comorbid diagnosis of ASD and IDD,
- 13:36the social communication should be way below that expected for the general developmental level.
- 13:42And then, according to the DSFI, one of the specifiers is the level of support.
- 13:49So if you see level one, level two, level three, that basically indicates the
- 13:54level of support that they need.
- 13:56Previously, it used to be called high functioning
- 13:59autism or low functioning autism but those
- 14:03are outdated and they're somewhat like dangerous
- 14:06because it doesn't truly depict the
- 14:09strengths and the challenges of an individual so
- 14:13instead of that the better way to kind of describe it is the level of support
- 14:18that they would need level one being like the minimal support that they would
- 14:21need and level three being the highest level of support they would need for
- 14:25example in level one they might just need some therapy individual therapy or
- 14:29life skills coaching because they don't,
- 14:32their deficits are very subtle or the stress is like not as intense,
- 14:39when they're during transitions level two they require substantial support let's
- 14:44say because of their atypical social behaviors or like excessive interest in
- 14:49the specific topics or the distress is like much more noticeable when faced with the change,
- 14:55This level would be like the accommodations that we talk in school,
- 14:59like help with their reading, their social skills support. They might need social skills training.
- 15:05Level three, requiring very substantial support.
- 15:08That means these individuals have severe problems with communication or severe stemming behaviors.
- 15:16The distress is too extreme when asked to switch tasks or with transitioning.
- 15:23These individuals with level three they might need one-on-one
- 15:26aids and for communications
- 15:29they might need aac tools like augmentative
- 15:33and alternative tools picture symbols or like electronic devices to communicate
- 15:37so now we looked at the diagnostic criteria based on dsm-5 now let's say when
- 15:45should we screen and how do we diagnose autism so the screening tools more than me.
- 15:52Pediatricians in the group can definitely are more familiar with that.
- 15:55I'm familiar with the MCHAT and the ASQs, but not with the other screening tools.
- 15:58The American Academy of Pediatrics suggests that autism screening should be
- 16:02a part of standard 18 and 24-month well visits.
- 16:07And the National Center on Birth Defects and Developmental Disabilities recommends
- 16:11that all children should be screened at ages 9, 18, 24, and 30.
- 16:16The MCHAT, which is the one that's
- 16:18frequently used is basically a modified checklist for autism in toddlers.
- 16:23It's a specific screening tool for autism recommended by the AAB that should
- 16:27be administered around 18 and 24 months.
- 16:30It consists about 20 questions about the child behavior, and then the results
- 16:36will let one know if they need a further evaluation for autism.
- 16:40The ASQs, on the other hand, they're not specifically designed for like autism
- 16:45screening but they can be used to identify children who may require further
- 16:49evaluation by especially if their communication domain score is like below the cutoff.
- 16:55Once the screening is done, then you can either administer the diagnostic tools
- 17:00or refer them to a psychologist or people who are trained to administer the diagnostic tools.
- 17:07The CARS and the GARS, those are the Childhood Autism Rating Scale and the Gilliam Autism Rating Scale.
- 17:12They don't need very specific training to administer them.
- 17:17It usually takes input from the teachers or for the parents in the first and
- 17:21then some of the other caregivers or teachers.
- 17:25And they can kind of indicate the possibility of autism spectrum.
- 17:33It was the autism diagnostic observation schedule that is kind of the gold standard
- 17:37for collecting objective information about social communication.
- 17:42And however, one of the major limitations is that it is more time consuming
- 17:47and it requires specialized training to administer the test.
- 17:52However, it has strong psychometric support and is widely used in clinical settings.
- 17:56Often times insurance companies want the diagnosis to be made using an ADOS
- 18:01so that they can approve those services like the AV therapy.
- 18:07It's important to diagnose or catch the diagnosis of autism at an early age
- 18:12because there are several benefits.
- 18:15At an individual level, because of the brain plasticity in early childhood,
- 18:23if there is early intervention, there is enhanced better outcomes with cognitive,
- 18:29language, and social-emotional functioning.
- 18:32This can reduce the child's frustration and also enhance the quality of life.
- 18:37It reduces the risk for developing psychiatric comorbidities like anxiety and
- 18:42depression later on in life.
- 18:43At a family level, it provides them with the support, with the knowledge at
- 18:50an early time, which can kind of help them facilitate better coping mechanisms with the kids.
