302-Senescence: Double-Edged Sword in Precancer Interception

Paper Talk · Dec 7, 2025 · 14m

This commentary examines the ambivalent role of cellular senescence in the earliest stages of cancer, noting that it initially serves as a vital but transient tumor-suppressive barrier that eventually transitions into a pro-tumorigenic state. The authors analyze how this process extends beyond epithelial cells, highlighting the deleterious impact of senescence in stromal and immune cells that collectively reshape the precancer tissue microenvironment (PreTME). The text reviews promising precision interception strategies, including pharmacological agents (senolytics and senomorphics) and…