- 18:57And it also reduces parental stress, has improved better family outcomes.
- 19:03And from a society or the community point of view,
- 19:07it definitely has some significant long-term cost savings because there is reduced
- 19:12need for intensive interventions like crisis interventions in patient psychiatric hospitalizations.
- 19:19There is also better social outcomes when we intervene early and because of
- 19:25that, they are easily integrated into the society and have greater independence in adulthood.
- 19:31All right. Now, while there are benefits, there are also some dangers of early diagnosis.
- 19:36However, I believe the benefits definitely outweigh the risks.
- 19:41Some of the potential risks are like there is a danger for being labeled and
- 19:46stigmatization, which can again impact the self-esteem of the individual.
- 19:51There is a risk for over diagnosis or misdiagnosis although it can provoke anxiety
- 19:57and high stress level in parents again the risks of that are like the benefits
- 20:03of that outweigh the risks because,
- 20:05with early intervention later on the stress levels and anxiety can be better.
- 20:11What are some of the challenges with making the diagnosis? We have the definitive diagnostic criteria.
- 20:16We have several diagnostic tables. What are the challenges or barriers for making a diagnosis?
- 20:22One, as you already probably understand, we have to rely on the parent report a lot.
- 20:29And if the parents have their own biases or if they are not cognizant or not
- 20:32too aware of recognizing some of the subtle symptoms, it can be challenging.
- 20:38They may not bring the it for like evaluations or even when they bring in for
- 20:44the evaluations their report could be biased or not sufficient now the individuals
- 20:52themselves or the patients they themselves can have like,
- 20:55not much insight into the symptoms so
- 20:59they might not be able to convey the information appropriately now
- 21:03with our reducing times appointment times we are only seeing like a snapshot
- 21:09of the system or like of the individual so that we don't know what are some
- 21:13of the struggles they're experiencing in school or in like other areas unless it's like severe.
- 21:21Presence of like other neurodevelopmental disorders like
- 21:24adhd language delays speech delays
- 21:27or idd they can kind of impact
- 21:31our ability to diagnose accurately and
- 21:35sometimes during the short visits that they are brought in
- 21:38the individuals can like mask the symptoms for
- 21:41a while some of the differential diagnosis again
- 21:44idd it can exist it
- 21:47can be diagnosed along with autism spectrum disorder speech delays language
- 21:52disorders that's another area social pragmatic communication disorder or spcd
- 21:58this is something that has been introduced in the dsm-5 in a minute we'll look
- 22:02at how to differentiate between ASD and social pragmatic communication disorder,
- 22:07social anxiety, and ADHD.
- 22:10Now, ADHD is highly comorbid with autism spectrum disorder, almost like one in two kids.
- 22:16So one in two or three kids. So it's about like 30 to 50% overlap in the symptoms.
- 22:24There's a lot of overlap of the symptoms between ADHD and autism spectrum.
- 22:28Let's say there is a kid who has short attention span or they have impulsive
- 22:34behaviors or because of their hyperactivity, they are not able to sustain a
- 22:40conversation with an individual.
- 22:41This can be perceived as poor social communication.
- 22:45Also, because of their impulsivity, they might not be disliked and might have
- 22:50problems with making relationships or friendships with other individuals.
- 22:55And so this can be mistaken for autism spectrum. And there is a high overlap
- 22:59between the two, in any ways.
- 23:02So one of the things that can be done is probably treat the ADHD first and then
- 23:06evaluate if there is a suspicion for both of them.
- 23:09What is social pragmatic communication disorder and how is it different from autism spectrum.
- 23:15Superficially social pragmatic communication disorder is
- 23:18asd minus the restricted and derivative behavior so if they meet the criteria
- 23:24remember the criteria a part a criteria for making asd diagnosis if they only
- 23:30have that not the criteria b then it's basically social pragmatic communication disorder,
- 23:36they would benefit from social skills training.
- 23:39Now, autism and social anxiety disorder, sometimes social anxiety disorder can be perceived as autism.
- 23:45In autism, there is a difficulty in understanding the social norms regardless
- 23:49of the judgment, whereas in social anxiety, there is a fear of social judgment.
- 23:54Now, individuals with autism can still develop
- 23:57social anxiety when social anxiety when it's social anxiety just by itself there
- 24:03is preserved social skills like in asd autism ocd they also have an overlap
- 24:09of symptoms so it's important to differentiate when it is ocd and when it is
- 24:14the serial stereotypical behaviors from,
- 24:17autism in ocd there is like intrusive thoughts and the rituals are like driven
- 24:22by anxiety there is a lot of anxiety.
- 24:25Whereas in ASD, the stereotypical behaviors or repetitive behaviors are just
- 24:29comfort seeking. They're not driven by anxiety.
- 24:33Again, this is a picture or table depicting the common comorbidities in ASD.
- 24:39As we can see, this is only from one study, so I would take it with a grain of salt.
- 24:44If you look at it, there is a very high comorbidity with ADHD, almost like 50% plus.
- 24:50Then there is like anxiety spectrum disorders, whether it's generalized anxiety.
- 24:54I'm surprised that's only 2.4%, but there's like very high specific phobia and social phobia.
- 25:00Then there's mood disorders. I hear only MDD is shown in the picture, which is about 20%.
- 25:07And then there is OCD, which is about like 40%, if you consider the subsyndromal symptoms.
- 25:13They did not show like, again, schizophrenia. I highly doubt it.
- 25:17Still seen in kids or individuals with autism spectrum still have schizophrenia.
- 25:22Now, as we discussed earlier, you know, because of the sensory and the texture
- 25:26issues, individuals who have autism spectrum are at a very high risk for feeding disorders.
- 25:33One in three, or I'm sorry, one in three out of four kids who have autism spectrum
- 25:38disorder have problems related to eating, and they can manifest as either pica
- 25:42or rumination disorder, ARFID, which is the avoidant and restrictive food intake disorder.
- 25:48PICA and ARFID are the ones that are most commonly seen.
- 25:51And then rumination disorder and then anorexia, bulimia, they're seen less frequently.
- 25:58Another picture basically showing the high comorbidity with intellectual disability,
- 26:03ADHD, and some of the associated features.
- 26:07Anxiety, problems with mood, sleep issues, that's a big thing.
- 26:12Again, GI issues because of sensory issues, that is another big thing.
- 26:17Seizures is also very highly, about one-third of the individuals with autism
- 26:21spectrum can have seizure disorders.
- 26:23Now how do we manage
- 26:26autism so this is a very important
- 26:30part again it needs a team effort
- 26:33pediatricians behavioral therapists
- 26:37speech-language pathologists occupational therapists psychiatrists
- 26:41child psychiatrists psychologists school counselors
- 26:45all everybody plays an important part
- 26:48along with parents of course during management of
- 26:51autisms oftentimes you need to make several referrals
- 26:54including for like if for its diagnostic purposes neuropsychology
- 26:58or autism diagnostic evaluations for speech
- 27:02delays they need speech therapy for sensory issues occupational therapy or feeding
- 27:07therapy behavioral therapy for like aba dir or teach again they need They probably
- 27:14need like several accommodations in school and support and advocacy is a very important part.
- 27:21I know there were some questions about support and advocacy and I'll answer when we get to the end.
- 27:29The different types of behavioral therapy available for autism aba that's kind
- 27:34of like the most known and the gold standard it's most approved by insurance companies also,
- 27:39it's basically breaking down the skills into manageable parts and it uses positive
- 27:43reinforcement to get the desired behaviors it is you need a trained bcba for investing aba,
- 27:52or like at least a registered behavioral technician and it's delivered for about
- 27:5720 to 40 hours for it to be most of per week for it to be most effective the
- 28:02dir or floor time as it's known,
- 28:05this basically involves one to get on
- 28:08the floor with the child to play and do the activities they like it's meant
- 28:11to support emotional and intellectual growth by helping them learn skills
- 28:14around communication and emotions another therapy
- 28:19is teach which is treatment and education of autistic and related communication
- 28:22handicapped children this was developed at unc this treatment uses visual cues
- 28:27just picture cards to help your help one's child to learn everyday skills like
- 28:32getting dressed information is broken down into small steps so they can learn it more easily,
- 28:38then there's another one called the pecs the picture exchange communication
- 28:41system this is another visual based one it uses symbols and stop picture cards
- 28:45and the child learns to ask questions and communicate through special symbols
- 28:50again of all the behavioral therapies aba seems to be the most evidence-based and goal standard.
- 28:58Occupational therapy can be helpful for sensory integration,
- 29:01improving fine motor skills and daily living skills.
- 29:04Social skills training is more useful for older children and adolescents.
- 29:09In this, there's role-playing, peer interaction, and it can be both individual as well as group.
- 29:16Pharmacotherapy, this is basically where we as child psychiatrists come.
- 29:20Of course, we also play a role in care coordination, but most of the times the
- 29:25kids are referred to us for medications.
- 29:29Now, there is only two FDA-approved medications for management of symptoms in ASD.
- 29:34One's risperidone from the ages of 5 plus is for irritability and aggression,
- 29:39and eryproprazole Abilify, age 6 plus, again approved for irritability.
- 29:45Now because these medications are approved for FDA, these are not the only medications.
- 29:49We use several other second generation antipsychotics off-label.
- 29:53Most important thing when using these medications is to monitor for the metabolic
- 29:57side effects and extrapyramidal side effects.
- 30:00Especially with Iroproposol Abilify, you can see like a paradoxical reaction
- 30:04like increased aggression and irritability.
- 30:07That's probably especially in the individuals who are non-verbal they can experience
- 30:13akathisia but they do not know how to express and then that comes out as irritability and aggression.
- 30:20So monitoring for like EPS is very important now there are like several medications
- 30:25we use off-label if there is autism with like comorbid ADHD we use stimulants
- 30:31as still as the first line medication we just need to monitor for like any increased
- 30:35aggression alpha-agnes like guanfacine and clonidine are used.
- 30:39Whenever we're using medications, we need to make sure that we start at low
- 30:44doses and titrate them very gradually.
- 30:49And for managing autism and anxiety, we still use SSRIs like fluoxetines or loft.
- 30:57Just we need to make sure we're monitoring. We need to monitor for activation side effects.
- 31:03Autism and OCD, again, SSRIs. higher doses are not often required but still
- 31:08behavioral therapy which is exposure and response prevention adapted for asd
- 31:12it's it is the main state of treatment,
- 31:17Again, for sleep, melatonin, clonidine, we have several other medications that
- 31:22we use, but the most commonly used ones are melatonin, clonidine, and hydroxine.
- 31:29Again, each individual is very different, and so we have to adjust the medications accordingly.
- 31:40I think we have time to go over a case. Okay, yeah, I think we can go over a
- 31:46case. This is a case example.
- 31:48This is a 12-year-old boy who presented with temper tantrums.
- 31:51He was brought in by his mother for psychiatric evaluation of temper tantrums
- 31:55after being referred by the school.
- 31:56There was also some declining school performance.
- 32:00Shortly after starting middle school, Brandon started complaining of stomachaches
- 32:04on a school day morning and was often reluctant to go to school.
- 32:08After reading till here, my first thought would be social anxiety,
- 32:13which is still the case. I would suspect school refusal with social anxiety
- 32:17or some possible bullying.
- 32:19Those would be my different shoots.
- 32:22Brandon's sixth grade teachers reported that he was academically capable.
- 32:26So it's not in learning disability mostly, but he had a hard time making,
- 32:32he had little ability to make friends.
- 32:35Okay, so there are some social concerns here. He seemed to mistrust the intentions
- 32:39of classmates who tried to be nice to him, but attempted to befriend others
- 32:43who laughingly feigned interest in toy cars and trucks that he brought to school.
- 32:49So the statement indicates two features, which is basically,
- 32:53you know, he has a hard time reading others, misinterpreting others' intentions.
- 33:01So there is some problems with social
- 33:04communication, and he also seemed an interest in toy cars and trucks.
- 33:10If it was an elementary school kid, that's a little different for someone to
- 33:13be excessively interested in cars and toys in a middle school. It's slightly typical.
- 33:18When interviewed alone, Brandon responded with non-spontaneous mumbles.
- 33:22When asked questions about school, classmates and his family,
- 33:25when the examiner asked if he was interested in toy cars, Brandon lit up.
- 33:30He pulled several cars, trucks and airplanes from his backpack and while not
- 33:35making good eye contact.
- 33:37They've talked at length about vehicles using their apparently accurate names,
- 33:43front-head loader, V-52, Jaguar, etc.
- 33:46And then asked again about school, Brandon pulled out his cell phone and showed
- 33:49a string of text messages like, Dumbo, Mr.
- 33:52Stutter, Loser, Freak, Everybody Hates You.
- 33:55So now this raises the suspicion of problems with social communication and again,
- 34:01the increased interest or fixation on cars and trucks.
- 34:06Brandon added that other boys would whisper bad words to him in class and then
- 34:11scream in his ears in the hallway.
- 34:14And I hate loud noises. So some hypersensitivity to sounds.
- 34:20He also told the examiner that he sometimes wished that he had never been born.
- 34:24Now, that is a little concerning. We always have to pay attention to those. and evaluate further.
- 34:31Developmentally, Brandon spoke his first words at the age of 11 months and began
- 34:35to use short sentences by age three.
- 34:38So his speech language skills seemed to be appropriate at that age, at least.
- 34:43He had always been very focused on trucks, cars, and trains.
- 34:47According to his mother, he has always been very shy and never had a best friend.
- 34:52So somewhat thriving in isolation as he has gotten older it has become more
- 34:59apparent that he struggles with jokes and typical adolescent banter because
- 35:04he takes things so literally.
- 35:07He has issues with, this would be the part where they not only misinterpret.
- 35:14Brandon's mother had also seen this behavior as a little odd,
- 35:18but added that it was not much different from that of Brandon's father,
- 35:22a successful attorney who had similarly focused interests.
- 35:26Both of them were sticklers of routine, who lacked a sense of humor,
- 35:30because they probably don't understand humor, then the high rigidity.
- 35:35Brandon's mother noted that he had made efforts to conceal his interest in trucks,
- 35:38cars, and trains outside of the home But would eagerly speak about them when
- 35:42encouraged So there seems to be, he has learned masking behaviors and develops some coping skills,
- 35:49Brandon had shared with his mother that he tries to appear normal So he has
- 35:53some awareness that he is probably not typical when interacting with peers at
- 35:58school, which is exhausting,
- 36:00He often feels nervous around peers and generally tries to avoid socializing.
- 36:05On examination, Brandon was shy and generally not spontaneous.
- 36:09He made below-average eye contact. His speech was coherent and goal-directed.
- 36:14At times, Brandon stumbled over his words, paused excessively,
- 36:17and sometimes rapidly repeated words or parts of the words.
- 36:21So, probably some stuttering. Brandon said he felt okay but added that he was
- 36:27scared of school, particularly when around other children.
- 36:30He appeared sad, brightening only when discussing his toy cars.
- 36:34He denied current suicidal ideations or plans, as well as hovicidality.
- 36:39He denied psychotic symptoms. He was cognitively intact.
- 36:43Any thoughts? Okay, so basically, he would meet all the three criteria for social
- 36:53communication, deficits in social communication.
- 36:55He at least has two of the criteria for
- 36:59like the repetitive restricted interests and
- 37:02patterns of behavior so i think
- 37:05he would meet a diagnosis of autism spectrum disorder and
- 37:08in addition possibly no intellectual disability
- 37:11at least based on the information that we have here i would
- 37:15say he would probably be level two and would
- 37:18need some at least some accommodations in school at social skills training he
- 37:24i would say in addition to autism he probably also has stuttering disorder all
- 37:32right okay that's that's my case again,
- 37:37thank you everyone for all that you do i know you play a very important role
- 37:41in coordinating care for some individuals who have Autism Spectrum Disorder.
- 37:48I can take questions now,
- 37:53Dr. Badapati for that excellent talk. Looks like we do have a few questions in the chat.
- 37:58I can go ahead and read those off to you. Looks like we had one say,
- 38:03sometimes as patients grow up, the parents request retesting to see if autism label can be removed.
- 38:10Can the label be removed if patient is doing better with time?
- 38:14So again, if it is true, if they were rightly diagnosed as autism spectrum disorder,
- 38:22then it probably is not going away.
- 38:25It is possible that when they were diagnosed earlier, it could be a misdiagnosis.
- 38:30That can be a time when it can be helpful.
- 38:33And again, I understand the parent's concern that they don't want to label the
- 38:37child as autism spectrum.
- 38:39Again, if they are not needing any supports or services, then it probably need
- 38:46not be included in the chart.
- 38:48But at some point or the other, it might probably again come up.
- 38:52Thank you. And then another question read, can a patient with autism diagnosis
- 38:57also be diagnosed with mental retardation or diagnosis?
- 39:02Yes, definitely. So we don't use mental retardation anymore,
- 39:05but the intellectual developmental disability in the DSM-5, they can both coexist.
- 39:12However, if one has a diagnosis of intellectual disability disorder,
- 39:16as we discussed earlier, the social functioning should be lower.
- 39:21So, for example, let's say because of IDD, the kid's developmental level is at five.
- 39:26They could be 10, but the development level is at a five-year-old.
- 39:30The social communication issue should be below that of a five-year-old.
- 39:35And that's when we can co-diagnose autism spectrum along with IDD.
- 39:39So yes, they can both be diagnosed together, IDD and ASD.
- 39:48Another question reads, when a diagnosis is made, does it specifically state
- 39:52in the diagnosis which level the patient is experiencing?
- 39:57It's a specifier. So the diagnosis of autism can be made and then the level of support that can be.
- 40:04Does it specifically state in the diagnosis which level the patient is experiencing?
- 40:09So that is something that can probably change over time, you know,
- 40:13depending on the support level that they need.
- 40:16Okay but just because there is a diagnosis we
- 40:19don't they again if it's done by a psychologist then they will probably put
- 40:24like the level of support it's a space fire and i think someone said why is
- 40:30the case level two and not one i think i'm guessing it's about the case that we discussed,
- 40:39So I would say two, because the kid is, the symptoms are pretty overt.
- 40:45He's the high fixation of interest. And I think he would need more than just
- 40:50individual therapy or like some life skills coaching.
- 40:53I think he would benefit from like social skills training.
- 40:56So that's probably why. And he probably needs some accommodations in school.
- 41:02So unbehavioral therapy, which is why I would probably put it at level two.
- 41:06I see another one does ABA include OT or do we have to make a separate referral
- 41:11to OT I think that would be a different the occupational therapy referral would
- 41:14be different than that of ABA.
- 41:18Any autism support groups in san antonio
- 41:22for parents yes there are definitely autism speaks is
- 41:25a good one and then if you are already
- 41:28not familiar with the morgan's mac they have
- 41:31the multi-access center where they have
- 41:34a it's like a one-stop shop it's
- 41:37not only exclusive it's not exclusive for kids who are
- 41:40on the autism spectrum any with any developmental disabilities
- 41:44or even other disabilities they can actually access the mac and they can they're
- 41:49assigned a care navigator who can coordinate the care for like they can support
- 41:54the family they can support the patient or individual so that can be a good
- 41:58resource as well patient appears would benefit with.
- 42:03Noise canceling headphones i'm guessing it's about the care case yes i think
- 42:07yeah some individuals we actually recommend like noise-canceling headphones.
- 42:13And in the case, yes, it can be one of the accommodations that the person, that the kid could get.
- 42:21Any autism support in San Antonio for older kids, teens, who may be never,
- 42:27who have never completed ABA a form that most ABA centers are for young kids?
- 42:33It is true, yeah, I know a lot of the autisms, the ABA
- 42:36providers are kind of have like an age restriction or
- 42:39cutoff but it can be even for like older teens and adolescents it's just that
- 42:43there is like limited support again one of the best resources I would recommend
- 42:47is trying the Morgan's multi-assistance center and I can probably also email
- 42:55I have a list of some places that I can probably share Mr.
- 42:58Silva if I share with you you can probably send it to the group yeah okay can
- 43:03school-age patients with autism who have aggressive and self-injurious behaviors
- 43:07benefit from a behavior modification plan.
- 43:11Yes the behavioral plans can i
- 43:14mean the aggressive behaviors and self-injurious behaviors they have like different
- 43:18behavioral modification plans oftentimes they kind of identify what could be
- 43:22the triggers to modify the setting sometimes even when there's like no apparent
- 43:27triggers they I also give them like helmets or like long sleeves and other issues.
- 43:33Do you see patients, young patients? Yes, I see ages four plus.
- 43:39I've actually seen kids as young as three in the dual diagnosis.
- 43:42Music.
- 43:48We hope you've enjoyed this episode of Pediatrics Now.
- 43:52Click on the link for free credit if you're a practitioner. You can also email
- 43:56us with questions or episode ideas.
- 43:58That address is pediatricsnow at uthscsa.edu.
- 44:04We release a new episode every Friday.
- 44:07I'm Holly Wehman. I hope you can join us for our next episode.